• 8086 Citations
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1976 …2020

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Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

Burrage, L. C., Sun, Q., Elsea, S. H., Jiang, M. M., Nagamani, S. C. S., Frankel, A. E., Stone, E., Alters, S. E., Johnson, D. E., Rowlinson, S. W., Georgiou, G. & Lee, B. H., 2015, In : Human Molecular Genetics. 24, 22, p. 6417-6427 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

Tanios, R., Bekdash, A., Kassab, E., Stone, E., Georgiou, G., Frankel, A. E. & Abi-Habib, R. J., Nov 1 2013, In : Leukemia Research. 37, 11, p. 1565-1571 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

Khoury, O., Ghazale, N., Stone, E., El-Sibai, M., Frankel, A. E. & Abi-Habib, R. J., Jan 1 2015, In : Journal of Neuro-Oncology. 122, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Humoral Immune Response to a Ricin A Chain Immunotoxin in Patients with Metastatic Melanoma

Herlter, A. A., Spitler, L. E. & Frankel, A. E., Jan 1 1987, In : Cancer Drug Delivery. 4, 4, p. 245-253 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

IgA and IgM rheumatoid factors in serum, saliva and other secretions: Relationship to immunoglobulin ratios in systemic sicca syndrome and rheumatoid arthritis

Elkon, K. B., Gharavi, A. E., Patel, B. M., Hughes, G. R. & Frankel, A., Jun 2 1983, In : Clinical and Experimental Immunology. 52, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

IL2 fused to lectin-deficient ricin is toxic to human leukemia cells expressing the IL2 receptor

Frankel, A. E., Fu, T., Burbage, C., Chandler, J., Willingham, M. C. & Tagge, E. P., Jan 1 1997, In : Leukemia. 11, 1, p. 22-30 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

IL2-Ricin Fusion Toxin is Selectively Cytotoxic in Vitro to IL2 Receptor-Bearing Tumor Cells

Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. & Willingham, M., Jan 1 1995, In : Bioconjugate Chemistry. 6, 6, p. 666-672 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Immunotherapy of acute myeloid leukemia

Frankel, A. E., Baer, M. R., Hogge, D. E. & Stuart, R. K., Sep 11 2001, In : Current Pharmaceutical Biotechnology. 2, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunotoxins in the therapy of leukemias and lymphomas

Hertler, A. A. & Frankel, A. E., Jan 1 1991, In : Cancer Investigation. 9, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immunotoxin therapy of hematologic malignancies

Frankel, A. E., Neville, D. M., Bugge, T. A., Kreitman, R. J. & Leppla, S. H., Aug 2003, In : Seminars in oncology. 30, 4, p. 545-557 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2-mutated blastic plasmacytoid dendritic cell neoplasm

Rakheja, D., Fuda, F. S., Vandergriff, T. W., Boriack, R., Medeiros, B. C., Frankel, A. E. & Chen, W., Feb 1 2015, In : Human Pathology. 46, 2, p. 322-326 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Ortiz, J. M., Lairmore, T. C., Duesbery, N. S., Mitchell, I. C., Nwariaku, F. & Frankel, A. E., Jan 1 2010, In : Molecular Cancer Therapeutics. 9, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interleukin 2 (IL-2) receptor expression and sensitivity to diphtheria fusion toxin DAB389IL-2 in cultured hematopoietic cells

Re, G. G., Waters, C., Poisson, L., Willingham, M. C., Sugamura, K. & Frankel, A. E., Jun 1 1996, In : Cancer Research. 56, 11, p. 2590-2595 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice

Liu, T. F., Hall, P. D., Cohen, K. A., Willingham, M. C., Cai, J., Thorburn, A. & Frankel, A. E., Jan 1 2005, In : Clinical Cancer Research. 11, 1, p. 329-334 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

In vitro interleukin-3 binding to leukemia cells predicts cytotoxicity of a diphtheria toxin/IL-3 fusion protein

Alexander, R. L., Kucera, G. L., Klein, B. & Frankel, A. E., Jul 1 2000, In : Bioconjugate Chemistry. 11, 4, p. 564-568 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to sl-401, an interleukin-3 receptor targeted biologic agent

Angelot-Delettre, F., Roggy, A., Frankel, A. E., Lamarthee, B., Seilles, E., Biichle, S., Royer, B., Deconinck, E., Rowinsky, E. K., Brooks, C., Bardet, V., Benet, B., Bennani, H., Benseddik, Z., Debliquis, A., Lusina, D., Roussel, M., Solly, F., Ticchioni, M., Saas, P. & 1 others, Garnache-Ottou, F., Jan 1 2015, In : Haematologica. 100, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts

Agrawal, V., Woo, J. H., Mauldin, J. P., Stone, E. M., Meininger, C. J., Jo, C., Kleypas, K., Frenkel, E. P. & Frankel, A. E., Dec 10 2014, In : Melanoma research. 24, 6, p. 556-567 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Laboratory preparation of a deglycosylated ricin toxin A chain containing immunotoxin directed against a CD7 T lineage differentiation antigen for phase I human clinical studies involving T cell malignancies

