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Research Output 1976 2019

  • 7928 Citations
  • 47 h-Index
  • 241 Article
  • 8 Chapter
  • 4 Review article
  • 1 Comment/debate
2019
Bell Palsy
Immunotherapy
Melanoma
Therapeutics
Steroids
1 Citation (Scopus)

Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Frankel, A. E., Deshmukh, S., Reddy, A., Lightcap, J., Hayes, M., McClellan, S., Singh, S., Rabideau, B., Glover, T. G., Roberts, B. & Koh, A., Apr 1 2019, In : Integrative Cancer Therapies. 18

Research output: Contribution to journalReview article

Open Access
Tumor Microenvironment
Immunosuppressive Agents
Immunotherapy
Immune System
Bacteria
5 Citations (Scopus)
Open Access
Diphtheria Toxin
Interleukin-3
Hematologic Neoplasms
Stem cells
Molecular biology

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Khushman, M., Patel, G. K., Laurini, J. A., Bhardwaj, A., Roveda, K., Donnell, R., Sherling, K., Case, B., Frankel, A. E., Pai, S., Taylor, W., Tan, M. C. B., Mizrahi, M., Nelson, C., Wyatt, M., Patton, M., McClellan, S., Singh, S., Wang, B. & Singh, A. P., Jan 1 2019, In : Journal of Gastrointestinal Oncology. 10, 4, p. 695-702 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Disease-Free Survival
Immunohistochemistry
Survival
Staining and Labeling

The Human Microbiota in Multiple Myeloma and Proteasome Inhibitors

Alkharabsheh, O., Sidiqi, M. H., Aljama, M. A., Gertz, M. A. & Frankel, A. E., Jan 1 2019, In : Acta Haematologica.

Research output: Contribution to journalReview article

Open Access
Proteasome Inhibitors
Microbiota
Multiple Myeloma
Clonal Evolution
Alkylating Agents

The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis

Maharjan, A. S., McMillin, G. A., Patel, G. K., Awan, S., Taylor, W. R., Pai, S., Frankel, A. E., Nelson, C., Wang, B., Hosein, P. J., Singh, A. P. & Khushman, M., Jan 1 2019, In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Genetic Association Studies
Genotype
Genes
Neoplasms
2018
3 Citations (Scopus)

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Gerber, D. E., Beg, M. S., Fattah, F., Frankel, A. E., Fatunde, O., Arriaga, Y., Dowell, J. E., Bisen, A., Leff, R. D., Meek, C. C., Putnam, W. C., Kallem, R. R., Subramaniyan, I., Dong, Y., Bolluyt, J., Sarode, V., Luo, X., Xie, Y., Schwartz, B. & Boothman, D. A., Oct 16 2018, In : British Journal of Cancer. 119, 8, p. 928-936 9 p.

Research output: Contribution to journalArticle

Necrosis
Neoplasms
Methemoglobinemia
Anemia
Oxidoreductases
2 Citations (Scopus)

Tumor endothelial marker 8 promotes cancer progression and metastasis

Høye, A. M., Tolstrup, S. D., Horton, E. R., Nicolau, M., Frost, H., Woo, J. H., Mauldin, J. P., Frankel, A. E., Cox, T. R. & Erler, J. T., Jul 10 2018, In : Oncotarget. 9, 53, p. 30173-30188 16 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Neoplasm Metastasis
Neoplasms
Colorectal Neoplasms
Breast Neoplasms
2017

Academic cancer center phase i program development

Frankel, A. E., Flaherty, K. T., Weiner, G. J., Chen, R., Azad, N. S., Pishvaian, M. J., Thompson, J. A., Taylor, M. H., Mahadevan, D., Lockhart, A. C., Vaishampayan, U. N., Berlin, J. D., Smith, D. C., Sarantopoulos, J., Riese, M., Saleh, M. N., Ahn, C. & Frenkel, E. P., Apr 1 2017, In : Oncologist. 22, 4, p. 369-374 6 p.

Research output: Contribution to journalComment/debate

Program Development
Neoplasms
Research
Research Personnel
Clinical Trials
131 Citations (Scopus)

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

interferon
Interferons
genes
Tumors
tumors
5 Citations (Scopus)

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

Digoxin
Melanoma
Mitogen-Activated Protein Kinase Kinases
Cardenolides
Therapeutics
344 Citations (Scopus)

