• 8413 Citations
  • 47 h-Index
1976 …2020

Research output per year

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Research Output

2020

Epidermal growth factor receptor-activating mutation(E746_T751>VP) in pancreatic ductal adenocarcinoma responds to erlotinib, followed by epidermal growth factor receptor resistance-mediating mutation (A647T): A case report and literature review

Patel, G. K., Perry, J. B., Abdul-Rahim, O., Frankel, A. E., Cameron, D., Taylor, W., Rocconi, R. P., Abushahin, L., Nelson, C., Singh, A. P. & Khushman, M., Jul 1 2020, In : Journal of Cancer Research and Therapeutics. 16, 4, p. 950-954 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

HIF-2 complex dissociation, target inhibition, and acquired resistance with PT2385, a first-in-class HIF-2 inhibitor, in patients with clear cell renal cell carcinoma

Courtney, K. D., Ma, Y., de Leon, A. D., Christie, A., Xie, Z., Woolford, L., Singla, N., Joyce, A., Hill, H., Madhuranthakam, A. J., Yuan, Q., Xi, Y., Zhang, Y., Chang, J., Fatunde, O., Arriaga, Y., Frankel, A. E., Kalva, S., Zhang, S., McKenzie, T. & 8 others, Torras, O. R., Figlin, R. A., Rini, B. I., McKay, R. M., Kapur, P., Wang, T., Pedrosa, I. & Brugarolas, J., Feb 15 2020, In : Clinical Cancer Research. 26, 4, p. 793-803 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

The human microbiota in multiple myeloma and proteasome inhibitors

Alkharabsheh, O., Sidiqi, M. H., Aljama, M. A., Gertz, M. A. & Frankel, A. E., Mar 1 2020, In : Acta Haematologica. 143, 2, p. 118-123 6 p.

Research output: Contribution to journalReview article

Open Access
2019

Autoimmune Bell's Palsy following Immunotherapy for Metastatic Melanoma: A Report of 2 Cases

Zieman, D. & Frankel, A. E., Oct 1 2019, In : Journal of Immunotherapy. 42, 8, p. 318-320 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Frankel, A. E., Deshmukh, S., Reddy, A., Lightcap, J., Hayes, M., McClellan, S., Singh, S., Rabideau, B., Glover, T. G., Roberts, B. & Koh, A. Y., Apr 1 2019, In : Integrative Cancer Therapies. 18

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
Open Access
12 Scopus citations

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Khushman, M., Patel, G. K., Laurini, J. A., Bhardwaj, A., Roveda, K., Donnell, R., Sherling, K., Case, B., Frankel, A. E., Pai, S., Taylor, W., Tan, M. C. B., Mizrahi, M., Nelson, C., Wyatt, M., Patton, M., McClellan, S., Singh, S., Wang, B. & Singh, A. P., Jan 1 2019, In : Journal of Gastrointestinal Oncology. 10, 4, p. 695-702 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Roles of the cGAS-STING pathway in cancer immunosurveillance and immunotherapy

Yum, S., Li, M., Frankel, A. E. & Chen, Z. J., Jan 1 2019, In : Annual Review of Cancer Biology. 3, 1, p. 323-344 22 p.

Research output: Contribution to journalReview article

8 Scopus citations

The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis

Maharjan, A. S., McMillin, G. A., Patel, G. K., Awan, S., Taylor, W. R., Pai, S., Frankel, A. E., Nelson, C., Wang, B., Hosein, P. J., Singh, A. P. & Khushman, M., Sep 2019, In : Clinical colorectal cancer. 18, 3, p. e280-e286

Research output: Contribution to journalArticle

2018

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Gerber, D. E., Beg, M. S., Fattah, F., Frankel, A. E., Fatunde, O., Arriaga, Y., Dowell, J. E., Bisen, A., Leff, R. D., Meek, C. C., Putnam, W. C., Kallem, R. R., Subramaniyan, I., Dong, Y., Bolluyt, J., Sarode, V., Luo, X., Xie, Y., Schwartz, B. & Boothman, D. A., Oct 16 2018, In : British journal of cancer. 119, 8, p. 928-936 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tumor endothelial marker 8 promotes cancer progression and metastasis

Høye, A. M., Tolstrup, S. D., Horton, E. R., Nicolau, M., Frost, H., Woo, J. H., Mauldin, J. P., Frankel, A. E., Cox, T. R. & Erler, J. T., Jul 10 2018, In : Oncotarget. 9, 53, p. 30173-30188 16 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Academic cancer center phase i program development

Frankel, A. E., Flaherty, K. T., Weiner, G. J., Chen, R., Azad, N. S., Pishvaian, M. J., Thompson, J. A., Taylor, M. H., Mahadevan, D., Lockhart, A. C., Vaishampayan, U. N., Berlin, J. D., Smith, D. C., Sarantopoulos, J., Riese, M., Saleh, M. N., Ahn, C. & Frenkel, E. P., Apr 2017, In : Oncologist. 22, 4, p. 369-374 6 p.

Research output: Contribution to journalComment/debate

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

199 Scopus citations

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Stein, E. M., DiNardo, C. D., Pollyea, D. A., Fathi, A. T., Roboz, G. J., Altman, J. K., Stone, R. M., Deangelo, D. J., Levine, R. L., Flinn, I. W., Kantarjian, H. M., Collins, R., Patel, M. R., Frankel, A. E., Stein, A., Sekeres, M. A., Swords, R. T., Medeiros, B. C., Willekens, C., Vyas, P. & 7 others, Tosolini, A., Xu, Q., Knight, R. D., Yen, K. E., Agresta, S., De Botton, S. & Tallman, M. S., Aug 10 2017, In : Blood. 130, 6, p. 722-731 10 p.

Research output: Contribution to journalArticle

460 Scopus citations
113 Scopus citations

Substance P-saporin for the treatment of intractable pain

Nymeyer, H., Lappi, D. A., Higgins, D., Noe, C. E. & Frankel, A. E., 2017, Milestones in Drug Therapy. Springer Basel, p. 107-130 24 p. (Milestones in Drug Therapy).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016
2 Scopus citations

Developing EZH2-targeted therapy for lung cancer

Frankel, A. E., Liu, X. & Minna, J. D., Sep 2016, In : Cancer discovery. 6, 9, p. 949-952 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intrathecal substance P-saporin for the treatment of intractable cancer pain

Nymeyer, H., Lappi, D. A., Higgins, D., Noe, C. E. & Frankel, A. E., Jan 1 2016, Techniques of Neurolysis. Springer International Publishing, p. 197-206 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Non-cell-autonomous effects of autophagy inhibition in tumor cells promote growth of drug-resistant cells

Thorburn, J., Staskiewicz, L., Goodall, M. L., Dimberg, L., Frankel, A. E., Ford, H. L. & Thorburn, A., 2016, In : Molecular Pharmacology. 91, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2015

Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

Burrage, L. C., Sun, Q., Elsea, S. H., Jiang, M. M., Nagamani, S. C. S., Frankel, A. E., Stone, E., Alters, S. E., Johnson, D. E., Rowlinson, S. W., Georgiou, G. & Lee, B. H., 2015, In : Human molecular genetics. 24, 22, p. 6417-6427 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

Khoury, O., Ghazale, N., Stone, E., El-Sibai, M., Frankel, A. E. & Abi-Habib, R. J., Jan 1 2015, In : Journal of Neuro-Oncology. 122, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm

Rakheja, D., Fuda, F. S., Vandergriff, T. W., Boriack, R., Medeiros, B. C., Frankel, A. E. & Chen, W., Feb 1 2015, In : Human Pathology. 46, 2, p. 322-326 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to sl-401, an interleukin-3 receptor targeted biologic agent

Angelot-Delettre, F., Roggy, A., Frankel, A. E., Lamarthee, B., Seilles, E., Biichle, S., Royer, B., Deconinck, E., Rowinsky, E. K., Brooks, C., Bardet, V., Benet, B., Bennani, H., Benseddik, Z., Debliquis, A., Lusina, D., Roussel, M., Solly, F., Ticchioni, M., Saas, P. & 1 others, Garnache-Ottou, F., 2015, In : Haematologica. 100, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Phase i study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies

Bachanova, V., Frankel, A. E., Cao, Q., Lewis, D., Grzywacz, B., Verneris, M. R., Ustun, C., Lazaryan, A., McClune, B., Warlick, E. D., Kantarjian, H., Weisdorf, D. J., Miller, J. S. & Vallera, D. A., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Phospho-MEK1/2 and uPAR expression determine sensitivity of AML blasts to a urokinase-activated anthrax lethal toxin (PrAgU2/LF)

Bekdash, A., Darwish, M., Timsah, Z., Kassab, E., Ghanem, H., Najjar, V., Ghosn, M., Nasser, S., El-Hajj, H., Bazerbachi, A., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2015, In : Translational Oncology. 8, 5, p. 347-357 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma

Frankel, A. E., Woo, J. H., Ahn, C., Foss, F. M., Duvic, M., Neville, P. H. & Neville, D. M., 2015, In : Haematologica. 100, 6, p. 794-800 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

Frankel, A. E., Woo, J. H., Ahn, C., Pemmaraju, N., Medeiros, B. C., Carraway, H. E., Frankfurt, O., Forman, S. J., Yang, X. A., Konopleva, M., Garnache-Ottou, F., Angelot-Delettre, F., Brooks, C., Szarek, M. & Rowinsky, E., Jul 17 2014, In : Blood. 124, 3, p. 385-392 8 p.

Research output: Contribution to journalArticle

131 Scopus citations

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

Testa, U., Pelosi, E. & Frankel, A., Feb 10 2014, In : Biomarker Research. 2, 1, 4.

