• 10528 Citations
  • 56 h-Index
19992020

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Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

Mercier, I., Casimiro, M. C., Wang, C., Rosenberg, A. L., Quong, J., Minkeu, A., Allen, K. G., Danilo, C., Sotgia, F., Bonuccelli, G., Jasmin, J. F., Xu, H., Bosco, E., Aronow, B., Witkiewicz, A., Pestell, R. G., Knudsen, E. S. & Lisanti, M. P., Aug 2008, In : Cancer Biology and Therapy. 7, 8, p. 1212-1225 14 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

HuR's post-transcriptional regulation of death receptor 5 in pancreatic cancer cells

Pineda, D. M., Rittenhouse, D. W., Valley, C. C., Cozzitorto, J. A., Burkhart, R. A., Leiby, B., Winter, J. M., Weber, M. C., Londin, E. R., Rigoutsos, I., Yeo, C. J., Gorospe, M., Witkiewicz, A. K., Sachs, J. N. & Brody, J. R., Aug 1 2012, In : Cancer Biology and Therapy. 13, 10, p. 946-955 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients

Richards, N. G., Rittenhouse, D. W., Freydin, B., Cozzitorto, J. A., Grenda, D., Rui, H., Gonye, G., Kennedy, E. P., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Sep 2010, In : Annals of surgery. 252, 3, p. 499-505 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., Pavlides, S., Tsirigos, A., Ertel, A., Pestell, R. G., Broda, P., Minetti, C., Lisanti, M. P. & Sotgia, F., Dec 1 2011, In : Cell Cycle. 10, 23, p. 4047-4064 18 p.

Research output: Contribution to journalArticle

165 Scopus citations

IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

Marzec, M., Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Odum, N. & Wasik, M. A., Feb 15 2008, In : Blood. 111, 4, p. 2181-2189 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Immunologic and metabolic features of pancreatic ductal adenocarcinoma define prognostic subtypes of disease

Hutcheson, J., Balaji, U., Porembka, M. R., Wachsmann, M. B., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3606-3617 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

Toll, A. D., Dasgupta, A., Potoczek, M., Yeo, C. J., Kleer, C. G., Brody, J. R. & Witkiewicz, A. K., Sep 1 2010, In : Human Pathology. 41, 9, p. 1205-1209 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins

Witkiewicz, A. K., McConnell, T., Potoczek, M., Emmons, R. V. B. & Kurman, R. J., Jan 1 2010, In : Human Pathology. 41, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma

Behling, K. C., Tang, A., Freydin, B., Chervoneva, I., Kadakia, S., Schwartz, G. F., Rui, H. & Witkiewicz, A. K., Oct 1 2011, In : Breast Cancer Research and Treatment. 129, 3, p. 717-724 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: Role of osteopontin

Lazar, M., Sullivan, J., Chipitsyna, G., Aziz, T., Salem, A. F., Gong, Q., Witkiewicz, A., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Jun 25 2010, In : Surgery. 148, 2, p. 298-309 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Witkiewicz, A. K., Balaji, U., Eslinger, C., McMillan, E., Conway, W., Posner, B., Mills, G. B., O'Reilly, E. M. & Knudsen, E. S., Aug 16 2016, In : Cell Reports. 16, 7, p. 2017-2031 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Grant, A. D., Vail, P., Padi, M., Witkiewicz, A. K. & Knudsen, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 12766.

Research output: Contribution to journalArticle

Open Access

Intraductal Papillary Mucinous Neoplasm (IPMN) with Extra-Pancreatic Mucin: A Case Series and Review of the Literature

Rosenberger, L. H., Stein, L. H., Witkiewicz, A. K., Kennedy, E. P. & Yeo, C. J., Apr 1 2012, In : Journal of Gastrointestinal Surgery. 16, 4, p. 762-770 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

Lazar, M., Sullivan, J., Chipitsyna, G., Gong, Q., Ng, C. Y., Salem, A. F., Aziz, T., Witkiewicz, A., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Sep 8 2010, In : Journal of Gastrointestinal Surgery. 14, 10, p. 1566-1577 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

Valsecchi, M. E., Holdbrook, T., Leiby, B. E., Pequignot, E., Littman, S. J., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Mar 22 2012, In : BMC Cancer. 12, 104.