Vallera, D. A., Burns, L. J., Frankel, A. E., Sicheneder, A. R., Gunther, R., Gajl-Peczalska, K., Pennell, C. A. & Kersey, J. H., Oct 16 1996, In : Journal of Immunological Methods. 197, 1-2, p. 69-83 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Lectin-deficient ricin toxin indicates cells bearing the D-mannose receptor

Frankel, A. E., Fu, T., Burbage, C., Tagge, E., Harris, B., Vesely, J. & Willingham, M. C., May 16 1997, In : Carbohydrate Research. 300, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

Watson, L. E., Mock, J., Lal, H., Lu, G., Bourdeau, R. W., Tang, W. J., Leppla, S. H., Dostal, D. E. & Frankel, A. E., May 1 2007, In : Frontiers in Bioscience. 12, 12, p. 4670-4675 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein

Hogge, D. E., Willman, C. L., Kreitman, R. J., Berger, M., Hall, P. D., Kopecky, K. J., McLain, C., Tagge, E. P., Eaves, C. J. & Frankel, A. E., Jul 15 1998, In : Blood. 92, 2, p. 589-595 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Malignant progenitors from patients with CD87+ acute myelogenous leukemia are sensitive to a diphtheria toxin-urokinase fusion protein

Frankel, A. E., Beran, M., Hogge, D. E., Powell, B. L., Thorburn, A., Chen, Y. Q. & Vallera, D. A., Nov 1 2002, In : Experimental Hematology. 30, 11, p. 1316-1323 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

Liu, S., Wang, H., Currie, B. M., Molinolo, A., Leung, H. J., Moayeri, M., Basile, J. R., Alfano, R. W., Gutkind, J. S., Frankel, A. E., Bugge, T. H. & Leppla, S. H., Jan 4 2008, In : Journal of Biological Chemistry. 283, 1, p. 529-540 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Meininger, C. J., Lairmore, T. C., Mulne, A. F., Davis, S. H., Duesbery, N. S. & Frankel, A. E., Apr 1 2009, In : Molecular Cancer Research. 7, 4, p. 452-461 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
79 Scopus citations

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

Ding, Y., Boguslawski, E. A., Berghuis, B. D., Young, J. J., Zhang, Z., Hardy, K., Furge, K., Kort, E., Frankel, A. E., Hay, R. V., Resau, J. H. & Duesbery, N. S., Mar 1 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 648-658 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein

Frankel, A. E., Hall, P. D., Burbage, C., Vesely, J., Willingham, M., Bhalla, K. & Kreitman, R. J., Nov 15 1997, In : Blood. 90, 9, p. 3654-3661 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Monoclonal Antibodies to a Human Prostate Antigen

Frankel, A. E., Rouse, R. V., Wang, M. C., Chu, T. M. & Herzenberg, L. A., Sep 1 1982, In : Cancer research. 42, 9, p. 3714-3718 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Monoclonal antobodies, benign breast disease, and breast cancer. A panel discussion

McGuire, W. L., Ceriani, R. L., Schlom, J. & Frankel, A. E., Jan 1 1985, In : Breast Cancer Research and Treatment. 6, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nature and distribution of feline sarcoma virus nucleotide sequences

Frankel, A. E., Gilbert, J. H., Porzig, K. J., Scolnick, E. M. & Aaronson, S. A., Jan 1 1979, In : Unknown Journal. 30, 3, p. 821-827 7 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells

Thorburn, J., Staskiewicz, L., Goodall, M. L., Dimberg, L., Frankel, A. E., Ford, H. L. & Thorburn, A., Jan 1 2017, In : Molecular Pharmacology. 91, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus

Frankel, A. E. & Fischinger, P. J., Jan 1 1976, In : Proceedings of the National Academy of Sciences of the United States of America. 73, 10, p. 3705-3709 5 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice

Kiser, M., McCubrey, J. A., Steelman, L. S., Shelton, J. G., Ramage, J., Alexander, R. L., Kucera, G. L., Pettenati, M., Willingham, M. C., Miller, M. S. & Frankel, A. E., Jan 1 2001, In : Leukemia. 15, 5, p. 814-818 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Pathophysiology of anthrax

Frankel, A. E., Kuo, S. R., Dostal, D., Watson, L., Duesbery, N. S., Cheng, C. P., Cheng, H. J., Tang, W. J. & Leppla, S. H., Jan 1 2009, In : Frontiers in Bioscience. 14, 12, p. 4516-4524 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials.

Woo, J. H., Lee, Y. J., Neville, D. M. & Frankel, A. E., Nov 12 2010, In : Methods in molecular biology (Clifton, N.J.). 651, p. 157-175 19 p.