Research output: Contribution to journalReview article

Open Access
105 Scopus citations

In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts

Agrawal, V., Woo, J. H., Mauldin, J. P., Stone, E. M., Meininger, C. J., Jo, C., Kleypas, K., Frenkel, E. P. & Frankel, A. E., Dec 10 2014, In : Melanoma research. 24, 6, p. 556-567 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia

Frolova, O., Benito, J., Brooks, C., Wang, R. Y., Korchin, B., Rowinsky, E. K., Cortes, J., Kantarjian, H., Andreeff, M., Frankel, A. E. & Konopleva, M., Sep 2014, In : British Journal of Haematology. 166, 6, p. 862-874 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Classic Immunotoxins with Plant or Microbial Toxins

Woo, J. H. & Frankel, A., Feb 12 2013, Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. John Wiley and Sons, p. 271-293 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

Kassab, E., Darwish, M., Timsah, Z., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2013, In : Translational Oncology. 6, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Diphtheria toxin-epidermal growth factor fusion protein DAB 389EGF for the treatment of bladder cancer

Yang, X., Kessler, E., Su, L. J., Thorburn, A., Frankel, A. E., Li, Y., La Rosa, F. G., Shen, J., Li, C. Y., Varella-Garcia, M., Glodé, L. M. & Flaig, T. W., Jan 1 2013, In : Clinical Cancer Research. 19, 1, p. 148-157 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Foreword

Frankel, A., Feb 2013, In : Expert Opinion on Biological Therapy. 13, 2

Research output: Contribution to journalArticle

Foreword

Frankel, A., Feb 1 2013, In : Expert Opinion on Biological Therapy. 13, 2, p. i-ii

Research output: Contribution to journalEditorial

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

Tanios, R., Bekdash, A., Kassab, E., Stone, E., Georgiou, G., Frankel, A. E. & Abi-Habib, R. J., Nov 1 2013, In : Leukemia Research. 37, 11, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Red blood cell-encapsulated L-asparaginase: Potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia

Agrawal, V., Woo, J. H., Borthakur, G., Kantarjian, H. & Frankel, A. E., Apr 2013, In : Protein and Peptide Letters. 20, 4, p. 392-402 11 p.

Research output: Contribution to journalReview article

34 Scopus citations
2012

Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics

Kuo, S. R., Tahir, S. A., Park, S., Thompson, T. C., Coffield, S., Frankel, A. E. & Liu, J. S., Apr 1 2012, In : Hybridoma. 31, 2, p. 77-86 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Arginine deprivation therapy for malignant melanoma

Yoon, J. K., Frankel, A. E., Feun, L. G., Ekmekcioglu, S. & Kim, K. B., Dec 21 2012, In : Clinical Pharmacology: Advances and Applications. 5, 1, p. 11-19 9 p.

Research output: Contribution to journalReview article

21 Scopus citations
15 Scopus citations

Cytotoxicity of human recombinant arginase i (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

Agrawal, V., Woo, J. H., Mauldin, J. P., Jo, C., Stone, E. M., Georgiou, G. & Frankel, A. E., Jan 1 2012, In : Anti-Cancer Drugs. 23, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recombinant human arginase Toxicity in mice is reduced by citrulline supplementation

Mauldin, J. P., Zeinali, I., Kleypas, K., Woo, J. H., Blackwood, R. S., Jo, C. H., Stone, E. M., Georgiou, G. & Frankel, A. E., Feb 2012, In : Translational Oncology. 5, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Targeting methionine auxotrophy in cancer: Discovery & exploration

Agrawal, V., Alpini, S. E. J., Stone, E. M., Frenkel, E. P. & Frankel, A. E., Jan 1 2012, In : Expert Opinion on Biological Therapy. 12, 1, p. 53-61 9 p.

Research output: Contribution to journalReview article

18 Scopus citations

Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: Role of autophagy

Kandadi, M. R., Frankel, A. E. & Ren, J., Oct 2012, In : British Journal of Pharmacology. 167, 3, p. 612-626 15 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

Schimmer, A. D., Herr, W., Hänel, M., Borthakur, G., Frankel, A., Horst, H. A., Martin, S., Kassis, J., Desjardins, P., Seiter, K., Fiedler, W., Noppeney, R., Giagounidis, A., Jacob, C., Jolivet, J., Tallman, M. S. & Koschmieder, S., Oct 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Dr Frankel

Frankel, A. E., Nov 21 2011, In : Clinical Pharmacology: Advances and Applications. 3, 1

Research output: Contribution to journalEditorial

TEM8 targeted cancer therapy

Frankel, A. E., Carter, C., Kuo, S. R., Woo, J. H., Mauldin, J. & Liu, J. S., Dec 2011, In : Anti-Cancer Agents in Medicinal Chemistry. 11, 10, p. 983-992 10 p.

Research output: Contribution to journalArticle

2 Scopus citations