• 8086 Citations
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1976 …2020

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Combination fusion protein therapy of refractory brain tumors: Demonstration of efficacy in cell culture

Liu, T. F., Cohen, K. A., Willingham, M. C., Tatter, S. B., Puri, R. K. & Frankel, A. E., Oct 1 2003, In : Journal of Neuro-Oncology. 65, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

Kassab, E., Darwish, M., Timsah, Z., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., Jan 1 2013, In : Translational Oncology. 6, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cytotoxicity of human recombinant arginase i (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells

Agrawal, V., Woo, J. H., Mauldin, J. P., Jo, C., Stone, E. M., Georgiou, G. & Frankel, A. E., Jan 1 2012, In : Anti-Cancer Drugs. 23, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi

Tagge, E., Chandler, J., Tang, B. L., Hong, W., Willingham, M. C. & Frankel, A., Feb 1996, In : Journal of Histochemistry and Cytochemistry. 44, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Herlyn, M., Smalley, K. S., Bromberg-White, J. L., Duesbery, N. S. & Frankel, A. E., Oct 13 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dab389IL2 diphtheria fusion toxin produces clinical responses in tumor stage cutaneous T cell lymphoma

Duvic, M., Cather, J., Maize, J. & Frankel, A. E., May 1 1998, In : American Journal of Hematology. 58, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Developing EZH2-targeted therapy for lung cancer

Frankel, A. E., Liu, X. & Minna, J. D., Sep 1 2016, In : Cancer Discovery. 6, 9, p. 949-952 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differentiating hepatic abscess from tumor: Combined 111In white blood cell and 99mTc liver scans

Fawcett, H. D., Lantieri, R. L., Frankel, A. & McDougall, I. R., Jan 1 1980, In : American Journal of Roentgenology. 135, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Digoxin Plus Trametinib Therapy Achieves Disease Control in BRAF Wild-Type Metastatic Melanoma Patients

Frankel, A. E., Eskiocak, U., Gill, J. G., Yuan, S., Ramesh, V., Froehlich, T. W., Ahn, C. & Morrison, S. J., Apr 1 2017, In : Neoplasia (United States). 19, 4, p. 255-260 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Diphtheria Toxin-Epidermal Growth Factor Fusion Protein and Pseudomonas Exotoxin-Interleukin 13 Fusion Protein Exert Synergistic Toxicity against Human Glioblastoma Multiforme Cells

Liu, T. F., Willingham, M. C., Tatter, S. B., Cohen, K. A., Corinne Lowe, A., Thorburn, A. & Frankel, A. E., Nov 1 2003, In : Bioconjugate Chemistry. 14, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Diphtheria toxin-epidermal growth factor fusion protein DAB 389EGF for the treatment of bladder cancer

Yang, X., Kessler, E., Su, L. J., Thorburn, A., Frankel, A. E., Li, Y., La Rosa, F. G., Shen, J., Li, C. Y., Varella-Garcia, M., Glodé, L. M. & Flaig, T. W., Jan 1 2013, In : Clinical Cancer Research. 19, 1, p. 148-157 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Diphtheria toxin fused to GM-CSF in combination with ARA-C exerts synergistic toxicity to human AML (HL60) cells

Bhalia, K. M., Kreitman, R. J., Hall, P. & Frankel, A., Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells

Kim, C. N., Bhalla, K., Kreitman, R. J., Willingham, M. C., Hall, P., Tagge, E. P., Jia, T. & Frankel, A. E., Jun 1 1999, In : Leukemia Research. 23, 6, p. 527-538 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia

Frankel, A. E., Lilly, M., Kreitman, R., Hogge, D., Beran, M., Freedman, M. H., Emanuel, P. D., McLain, C., Hall, P., Tagge, E., Berger, M. & Eaves, C., Dec 1 1998, In : Blood. 92, 11, p. 4279-4286 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Diphtheria toxin fused to human gm-csf is toxic to primary malignant progenitors from patients with AML, JMML and CMML

Frankel, A., Eaves, C., Hall, P., Kreitman, R., Lilly, M., Heran, M. & Bc, Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

Frankel, A. E., McCubrey, J. A., Miller, M. S., Delatte, S., Ramage, J., Kiser, M., Kucera, G. L., Alexander, R. L., Beran, M., Tagge, E. P., Kreitman, R. J. & Hogge, D. E., Jan 1 2000, In : Leukemia. 14, 4, p. 576-585 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

Testa, U., Riccioni, R., Biffoni, M., Diverio, D., Lo-Coco, F., Foà, R., Peschle, C. & Frankel, A. E., Oct 1 2005, In : Blood. 106, 7, p. 2527-2529 3 p.

