• 10528 Citations
  • 56 h-Index
19992020

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γc-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes

Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Hong, Y. W., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., Aug 15 2008, In : Journal of Immunology. 181, 4, p. 2506-2512 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

α-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis

Witkiewicz, A. K., Varambally, S., Shen, R., Mehra, R., Sabel, M. S., Ghosh, D., Chinnaiyan, A. M., Rubin, M. A. & Kleer, C. G., Jun 1 2005, In : Cancer Epidemiology Biomarkers and Prevention. 14, 6, p. 1418-1423 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W. C., Mansour, J., Mollaee, M., Wagner, K. U., Koduru, P., Yopp, A., Choti, M. A., Yeo, C. J., McCue, P., White, M. A. & Knudsen, E. S., Apr 10 2015, In : Nature communications. 6, 6744.

Research output: Contribution to journalArticle

435 Scopus citations

Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

Witkiewicz, A. K., Whitaker-Menezes, D., Dasgupta, A., Philp, N. J., Lin, Z., Gandara, R., Sneddon, S., Martinez-Outschoorn, U. E., Sotgia, F. & Lisanti, M. P., Mar 15 2012, In : Cell Cycle. 11, 6, p. 1108-1117 10 p.

Research output: Contribution to journalArticle

153 Scopus citations

Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation

Mercier, I., Bryant, K. G., Sotgia, F., Bonuccelli, G., Witkiewicz, A. K., Dasgupta, A., Jasmin, J. F., Pestell, R. G. & Lisanti, M. P., May 1 2009, In : Cell Cycle. 8, 9, p. 1396-1401 6 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Unique metabolic features of pancreatic cancer stroma: Relevance to the tumor compartment, prognosis, and invasive potential

Knudsen, E. S., Balaji, U., Freinkman, E., McCue, P. & Witkiewicz, A. K., 2016, In : Oncotarget. 7, 48, p. 78396-78411 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Martinez-Outschoorn, U. E., Pavlides, S., Whitaker-Menezes, D., Daumer, K. M., Milliman, J. N., Chiavarina, B., Migneco, G., Witkiewicz, A. K., Martinez-Cantarin, M. P., Flomenberg, N., Howell, A., Pestell, R. G., Lisanti, M. P. & Sotgia, F., Jun 15 2010, In : Cell Cycle. 9, 12, p. 2423-2433 11 p.

Research output: Contribution to journalArticle

164 Scopus citations

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase

Costantino, C. L., Witkiewicz, A. K., Kuwano, Y., Cozzitorto, J. A., Kennedy, E. P., Dasgupta, A., Keen, J. C., Yeo, C. J., Gorospe, M. & Brody, J. R., Jun 1 2009, In : Cancer research. 69, 11, p. 4567-4572 6 p.

Research output: Contribution to journalArticle

127 Scopus citations

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., Casimiro, M. C., Wang, C., Fortina, P., Addya, S., Pestell, R. G., Martinez-Outschoorn, U. E., Sotgia, F. & Lisanti, M. P., Dec 1 2009, In : Cell Cycle. 8, 23, p. 3984-4001 18 p.

Research output: Contribution to journalArticle

Open Access
655 Scopus citations

The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Bonuccelli, G., Whitaker-Menezes, D., Castello-Cros, R., Pavlides, S., Pestell, R. G., Fatatis, A., Witkiewicz, A. K., Vander Heiden, M. G., Migneco, G., Chiavarina, B., Frank, P. G., Capozza, F., Flomenberg, N., Martinez-Outschoorn, U. E., Sotgia, F. & Lisanti, M. P., May 15 2010, In : Cell Cycle. 9, 10, p. 1960-1971 12 p.

Research output: Contribution to journalArticle

132 Scopus citations

The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

Witkiewicz, A. K., Cox, D. W., Rivadeneira, D., Ertel, A. E., Fortina, P., Schwartz, G. F. & Knudsen, E. S., Jul 24 2014, In : Oncogene. 33, 30, p. 3980-3991 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression

Sharma, A., Yeow, W. S., Ertel, A., Coleman, I., Clegg, N., Thangavel, C., Morrissey, C., Zhang, X., Comstock, C. E. S., Witkiewicz, A. K., Gomella, L., Knudsen, E. S., Nelson, P. S. & Knudsen, K. E., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4478-4492 15 p.

Research output: Contribution to journalArticle

194 Scopus citations

The RB tumor suppressor at the intersection of proliferation and immunity: Relevance to disease immune evasion and immunotherapy

Hutcheson, J., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3812-3819 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors

Dean, J. L., McClendon, A. K., Hickey, T. E., Butler, L. M., Tilley, W. D., Witkiewicz, A. K. & Knudsen, E. S., Jul 15 2012, In : Cell Cycle. 11, 14, p. 2756-2761 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapy-resistant breast cancer

Thangavel, C., Dean, J. L., Ertel, A., Knudsen, K. E., Aldaz, C. M., Witkiewicz, A. K., Clarke, R. & Knudsen, E. S., Jun 1 2011, In : Endocrine-Related Cancer. 18, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

155 Scopus citations

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

Blanco, F. F., Jimbo, M., Wulfkuhle, J., Gallagher, I., Deng, J., Enyenihi, L., Meisner-Kober, N., Londin, E., Rigoutsos, I., Sawicki, J. A., Risbud, M. V., Witkiewicz, A. K., McCue, P. A., Jiang, W., Rui, H., Yeo, C. J., Petricoin, E., Winter, J. M. & Brody, J. R., May 1 2016, In : Oncogene. 35, 19, p. 2529-2541 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

Witkiewicz, A. K., Chung, S., Brough, R., Vail, P., Franco, J., Lord, C. J. & Knudsen, E. S., Jan 30 2018, In : Cell Reports. 22, 5, p. 1185-1199 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers

Witkiewicz, A. K., Balaji, U. & Knudsen, E. S., Sep 15 2014, In : Clinical Cancer Research. 20, 18, p. 4837-4848 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature

Witkiewicz, A. K., Kennedy, E. P., Kennyon, L., Yeo, C. J. & Hruban, R. H., Oct 1 2008, In : Human Pathology. 39, 10, p. 1548-1551 4 p.

Research output: Contribution to journalArticle

88 Scopus citations

Superficial (early) endocervical adenocarcinoma in situ: A study of 12 cases and comparison to conventional AIS

Witkiewicz, A., Lee, K. R., Brodsky, G., Cviko, A., Brodsky, J. & Crum, C. P., Dec 2005, In : American Journal of Surgical Pathology. 29, 12, p. 1609-1614 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Subject Review: Pancreatic Ductal Adenocarcinoma in the Setting of Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Gene: Case Report and Review of the Literature

Rittenhouse, D. W., Talbott, V. A., Anklesaria, Z., Brody, J. R., Witkiewicz, A. K. & Yeo, C. J., Dec 1 2011, In : Journal of Gastrointestinal Surgery. 15, 12, p. 2284-2290 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence

Witkiewicz, A. K., Freydin, B., Chervoneva, I., Potoczek, M., Rizzo, W., Rui, H., Brody, J. R., Schwartz, G. F. & Lisanti, M. P., Aug 15 2010, In : Cancer Biology and Therapy. 10, 4, p. 391-396 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

Witkiewicz, A. K., Dasgupta, A., Nguyen, K. H., Liu, C., Kovatich, A. J., Schwartz, G. F., Pestell, R. G., Sotgia, F., Rui, H. & Lisanti, M. P., Jun 1 2009, In : Cancer Biology and Therapy. 8, 11, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

Open Access
104 Scopus citations

Stratification of pancreatic ductal adenocarcinoma: Combinatorial genetic, stromal, and immunologic markers

Knudsen, E. S., Vail, P., Balaji, U., Ngo, H., Botros, I. W., Makarov, V., Riaz, N., Balachandran, V., Leach, S., Thompson, D. M., Chan, T. A. & Witkiewicz, A. K., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4429-4440 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

