• 8086 Citations
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1976 …2020

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Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Singh, R., Browning, J. L., Abi-Habib, R., Wong, K., Williams, S. A., Merchant, R., Denmeade, S. R., Buckley, T. J. & Frankel, A. E., Aug 1 2007, In : Anti-Cancer Drugs. 18, 7, p. 809-816 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Recombinant ricin B chain produced in Escherichia coli is biologically active

Tonevitsky, A. G., Toptygin Yu., A., Agapov, I. I., Rakhmanova, V. A., Shamshiev, A. T., Alekseev Yu., O., Pfuller, U. & Frankel, A., Jan 1 1995, In : Molekulyarnaya Biologiya. 29, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

Reducing anti-DT IgG concentrations to improve the efficacy of a diphtheria fusion protein

Hall, P. D., Beagle, K. L., Garrett-Mayer, E. & Frankel, A. E., Nov 1 2008, In : Anti-Cancer Drugs. 19, 10, p. 1007-1011 5 p.

Research output: Contribution to journalArticle

Regulation of HMGB1 release by autophagy

Thorburn, J., Frankel, A. E. & Thorburn, A., Feb 16 2009, In : Autophagy. 5, 2, p. 247-249 3 p.

Research output: Contribution to journalArticle

38 Scopus citations

Renaturated ricin toxin B chain made in Escherichia coli is soluble, stable, and biologically active

Tonevitsky, A., Toptygin, A., Agapov, I., Pfueller, U. & Frankel, A., Jan 1 1994, In : Biochemistry and Molecular Biology International. 32, 6, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Resimmune, an anti-CD3ε recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma

Frankel, A. E., Woo, J. H., Ahn, C., Foss, F. M., Duvic, M., Neville, P. H. & Neville, D. M., 2015, In : Haematologica. 100, 6, p. 794-800 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells

Burbage, C., Tagge, E. P., Harris, B., Hall, P., Fu, T., Willingham, M. C. & Frankel, A. E., Jul 1 1997, In : Leukemia Research. 21, 7, p. 681-690 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1α, 1β, and 2γ

Frankel, A. E., Burbage, C., Fu, T., Tagge, E., Chandler, J. & Willingham, M. C., Nov 26 1996, In : Biochemistry. 35, 47, p. 14749-14756 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Ricin toxin contains three lectin sites which contribute to its in vivo toxicity

Fu, T., Burbage, C., Tagge, E. P., Brothers, T., Willingham, M. C. & Frankel, A. E., Dec 1996, In : International Journal of Immunopharmacology. 18, 12, p. 685-689 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

RLIP76 and Cancer

Awasthi, S., Singhal, S. S., Awasthi, Y. C., Martin, B., Woo, J. H., Cunningham, C. C. & Frankel, A. E., Jul 15 2008, In : Clinical Cancer Research. 14, 14, p. 4372-4384 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

Role of arginine 180 and glutamic acid 177 of ricin toxin a chain in enzymatic inactivation of ribosomes

Frankel, A., Welsh, P., Richardson, J. & Robertus, J. D., Jan 1 1990, In : Molecular and cellular biology. 10, 12, p. 6257-6263 7 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes.

Schlossman, D., Withers, D., Welsh, P., Alexander, A., Robertus, J. & Frankel, A., Nov 1989, In : Molecular and cellular biology. 9, 11, p. 5012-5021 10 p.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey

Cohen, K. A., Liu, T. F., Cline, J. M., Wagner, J. D., Hall, P. D. & Frankel, A. E., Jul 1 2005, In : Cancer Immunology, Immunotherapy. 54, 8, p. 799-806 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Selection and characterization of ricin toxin A-chain mutations in Saccharomyces cerevisiae.