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Stein, E. M., DiNardo, C. D., Pollyea, D. A., Fathi, A. T., Roboz, G. J., Altman, J. K., Stone, R. M., Deangelo, D. J., Levine, R. L., Flinn, I. W., Kantarjian, H. M., Collins, R., Patel, M. R., Frankel, A. E., Stein, A., Sekeres, M. A., Swords, R. T., Medeiros, B. C., Willekens, C., Vyas, P. & 7 others, Tosolini, A., Xu, Q., Knight, R. D., Yen, K. E., Agresta, S., De Botton, S. & Tallman, M. S., Aug 10 2017, In : Blood. 130, 6, p. 722-731 10 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Acute Myeloid Leukemia
Refractory materials
Pharmacodynamics
Pharmacokinetics
66 Citations (Scopus)
Metagenomics
Metabolomics
Firearms
Melanoma
Bacteroides
6 Citations (Scopus)

Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells

Thorburn, J., Staskiewicz, L., Goodall, M. L., Dimberg, L., Frankel, A. E., Ford, H. L. & Thorburn, A., Jan 1 2017, In : Molecular Pharmacology. 91, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

Autophagy
Growth
Pharmaceutical Preparations
Neoplasms
Caspases

Substance P-saporin for the treatment of intractable pain

Nymeyer, H., Lappi, D. A., Higgins, D., Noe, C. E. & Frankel, A. E., 2017, Milestones in Drug Therapy. Springer Basel, p. 107-130 24 p. (Milestones in Drug Therapy).

Research output: Chapter in Book/Report/Conference proceedingChapter

Intractable Pain
Immunotoxins
Pain
Biological Toxins
Therapeutics
2016
1 Citation (Scopus)
Dendritic Cells
Neoplasms
10 Citations (Scopus)

Developing EZH2-targeted therapy for lung cancer

Frankel, A. E., Liu, X. & Minna, J. D., Sep 1 2016, In : Cancer Discovery. 6, 9, p. 949-952 4 p.

Research output: Contribution to journalArticle

Drug Discovery
Epigenomics
Lung Neoplasms
Neoplasms
Therapeutics

Intrathecal substance P-saporin for the treatment of intractable cancer pain

Nymeyer, H., Lappi, D. A., Higgins, D., Noe, C. E. & Frankel, A. E., Jan 1 2016, Techniques of Neurolysis. Springer International Publishing, p. 197-206 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intractable Pain
Immunotoxins
Substance P
Biological Toxins
Therapeutics
2015
18 Citations (Scopus)

Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

Burrage, L. C., Sun, Q., Elsea, S. H., Jiang, M. M., Nagamani, S. C. S., Frankel, A. E., Stone, E., Alters, S. E., Johnson, D. E., Rowlinson, S. W., Georgiou, G. & Lee, B. H., 2015, In : Human Molecular Genetics. 24, 22, p. 6417-6427 11 p.

Research output: Contribution to journalArticle

Hyperargininemia
Arginase
Arginine
Enzymes
Hyperammonemia
22 Citations (Scopus)

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

Khoury, O., Ghazale, N., Stone, E., El-Sibai, M., Frankel, A. E. & Abi-Habib, R. J., 2015, In : Journal of Neuro-Oncology. 122, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Arginine
Argininosuccinate Synthase
Citrulline
Autophagy
6 Citations (Scopus)

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm

Rakheja, D., Fuda, F. S., Vandergriff, T. W., Boriack, R., Medeiros, B. C., Frankel, A. E. & Chen, W., Feb 1 2015, In : Human Pathology. 46, 2, p. 322-326 5 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Dendritic Cells
Mutation
Neoplasms
Chondrosarcoma
29 Citations (Scopus)

In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to sl-401, an interleukin-3 receptor targeted biologic agent

Angelot-Delettre, F., Roggy, A., Frankel, A. E., Lamarthee, B., Seilles, E., Biichle, S., Royer, B., Deconinck, E., Rowinsky, E. K., Brooks, C., Bardet, V., Benet, B., Bennani, H., Benseddik, Z., Debliquis, A., Lusina, D., Roussel, M., Solly, F., Ticchioni, M., Saas, P. & 1 others, Garnache-Ottou, F., 2015, In : Haematologica. 100, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Interleukin-3 Receptors
Biological Factors
Dendritic Cells
Neoplasms
In Vitro Techniques
21 Citations (Scopus)

Phase i study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies

Bachanova, V., Frankel, A. E., Cao, Q., Lewis, D., Grzywacz, B., Verneris, M. R., Ustun, C., Lazaryan, A., McClune, B., Warlick, E. D., Kantarjian, H., Weisdorf, D. J., Miller, J. S. & Vallera, D. A., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Ligands
Neoplasms
Single-Chain Antibodies
Bispecific Antibodies
6 Citations (Scopus)

Phospho-MEK1/2 and uPAR expression determine sensitivity of AML blasts to a urokinase-activated anthrax lethal toxin (PrAgU2/LF)

Bekdash, A., Darwish, M., Timsah, Z., Kassab, E., Ghanem, H., Najjar, V., Ghosn, M., Nasser, S., El-Hajj, H., Bazerbachi, A., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2015, In : Translational Oncology. 8, 5, p. 347-357 11 p.