Research output: Contribution to journalArticle

36 Scopus citations

Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity

Liu, T. F., Urieto, J. O., Moore, J. E., Miller, M. S., Lowe, A. C., Thorburn, A. & Frankel, A. E., Mar 1 2004, In : Experimental Hematology. 32, 3, p. 277-281 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Diphtheria-toxin-interleukin-3 fusion protein (DT388IL3) prolongs disease-free survival of leukemic immunocompromised mice

Black, J. H., McCubrey, J. A., Willingham, M. C., Ramage, J., Hogge, D. E. & Frankel, A. E., Jan 1 2003, In : Leukemia. 17, 1, p. 155-159 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells

Westcott, M. M., Abi-Habib, R. J., Cohen, K. A., Willingham, M. C., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Dec 1 2004, In : Molecular Cancer Therapeutics. 3, 12, p. 1681-1689 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation

Lilly, M. B., Zemskova, M., Frankel, A. E., Salo, J. & Kraft, A. S., Mar 15 2001, In : Blood. 97, 6, p. 1662-1670 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Distribution and Physical Properties of BCA200, a Mr 200,000 Glycoprotein Selectively Associated with Human Breast Cancer

Ring, D. B., Kassel, J. A., Hsieh-Ma, S. T., Bjorn, M. J., Tringale, F., Eaton, A. M., Reid, S. A., Frankel, A. E. & Nadji, M., Jun 1 1989, In : Cancer research. 49, 11, p. 3070-3080 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Double-lectin site ricin B chain mutants expressed in insect cells have residual galactose binding: Evidence for more than two lectin sites on the ricin toxin B chain

Fu, T., Burbage, C., Tagge, E., Chandler, J., Willingham, M. & Frankel, A., Nov 1 1996, In : Bioconjugate Chemistry. 7, 6, p. 651-658 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Double-site ricin B chain mutants retain galactose binding

Frankel, A., Tagge, E., Chandler, J., Burbage, C. & Willingham, M., Apr 1 1996, In : Protein Engineering. 9, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
Open Access
38 Scopus citations

Effective targeted cytotoxicity of neuroblastoma cells

Thomas, P. B., Delatte, S. J., Sutphin, A., Frankel, A. E. & Tagge, E. P., Jan 1 2002, In : Journal of Pediatric Surgery. 37, 3, p. 539-544 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Effect of helper virus on the number of murine sarcoma virus DNA copies in infected mammalian cells

Frankel, A. E., Gilbert, J. H. & Fischinger, P. J., Dec 1 1977, In : Journal of virology. 23, 3, p. 492-502 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy and safety of gemtuzumab ozogamicin in patients with poor-prognosis acute myeloid leukemia

Roboz, G. J., Knovich, M. A., Bayer, R. L., Schuster, M. W., Seiter, K., Powell, B. L., Woodruff, R. D., Silver, R. T., Frankel, A. E. & Feldman, E. J., Oct 1 2002, In : Leukemia and Lymphoma. 43, 10, p. 1951-1955 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins

Horita, H., Thorburn, J., Frankel, A. E. & Thorburn, A., May 18 2009, In : Journal of Neuro-Oncology. 95, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

Frankel, A. E., Haapala, D. K., Neubauer, R. L. & Fischinger, P. J., Jan 1 1976, In : Science. 191, 4233, p. 1264-1266 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Stein, E. M., DiNardo, C. D., Pollyea, D. A., Fathi, A. T., Roboz, G. J., Altman, J. K., Stone, R. M., Deangelo, D. J., Levine, R. L., Flinn, I. W., Kantarjian, H. M., Collins, R., Patel, M. R., Frankel, A. E., Stein, A., Sekeres, M. A., Swords, R. T., Medeiros, B. C., Willekens, C., Vyas, P. & 7 others, Tosolini, A., Xu, Q., Knight, R. D., Yen, K. E., Agresta, S., De Botton, S. & Tallman, M. S., Aug 10 2017, In : Blood. 130, 6, p. 722-731 10 p.

Research output: Contribution to journalArticle

388 Scopus citations

Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT388-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF

Senchenkov, A., Han, T. Y., Wang, H., Frankel, A. E., Kottke, T. J., Kaufmann, S. H. & Cabot, M. C., Sep 15 2001, In : Blood. 98, 6, p. 1927-1934 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation off Monoclonal Antibodies for the Development off Breast Cancer Immunotoxins

Bjorn, M. J., Ring, D. & Frankel, A., Mar 1 1985, In : Cancer Research. 45, 3, p. 1214-1221 8 p.

