• 10528 Citations
  • 56 h-Index
19992020

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Article
2010

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Martinez-Outschoorn, U. E., Trimmer, C., Lin, Z., Whitaker-Menezes, D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Martinez-Cantarin, M. P., Capozza, F., Witkiewicz, A. K., Flomenberg, N., Howell, A., Pestell, R. G., Caro, J., Lisanti, M. P. & Sotgia, F., Sep 1 2010, In : Cell Cycle. 9, 17, p. 3515-3533 19 p.

Research output: Contribution to journalArticle

247 Scopus citations

A western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer

Llaverias, G., Danilo, C., Wang, Y., Witkiewicz, A. K., Daumer, K., Lisanti, M. P. & Frank, P. G., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3180-3191 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Detection of merkel cell carcinoma polyomavirus in mucosal merkel cell carcinoma

Wu, K. N., McCue, P. A., Berger, A., Spiegel, J. R., Wang, Z. X. & Witkiewicz, A. K., Oct 2010, In : International Journal of Surgical Pathology. 18, 5, p. 342-346 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients

Richards, N. G., Rittenhouse, D. W., Freydin, B., Cozzitorto, J. A., Grenda, D., Rui, H., Gonye, G., Kennedy, E. P., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Sep 2010, In : Annals of surgery. 252, 3, p. 499-505 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

Toll, A. D., Dasgupta, A., Potoczek, M., Yeo, C. J., Kleer, C. G., Brody, J. R. & Witkiewicz, A. K., Sep 1 2010, In : Human Pathology. 41, 9, p. 1205-1209 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins

Witkiewicz, A. K., McConnell, T., Potoczek, M., Emmons, R. V. B. & Kurman, R. J., Jan 1 2010, In : Human Pathology. 41, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: Role of osteopontin

Lazar, M., Sullivan, J., Chipitsyna, G., Aziz, T., Salem, A. F., Gong, Q., Witkiewicz, A., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Jun 25 2010, In : Surgery. 148, 2, p. 298-309 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

Lazar, M., Sullivan, J., Chipitsyna, G., Gong, Q., Ng, C. Y., Salem, A. F., Aziz, T., Witkiewicz, A., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Sep 8 2010, In : Journal of Gastrointestinal Surgery. 14, 10, p. 1566-1577 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

Witkiewicz, A. K., Dasgupta, A., Sammons, S., Er, O., Potoczek, M. B., Guiles, F., Sotgia, F., Brody, J. R., Mitchell, E. P. & Lisanti, M. P., Jul 15 2010, In : Cancer Biology and Therapy. 10, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations

Malignant melanoma presenting as obstructive jaundice secondary to metastasis to the ampulla of vater

Marks, J. A., Rao, A. S., Loren, D., Witkiewicz, A., Mastrangelo, M. J. & Berger, A. C., Mar 2010, In : Journal of the Pancreas. 11, 2, p. 173-175 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

MR imaging for predicting the recurrence of pancreatic carcinoma after surgical resection

Zhang, X. M., Mitchell, D. G., Byun, J. H., Verma, S. K., Bergin, D. & Witkiewicz, A., Mar 1 2010, In : European Journal of Radiology. 73, 3, p. 572-578 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway

Showalter, S. L., Wang, Z., Costantino, C. L., Witkiewicz, A. K., Yeo, C. J., Brody, J. R. & Carr, B. I., Apr 2010, In : Journal of Gastroenterology and Hepatology (Australia). 25, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

One year survival with poorly differentiated metastatic pancreatic carcinoma following chemoembolization with gemcitabine and cisplatin

Brown, D. B., Gonsalves, C. F., Yeo, C. J., Witkiewicz, A. K. & Carr, B. I., Sep 1 2010, In : Oncology reports. 24, 3, p. 767-769 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

Martinez-Outschoorn, U. E., Balliet, R. M., Rivadeneira, D. B., Chiavarina, B., Pavlides, S., Wang, C., Whitaker-Menezes, D., Daumer, K. M., Lin, Z., Witkiewicz, A. K., Flomenberg, N., Howell, A., Pestell, R. G., Knudsen, E. S., Sotgia, F. & Lisanti, M. P., Aug 15 2010, In : Cell Cycle. 9, 16, p. 3256-3276 21 p.