Research output: Contribution to journalArticle

24 Scopus citations

Juvenile amyopathic dermatomyositis

Henning, J. S., Witkiewicz, A., Schaffer, J. V. & Orlow, S. J., Jan 1 2005, In : Dermatology online journal. 11, 4

Research output: Contribution to journalArticle

4 Scopus citations

Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

Jansen, V. M., Bhola, N. E., Bauer, J. A., Formisano, L., Lee, K. M., Hutchinson, K. E., Witkiewicz, A. K., Moore, P. D., Estrada, M. V., Sánchez, V., Ericsson, P. G., Sanders, M. E., Pohlmann, P. R., Pishvaian, M. J., Riddle, D. A., Dugger, T. C., Wei, W., Knudsen, E. S. & Arteaga, C. L., May 1 2017, In : Cancer research. 77, 9, p. 2488-2499 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., Nov 12 2018, In : Cancer Cell. 34, 5, p. 807-822.e7

Research output: Contribution to journalArticle

28 Scopus citations

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

Sotgia, F., Casimiro, M. C., Bonuccelli, G., Liu, M., Whitaker-Menezes, D., Er, O., Daumer, K. M., Mercier, I., Witkiewicz, A. K., Minetti, C., Capozza, F., Gormley, M., Quong, A. A., Rui, H., Frank, P. G., Milliman, J. N., Knudsen, E. S., Zhou, J., Wang, C., Pestell, R. G. & 1 others, Lisanti, M. P., Feb 2009, In : American Journal of Pathology. 174, 2, p. 613-629 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure

Peck, A. R., Witkiewicz, A. K., Liu, C., Stringer, G. A., Klimowicz, A. C., Pequignot, E., Freydin, B., Tran, T. H., Yang, N., Rosenberg, A. L., Hooke, J. A., Kovatich, A. J., Nevalainen, M. T., Shriver, C. D., Hyslop, T., Sauter, G., Rimm, D. L., Magliocco, A. M. & Rui, H., Jun 20 2011, In : Journal of Clinical Oncology. 29, 18, p. 2448-2458 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma.

Witkiewicz, A., Raghunath, P., Wasik, A., Junkins-Hopkins, J. M., Jones, D., Zhang, Q., Odum, N. & Wasik, M. A., Mar 1 2007, In : Human Pathology. 38, 3, p. 462-467 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Loss of stromal Caveolin-1 expression in malignant melanoma metastases predicts poor survival

Wu, K. N., Queenan, M., Brody, J. R., Potoczek, M., Sotgia, F., Lisanti, M. P. & Witkiewicz, A. K., Dec 15 2011, In : Cell Cycle. 10, 24, p. 4250-4255 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

Witkiewicz, A. K., Dasgupta, A., Sammons, S., Er, O., Potoczek, M. B., Guiles, F., Sotgia, F., Brody, J. R., Mitchell, E. P. & Lisanti, M. P., Jul 15 2010, In : Cancer Biology and Therapy. 10, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations

Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

Peck, A. R., Witkiewicz, A. K., Liu, C., Klimowicz, A. C., Stringer, G. A., Pequignot, E., Freydin, B., Yang, N., Ertel, A., Tran, T. H., Girondo, M. A., Rosenberg, A. L., Hooke, J. A., Kovatich, A. J., Shriver, C. D., Rimm, D. L., Magliocco, A. M., Hyslop, T. & Rui, H., Oct 4 2012, In : Breast Cancer Research. 14, 5, R130.