Research output: Contribution to journalArticle

23 Scopus citations

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Gerber, D. E., Beg, M. S., Fattah, F., Frankel, A. E., Fatunde, O., Arriaga, Y., Dowell, J. E., Bisen, A., Leff, R. D., Meek, C. C., Putnam, W. C., Kallem, R. R., Subramaniyan, I., Dong, Y., Bolluyt, J., Sarode, V., Luo, X., Xie, Y., Schwartz, B. & Boothman, D. A., Oct 16 2018, In : British journal of cancer. 119, 8, p. 928-936 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia

Frankel, A., Liu, J. S., Rizzieri, D. & Hogge, D., Mar 1 2008, In : Leukemia and Lymphoma. 49, 3, p. 543-553 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Phase I Evaluation of an Anti-Breast Carcinoma Monoclonal Antibody 260F9-Recombinant Ricin A Chain Immunoconjugate

Weiner, L. M., O'Dwyer, J., Kitson, J., Comis, R. L., Frankel, A. E., Bauer, R. J., Konrad, M. S. & Groves, E. S., Jul 15 1989, In : Cancer Research. 49, 14, p. 4062-4067 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Phase II clinical studies of denileukin diftitox diphtheria toxin fusion protein in patients with previously treated chronic lymphocytic leukemia

Frankel, A. E., Surendranathan, A., Black, J. H., White, A., Ganjoo, K. & Cripe, L. D., May 15 2006, In : Cancer. 106, 10, p. 2158-2164 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Phase i study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies

Bachanova, V., Frankel, A. E., Cao, Q., Lewis, D., Grzywacz, B., Verneris, M. R., Ustun, C., Lazaryan, A., McClune, B., Warlick, E. D., Kantarjian, H., Weisdorf, D. J., Miller, J. S. & Vallera, D. A., Mar 15 2015, In : Clinical Cancer Research. 21, 6, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Phase I study of an anti-breast cancer immunotoxin by continuous infusion: Report of a targeted toxic effect not predicted by animal studies

Gould, B. J., Borowitz, M. J., Groves, E. S., Carter, P. W., Anthony, D., Weiner, L. M. & Frankel, A. E., May 22 1989, In : Journal of the National Cancer Institute. 81, 10, p. 775-781 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia

Frankel, A. E., Powell, B. L., Hall, P. D., Case, L. D. & Kreitman, R. J., May 2002, In : Clinical Cancer Research. 8, 5, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Phase I trial of H65-RTA immunoconjugate in patients with cutaneous T-cell lymphoma

LeMaistre, C. F., Rosen, S., Frankel, A., Kornfeld, S., Saria, E., Meneghetti, C., Drajesk, J., Fishwild, D., Scannon, P. & Byers, V., Jan 1 1991, In : Blood. 78, 5, p. 1173-1182 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Phospho-MEK1/2 and uPAR expression determine sensitivity of AML blasts to a urokinase-activated anthrax lethal toxin (PrAgU2/LF)

Bekdash, A., Darwish, M., Timsah, Z., Kassab, E., Ghanem, H., Najjar, V., Ghosn, M., Nasser, S., El-Hajj, H., Bazerbachi, A., Liu, S., Leppla, S. H., Frankel, A. E. & Abi-Habib, R. J., 2015, In : Translational Oncology. 8, 5, p. 347-357 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma

Olsen, E., Duvic, M., Frankel, A., Kim, Y., Martin, A., Vonderheid, E., Jegasothy, B., Wood, G., Gordon, M., Heald, P., Oseroff, A., Pinter-Brown, L., Bowen, G., Kuzel, T., Fivenson, D., Foss, F., Glode, M., Molina, A., Knobler, E., Stewart, S. & 6 others, Cooper, K., Stevens, S., Craig, F., Reuben, J., Bacha, P. & Nichols, J., Jan 15 2001, In : Journal of Clinical Oncology. 19, 2, p. 376-388 13 p.

Research output: Contribution to journalArticle

530 Scopus citations

Preclinical studies in rats and squirrel monkeys for safety evaluation of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1)

Woo, J. H., Bour, S. H., Dang, T., Lee, Y. J., Park, S. K., Andreas, E., Kang, S. H., Liu, J. S., Neville, D. M. & Frankel, A. E., Aug 1 2008, In : Cancer Immunology, Immunotherapy. 57, 8, p. 1225-1239 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Preproricin expressed in Nicotiana tabacum cells in vitro is fully processed and biologically active

Tagge, E. P., Chandler, J., Harris, B., Czako, M., Marton, L., Willingham, M. C., Burbage, C., Afrin, L. & Frankel, A. E., Aug 1996, In : Protein Expression and Purification. 8, 1, p. 109-118 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rate of divergence of cellular sequences homologous to segments of Moloney sarcoma virus

Frankel, A. E. & Fischinger, P. J., Jan 1 1977, In : Journal of virology. 21, 1, p. 153-160 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Receptor upregulation enhances cell surface receptor targeted therapies

Frankel, A. E., Dec 1 2002, In : Leukemia Research. 26, 12, p. 1069-1071 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Recombinant human arginase Toxicity in mice is reduced by citrulline supplementation

Mauldin, J. P., Zeinali, I., Kleypas, K., Woo, J. H., Blackwood, R. S., Jo, C. H., Stone, E. M., Georgiou, G. & Frankel, A. E., Feb 2012, In : Translational Oncology. 5, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

21 Scopus citations