Research output: Contribution to journalArticle

300 Scopus citations

Periampullary and duodenal neoplasms in neurofibromatosis type 1: Two cases and an updated 20-year review of the literature yielding 76 cases

Relles, D., Baek, J., Witkiewicz, A. & Yeo, C. J., May 26 2010, In : Journal of Gastrointestinal Surgery. 14, 6, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs

Williams, T. K., Costantino, C. L., Bildzukewicz, N. A., Richards, N. G., Rittenhouse, D. W., Einstein, L., Cozzitorto, J. A., Keen, J. C., Dasgupta, A., Gorospe, M., Gonye, G. E., Yeo, C. J., Witkiewicz, A. K. & Brody, J. R., Dec 10 2010, In : PloS one. 5, 11, e15455.

Research output: Contribution to journalArticle

31 Scopus citations

Prolactin inhibits BCL6 expression in breast cancer through a stat5a-dependent mechanism

Tran, T. H., Utama, F. E., Lin, J., Yang, N., Sjolund, A. B., Ryder, A., Johnson, K. J., Neilson, L. M., Liu, C., Brill, K. L., Rosenberg, A. L., Witkiewicz, A. K. & Rui, H., Feb 15 2010, In : Cancer research. 70, 4, p. 1711-1721 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

PTP1B suppresses prolactin activation of Stat5 in breast cancer cells

Johnson, K. J., Peck, A. R., Liu, C., Tran, T. H., Utama, F. E., Sjolund, A. B., Schaber, J. D., Witkiewicz, A. K. & Rui, H., Dec 2010, In : American Journal of Pathology. 177, 6, p. 2971-2983 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

RB-pathway disruption in breast cancer: Differential association with disease subtypes, disease-specific prognosis and therapeutic response

Ertel, A., Dean, J. L., Rui, H., Liu, C., Witkiewicz, A. K., Knudsen, K. E. & Knudsen, E. S., Oct 15 2010, In : Cell Cycle. 9, 20, p. 4153-4163 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence

Witkiewicz, A. K., Freydin, B., Chervoneva, I., Potoczek, M., Rizzo, W., Rui, H., Brody, J. R., Schwartz, G. F. & Lisanti, M. P., Aug 15 2010, In : Cancer Biology and Therapy. 10, 4, p. 391-396 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression

Sharma, A., Yeow, W. S., Ertel, A., Coleman, I., Clegg, N., Thangavel, C., Morrissey, C., Zhang, X., Comstock, C. E. S., Witkiewicz, A. K., Gomella, L., Knudsen, E. S., Nelson, P. S. & Knudsen, K. E., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4478-4492 15 p.

Research output: Contribution to journalArticle

194 Scopus citations

The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Bonuccelli, G., Whitaker-Menezes, D., Castello-Cros, R., Pavlides, S., Pestell, R. G., Fatatis, A., Witkiewicz, A. K., Vander Heiden, M. G., Migneco, G., Chiavarina, B., Frank, P. G., Capozza, F., Flomenberg, N., Martinez-Outschoorn, U. E., Sotgia, F. & Lisanti, M. P., May 15 2010, In : Cell Cycle. 9, 10, p. 1960-1971 12 p.

Research output: Contribution to journalArticle

132 Scopus citations

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Martinez-Outschoorn, U. E., Pavlides, S., Whitaker-Menezes, D., Daumer, K. M., Milliman, J. N., Chiavarina, B., Migneco, G., Witkiewicz, A. K., Martinez-Cantarin, M. P., Flomenberg, N., Howell, A., Pestell, R. G., Lisanti, M. P. & Sotgia, F., Jun 15 2010, In : Cell Cycle. 9, 12, p. 2423-2433 11 p.

Research output: Contribution to journalArticle

164 Scopus citations
2011

Association of RB/p16-pathway perturbations with DCIS recurrence: Dependence on tumor versus tissue microenvironment

Witkiewicz, A. K., Rivadeneira, D. B., Ertel, A., Kline, J., Hyslop, T., Schwartz, G. F., Fortina, P. & Knudsen, E. S., Sep 1 2011, In : American Journal of Pathology. 179, 3, p. 1171-1178 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Caveolin-2-deficient mice show increased sensitivity to endotoxemia

De Almeida, C. J., Witkiewicz, A. K., Jasmin, J. F., Tanowitz, H. B., Sotgia, F., Frank, P. G. & Lisanti, M. P., Jul 1 2011, In : Cell Cycle. 10, 13, p. 2151-2161 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lin, Z., Ertel, A., Flomenberg, N., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pavlides, S., Gandara, R., Pestell, R. G., Sotgia, F., Philp, N. J. & Lisanti, M. P., Jun 1 2011, In : Cell Cycle. 10, 11, p. 1772-1783 12 p.

Research output: Contribution to journalArticle

230 Scopus citations

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., Pavlides, S., Tsirigos, A., Ertel, A., Pestell, R. G., Broda, P., Minetti, C., Lisanti, M. P. & Sotgia, F., Dec 1 2011, In : Cell Cycle. 10, 23, p. 4047-4064 18 p.

Research output: Contribution to journalArticle

165 Scopus citations

Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma

Behling, K. C., Tang, A., Freydin, B., Chervoneva, I., Kadakia, S., Schwartz, G. F., Rui, H. & Witkiewicz, A. K., Oct 1 2011, In : Breast Cancer Research and Treatment. 129, 3, p. 717-724 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure

Peck, A. R., Witkiewicz, A. K., Liu, C., Stringer, G. A., Klimowicz, A. C., Pequignot, E., Freydin, B., Tran, T. H., Yang, N., Rosenberg, A. L., Hooke, J. A., Kovatich, A. J., Nevalainen, M. T., Shriver, C. D., Hyslop, T., Sauter, G., Rimm, D. L., Magliocco, A. M. & Rui, H., Jun 20 2011, In : Journal of Clinical Oncology. 29, 18, p. 2448-2458 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Loss of stromal Caveolin-1 expression in malignant melanoma metastases predicts poor survival

Wu, K. N., Queenan, M., Brody, J. R., Potoczek, M., Sotgia, F., Lisanti, M. P. & Witkiewicz, A. K., Dec 15 2011, In : Cell Cycle. 10, 24, p. 4250-4255 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

Castello-Cros, R., Bonuccelli, G., Molchansky, A., Capozza, F., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pestell, R. G., Whitaker-Menezes, D., Sotgia, F. & Lisanti, M. P., Jun 15 2011, In : Cell Cycle. 10, 12, p. 2021-2034 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

Witkiewicz, A. K., Kline, J., Queenan, M., Brody, J. R., Tsirigos, A., Bilal, E., Pavlides, S., Ertel, A., Sotgia, F. & Lisanti, M. P., Jun 1 2011, In : Cell Cycle. 10, 11, p. 1794-1809 16 p.

Research output: Contribution to journalArticle

66 Scopus citations

Pyruvate kinase expression (PKM1 and PKM2) in cancer associated fibroblasts drives stromal nutrient production and tumor growth

Chiavarina, B., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pestell, R. G., Smith, J., Daniel, R., Sotgia, F. & Lisanti, M. P., Dec 15 2011, In : Cancer Biology and Therapy. 12, 12, p. 1101-1113 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage

McClendon, A. K., Dean, J. L., Ertel, A., Fu, Z., Rivadeneira, D. B., Reed, C. A., Bourgo, R. J., Witkiewicz, A., Addya, S., Mayhew, C. N., Grimes, H. L., Fortina, P. & Knudsen, E. S., Oct 2011, In : Gastroenterology. 141, 4, p. 1439-1450 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

RB Restricts DNA Damage-Initiated Tumorigenesis through an LXCXE-Dependent Mechanism of Transcriptional Control

Bourgo, R. J., Thangavel, C., Ertel, A., Bergseid, J., Kathleen McClendon, A., Wilkens, L., Witkiewicz, A. K., Wang, J. Y. J. & Knudsen, E. S., Aug 19 2011, In : Molecular cell. 43, 4, p. 663-672 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Subject Review: Pancreatic Ductal Adenocarcinoma in the Setting of Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Gene: Case Report and Review of the Literature

Rittenhouse, D. W., Talbott, V. A., Anklesaria, Z., Brody, J. R., Witkiewicz, A. K. & Yeo, C. J., Dec 1 2011, In : Journal of Gastrointestinal Surgery. 15, 12, p. 2284-2290 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapy-resistant breast cancer

Thangavel, C., Dean, J. L., Ertel, A., Knudsen, K. E., Aldaz, C. M., Witkiewicz, A. K., Clarke, R. & Knudsen, E. S., Jun 1 2011, In : Endocrine-Related Cancer. 18, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

155 Scopus citations
2012

A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome

Gong, P., Charles, S., Rosenblum, N., Wang, Z. & Witkiewicz, A. K., Aug 2012, In : Gynecologic Oncology Reports. 2, 3, p. 69-72 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma

Mahipal, A., McDonald, M. J., Witkiewicz, A. & Carr, B. I., Mar 1 2012, In : Medical Oncology. 29, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

Valsecchi, M. E., McDonald, M., Brody, J. R., Hyslop, T., Freydin, B., Yeo, C. J., Solomides, C., Peiper, S. C. & Witkiewicz, A. K., Jul 15 2012, In : Cancer. 118, 14, p. 3484-3493 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

HuR's post-transcriptional regulation of death receptor 5 in pancreatic cancer cells

Pineda, D. M., Rittenhouse, D. W., Valley, C. C., Cozzitorto, J. A., Burkhart, R. A., Leiby, B., Winter, J. M., Weber, M. C., Londin, E. R., Rigoutsos, I., Yeo, C. J., Gorospe, M., Witkiewicz, A. K., Sachs, J. N. & Brody, J. R., Aug 1 2012, In : Cancer Biology and Therapy. 13, 10, p. 946-955 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Intraductal Papillary Mucinous Neoplasm (IPMN) with Extra-Pancreatic Mucin: A Case Series and Review of the Literature

Rosenberger, L. H., Stein, L. H., Witkiewicz, A. K., Kennedy, E. P. & Yeo, C. J., Apr 1 2012, In : Journal of Gastrointestinal Surgery. 16, 4, p. 762-770 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

Valsecchi, M. E., Holdbrook, T., Leiby, B. E., Pequignot, E., Littman, S. J., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Mar 22 2012, In : BMC Cancer. 12, 104.

Research output: Contribution to journalArticle

24 Scopus citations

Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

Peck, A. R., Witkiewicz, A. K., Liu, C., Klimowicz, A. C., Stringer, G. A., Pequignot, E., Freydin, B., Yang, N., Ertel, A., Tran, T. H., Girondo, M. A., Rosenberg, A. L., Hooke, J. A., Kovatich, A. J., Shriver, C. D., Rimm, D. L., Magliocco, A. M., Hyslop, T. & Rui, H., Oct 4 2012, In : Breast Cancer Research. 14, 5, R130.

Research output: Contribution to journalArticle

45 Scopus citations

Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue

Sotgia, F., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., Philp, N. J., Pestell, R. G. & Lisanti, M. P., Apr 1 2012, In : Cell Cycle. 11, 7, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Molecular profiling of synchronous and metachronous cancers of the pancreas reveal molecular mimicry between samples from the same patient

Talbott, V. A., Yeo, C. J., Brody, J. R. & Witkiewicz, A. K., Jul 1 2012, In : Journal of Surgical Research. 176, 1, p. 154-158 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer

Su, Y., Li, J., Witkiewicz, A. K., Brennan, D., Neill, T., Talarico, J. & Radice, G. L., Oct 11 2012, In : Oncogene. 31, 41, p. 4484-4489 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia

Knudsen, E. S., Ertel, A., Davicioni, E., Kline, J., Schwartz, G. F. & Witkiewicz, A. K., Jun 1 2012, In : Breast Cancer Research and Treatment. 133, 3, p. 1009-1024 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer

Witkiewicz, A. K., Ertel, A., McFalls, J., Valsecchi, M. E., Schwartz, G. & Knudsen, E. S., Sep 15 2012, In : Clinical Cancer Research. 18, 18, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Retinoblastoma and phosphate and tensin homolog tumor suppressors: Impact on ductal carcinoma in situ progression

Knudsen, E. S., Pajak, T. F., Qeenan, M., Mcclendon, A. K., Armon, B. D., Schwartz, G. F. & Witkiewicz, A. K., Dec 1 2012, In : Journal of the National Cancer Institute. 104, 23, p. 1825-1836 12 p.

Research output: Contribution to journalArticle

18 Scopus citations