• 8049 Citations
  • 47 h-Index
1976 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
Article

1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

Su, Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S. & Frankel, A. E., Aug 31 2007, In : Breast Cancer Research. 9, 4, R56.

Research output: Contribution to journalArticle

15 Scopus citations

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Vanderlaag, K., Su, Y., Frankel, A. E., Burghardt, R. C., Barhoumi, R., Chadalapaka, G., Jutooru, I. & Safe, S., Dec 3 2010, In : BMC Cancer. 10, 669.

Research output: Contribution to journalArticle

11 Scopus citations

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways

Vanderlaag, K., Su, Y., Frankel, A. E., Grage, H., Smith, R., Khan, S. & Safe, S., May 1 2008, In : Breast Cancer Research and Treatment. 109, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

Frankel, A. E., Woo, J. H., Ahn, C., Pemmaraju, N., Medeiros, B. C., Carraway, H. E., Frankfurt, O., Forman, S. J., Yang, X. A., Konopleva, M., Garnache-Ottou, F., Angelot-Delettre, F., Brooks, C., Szarek, M. & Rowinsky, E., Jul 17 2014, In : Blood. 124, 3, p. 385-392 8 p.

Research output: Contribution to journalArticle

121 Scopus citations
22 Scopus citations

Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms

Horita, H., Frankel, A. E. & Thorburn, A., Dec 11 2008, In : PloS one. 3, 12, e3909.

Research output: Contribution to journalArticle

38 Scopus citations

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

Schimmer, A. D., Herr, W., Hänel, M., Borthakur, G., Frankel, A., Horst, H. A., Martin, S., Kassis, J., Desjardins, P., Seiter, K., Fiedler, W., Noppeney, R., Giagounidis, A., Jacob, C., Jolivet, J., Tallman, M. S. & Koschmieder, S., Oct 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells

Liu, T. F., Cohen, K. A., Ramage, J. G., Willingham, M. C., Thorburn, A. M. & Frankel, A. E., Apr 15 2003, In : Cancer research. 63, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors

Feuring-Buske, M., Frankel, A. E., Alexander, R. L., Gerhard, B. & Hogge, D. E., Mar 15 2002, In : Cancer research. 62, 6, p. 1730-1736 7 p.

Research output: Contribution to journalArticle

100 Scopus citations
15 Scopus citations

Advances in immunotoxin biology and therapy: A summary of the Fourth International Symposium on Immunotoxins

Frankel, A. E., FitzGerald, D., Siegall, C. & Press, O. W., Feb 22 1996, In : Cancer Research. 56, 4, p. 926-932 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Advances in immunotoxins

Oeltmann, T. N. & Frankel, A. E., Sep 4 1991, In : FASEB Journal. 5, 10, p. 2334-2337 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes

Gould, J. H., Hartley, M. R., Welsh, P. C., Hoshizaki, D. K., Frankel, A., Roberts, L. M. & Lord, J. M., Nov 1 1991, In : MGG Molecular & General Genetics. 230, 1-2, p. 81-90 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

A model scheme for human hematopoietic cell differentiation as determined by multiple markers of leukemia-lymphomas.

Minowada, J., Minato, K., Tatsumi, E., Sugimoto, T., Nakazawa, S., Ohnuma, T., Kubonishi, I., Miyoshi, I., Frankel, A. & Gallo, R. C., Jan 1 1983, In : Hamatologie und Bluttransfusion. 28, p. 348-350 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

An anti‐CD5 immunotoxin for chronic lymphocytic leukemia: Enhancement of cytotoxicity with human serum albumin‐monensin

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Blythman, H. E., Casellas, P. & Frankel, A. E., Feb 15 1989, In : International Journal of Cancer. 43, 2, p. 215-219 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Poplack, D. G. & Frankel, A. E., Jan 1 1989, In : Cancer Immunology Immunotherapy. 28, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral G protein-coupled receptor

Depeille, P., Young, J. J., Boguslawski, E. A., Berghuis, B. D., Kort, E. J., Resau, J. H., Frankel, A. E. & Duesbery, N. S., Oct 1 2007, In : Clinical Cancer Research. 13, 19, p. 5926-5934 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Anthrax lethal toxin suppresses murine cardiomyocyte contractile function and intracellular Ca2+ handling via a NADPH oxidase-dependent mechanism

Kandadi, M. R., Hua, Y., Ma, H., Li, Q., Kuo, S. R., Frankel, A. E. & Ren, J., Oct 13 2010, In : PloS one. 5, 10, e13335.

Research output: Contribution to journalArticle

26 Scopus citations

Anthrax toxin: Pathologic effects on the cardiovascular system

Golden, H. B., Watson, L. E., Lal, H., Verma, S. K., Foster, D. M., Kuo, S. R., Sharma, A., Frankel, A. & Dostal, D. E., Jan 1 2009, In : Frontiers in Bioscience. 14, 6, p. 2335-2357 23 p.

Research output: Contribution to journalArticle

19 Scopus citations

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

Kuo, S. R., Willingham, M. C., Bour, S. H., Andreas, E. A., Park, S. K., Jackson, C., Duesbery, N. S., Leppla, S. H., Tang, W. J. & Frankel, A. E., Jun 1 2008, In : Microbial Pathogenesis. 44, 6, p. 467-472 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

Watson, L. E., Kuo, S. R., Katki, K., Dang, T., Park, S. K., Dostal, D. E., Tang, W. J., Leppla, S. H. & Frankel, A. E., May 23 2007, In : PloS one. 2, 5, e466.

Research output: Contribution to journalArticle

49 Scopus citations

Antibody internalization after cell surface antigen binding is critical for immunotoxin development

Kuo, S. R., Alfano, R. W., Frankel, A. E. & Liu, J. S., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1975-1982 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
44 Scopus citations

Antibody-toxin hybrids: A clinical review of their use

Frankel, A. E., Oct 1985, In : Journal of Biological Response Modifiers. 4, 5, p. 437-446 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics

Kuo, S. R., Tahir, S. A., Park, S., Thompson, T. C., Coffield, S., Frankel, A. E. & Liu, J. S., Apr 1 2012, In : Hybridoma. 31, 2, p. 77-86 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Antitumor Activity of an Immunotoxin in a Nude Mouse Model of Human Ovarian Cancer

Fitzgerald, D. J., Bjorn, M. J., Ferris, R. J., Winkelhake, J. L., Frankel, A. E., Hamilton, T. C., Ozols, R. F., Willingham, M. C. & Pastan, I., Mar 1987, In : Cancer Research. 47, 5, p. 1407-1410 4 p.

Research output: Contribution to journalArticle

55 Scopus citations

A phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia

Frankel, A. E., Fleming, D. R., Hall, P. D., Powell, B. L., Black, J. H., Leftwich, C. & Gartenhaus, R., Oct 1 2003, In : Clinical Cancer Research. 9, 10 I, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

A phase I study of T101-ricin a chain immunotoxin in refractory chronic lymphocytic leukemia

Hertler, A. A., Schlossman, D. M., Borowitz, M. J., Laurent, G., Jansen, F. K., Schmidt, C. & Frankel, A. E., Feb 1988, In : Journal of Biological Response Modifiers. 7, 1, p. 97-113 17 p.

Research output: Contribution to journalArticle

71 Scopus citations

Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein

Thorburn, J., Frankel, A. E. & Thorburn, A., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 861-865 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

A STING-activating nanovaccine for cancer immunotherapy

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y. X., Chen, Z. J. & Gao, J., Jul 1 2017, In : Nature Nanotechnology. 12, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

147 Scopus citations

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Abi-Habib, R. J., Singh, R., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 1 2006, In : Molecular Cancer Therapeutics. 5, 10, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Abi-Habib, R. J., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 1 2004, In : Blood. 104, 7, p. 2143-2148 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

Thorburn, J., Horita, H., Redzic, J., Hansen, K., Frankel, A. E. & Thorburn, A., Jan 1 2009, In : Cell Death and Differentiation. 16, 1, p. 175-183 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

Vallera, D. A., Oh, S., Chen, H., Shu, Y. & Frankel, A. E., Jun 1 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1872-1883 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Biological, immunological, and biochemical evidence that HIX virus is a recombinant between moloney leukemia virus and a murine xenotropic C type virus

Fischinger, P. J., Frankel, A. E., Elder, J. H., Lerner, R. A., Ihle, J. N. & Bolognesi, D. P., Oct 15 1978, In : Virology. 90, 2, p. 241-254 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Biological, Immunological, and Molecular Properties of Revertants of Cat Cells Transformed by Murine Sarcoma Virus

Fischinger, P. J., Blevins, C. S., Frankel, A. E., Tuttle-Fuller, N., Haapala, D. K., Nomura, S. & Robey, W. G., Mar 1 1981, In : Cancer research. 41, 3, p. 958-965 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

BRAF status and mitogen-activated protein/extracellular signal regulated kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Abi-Habib, R. J., Urieto, J. O., Liu, S., Leppla, S. H., Duesbery, N. S. & Frankel, A. E., Sep 1 2005, In : Molecular Cancer Therapeutics. 4, 9, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Breast cancer immunotoxins

Winkelhake, J., Frankel, A. E. & Ring, D., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 7443

Research output: Contribution to journalArticle

1 Scopus citations
14 Scopus citations

Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF

Frankel, A. E., Hall, P. D., McLain, C., Safa, A. R., Tagge, E. P. & Kreitman, R. J., Jul 1 1998, In : Bioconjugate Chemistry. 9, 4, p. 490-496 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of an Ovarian Cancer Activating Factor in Ascites From Ovarian Cancer Patients

Xu, Y., Gaudette, D. C., Boynton, J. D., Frankel, A., Fang, X. J., Sharma, A., Hurteau, J., Casey, G., Goodbody, A., Mellors, A., Holub, B. J. & Mills, G. B., Oct 1 1995, In : Clinical Cancer Research. 1, 10, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

284 Scopus citations

Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor

Frankel, A. E., Burbage, C., Fu, T., Tagge, E., Chandler, J. & Willingham, M., Oct 1 1996, In : Protein Engineering. 9, 10, p. 913-919 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor

Frankel, A. E., Ramage, J., Kiser, M., Alexander, R., Kucera, G. & Miller, M. S., Oct 3 2000, In : Protein Engineering. 13, 8, p. 575-581 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Characterization of immunotoxins active against ovarian cancer cell lines

Pirker, R., FitzGerald, D. J. P., Hamilton, T. C., Ozols, R. F., Laird, W., Frankel, A. E., Willingham, M. C. & Pastan, I., Jan 1 1985, In : Journal of Clinical Investigation. 76, 3, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Characterization of single site ricin toxin B chain mutants

Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. & Willingham, M., Jan 1 1996, In : Bioconjugate Chemistry. 7, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of variant diphtheria toxin-interleukin-3 fusion protein, DTIL3K116W, for phase I clinical trials

Su, Y., Li, S. Y., Ghosh, S., Ortiz, J., Hogge, D. E. & Frankel, A. E., Jan 1 2010, In : Biologicals. 38, 1, p. 144-149 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer

Pai, L. H., Bookman, M. A., Ozols, R. F., Young, R. C., Smith, J. W., Longo, D. L., Gould, B., Frankel, A., McClay, E. F., Howell, S., Reed, E., Willingham, M. C., FitzGerald, D. J. & Pastan, I., Jan 1 1991, In : Journal of Clinical Oncology. 9, 12, p. 2095-2103 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Clinical trials of targeted toxins

Frankel, A. E., Tagge, E. P. & Willingham, M. C., Jan 1 1995, In : Seminars in Cancer Biology. 6, 5, p. 307-317 11 p.

Research output: Contribution to journalArticle

60 Scopus citations