Bendris, N., Stearns, C. J. S., Reis, C. R., Rodriguez-Canales, J., Liu, H., Witkiewicz, A. W. & Schmid, S. L., Jul 15 2016, In : Journal of cell science. 129, 14, p. 2804-2816 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma

Valsecchi, M. E., Coronel, M., Intenzo, C. M., Kim, S. M., Witkiewicz, A. K. & Sato, T., Feb 1 2013, In : Melanoma research. 23, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Single nucleotide polymorphismin RECQL and survival in resectable pancreatic adenocarcinoma

Cotton, R. T., Li, D., Scherer, S. E., Muzny, D. M., Hodges, S. E., Catania, R. L., Witkiewicz, A. K., Brody, J. R., Kennedy, E. P., Yeo, C. J., Brunicardl, F. C., Gibbs, R. G., Gingras, M. C. & Fisher, W. E., Jan 1 2009, In : HPB. 11, 5, p. 435-444 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors

Mannakee, B. K., Balaji, U., Witkiewicz, A. K., Gutenkunst, R. N. & Knudsen, E. S., May 15 2018, In : Bioinformatics. 34, 10, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Witkiewicz, A. K., Borja, N. A., Franco, J., Brody, J. R., Yeo, C. J., Mansour, J., Choti, M. A., McCue, P. & Knudsen, E. S., 2015, In : Oncotarget. 6, 18, p. 15788-15801 14 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Sampling strategies to capture single-cell heterogeneity

Rajaram, S., Heinrich, L. E., Gordan, J. D., Avva, J., Bonness, K. M., Witkiewicz, A. K., Malter, J. S., Atreya, C. E., Warren, R. S., Wu, L. F. & Altschuler, S. J., Oct 1 2017, In : Nature methods. 14, 10, p. 967-970 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Retinoblastoma protein potentiates the innate immune response in hepatocytes: Significance for hepatocellular carcinoma

Hutcheson, J., Bourgo, R. J., Balaji, U., Ertel, A., Witkiewicz, A. K. & Knudsen, E. S., Oct 1 2014, In : Hepatology. 60, 4, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Retinoblastoma and phosphate and tensin homolog tumor suppressors: Impact on ductal carcinoma in situ progression

Knudsen, E. S., Pajak, T. F., Qeenan, M., Mcclendon, A. K., Armon, B. D., Schwartz, G. F. & Witkiewicz, A. K., Dec 1 2012, In : Journal of the National Cancer Institute. 104, 23, p. 1825-1836 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Renal cell carcinoma metastatic to the duodenum: Treatment by classic pancreaticoduodenectomy and review of the literature

Adamo, R., Greaney, P. J., Witkiewicz, A., Kennedy, E. P. & Yeo, C. J., Aug 2008, In : Journal of Gastrointestinal Surgery. 12, 8, p. 1465-1468 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulation of miR106b cluster through the RB pathway: Mechanismand functional targets

Thangavel, C., Boopathi, E., Ertel, A., Lim, M., Addya, S., Fortina, P., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2013, In : Cell Cycle. 12, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia

Brody, J. R., Witkiewicz, A., Williams, T. K., Kadkol, S. S., Cozzitorto, J., Durkan, B., Pasternack, G. R. & Yeo, C. J., Dec 14 2007, In : Modern Pathology. 20, 12, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

RB tumor suppressive function in response to xenobiotic hepatocarcinogens

Reed, C., Hutcheson, J., Mayhew, C. N., Witkiewicz, A. K. & Knudsen, E. S., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

RB Restricts DNA Damage-Initiated Tumorigenesis through an LXCXE-Dependent Mechanism of Transcriptional Control

Bourgo, R. J., Thangavel, C., Ertel, A., Bergseid, J., Kathleen McClendon, A., Wilkens, L., Witkiewicz, A. K., Wang, J. Y. J. & Knudsen, E. S., Aug 19 2011, In : Molecular cell. 43, 4, p. 663-672 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer

Witkiewicz, A. K., Ertel, A., McFalls, J., Valsecchi, M. E., Schwartz, G. & Knudsen, E. S., Sep 15 2012, In : Clinical Cancer Research. 18, 18, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