Research output: Contribution to journalArticle

45 Scopus citations

Malignant melanoma of the gallbladder: A report of two cases and review of the literature

Samplaski, M. K., Rosato, E. L., Witkiewicz, A. K., Mastrangelo, M. J. & Berger, A. C., Jun 1 2008, In : Journal of Gastrointestinal Surgery. 12, 6, p. 1123-1126 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Malignant melanoma presenting as obstructive jaundice secondary to metastasis to the ampulla of vater

Marks, J. A., Rao, A. S., Loren, D., Witkiewicz, A., Mastrangelo, M. J. & Berger, A. C., Mar 2010, In : Journal of the Pancreas. 11, 2, p. 173-175 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

Castello-Cros, R., Bonuccelli, G., Molchansky, A., Capozza, F., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pestell, R. G., Whitaker-Menezes, D., Sotgia, F. & Lisanti, M. P., Jun 15 2011, In : Cell Cycle. 10, 12, p. 2021-2034 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

Baek, G. H., Tse, Y. F., Hu, Z., Cox, D., Buboltz, N., McCue, P., Yeo, C. J., White, M. A., DeBerardinis, R. J., Knudsen, E. S. & Witkiewicz, A. K., Dec 24 2014, In : Cell Reports. 9, 6, p. 2233-2249 17 p.

Research output: Contribution to journalArticle

86 Scopus citations

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Abel, E. V., Basile, K. J., Kugel, C. H., Witkiewicz, A. K., Le, K., Amaravadi, R. K., Karakousis, G. C., Xu, X., Xu, W., Schuchter, L. M., Lee, J. B., Ertel, A., Fortina, P. & Aplin, A. E., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 2155-2168 14 p.

Research output: Contribution to journalArticle

152 Scopus citations

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K. & Knudsen, E. S., Feb 9 2016, In : Cell Reports. 14, 5, p. 979-990 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Metastatic melanoma causing jejunal intussusception

Mucci, T., Long, W., Witkiewicz, A., Mastrangelo, M. J., Rosato, E. L. & Berger, A. C., Dec 1 2007, In : Journal of Gastrointestinal Surgery. 11, 12, p. 1755-1757 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Microglandular hyperplasia: A model for the de novo emergence and evolution of endocervical reserve cells

Witkiewicz, A. K., Hecht, J. L., Cviko, A., McKeon, F. D., Ince, T. A. & Crum, C. P., Feb 2005, In : Human Pathology. 36, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue

Sotgia, F., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., Philp, N. J., Pestell, R. G. & Lisanti, M. P., Apr 1 2012, In : Cell Cycle. 11, 7, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival

Burkhart, R. A., Peng, Y., Norris, Z. A., Tholey, R. M., Talbott, V. A., Liang, Q., Ai, Y., Miller, K., Lal, S., Cozzitorto, J. A., Witkiewicz, A. K., Yeo, C. J., Gehrmann, M., Napper, A., Winter, J. M., Sawicki, J. A., Zhuang, Z. & Brody, J. R., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 901-911 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

Witkiewicz, A. K., Kline, J., Queenan, M., Brody, J. R., Tsirigos, A., Bilal, E., Pavlides, S., Ertel, A., Sotgia, F. & Lisanti, M. P., Jun 1 2011, In : Cell Cycle. 10, 11, p. 1794-1809 16 p.

Research output: Contribution to journalArticle

66 Scopus citations

Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient

Talbott, V. A., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Jul 1 2012, In : Journal of Surgical Research. 176, 1, p. 154-158 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

MR imaging for predicting the recurrence of pancreatic carcinoma after surgical resection

Zhang, X. M., Mitchell, D. G., Byun, J. H., Verma, S. K., Bergin, D. & Witkiewicz, A., Mar 1 2010, In : European Journal of Radiology. 73, 3, p. 572-578 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

MUC1 promoter-driven DTA as a targeted therapeutic strategy against pancreatic cancer

Tholey, R. M., Lal, S., Jimbo, M., Burkhart, R. A., Blanco, F. F., Cozzitorto, J. A., Eisenberg, J. D., Jiang, W., Iacobuzio-Donahue, C. A., Witkiewicz, A. K., Glbert, M., Yeo, C. J., Brody, J. R., Sawicki, J. A. & Winter, J. M., Mar 1 2015, In : Molecular Cancer Research. 13, 3, p. 439-448 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mucocutaneous neuromas: An underrecognized manifestation of PTEN hamartoma-tumor syndrome

