• 8086 Citations
  • 47 h-Index
1976 …2020

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2019

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Khushman, M., Patel, G. K., Laurini, J. A., Bhardwaj, A., Roveda, K., Donnell, R., Sherling, K., Case, B., Frankel, A. E., Pai, S., Taylor, W., Tan, M. C. B., Mizrahi, M., Nelson, C., Wyatt, M., Patton, M., McClellan, S., Singh, S., Wang, B. & Singh, A. P., Jan 1 2019, In : Journal of Gastrointestinal Oncology. 10, 4, p. 695-702 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis

Maharjan, A. S., McMillin, G. A., Patel, G. K., Awan, S., Taylor, W. R., Pai, S., Frankel, A. E., Nelson, C., Wang, B., Hosein, P. J., Singh, A. P. & Khushman, M., Jan 1 2019, In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

2018

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Gerber, D. E., Beg, M. S., Fattah, F., Frankel, A. E., Fatunde, O., Arriaga, Y., Dowell, J. E., Bisen, A., Leff, R. D., Meek, C. C., Putnam, W. C., Kallem, R. R., Subramaniyan, I., Dong, Y., Bolluyt, J., Sarode, V., Luo, X., Xie, Y., Schwartz, B. & Boothman, D. A., Oct 16 2018, In : British journal of cancer. 119, 8, p. 928-936 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tumor endothelial marker 8 promotes cancer progression and metastasis

Høye, A. M., Tolstrup, S. D., Horton, E. R., Nicolau, M., Frost, H., Woo, J. H., Mauldin, J. P., Frankel, A. E., Cox, T. R. & Erler, J. T., Jul 10 2018, In : Oncotarget. 9, 53, p. 30173-30188 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

159 Scopus citations

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Stein, E. M., DiNardo, C. D., Pollyea, D. A., Fathi, A. T., Roboz, G. J., Altman, J. K., Stone, R. M., Deangelo, D. J., Levine, R. L., Flinn, I. W., Kantarjian, H. M., Collins, R., Patel, M. R., Frankel, A. E., Stein, A., Sekeres, M. A., Swords, R. T., Medeiros, B. C., Willekens, C., Vyas, P. & 7 others, Tosolini, A., Xu, Q., Knight, R. D., Yen, K. E., Agresta, S., De Botton, S. & Tallman, M. S., Aug 10 2017, In : Blood. 130, 6, p. 722-731 10 p.

Research output: Contribution to journalArticle

388 Scopus citations
79 Scopus citations

Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells

Thorburn, J., Staskiewicz, L., Goodall, M. L., Dimberg, L., Frankel, A. E., Ford, H. L. & Thorburn, A., Jan 1 2017, In : Molecular Pharmacology. 91, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016
1 Scopus citations

Developing EZH2-targeted therapy for lung cancer

Frankel, A. E., Liu, X. & Minna, J. D., Sep 1 2016, In : Cancer Discovery. 6, 9, p. 949-952 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

Burrage, L. C., Sun, Q., Elsea, S. H., Jiang, M. M., Nagamani, S. C. S., Frankel, A. E., Stone, E., Alters, S. E., Johnson, D. E., Rowlinson, S. W., Georgiou, G. & Lee, B. H., 2015, In : Human Molecular Genetics. 24, 22, p. 6417-6427 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

Khoury, O., Ghazale, N., Stone, E., El-Sibai, M., Frankel, A. E. & Abi-Habib, R. J., Jan 1 2015, In : Journal of Neuro-Oncology. 122, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm

Rakheja, D., Fuda, F. S., Vandergriff, T. W., Boriack, R., Medeiros, B. C., Frankel, A. E. & Chen, W., Feb 1 2015, In : Human Pathology. 46, 2, p. 322-326 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to sl-401, an interleukin-3 receptor targeted biologic agent

Angelot-Delettre, F., Roggy, A., Frankel, A. E., Lamarthee, B., Seilles, E., Biichle, S., Royer, B., Deconinck, E., Rowinsky, E. K., Brooks, C., Bardet, V., Benet, B., Bennani, H., Benseddik, Z., Debliquis, A., Lusina, D., Roussel, M., Solly, F., Ticchioni, M., Saas, P. & 1 others, Garnache-Ottou, F., Jan 1 2015, In : Haematologica. 100, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phase i study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies

Bachanova, V., Frankel, A. E., Cao, Q., Lewis, D., Grzywacz, B., Verneris, M. R., Ustun, C., Lazaryan, A., McClune, B., Warlick, E. D., Kantarjian, H., Weisdorf, D. J., Miller, J. S. & Vallera, D. A., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Phospho-MEK1/2 and uPAR expression determine sensitivity of AML blasts to a urokinase-activated anthrax lethal toxin (PrAgU2/LF)

Bekdash, A., Darwish, M., Timsah, Z., Kassab, E., Ghanem, H., Najjar, V., Ghosn, M., Nasser, S., El-Hajj, H., Bazerbachi, A., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2015, In : Translational Oncology. 8, 5, p. 347-357 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma

Frankel, A. E., Woo, J. H., Ahn, C., Foss, F. M., Duvic, M., Neville, P. H. & Neville, D. M., 2015, In : Haematologica. 100, 6, p. 794-800 7 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

Frankel, A. E., Woo, J. H., Ahn, C., Pemmaraju, N., Medeiros, B. C., Carraway, H. E., Frankfurt, O., Forman, S. J., Yang, X. A., Konopleva, M., Garnache-Ottou, F., Angelot-Delettre, F., Brooks, C., Szarek, M. & Rowinsky, E., Jul 17 2014, In : Blood. 124, 3, p. 385-392 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts

Agrawal, V., Woo, J. H., Mauldin, J. P., Stone, E. M., Meininger, C. J., Jo, C., Kleypas, K., Frenkel, E. P. & Frankel, A. E., Dec 10 2014, In : Melanoma research. 24, 6, p. 556-567 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia

Frolova, O., Benito, J., Brooks, C., Wang, R. Y., Korchin, B., Rowinsky, E. K., Cortes, J., Kantarjian, H., Andreeff, M., Frankel, A. E. & Konopleva, M., Sep 2014, In : British Journal of Haematology. 166, 6, p. 862-874 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

Kassab, E., Darwish, M., Timsah, Z., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., Jan 1 2013, In : Translational Oncology. 6, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Diphtheria toxin-epidermal growth factor fusion protein DAB 389EGF for the treatment of bladder cancer

Yang, X., Kessler, E., Su, L. J., Thorburn, A., Frankel, A. E., Li, Y., La Rosa, F. G., Shen, J., Li, C. Y., Varella-Garcia, M., Glodé, L. M. & Flaig, T. W., Jan 1 2013, In : Clinical Cancer Research. 19, 1, p. 148-157 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Foreword

Frankel, A., Feb 2013, In : Expert Opinion on Biological Therapy. 13, 2

Research output: Contribution to journalArticle

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

Tanios, R., Bekdash, A., Kassab, E., Stone, E., Georgiou, G., Frankel, A. E. & Abi-Habib, R. J., Nov 1 2013, In : Leukemia Research. 37, 11, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics

Kuo, S. R., Tahir, S. A., Park, S., Thompson, T. C., Coffield, S., Frankel, A. E. & Liu, J. S., Apr 1 2012, In : Hybridoma. 31, 2, p. 77-86 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
14 Scopus citations

Cytotoxicity of human recombinant arginase i (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

Agrawal, V., Woo, J. H., Mauldin, J. P., Jo, C., Stone, E. M., Georgiou, G. & Frankel, A. E., Jan 1 2012, In : Anti-Cancer Drugs. 23, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Recombinant human arginase Toxicity in mice is reduced by citrulline supplementation

Mauldin, J. P., Zeinali, I., Kleypas, K., Woo, J. H., Blackwood, R. S., Jo, C. H., Stone, E. M., Georgiou, G. & Frankel, A. E., Feb 2012, In : Translational Oncology. 5, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: Role of autophagy

Kandadi, M. R., Frankel, A. E. & Ren, J., Oct 1 2012, In : British Journal of Pharmacology. 167, 3, p. 612-626 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

Schimmer, A. D., Herr, W., Hänel, M., Borthakur, G., Frankel, A., Horst, H. A., Martin, S., Kassis, J., Desjardins, P., Seiter, K., Fiedler, W., Noppeney, R., Giagounidis, A., Jacob, C., Jolivet, J., Tallman, M. S. & Koschmieder, S., Oct 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

TEM8 targeted cancer therapy

Frankel, A. E., Carter, C., Kuo, S. R., Woo, J. H., Mauldin, J. & Liu, J. S., Dec 1 2011, In : Anti-Cancer Agents in Medicinal Chemistry. 11, 10, p. 983-992 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton

Yang, M. Y., Chaudhary, A., Seaman, S., Dunty, J., Stevens, J., Elzarrad, M. K., Frankel, A. E. & St.Croix, B., Jan 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2010

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Vanderlaag, K., Su, Y., Frankel, A. E., Burghardt, R. C., Barhoumi, R., Chadalapaka, G., Jutooru, I. & Safe, S., Dec 3 2010, In : BMC Cancer. 10, 669.

Research output: Contribution to journalArticle

11 Scopus citations
15 Scopus citations

Anthrax lethal toxin suppresses murine cardiomyocyte contractile function and intracellular Ca2+ handling via a NADPH oxidase-dependent mechanism

Kandadi, M. R., Hua, Y., Ma, H., Li, Q., Kuo, S. R., Frankel, A. E. & Ren, J., Oct 13 2010, In : PloS one. 5, 10, e13335.

Research output: Contribution to journalArticle

26 Scopus citations

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

Vallera, D. A., Oh, S., Chen, H., Shu, Y. & Frankel, A. E., Jun 1 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1872-1883 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Characterization of variant diphtheria toxin-interleukin-3 fusion protein, DTIL3K116W, for phase I clinical trials

Su, Y., Li, S. Y., Ghosh, S., Ortiz, J., Hogge, D. E. & Frankel, A. E., Jan 1 2010, In : Biologicals. 38, 1, p. 144-149 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Ortiz, J. M., Lairmore, T. C., Duesbery, N. S., Mitchell, I. C., Nwariaku, F. & Frankel, A. E., Jan 1 2010, In : Molecular Cancer Therapeutics. 9, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials.

Woo, J. H., Lee, Y. J., Neville, D. M. & Frankel, A. E., Nov 12 2010, In : Methods in molecular biology (Clifton, N.J.). 651, p. 157-175 19 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Anthrax toxin: Pathologic effects on the cardiovascular system

Golden, H. B., Watson, L. E., Lal, H., Verma, S. K., Foster, D. M., Kuo, S. R., Sharma, A., Frankel, A. & Dostal, D. E., Jan 1 2009, In : Frontiers in Bioscience. 14, 6, p. 2335-2357 23 p.

Research output: Contribution to journalArticle

19 Scopus citations

Antibody internalization after cell surface antigen binding is critical for immunotoxin development

Kuo, S. R., Alfano, R. W., Frankel, A. E. & Liu, J. S., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1975-1982 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

Thorburn, J., Horita, H., Redzic, J., Hansen, K., Frankel, A. E. & Thorburn, A., Jan 1 2009, In : Cell Death and Differentiation. 16, 1, p. 175-183 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins

Horita, H., Thorburn, J., Frankel, A. E. & Thorburn, A., May 18 2009, In : Journal of Neuro-Oncology. 95, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Meininger, C. J., Lairmore, T. C., Mulne, A. F., Davis, S. H., Duesbery, N. S. & Frankel, A. E., Apr 1 2009, In : Molecular Cancer Research. 7, 4, p. 452-461 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pathophysiology of anthrax

Frankel, A. E., Kuo, S. R., Dostal, D., Watson, L., Duesbery, N. S., Cheng, C. P., Cheng, H. J., Tang, W. J. & Leppla, S. H., Jan 1 2009, In : Frontiers in Bioscience. 14, 12, p. 4516-4524 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of HMGB1 release by autophagy

Thorburn, J., Frankel, A. E. & Thorburn, A., Feb 16 2009, In : Autophagy. 5, 2, p. 247-249 3 p.

Research output: Contribution to journalArticle

38 Scopus citations
2008

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways

Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S. & Safe, S., May 1 2008, In : Breast Cancer Research and Treatment. 109, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms

Horita, H., Frankel, A. E. & Thorburn, A., Dec 11 2008, In : PloS one. 3, 12, e3909.

Research output: Contribution to journalArticle

38 Scopus citations