Frankel, A., Schlossman, D., Welsh, P., Hertler, A., Withers, D. & Johnston, S., Feb 1989, In : Molecular and cellular biology. 9, 2, p. 415-420 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Selection of monoclonal antibodies for the development of breast cancer selective immunotoxins

Frankel, A., Ring, D., Kaplan, D. & Bjorn, M., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 11

Research output: Contribution to journalArticle

Selective cytotoxicity of a diphtheria toxin-interleukin-3 fusion protein on acute myleoid leukemia stem cells

Feuriag-Buske, M., Frankel, A., Alexander, R., Gerhard, G. & Hogge, D., Dec 1 2001, In : European Journal of Cancer. 37, SUPPL. 1, p. S12

Research output: Contribution to journalArticle

SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia

Frolova, O., Benito, J., Brooks, C., Wang, R. Y., Korchin, B., Rowinsky, E. K., Cortes, J., Kantarjian, H., Andreeff, M., Frankel, A. E. & Konopleva, M., Sep 2014, In : British Journal of Haematology. 166, 6, p. 862-874 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structure and activity of an active site substitution of ricin A chain

Day, P. J., Ernst, S. R., Frankel, A. E., Monzingo, A. F., Pascal, J. M., Molina-Svinth, M. C. & Robertus, J. D., Sep 22 1996, In : Biochemistry. 35, 34, p. 11098-11103 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Structure of a Ricin Mutant Showing Rescue of Activity by a Noncatalytic Residue

Kim, Y., Mlsna, D., Monzingo, A. F., Ready, M. P., Frankel, A. & Robertus, J. D., Jan 1 1992, In : Biochemistry. 31, 12, p. 3294-3296 3 p.

Research output: Contribution to journalArticle

55 Scopus citations

SU‐GG‐J‐145: Physics Support for Intraprostatic Treatment of Patients with Locally Recurrent Prostate Cancer with the PSA‐Activated Protoxin PRX302

Boyer, A., Coffield, S., Culp, L., Frankel, A., Merchant, N. & Abi‐habib, R., 2008, In : Medical Physics. 35, 6, p. 2712 1 p.

Research output: Contribution to journalArticle

Synthesis of green fluorescent protein-ricin and monitoring of its intracellular trafficking

Tagge, E., Harris, B., Burbage, C., Hall, P., Vesely, J., Willingham, M. & Frankel, A., Sep 1 1997, In : Bioconjugate Chemistry. 8, 5, p. 743-750 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

Su, Y., Ortiz, J., Liu, S., Bugge, T. H., Singh, R., Leppla, S. H. & Frankel, A. E., Apr 1 2007, In : Cancer research. 67, 7, p. 3329-3336 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Abi-Habib, R. J., Singh, R., Leppla, S. H., Greene, J. J., Ding, Y., Berghuis, B., Duesbery, N. S. & Frankel, A. E., Dec 15 2006, In : Clinical Cancer Research. 12, 24, p. 7437-7443 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

TEM8 targeted cancer therapy

Frankel, A. E., Carter, C., Kuo, S. R., Woo, J. H., Mauldin, J. & Liu, J. S., Dec 1 2011, In : Anti-Cancer Agents in Medicinal Chemistry. 11, 10, p. 983-992 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton

Yang, M. Y., Chaudhary, A., Seaman, S., Dunty, J., Stevens, J., Elzarrad, M. K., Frankel, A. E. & St.Croix, B., Jan 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells

Ramage, J. G., Vallera, D. A., Black, J. H., Aplan, P. D., Kees, U. R. & Frankel, A. E., Jan 1 2003, In : Leukemia Research. 27, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

Hogge, D. E., Feuring-Buske, M., Gerhard, B. & Frankel, A. E., Nov 1 2004, In : Leukemia Research. 28, 11, p. 1221-1226 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
3 Scopus citations

The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis

Maharjan, A. S., McMillin, G. A., Patel, G. K., Awan, S., Taylor, W. R., Pai, S., Frankel, A. E., Nelson, C., Wang, B., Hosein, P. J., Singh, A. P. & Khushman, M., Jan 1 2019, In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Therapy of Patients with T-cell Lymphomas and Leukemias Using an Anti-CD7 Monoclonal Antibody-Rich a Chain Immunotoxin

Frankel, A. E., Laver, J. H., Willingham, M. C., Burns, L. J., Kersey, J. H. & Vallera, D. A., Jan 1 1997, In : Leukemia and Lymphoma. 26, 42067, p. 287-298 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

The role of in-111 leukocyte scanning in pyoderma gangrenosum

Johnson, M. A., Wells, J., Frankel, A., Goris, M. L. & McDougall, I. R., Jan 1 1981, In : Unknown Journal. 6, 10, p. 491-494 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

The systemic administration of lethal toxin achieves a growth delay of human melanoma and neuroblastoma xenografts: Assessment of receptor contribution

Rouleau, C., Menon, K., Boutin, P., Guyre, C., Yoshida, H., Kataoka, S., Perricone, M., Shankara, S., Frankel, A. E., Duesbery, N. S., Vande Woude, G., Biemann, H. P. & Teicher, B. A., Apr 1 2008, In : International journal of oncology. 32, 4, p. 739-748 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Thrombotic thrombocytopenic purpura: Prolonged coma with recovery of neurologic function with intensive plasma exchange

Frankel, A. E., Rubenstein, M. D. & Wall, R. T., Jun 1981, In : American Journal of Hematology. 10, 4, p. 387-390 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tissue distribution of breast cancer-associated antigens defined by monoclonal antibodies

Frankel, A. E., Ring, D. B., Tringale, F. & Hsieh-Ma, S. T., Jun 1985, In : Journal of Biological Response Modifiers. 4, 3, p. 273-286 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Toll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: Role of autophagy

Kandadi, M. R., Frankel, A. E. & Ren, J., Oct 1 2012, In : British Journal of Pharmacology. 167, 3, p. 612-626 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
15 Scopus citations

Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys

Cohen, K. A., Liu, T. F., Cline, J. M., Wagner, J. D., Hall, P. D. & Frankel, A. E., Aug 1 2004, In : Leukemia and Lymphoma. 45, 8, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Toxicology and pharmacokinetics of DTGM, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor, in cynomolgus monkeys

Hotchkiss, C. E., Hall, P. D., Cline, J. M., Willingham, M. C., Kreitman, R. J., Gardin, J., Latimer, A., Ramage, J., Feely, T., DeLatte, S., Tagge, E. P. & Frankel, A. E., Jul 15 1999, In : Toxicology and Applied Pharmacology. 158, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Toxin conjugate therapy of cancer

Wong, L., Suh, D. Y. & Frankel, A. E., Dec 2005, In : Seminars in oncology. 32, 6, p. 591-595 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Treatment of leukemia patients with T101 ricin A chain immunotoxins.

Laurent, G., Frankel, A. E., Hertler, A. A., Schlossman, D. M., Casellas, P. & Jansen, F. K., Dec 1 1988, In : Cancer treatment and research. 37, p. 483-491 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Tumor endothelial marker 8 promotes cancer progression and metastasis

Høye, A. M., Tolstrup, S. D., Horton, E. R., Nicolau, M., Frost, H., Woo, J. H., Mauldin, J. P., Frankel, A. E., Cox, T. R. & Erler, J. T., Jul 10 2018, In : Oncotarget. 9, 53, p. 30173-30188 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Upregulation of b-fgf receptor expression after carotid bypass

Brothers, T. E., Robison, J. G., Elliott, B. M., Boggs, J. M., Frankel, A. E. & Willingham, M. C., Jan 1995, In : Journal of Surgical Research. 58, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating factor fusion protein for acute myelogenous leukemia stem cells

Feuring-Buske, M., Frankel, A., Gerhard, B. & Hogge, D., Dec 1 2000, In : Experimental Hematology. 28, 12, p. 1390-1400 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors

Hogge, D. E., Yalcintepe, L., Wong, S. H., Gerhard, B. & Frankel, A. E., Feb 15 2006, In : Clinical Cancer Research. 12, 4, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

VEGF and myeloid leukemias

Frankel, A. E. & Gill, P. S., Jul 2004, In : Leukemia Research. 28, 7, p. 675-677 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Vliianie glikozilirovaniia na strukturu, stabil'nost' i biologicheskuiu aktivnost' B-sub''edinitsy ritsina.

Translated title of the contribution: The effect of glycosylation on the structure, stability, and biological activity of the ricin B-subunitTonevitskiǐ, A. G., Toptygin, A. I., Agapov, I. I., Bushueva, T. L., Shamshnev, A. T., Frankel', A. & Debabov, V. G., Jun 1 1994, In : Doklady Akademii nauk / [Rossiiskaia akademii nauk]. 336, 5, p. 700-703 4 p.

Research output: Contribution to journalArticle