• 7958 Citations
  • 47 h-Index
1976 …2019

Research output per year

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Research Output

  • 7958 Citations
  • 47 h-Index
  • 241 Article
  • 8 Chapter
  • 4 Review article
  • 1 Comment/debate
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Article

1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

Su, Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S. & Frankel, A. E., Aug 31 2007, In : Breast Cancer Research. 9, 4, R56.

Research output: Contribution to journalArticle

15 Scopus citations

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Vanderlaag, K., Su, Y., Frankel, A. E., Burghardt, R. C., Barhoumi, R., Chadalapaka, G., Jutooru, I. & Safe, S., Dec 3 2010, In : BMC Cancer. 10, 669.

Research output: Contribution to journalArticle

11 Scopus citations

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways

Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S. & Safe, S., May 2008, In : Breast Cancer Research and Treatment. 109, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

14G2a anti-GD2 crossreactivity with the CD166 antigen

Agrawal, V. & Frankel, A. E., Nov 2010, In : Journal of Immunotherapy. 33, 9, p. 1014-1015 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

Frankel, A. E., Woo, J. H., Ahn, C., Pemmaraju, N., Medeiros, B. C., Carraway, H. E., Frankfurt, O., Forman, S. J., Yang, X. A., Konopleva, M., Garnache-Ottou, F., Angelot-Delettre, F., Brooks, C., Szarek, M. & Rowinsky, E., Jul 17 2014, In : Blood. 124, 3, p. 385-392 8 p.

Research output: Contribution to journalArticle

110 Scopus citations
21 Scopus citations

Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms

Horita, H., Frankel, A. E. & Thorburn, A., Dec 11 2008, In : PLoS One. 3, 12, e3909.

Research output: Contribution to journalArticle

38 Scopus citations

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

Schimmer, A. D., Herr, W., Hänel, M., Borthakur, G., Frankel, A., Horst, H. A., Martin, S., Kassis, J., Desjardins, P., Seiter, K., Fiedler, W., Noppeney, R., Giagounidis, A., Jacob, C., Jolivet, J., Tallman, M. S. & Koschmieder, S., Oct 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells

Liu, T. F., Cohen, K. A., Ramage, J. G., Willingham, M. C., Thorburn, A. M. & Frankel, A. E., Apr 15 2003, In : Cancer Research. 63, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors

Feuring-Buske, M., Frankel, A. E., Alexander, R. L., Gerhard, B. & Hogge, D. E., Mar 15 2002, In : Cancer Research. 62, 6, p. 1730-1736 7 p.

Research output: Contribution to journalArticle

99 Scopus citations
15 Scopus citations

Advances in AML immunotherapy: The case for T-bodies

Suh, D. Y. & Frankel, A. E., Feb 2007, In : Leukemia Research. 31, 2, p. 127-128 2 p.

Research output: Contribution to journalArticle

Advances in immunotoxin biology and therapy: A summary of the Fourth International Symposium on Immunotoxins

Frankel, A. E., FitzGerald, D., Siegall, C. & Press, O. W., 1996, In : Cancer Research. 56, 4, p. 926-932 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Advances in immunotoxins

Oeltmann, T. N. & Frankel, A. E., 1991, In : FASEB Journal. 5, 10, p. 2334-2337 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes

Gould, J. H., Hartley, M. R., Welsh, P. C., Hoshizaki, D. K., Frankel, A., Roberts, L. M. & Lord, J. M., Nov 1991, In : MGG Molecular & General Genetics. 230, 1-2, p. 81-90 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

A model scheme for human hematopoietic cell differentiation as determined by multiple markers of leukemia-lymphomas.

Minowada, J., Minato, K., Tatsumi, E., Sugimoto, T., Nakazawa, S., Ohnuma, T., Kubonishi, I., Miyoshi, I., Frankel, A. & Gallo, R. C., 1983, In : Hamatologie und Bluttransfusion. 28, p. 348-350 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

An anti-CD5 immunotoxin for chronic lymphocytic leukemia: enhancement of cytotoxicity with human serum albumin-monensin

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Blythman, H. E., Casellas, P. & Frankel, A. E., 1989, In : International Journal of Cancer. 43, 2, p. 215-219 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Poplack, D. G. & Frankel, A. E., Jan 1989, In : Cancer Immunology Immunotherapy. 28, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Anthrax fusion protein therapy of cancer

Frankel, A. E., Powell, B. L., Duesbery, N. S., Vande Woude, G. F. & Leppla, S. H., 2002, In : Current Protein and Peptide Science. 3, 4, p. 399-407 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral G protein-coupled receptor

Depeille, P., Young, J. J., Boguslawski, E. A., Berghuis, B. D., Kort, E. J., Resau, J. H., Frankel, A. E. & Duesbery, N. S., Oct 1 2007, In : Clinical Cancer Research. 13, 19, p. 5926-5934 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Anthrax lethal toxin suppresses murine cardiomyocyte contractile function and intracellular Ca2+ handling via a NADPH oxidase-dependent mechanism

Kandadi, M. R., Hua, Y., Ma, H., Li, Q., Kuo, S. R., Frankel, A. E. & Ren, J., Oct 13 2010, In : PLoS One. 5, 10, e13335.

Research output: Contribution to journalArticle

26 Scopus citations

Anthrax toxin: Pathologic effects on the cardiovascular system

Golden, H. B., Watson, L. E., Lal, H., Verma, S. K., Foster, D. M., Kuo, S. R., Sharma, A., Frankel, A. & Dostal, D. E., Jan 1 2009, In : Frontiers in Bioscience. 14, 6, p. 2335-2357 23 p.