RB-pathway disruption in breast cancer: Differential association with disease subtypes, disease-specific prognosis and therapeutic response

Ertel, A., Dean, J. L., Rui, H., Liu, C., Witkiewicz, A. K., Knudsen, K. E. & Knudsen, E. S., Oct 15 2010, In : Cell Cycle. 9, 20, p. 4153-4163 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

Knudsen, E. S., Kathleen McClendon, A., Franco, J., Ertel, A., Fortina, P. & Witkiewicz, A. K., Jan 1 2015, In : Cell Cycle. 14, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1

Reed, C. A., Mayhew, C. N., McClendon, A. K., Yang, X., Witkiewicz, A. & Knudsen, E. S., Dec 1 2009, In : Oncogene. 28, 50, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage

McClendon, A. K., Dean, J. L., Ertel, A., Fu, Z., Rivadeneira, D. B., Reed, C. A., Bourgo, R. J., Witkiewicz, A., Addya, S., Mayhew, C. N., Grimes, H. L., Fortina, P. & Knudsen, E. S., Oct 2011, In : Gastroenterology. 141, 4, p. 1439-1450 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pyruvate kinase expression (PKM1 and PKM2) in cancer associated fibroblasts drives stromal nutrient production and tumor growth

Chiavarina, B., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pestell, R. G., Smith, J., Daniel, R., Sotgia, F. & Lisanti, M. P., Dec 15 2011, In : Cancer Biology and Therapy. 12, 12, p. 1101-1113 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

PTP1B suppresses prolactin activation of Stat5 in breast cancer cells

Johnson, K. J., Peck, A. R., Liu, C., Tran, T. H., Utama, F. E., Sjolund, A. B., Schaber, J. D., Witkiewicz, A. K. & Rui, H., Dec 2010, In : American Journal of Pathology. 177, 6, p. 2971-2983 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Prolactin inhibits BCL6 expression in breast cancer through a stat5a-dependent mechanism

Tran, T. H., Utama, F. E., Lin, J., Yang, N., Sjolund, A. B., Ryder, A., Johnson, K. J., Neilson, L. M., Liu, C., Brill, K. L., Rosenberg, A. L., Witkiewicz, A. K. & Rui, H., Feb 15 2010, In : Cancer research. 70, 4, p. 1711-1721 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia

Knudsen, E. S., Ertel, A., Davicioni, E., Kline, J., Schwartz, G. F. & Witkiewicz, A. K., Jun 1 2012, In : Breast Cancer Research and Treatment. 133, 3, p. 1009-1024 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer

Harris, L. N., You, F., Schnitt, S. J., Witkiewicz, A., Lu, X., Sgroi, D., Ryan, P. D., Come, S. E., Burstein, H. J., Lesnikoski, B. A., Kamma, M., Friedman, P. N., Gelman, R., Iglehart, J. D. & Winer, E. P., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

182 Scopus citations

pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs

Williams, T. K., Costantino, C. L., Bildzukewicz, N. A., Richards, N. G., Rittenhouse, D. W., Einstein, L., Cozzitorto, J. A., Keen, J. C., Dasgupta, A., Gorospe, M., Gonye, G. E., Yeo, C. J., Witkiewicz, A. K. & Brody, J. R., Dec 10 2010, In : PloS one. 5, 11, e15455.

Research output: Contribution to journalArticle

31 Scopus citations

Pityriasis rubra pilaris, type IV

Bragg, J., Witkiewicz, A., Orlow, S. J. & Schaffer, J. V., Jan 1 2005, In : Dermatology online journal. 11, 4

Research output: Contribution to journalArticle

7 Scopus citations

Periampullary and duodenal neoplasms in neurofibromatosis type 1: Two cases and an updated 20-year review of the literature yielding 76 cases

Relles, D., Baek, J., Witkiewicz, A. & Yeo, C. J., May 26 2010, In : Journal of Gastrointestinal Surgery. 14, 6, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

61 Scopus citations