Research output: Contribution to journalArticle

101 Scopus citations

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Khushman, M., Patel, G. K., Laurini, J. A., Bhardwaj, A., Roveda, K., Donnell, R., Sherling, K., Case, B., Frankel, A. E., Pai, S., Taylor, W., Tan, M. C. B., Mizrahi, M., Nelson, C., Wyatt, M., Patton, M., McClellan, S., Singh, S., Wang, B. & Singh, A. P., Jan 1 2019, In : Journal of Gastrointestinal Oncology. 10, 4, p. 695-702 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials

Urieto, J. O., Liu, T., Black, J. H., Cohen, K. A., Hall, P. D., Willingham, M. C., Pennell, L. K., Hogge, D. E., Kreitman, R. J. & Frankel, A. E., Jan 2004, In : Protein Expression and Purification. 33, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Expression of active, processed ricin in transgenic tobacco

Sehnke, P. C., Pedrosa, L., Paul, A. L., Frankel, A. E. & Ferl, R. J., Sep 9 1994, In : Journal of Biological Chemistry. 269, 36, p. 22473-22476 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
45 Scopus citations

Expression of Oligohistidine-Tagged Ricin B Chain in Spodoptera frugiperda

Afrin, L. B., Gulick, H., Vesely, J., Willingham, M. & Frankel, A. E., Nov 1 1994, In : Bioconjugate Chemistry. 5, 6, p. 539-546 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Expression of ricin B chain in Spodoptera frugiperda

Frankel, A., Roberts, H., Afrin, L., Vesely, J. & Willingham, M., Jan 1 1994, In : Biochemical Journal. 303, 3, p. 787-794 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Fibrin matrix for local delivery of a mitotoxin to inhibit vascular smooth muscle cell proliferation

Brothers, T. E., Boggs, J., Goldsmith, C., Frankel, A. E. & Willingham, M. C., Dec 1 1996, In : FASEB Journal. 10, 3, p. A621

Research output: Contribution to journalArticle

Foreword

Frankel, A., Feb 2013, In : Expert Opinion on Biological Therapy. 13, 2

Research output: Contribution to journalArticle

Fractionation of DNA nucleotide transcripts from Moloney sarcoma virus and isolation of sarcoma virus specific complementary DNA

Frankel, A. E., Neubauer, R. L. & Fischinger, P. J., Dec 1 1976, In : Journal of virology. 18, 2, p. 481-490 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
4 Scopus citations

GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1) for phase I/II clinical trials

Woo, J. H., Liu, J. S., Kang, S. H., Singh, R., Park, S. K., Su, Y., Ortiz, J., Neville, D. M., Willingham, M. C. & Frankel, A. E., Mar 1 2008, In : Protein Expression and Purification. 58, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Growth factor receptor expression varies among high-grade gliomas and normal brain: Epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy

Liu, T. F., Tatter, S. B., Willingham, M. C., Yang, M., Hu, J. J. & Frankel, A. E., Aug 1 2003, In : Molecular Cancer Therapeutics. 2, 8, p. 783-787 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

High affinity interleukin-3 receptor expression on blasts from patients with acute myelogenous leukemia correlates with cytotoxicity of a diphtheria toxin/IL-3 fusion protein

Alexander, R. L., Ramage, J., Kucera, G. L., Caligiuri, M. A. & Frankel, A. E., Sep 4 2001, In : Leukemia Research. 25, 10, p. 875-881 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

High-level expression and purification of the recombinant diphtheria fusion toxin DTGM for PHASE I clinical trials

Frankel, A. E., Ramage, J., Latimer, A., Feely, T., Delatte, S., Hall, P., Tagge, E., Kreitman, R. & Willingham, M., Jun 1999, In : Protein Expression and Purification. 16, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

High-level expression and simplified purification of recombinant ricin A chain

Li, B. Y., Frankel, A. E. & Ramakrishnan, S., Oct 1992, In : Protein Expression and Purification. 3, 5, p. 386-394 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Human DRA functions as a sulfate transporter in Sf9 insect cells

Byeon, M. K., Frankel, A., Papas, T. S., Henderson, K. W. & Schweinfest, C. W., Feb 1998, In : Protein Expression and Purification. 12, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Human prostate specific and shared differentiation antigens defined by monoclonal antibodies

Frankel, A. E., Rouse, R. V. & Herzenberg, L. A., Jan 1 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 3 I, p. 903-907 5 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations