• 10389 Citations
  • 56 h-Index
19992020

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Article
2010

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Martinez-Outschoorn, U. E., Pavlides, S., Whitaker-Menezes, D., Daumer, K. M., Milliman, J. N., Chiavarina, B., Migneco, G., Witkiewicz, A. K., Martinez-Cantarin, M. P., Flomenberg, N., Howell, A., Pestell, R. G., Lisanti, M. P. & Sotgia, F., Jun 15 2010, In : Cell Cycle. 9, 12, p. 2423-2433 11 p.

Research output: Contribution to journalArticle

164 Scopus citations
2009

Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma

Brody, J. R., Costantino, C. L., Potoczek, M., Cozzitorto, J., McCue, P., Yeo, C. J., Hruban, R. H. & Witkiewicz, A. K., May 1 2009, In : Modern Pathology. 22, 5, p. 651-659 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

Witkiewicz, A. K., Dasgupta, A., Sotgia, F., Mercier, I., Pestell, R. G., Sabel, M., Kleer, C. G., Brody, J. R. & Lisanti, M. P., Jun 2009, In : American Journal of Pathology. 174, 6, p. 2023-2034 12 p.

Research output: Contribution to journalArticle

231 Scopus citations

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

Sotgia, F., Del Galdo, F., Casimiro, M. C., Bonuccelli, G., Mercier, I., Whitaker-Menezes, D., Daumer, K. M., Zhou, J., Wang, C., Katiyar, S., Xu, H., Bosco, E., Quong, A. A., Aronow, B., Witkiewicz, A. K., Minetti, C., Frank, P. G., Jimenez, S. A., Knudsen, E. S., Pestell, R. G. & 1 others, Lisanti, M. P., Mar 2009, In : American Journal of Pathology. 174, 3, p. 746-761 16 p.

Research output: Contribution to journalArticle

94 Scopus citations

Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

Millar, E. K. A., Dean, J. L., McNeil, C. M., O'Toole, S. A., Henshall, S. M., Tran, T., Lin, J., Quong, A., Comstock, C. E. S., Witkiewicz, A., Musgrove, E. A., Rui, H., Lemarchand, L., Setiawan, V. W., Haiman, C. A., Knudsen, K. E., Sutherland, R. L. & Knudsen, E. S., Apr 16 2009, In : Oncogene. 28, 15, p. 1812-1820 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma

Sullivan, J., Blair, L., Alnajar, A., Aziz, T., Ng, C. Y., Chipitsyna, G., Gong, Q., Witkiewicz, A., Weber, G. F., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Aug 1 2009, In : Surgery. 146, 2, p. 232-240 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival

Brody, J. R., Costantino, C. L., Berger, A. C., Sato, T., Lisanti, M. P., Yeo, C. J., Emmons, R. V. & Witkiewicz, A. K., Jun 15 2009, In : Cell Cycle. 8, 12, p. 1930-1934 5 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Expression of K homology domain containing protein (KOC) in pancreatic cytology with corresponding histology

Toll, A. D., Witkiewicz, A. K. & Bibbo, M., Jan 1 2009, In : Acta Cytologica. 53, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Extrapancreatic neural plexus invasion by pancreatic carcinoma: Characteristics on magnetic resonance imaging

Zhang, X. M., Mitchell, D. G., Witkiewicz, A., Verma, S. & Bergin, D., Sep 1 2009, In : Abdominal Imaging. 34, 5, p. 634-641 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin

Wu, K. N., Emmons, R. V. B., Lisanti, M. P., Farber, J. L. & Witkiewicz, A. K., Nov 1 2009, In : Cell Cycle. 8, 21, p. 3601-3605 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Gallbladder abnormalities in carcinoma of pancreatic head: Findings on MR imaging

Zhang, X. M., Mitchell, D. G., Byun, J. H., Verma, S. K., Bergin, D. & Witkiewicz, A., Jul 1 2009, In : Abdominal Imaging. 34, 4, p. 507-513 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

Mercier, I., Casimiro, M. C., Zhou, J., Wang, C., Plymire, C., Bryant, K. G., Daumer, K. M., Sotgia, F., Bonuccelli, G., Witkiewicz, A. K., Lin, J., Tran, T. H., Milliman, J., Frank, P. G., Jasmin, J. F., Rui, H., Pestell, R. G. & Lisanti, M. P., Apr 2009, In : American Journal of Pathology. 174, 4, p. 1172-1190 19 p.

Research output: Contribution to journalArticle

45 Scopus citations

Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target

Witkiewicz, A. K., Costantino, C. L., Metz, R., Muller, A. J., Prendergast, G. C., Yeo, C. J. & Brody, J. R., May 1 2009, In : Journal of the American College of Surgeons. 208, 5, p. 781-787 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

Sotgia, F., Casimiro, M. C., Bonuccelli, G., Liu, M., Whitaker-Menezes, D., Er, O., Daumer, K. M., Mercier, I., Witkiewicz, A. K., Minetti, C., Capozza, F., Gormley, M., Quong, A. A., Rui, H., Frank, P. G., Milliman, J. N., Knudsen, E. S., Zhou, J., Wang, C., Pestell, R. G. & 1 others, Lisanti, M. P., Feb 2009, In : American Journal of Pathology. 174, 2, p. 613-629 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1

Reed, C. A., Mayhew, C. N., McClendon, A. K., Yang, X., Witkiewicz, A. & Knudsen, E. S., Dec 1 2009, In : Oncogene. 28, 50, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Single nucleotide polymorphismin RECQL and survival in resectable pancreatic adenocarcinoma

Cotton, R. T., Li, D., Scherer, S. E., Muzny, D. M., Hodges, S. E., Catania, R. L., Witkiewicz, A. K., Brody, J. R., Kennedy, E. P., Yeo, C. J., Brunicardl, F. C., Gibbs, R. G., Gingras, M. C. & Fisher, W. E., Jan 1 2009, In : HPB. 11, 5, p. 435-444 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

Witkiewicz, A. K., Dasgupta, A., Nguyen, K. H., Liu, C., Kovatich, A. J., Schwartz, G. F., Pestell, R. G., Sotgia, F., Rui, H. & Lisanti, M. P., Jun 1 2009, In : Cancer Biology and Therapy. 8, 11, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., Casimiro, M. C., Wang, C., Fortina, P., Addya, S., Pestell, R. G., Martinez-Outschoorn, U. E., Sotgia, F. & Lisanti, M. P., Dec 1 2009, In : Cell Cycle. 8, 23, p. 3984-4001 18 p.

Research output: Contribution to journalArticle

Open Access
649 Scopus citations

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase

Costantino, C. L., Witkiewicz, A. K., Kuwano, Y., Cozzitorto, J. A., Kennedy, E. P., Dasgupta, A., Keen, J. C., Yeo, C. J., Gorospe, M. & Brody, J. R., Jun 1 2009, In : Cancer research. 69, 11, p. 4567-4572 6 p.

Research output: Contribution to journalArticle

125 Scopus citations

Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation

Mercier, I., Bryant, K. G., Sotgia, F., Bonuccelli, G., Witkiewicz, A. K., Dasgupta, A., Jasmin, J. F., Pestell, R. G. & Lisanti, M. P., May 1 2009, In : Cell Cycle. 8, 9, p. 1396-1401 6 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2008

Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders

Ayli, E. E., Li, W., Brown, T. T., Witkiewicz, A., Elenitsas, R. & Seykora, J. T., Mar 1 2008, In : Journal of Cutaneous Pathology. 35, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling

Anandanadesan, R., Gong, Q., Chipitsyna, G., Witkiewicz, A., Yeo, C. J. & Arafat, H. A., Jan 1 2008, In : Journal of Gastrointestinal Surgery. 12, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome

Witkiewicz, A. K., Nguyen, K. H., Dasgupta, A., Kennedy, E. P., Yeo, C. J., Lisanti, M. P. & Brody, J. R., Oct 1 2008, In : Cell Cycle. 7, 19, p. 3021-3025 5 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists

Wang, Y., Dean, J. L., Millar, E. K. A., Thai, H. T., McNeil, C. M., Burd, C. J., Henshall, S. M., Utama, F. E., Witkiewicz, A., Rui, H., Sutherland, R. L., Knudsen, K. E. & Knudsen, E. S., Jul 15 2008, In : Cancer research. 68, 14, p. 5628-5638 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

Hostetter, C., Licata, L. A., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Brody, J. R. & Keen, J. C., Sep 2008, In : Cancer Biology and Therapy. 7, 9, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

Hostetter, C., Licata, L. A., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Brody, J. R. & Keen, J. C., Sep 2008, In : Cancer Biology and Therapy. 7, 9, p. 1496-1506 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?

Showalter, S. L., Showalter, T. N., Witkiewicz, A., Havens, R., Kennedy, E. P., Hucl, T., Kern, S. E., Yeo, C. J. & Brody, J. R., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 986-994 9 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

Witkiewicz, A., Williams, T. K., Cozzitorto, J., Durkan, B., Showalter, S. L., Yeo, C. J. & Brody, J. R., May 1 2008, In : Journal of the American College of Surgeons. 206, 5, p. 849-854 6 p.

Research output: Contribution to journalArticle

105 Scopus citations

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

Mercier, I., Casimiro, M. C., Wang, C., Rosenberg, A. L., Quong, J., Minkeu, A., Allen, K. G., Danilo, C., Sotgia, F., Bonuccelli, G., Jasmin, J. F., Xu, H., Bosco, E., Aronow, B., Witkiewicz, A., Pestell, R. G., Knudsen, E. S. & Lisanti, M. P., Aug 2008, In : Cancer Biology and Therapy. 7, 8, p. 1212-1225 14 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations

IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

Marzec, M., Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Odum, N. & Wasik, M. A., Feb 15 2008, In : Blood. 111, 4, p. 2181-2189 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Malignant melanoma of the gallbladder: A report of two cases and review of the literature

Samplaski, M. K., Rosato, E. L., Witkiewicz, A. K., Mastrangelo, M. J. & Berger, A. C., Jun 1 2008, In : Journal of Gastrointestinal Surgery. 12, 6, p. 1123-1126 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells

Showalter, S. L., Huang, Y. H., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Green, J. J., Langer, R., Anderson, D. G., Sawicki, J. A. & Brody, J. R., Oct 2008, In : Cancer Biology and Therapy. 7, 10, p. 1584-1590 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Renal cell carcinoma metastatic to the duodenum: Treatment by classic pancreaticoduodenectomy and review of the literature

Adamo, R., Greaney, P. J., Witkiewicz, A., Kennedy, E. P. & Yeo, C. J., Aug 1 2008, In : Journal of Gastrointestinal Surgery. 12, 8, p. 1465-1468 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature

Witkiewicz, A. K., Kennedy, E. P., Kennyon, L., Yeo, C. J. & Hruban, R. H., Oct 1 2008, In : Human Pathology. 39, 10, p. 1548-1551 4 p.

Research output: Contribution to journalArticle

88 Scopus citations

γc-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes

Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Hong, Y. W., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., Aug 15 2008, In : Journal of Immunology. 181, 4, p. 2506-2512 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
2007

Gangliocytic paraganglioma: Case report and review of the literature

Witkiewicz, A., Galler, A., Yeo, C. J. & Gross, S. D., Oct 1 2007, In : Journal of Gastrointestinal Surgery. 11, 10, p. 1351-1354 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma.

Witkiewicz, A., Raghunath, P., Wasik, A., Junkins-Hopkins, J. M., Jones, D., Zhang, Q., Odum, N. & Wasik, M. A., Mar 1 2007, In : Human Pathology. 38, 3, p. 462-467 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Metastatic melanoma causing jejunal intussusception

Mucci, T., Long, W., Witkiewicz, A., Mastrangelo, M. J., Rosato, E. L. & Berger, A. C., Dec 1 2007, In : Journal of Gastrointestinal Surgery. 11, 12, p. 1755-1757 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer

Harris, L. N., You, F., Schnitt, S. J., Witkiewicz, A., Lu, X., Sgroi, D., Ryan, P. D., Come, S. E., Burstein, H. J., Lesnikoski, B. A., Kamma, M., Friedman, P. N., Gelman, R., Iglehart, J. D. & Winer, E. P., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1198-1207 10 p.

Research output: Contribution to journalArticle

181 Scopus citations

Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia

Brody, J. R., Witkiewicz, A., Williams, T. K., Kadkol, S. S., Cozzitorto, J., Durkan, B., Pasternack, G. R. & Yeo, C. J., Dec 14 2007, In : Modern Pathology. 20, 12, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Mucocutaneous neuromas: An underrecognized manifestation of PTEN hamartoma-tumor syndrome

Schaffer, J. V., Kamino, H., Witkiewicz, A., McNiff, J. M. & Orlow, S. J., May 1 2006, In : Archives of Dermatology. 142, 5, p. 625-632 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Mutations in the desmoglein 4 gene underlie localized autosomal recessive hypotrichosis with monilethrix hairs and congenital scalp erosions

Schaffer, J. V., Bazzi, H., Vitebsky, A., Witkiewicz, A., Kovich, O. I., Kamino, H., Shapiro, L. S., Amin, S. P., Orlow, S. J. & Christiano, A. M., Jun 1 2006, In : Journal of Investigative Dermatology. 126, 6, p. 1286-1291 6 p.

Research output: Contribution to journalArticle

55 Scopus citations
2005

Cylindroma (dermal analog tumor) of the breast: A comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast

Albores-Saavedra, J., Heard, S. C., McLaren, B., Kamino, H. & Witkiewicz, A. K., Jun 2005, In : American journal of clinical pathology. 123, 6, p. 866-873 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Juvenile amyopathic dermatomyositis

Henning, J. S., Witkiewicz, A., Schaffer, J. V. & Orlow, S. J., Jan 1 2005, In : Dermatology online journal. 11, 4

Research output: Contribution to journalArticle

4 Scopus citations

Microglandular hyperplasia: A model for the de novo emergence and evolution of endocervical reserve cells

Witkiewicz, A. K., Hecht, J. L., Cviko, A., McKeon, F. D., Ince, T. A. & Crum, C. P., Feb 2005, In : Human Pathology. 36, 2, p. 154-161 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pityriasis rubra pilaris, type IV

Bragg, J., Witkiewicz, A., Orlow, S. J. & Schaffer, J. V., Jan 1 2005, In : Dermatology online journal. 11, 4

Research output: Contribution to journalArticle

7 Scopus citations

Superficial (early) endocervical adenocarcinoma in situ: A study of 12 cases and comparison to conventional AIS

Witkiewicz, A., Lee, K. R., Brodsky, G., Cviko, A., Brodsky, J. & Crum, C. P., Dec 2005, In : American Journal of Surgical Pathology. 29, 12, p. 1609-1614 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

α-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis

Witkiewicz, A. K., Varambally, S., Shen, R., Mehra, R., Sabel, M. S., Ghosh, D., Chinnaiyan, A. M., Rubin, M. A. & Kleer, C. G., Jun 1 2005, In : Cancer Epidemiology Biomarkers and Prevention. 14, 6, p. 1418-1423 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
2004

Carotid body tumor (paraganglioma)

Witkiewicz, A., Goldsmith, J. & Pantanowitz, L., Jun 1 2004, In : Ear, Nose and Throat Journal. 83, 6, p. 384-385 2 p.

Research output: Contribution to journalArticle

6 Scopus citations
1999

Acute aortic regurgitation due to spontaneous rupture of a fenestrated cusp: Report in a 65-year-old man and review of seven additional cases

Blaszyk, H., Witkiewicz, A. K. & Edwards, W. D., Jul 1 1999, In : Cardiovascular Pathology. 8, 4, p. 213-216 4 p.

Research output: Contribution to journalArticle

12 Scopus citations