Research output: Contribution to journalArticle

Urokinase-Type Plasminogen Activator
Acute Myeloid Leukemia
Myeloid Cells
Cell Line
Maximum Tolerated Dose
24 Citations (Scopus)

Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma

Frankel, A. E., Woo, J. H., Ahn, C., Foss, F. M., Duvic, M., Neville, P. H. & Neville, D. M., 2015, In : Haematologica. 100, 6, p. 794-800 7 p.

Research output: Contribution to journalArticle

Immunotoxins
Cutaneous T-Cell Lymphoma
Large Granular Lymphocytic Leukemia
T-Cell Prolymphocytic Leukemia
Peripheral T-Cell Lymphoma
2014
110 Citations (Scopus)

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

Frankel, A. E., Woo, J. H., Ahn, C., Pemmaraju, N., Medeiros, B. C., Carraway, H. E., Frankfurt, O., Forman, S. J., Yang, X. A., Konopleva, M., Garnache-Ottou, F., Angelot-Delettre, F., Brooks, C., Szarek, M. & Rowinsky, E., Jul 17 2014, In : Blood. 124, 3, p. 385-392 8 p.

Research output: Contribution to journalArticle

Interleukin-3 Receptors
Dendritic Cells
Neoplasms
Therapeutics
Recurrence
86 Citations (Scopus)

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

Testa, U., Pelosi, E. & Frankel, A. E., Feb 10 2014, In : Biomarker Research. 2, 1, 4.

Research output: Contribution to journalReview article

Open Access
Biomarkers
Hematologic Neoplasms
Interleukin-3 Receptor alpha Subunit
Membranes
Lymphoid Leukemia
2 Citations (Scopus)

In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts

Agrawal, V., Woo, J. H., Mauldin, J. P., Stone, E. M., Meininger, C. J., Jo, C., Kleypas, K., Frenkel, E. P. & Frankel, A. E., Dec 10 2014, In : Melanoma Research. 24, 6, p. 556-567 12 p.

Research output: Contribution to journalArticle

Arginase
Heterografts
Melanoma
Argininosuccinate Synthase
Citrulline
26 Citations (Scopus)

SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia

Frolova, O., Benito, J., Brooks, C., Wang, R. Y., Korchin, B., Rowinsky, E. K., Cortes, J., Kantarjian, H., Andreeff, M., Frankel, A. E. & Konopleva, M., 2014, In : British Journal of Haematology. 166, 6, p. 862-874 13 p.

Research output: Contribution to journalArticle

Interleukin-3 Receptors
Leukemia, Myeloid, Chronic Phase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stem Cells
Growth
2013

Classic Immunotoxins with Plant or Microbial Toxins

Woo, J. H. & Frankel, A., Feb 12 2013, Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. John Wiley and Sons, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunotoxins
11 Citations (Scopus)

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

Kassab, E., Darwish, M., Timsah, Z., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2013, In : Translational Oncology. 6, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Myeloid Cells
Acute Myeloid Leukemia
Caspases
30 Citations (Scopus)

Diphtheria toxin-epidermal growth factor fusion protein DAB 389EGF for the treatment of bladder cancer

Yang, X., Kessler, E., Su, L. J., Thorburn, A., Frankel, A. E., Li, Y., La Rosa, F. G., Shen, J., Li, C. Y., Varella-Garcia, M., Glodé, L. M. & Flaig, T. W., Jan 1 2013, In : Clinical Cancer Research. 19, 1, p. 148-157 10 p.

Research output: Contribution to journalArticle

Diphtheria Toxin
Epidermal Growth Factor
Urinary Bladder Neoplasms
Proteins
Luciferases

Foreword

Frankel, A., Feb 2013, In : Expert Opinion on Biological Therapy. 13, 2

Research output: Contribution to journalArticle

Foreword. Monoclonal antibody treatment of human disease.

Frankel, A., Feb 2013, In : Expert Opinion on Biological Therapy. 13, 2, p. 1-2 2 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
27 Citations (Scopus)

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

Tanios, R., Bekdash, A., Kassab, E., Stone, E., Georgiou, G., Frankel, A. E. & Abi-Habib, R. J., Nov 2013, In : Leukemia Research. 37, 11, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Arginine
Cell Line
Citrulline
31 Citations (Scopus)

Red blood cell-encapsulated L-asparaginase: Potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia

Agrawal, V., Woo, J. H., Borthakur, G., Kantarjian, H. & Frankel, A. E., Apr 2013, In : Protein and Peptide Letters. 20, 4, p. 392-402 11 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Acute Myeloid Leukemia
Blood
Erythrocytes
Clinical Pharmacology
Immunity
Neoplasms
Proteins
Therapeutics
2012
15 Citations (Scopus)

Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics

Kuo, S. R., Tahir, S. A., Park, S., Thompson, T. C., Coffield, S., Frankel, A. E. & Liu, J. S., Apr 1 2012, In : Hybridoma. 31, 2, p. 77-86 10 p.

Research output: Contribution to journalArticle

Caveolin 1
Anti-Idiotypic Antibodies
Prostatic Neoplasms
Antibodies
Therapeutics
19 Citations (Scopus)

Arginine deprivation therapy for malignant melanoma

Yoon, J. K., Frankel, A. E., Feun, L. G., Ekmekcioglu, S. & Kim, K. B., Dec 21 2012, In : Clinical Pharmacology: Advances and Applications. 5, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

Arginine
Melanoma
Therapeutics
Argininosuccinate Synthase
Pharmaceutical Preparations
14 Citations (Scopus)
Autophagy
Cardiac Myocytes
Catalase
Oxidative Stress
Proteasome Endopeptidase Complex
19 Citations (Scopus)

Cytotoxicity of human recombinant arginase i (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

Agrawal, V., Woo, J. H., Mauldin, J. P., Jo, C., Stone, E. M., Georgiou, G. & Frankel, A. E., Jan 2012, In : Anti-Cancer Drugs. 23, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Arginase
Citrulline
Cobalt
Neoplasms
20 Citations (Scopus)

Recombinant human arginase Toxicity in mice is reduced by citrulline supplementation

Mauldin, J. P., Zeinali, I., Kleypas, K., Woo, J. H., Blackwood, R. S., Jo, C. H., Stone, E. M., Georgiou, G. & Frankel, A. E., Feb 2012, In : Translational Oncology. 5, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

Arginase
Citrulline
Blood Cell Count
Arginine
Maximum Tolerated Dose
16 Citations (Scopus)

Targeting methionine auxotrophy in cancer: Discovery & exploration

Agrawal, V., Alpini, S. E. J., Stone, E. M., Frenkel, E. P. & Frankel, A. E., Jan 2012, In : Expert Opinion on Biological Therapy. 12, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Methionine
Neoplasms
Pharmaceutical Preparations
Toxicity
Cells
10 Citations (Scopus)

Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: Role of autophagy

Kandadi, M. R., Frankel, A. E. & Ren, J., Oct 2012, In : British Journal of Pharmacology. 167, 3, p. 612-626 15 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Autophagy
Anthrax
Endoplasmic Reticulum Stress
Phosphatidylinositol 3-Kinases
2011
36 Citations (Scopus)

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

Schimmer, A. D., Herr, W., Hänel, M., Borthakur, G., Frankel, A., Horst, H. A., Martin, S., Kassis, J., Desjardins, P., Seiter, K., Fiedler, W., Noppeney, R., Giagounidis, A., Jacob, C., Jolivet, J., Tallman, M. S. & Koschmieder, S., Oct 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
Antisense Oligonucleotides
Acute Myeloid Leukemia
Drug Therapy
Induction Chemotherapy

Dr Frankel

Frankel, A. E., 2011, In : Clinical Pharmacology: Advances and Applications. 3, 1

Research output: Contribution to journalArticle

2 Citations (Scopus)

TEM8 targeted cancer therapy

Frankel, A. E., Carter, C., Kuo, S. R., Woo, J. H., Mauldin, J. & Liu, J. S., Dec 2011, In : Anti-Cancer Agents in Medicinal Chemistry. 11, 10, p. 983-992 10 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Vascular Tissue Neoplasms
Neoplasms
vadimezan
Therapeutics
29 Citations (Scopus)

The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton

Yang, M. Y., Chaudhary, A., Seaman, S., Dunty, J., Stevens, J., Elzarrad, M. K., Frankel, A. E. & St.Croix, B., Jan 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Actin Cytoskeleton
Monoclonal Antibodies
Vascular Tissue Neoplasms
Immunotoxins
2010
11 Citations (Scopus)

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Vanderlaag, K., Su, Y., Frankel, A. E., Burghardt, R. C., Barhoumi, R., Chadalapaka, G., Jutooru, I. & Safe, S., Dec 3 2010, In : BMC Cancer. 10, 669.

Research output: Contribution to journalArticle

Methane
Autophagy
Estrogen Receptors
Breast Neoplasms
Proteins
3 Citations (Scopus)

14G2a anti-GD2 crossreactivity with the CD166 antigen

Agrawal, V. & Frankel, A. E., Nov 2010, In : Journal of Immunotherapy. 33, 9, p. 1014-1015 2 p.

Research output: Contribution to journalArticle

Activated-Leukocyte Cell Adhesion Molecule
Neuronal Cell Adhesion Molecules
CD Antigens
Neuroectodermal Tumors
Fetal Proteins