Research output: Contribution to journalArticle

19 Scopus citations

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

Kuo, S. R., Willingham, M. C., Bour, S. H., Andreas, E. A., Park, S. K., Jackson, C., Duesbery, N. S., Leppla, S. H., Tang, W. J. & Frankel, A. E., Jun 2008, In : Microbial Pathogenesis. 44, 6, p. 467-472 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

Watson, L. E., Kuo, S. R., Katki, K., Dang, T., Park, S. K., Dostal, D. E., Tang, W. J., Leppla, S. H. & Frankel, A. E., May 23 2007, In : PLoS One. 2, 5, e466.

Research output: Contribution to journalArticle

49 Scopus citations

Antibody internalization after cell surface antigen binding is critical for immunotoxin development

Kuo, S. R., Alfano, R. W., Frankel, A. E. & Liu, J. S., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1975-1982 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
44 Scopus citations

Antibody-toxin hybrids: A clinical review of their use

Frankel, A. E., 1985, In : Journal of Biological Response Modifiers. 4, 5, p. 437-446 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics

Kuo, S. R., Tahir, S. A., Park, S., Thompson, T. C., Coffield, S., Frankel, A. E. & Liu, J. S., Apr 1 2012, In : Hybridoma. 31, 2, p. 77-86 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma

Frankel, A. E., Zuckero, S. L., Mankin, A. A., Grable, M., Mitchell, K., Lee, Y. J., Neville, D. M. & Woo, J. H., 2009, In : Current Drug Targets. 10, 2, p. 104-109 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer

Fitzgerald, D. J., Bjorn, M. J., Ferris, R. J., Winkelhake, J. L., Frankel, A. E., Hamilton, T. C., Ozols, R. F., Willingham, M. C. & Pastan, I., 1987, In : Cancer Research. 47, 5, p. 1407-1410 4 p.

Research output: Contribution to journalArticle

55 Scopus citations

A phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia

Frankel, A. E., Fleming, D. R., Hall, P. D., Powell, B. L., Black, J. H., Leftwich, C. & Gartenhaus, R., Oct 1 2003, In : Clinical Cancer Research. 9, 10 I, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

A phase I study of T101-ricin A chain immunotoxin in refractory chronic lymphocytic leukemia

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Laurent, G., Jansen, F. K., Schmidt, C. & Frankel, A. E., 1988, In : Journal of Biological Response Modifiers. 7, 1, p. 97-113 17 p.

Research output: Contribution to journalArticle

71 Scopus citations

Apoptosis and anthracycline cardiotoxicity

Thorburn, A. & Frandel, A. E., Feb 2006, In : Molecular Cancer Therapeutics. 5, 2, p. 197-199 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein

Thorburn, J., Frankel, A. E. & Thorburn, A., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 861-865 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Arginine deprivation therapy for malignant melanoma

Yoon, J. K., Frankel, A. E., Feun, L. G., Ekmekcioglu, S. & Kim, K. B., Dec 21 2012, In : Clinical Pharmacology: Advances and Applications. 5, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

139 Scopus citations

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Abi-Habib, R. J., Singh, R., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 2006, In : Molecular Cancer Therapeutics. 5, 10, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Abi-Habib, R. J., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 1 2004, In : Blood. 104, 7, p. 2143-2148 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

Thorburn, J., Horita, H., Redzic, J., Hansen, K., Frankel, A. E. & Thorburn, A., 2009, In : Cell Death and Differentiation. 16, 1, p. 175-183 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

Vallera, D. A., Oh, S., Chen, H., Shu, Y. & Frankel, A. E., Jun 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1872-1883 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Biological, immunological, and biochemical evidence that HIX virus is a recombinant between moloney leukemia virus and a murine xenotropic C type virus

Fischinger, P. J., Frankel, A. E., Elder, J. H., Lerner, R. A., Ihle, J. N. & Bolognesi, D. P., Oct 15 1978, In : Virology. 90, 2, p. 241-254 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Biological, immunological, and molecular properties of revertants of cat cells transformed by murine sarcoma virus

Fischinger, P. J., Blevins, C. S., Frankel, A. E., Tuttle-Fuller, N., Haapala, D. K., Nomura, S. & Robey, W. G., 1981, In : Cancer Research. 41, 3, p. 958-965 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Bispecific immunotoxins

Frankel, A. E. & Woo, J. H., Sep 2009, In : Leukemia Research. 33, 9, p. 1173-1174 2 p.

Research output: Contribution to journalArticle

8 Scopus citations
1 Scopus citations

BRAF status and mitogen-activated protein/extracellular signal regulated kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Abi-Habib, R. J., Urieto, J. O., Liu, S., Leppla, S. H., Duesbery, N. S. & Frankel, A. E., Sep 2005, In : Molecular Cancer Therapeutics. 4, 9, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Breast cancer immunotoxins

Winkelhake, J., Frankel, A. E. & Ring, D., 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

1 Scopus citations
14 Scopus citations

Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF

Frankel, A. E., Hall, P. D., McLain, C., Safa, A. R., Tagge, E. P. & Kreitman, R. J., Jul 1998, In : Bioconjugate Chemistry. 9, 4, p. 490-496 7 p.

Research output: Contribution to journalArticle

31 Scopus citations