Schaffer, J. V., Kamino, H., Witkiewicz, A., McNiff, J. M. & Orlow, S. J., May 1 2006, In : Archives of Dermatology. 142, 5, p. 625-632 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Mutations in the desmoglein 4 gene underlie localized autosomal recessive hypotrichosis with monilethrix hairs and congenital scalp erosions

Schaffer, J. V., Bazzi, H., Vitebsky, A., Witkiewicz, A., Kovich, O. I., Kamino, H., Shapiro, L. S., Amin, S. P., Orlow, S. J. & Christiano, A. M., Jun 1 2006, In : Journal of Investigative Dermatology. 126, 6, p. 1286-1291 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells

Showalter, S. L., Huang, Y. H., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Green, J. J., Langer, R., Anderson, D. G., Sawicki, J. A. & Brody, J. R., Oct 2008, In : Cancer Biology and Therapy. 7, 10, p. 1584-1590 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway

Showalter, S. L., Wang, Z., Costantino, C. L., Witkiewicz, A. K., Yeo, C. J., Brody, J. R. & Carr, B. I., Apr 2010, In : Journal of Gastroenterology and Hepatology (Australia). 25, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer

Su, Y., Li, J., Witkiewicz, A. K., Brennan, D., Neill, T., Talarico, J. & Radice, G. L., Oct 11 2012, In : Oncogene. 31, 41, p. 4484-4489 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

One year survival with poorly differentiated metastatic pancreatic carcinoma following chemoembolization with gemcitabine and cisplatin

Brown, D. B., Gonsalves, C. F., Yeo, C. J., Witkiewicz, A. K. & Carr, B. I., Sep 1 2010, In : Oncology reports. 24, 3, p. 767-769 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

Martinez-Outschoorn, U. E., Balliet, R. M., Rivadeneira, D. B., Chiavarina, B., Pavlides, S., Wang, C., Whitaker-Menezes, D., Daumer, K. M., Lin, Z., Witkiewicz, A. K., Flomenberg, N., Howell, A., Pestell, R. G., Knudsen, E. S., Sotgia, F. & Lisanti, M. P., Aug 15 2010, In : Cell Cycle. 9, 16, p. 3256-3276 21 p.

Research output: Contribution to journalArticle

300 Scopus citations

P27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., Bunch, K. L., Tripathi, S., Knudsen, E. S., Witkiewicz, A. K., Shokat, K. M. & Rubin, S. M., Dec 13 2019, In : Science. 366, 6471, eaaw2106.

Research output: Contribution to journalArticle

9 Scopus citations

Pan-cancer molecular analysis of the RB tumor suppressor pathway

Knudsen, E. S., Nambiar, R., Rosario, S. R., Smiraglia, D. J., Goodrich, D. W. & Witkiewicz, A. K., Dec 1 2020, In : Communications Biology. 3, 1, 158.

Research output: Contribution to journalArticle

Open Access

Pancreatic cancer cell lines as patient-derived avatars: Genetic characterisation and functional utility

Knudsen, E. S., Balaji, U., Mannakee, B., Vail, P., Eslinger, C., Moxom, C., Mansour, J. & Witkiewicz, A. K., Jan 10 2017, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

28 Scopus citations

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., Asara, J. M., Evans, R. M., Cantley, L. C., Lyssiotis, C. A. & Kimmelman, A. C., Aug 10 2016, In : Nature. 536, 7617, p. 479-483 5 p.

Research output: Contribution to journalArticle

315 Scopus citations

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

Briggs, KJ. J., Koivunen, P., Cao, S., Backus, KM. M., Olenchock, BA. A., Patel, H., Zhang, Q., Signoretti, S., Gerfen, GJ. J., Richardson, AL. L., Witkiewicz, AK. K., Cravatt, BF. F., Clardy, J. & Kaelin, WG. G., Jun 30 2016, In : Cell. 166, 1, p. 126-139 14 p.

Research output: Contribution to journalArticle

73 Scopus citations