• 8049 Citations
  • 47 h-Index
1976 …2019

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Article
2002

Receptor upregulation enhances cell surface receptor targeted therapies

Frankel, A. E., Dec 1 2002, In : Leukemia Research. 26, 12, p. 1069-1071 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations
2001
44 Scopus citations

Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation

Lilly, M. B., Zemskova, M., Frankel, A. E., Salo, J. & Kraft, A. S., Mar 15 2001, In : Blood. 97, 6, p. 1662-1670 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT388-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF

Senchenkov, A., Han, T. Y., Wang, H., Frankel, A. E., Kottke, T. J., Kaufmann, S. H. & Cabot, M. C., Sep 15 2001, In : Blood. 98, 6, p. 1927-1934 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

High affinity interleukin-3 receptor expression on blasts from patients with acute myelogenous leukemia correlates with cytotoxicity of a diphtheria toxin/IL-3 fusion protein

Alexander, R. L., Ramage, J., Kucera, G. L., Caligiuri, M. A. & Frankel, A. E., Sep 4 2001, In : Leukemia Research. 25, 10, p. 875-881 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Immunotherapy of acute myeloid leukemia

Frankel, A. E., Baer, M. R., Hogge, D. E. & Stuart, R. K., Sep 11 2001, In : Current Pharmaceutical Biotechnology. 2, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice

Kiser, M., McCubrey, J. A., Steelman, L. S., Shelton, J. G., Ramage, J., Alexander, R. L., Kucera, G. L., Pettenati, M., Willingham, M. C., Miller, M. S. & Frankel, A. E., Jan 1 2001, In : Leukemia. 15, 5, p. 814-818 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma

Olsen, E., Duvic, M., Frankel, A., Kim, Y., Martin, A., Vonderheid, E., Jegasothy, B., Wood, G., Gordon, M., Heald, P., Oseroff, A., Pinter-Brown, L., Bowen, G., Kuzel, T., Fivenson, D., Foss, F., Glode, M., Molina, A., Knobler, E., Stewart, S. & 6 others, Cooper, K., Stevens, S., Craig, F., Reuben, J., Bacha, P. & Nichols, J., Jan 15 2001, In : Journal of Clinical Oncology. 19, 2, p. 376-388 13 p.

Research output: Contribution to journalArticle

530 Scopus citations

Selective cytotoxicity of a diphtheria toxin-interleukin-3 fusion protein on acute myleoid leukemia stem cells

Feuriag-Buske, M., Frankel, A., Alexander, R., Gerhard, G. & Hogge, D., Dec 1 2001, In : European Journal of Cancer. 37, SUPPL. 1, p. S12

Research output: Contribution to journalArticle

2000

Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor

Frankel, A. E., Ramage, J., Kiser, M., Alexander, R., Kucera, G. & Miller, M. S., Oct 3 2000, In : Protein Engineering. 13, 8, p. 575-581 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

Frankel, A. E., McCubrey, J. A., Miller, M. S., Delatte, S., Ramage, J., Kiser, M., Kucera, G. L., Alexander, R. L., Beran, M., Tagge, E. P., Kreitman, R. J. & Hogge, D. E., Jan 1 2000, In : Leukemia. 14, 4, p. 576-585 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

In vitro interleukin-3 binding to leukemia cells predicts cytotoxicity of a diphtheria toxin/IL-3 fusion protein

Alexander, R. L., Kucera, G. L., Klein, B. & Frankel, A. E., Jul 1 2000, In : Bioconjugate Chemistry. 11, 4, p. 564-568 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating factor fusion protein for acute myelogenous leukemia stem cells

Feuring-Buske, M., Frankel, A., Gerhard, B. & Hogge, D., Dec 1 2000, In : Experimental Hematology. 28, 12, p. 1390-1400 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
1999

Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells

Kim, C. N., Bhalla, K., Kreitman, R. J., Willingham, M. C., Hall, P., Tagge, E. P., Jia, T. & Frankel, A. E., Jun 1 1999, In : Leukemia Research. 23, 6, p. 527-538 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
Open Access
38 Scopus citations

High-level expression and purification of the recombinant diphtheria fusion toxin DTGM for PHASE I clinical trials

Frankel, A. E., Ramage, J., Latimer, A., Feely, T., Delatte, S., Hall, P., Tagge, E., Kreitman, R. & Willingham, M., Jun 1999, In : Protein Expression and Purification. 16, 1, p. 190-201 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Toxicology and pharmacokinetics of DTGM, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor, in cynomolgus monkeys

Hotchkiss, C. E., Hall, P. D., Cline, J. M., Willingham, M. C., Kreitman, R. J., Gardin, J., Latimer, A., Ramage, J., Feely, T., DeLatte, S., Tagge, E. P. & Frankel, A. E., Jul 15 1999, In : Toxicology and Applied Pharmacology. 158, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
1998

Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF

Frankel, A. E., Hall, P. D., McLain, C., Safa, A. R., Tagge, E. P. & Kreitman, R. J., Jul 1 1998, In : Bioconjugate Chemistry. 9, 4, p. 490-496 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Dab389IL2 diphtheria fusion toxin produces clinical responses in tumor stage cutaneous T cell lymphoma

Duvic, M., Cather, J., Maize, J. & Frankel, A. E., May 1 1998, In : American Journal of Hematology. 58, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Diphtheria toxin fused to GM-CSF in combination with ARA-C exerts synergistic toxicity to human AML (HL60) cells

Bhalia, K. M., Kreitman, R. J., Hall, P. & Frankel, A., Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia

Frankel, A. E., Lilly, M., Kreitman, R., Hogge, D., Beran, M., Freedman, M. H., Emanuel, P. D., McLain, C., Hall, P., Tagge, E., Berger, M. & Eaves, C., Dec 1 1998, In : Blood. 92, 11, p. 4279-4286 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Diphtheria toxin fused to human gm-csf is toxic to primary malignant progenitors from patients with AML, JMML and CMML

Frankel, A., Eaves, C., Hall, P., Kreitman, R., Lilly, M., Heran, M. & Bc, Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Human DRA functions as a sulfate transporter in Sf9 insect cells

Byeon, M. K., Frankel, A., Papas, T. S., Henderson, K. W. & Schweinfest, C. W., Feb 1998, In : Protein Expression and Purification. 12, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein

Hogge, D. E., Willman, C. L., Kreitman, R. J., Berger, M., Hall, P. D., Kopecky, K. J., McLain, C., Tagge, E. P., Eaves, C. J. & Frankel, A. E., Jul 15 1998, In : Blood. 92, 2, p. 589-595 7 p.

Research output: Contribution to journalArticle

48 Scopus citations
15 Scopus citations
1997

IL2 fused to lectin-deficient ricin is toxic to human leukemia cells expressing the IL2 receptor

Frankel, A. E., Fu, T., Burbage, C., Chandler, J., Willingham, M. C. & Tagge, E. P., Jan 1 1997, In : Leukemia. 11, 1, p. 22-30 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Lectin-deficient ricin toxin indicates cells bearing the D-mannose receptor

Frankel, A. E., Fu, T., Burbage, C., Tagge, E., Harris, B., Vesely, J. & Willingham, M. C., May 16 1997, In : Carbohydrate Research. 300, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein

Frankel, A. E., Hall, P. D., Burbage, C., Vesely, J., Willingham, M., Bhalla, K. & Kreitman, R. J., Nov 15 1997, In : Blood. 90, 9, p. 3654-3661 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells

Burbage, C., Tagge, E. P., Harris, B., Hall, P., Fu, T., Willingham, M. C. & Frankel, A. E., Jul 1 1997, In : Leukemia Research. 21, 7, p. 681-690 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synthesis of green fluorescent protein-ricin and monitoring of its intracellular trafficking

Tagge, E., Harris, B., Burbage, C., Hall, P., Vesely, J., Willingham, M. & Frankel, A., Sep 1 1997, In : Bioconjugate Chemistry. 8, 5, p. 743-750 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Therapy of Patients with T-cell Lymphomas and Leukemias Using an Anti-CD7 Monoclonal Antibody-Rich a Chain Immunotoxin

Frankel, A. E., Laver, J. H., Willingham, M. C., Burns, L. J., Kersey, J. H. & Vallera, D. A., Jan 1 1997, In : Leukemia and Lymphoma. 26, 42067, p. 287-298 12 p.

Research output: Contribution to journalArticle

64 Scopus citations
1996

Advances in immunotoxin biology and therapy: A summary of the Fourth International Symposium on Immunotoxins

Frankel, A. E., FitzGerald, D., Siegall, C. & Press, O. W., Feb 22 1996, In : Cancer Research. 56, 4, p. 926-932 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor

Frankel, A. E., Burbage, C., Fu, T., Tagge, E., Chandler, J. & Willingham, M., Oct 1 1996, In : Protein Engineering. 9, 10, p. 913-919 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of single site ricin toxin B chain mutants

Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. & Willingham, M., Jan 1 1996, In : Bioconjugate Chemistry. 7, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi

Tagge, E., Chandler, J., Tang, B. L., Hong, W., Willingham, M. C. & Frankel, A., Feb 1996, In : Journal of Histochemistry and Cytochemistry. 44, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Double-lectin site ricin B chain mutants expressed in insect cells have residual galactose binding: Evidence for more than two lectin sites on the ricin toxin B chain

Fu, T., Burbage, C., Tagge, E., Chandler, J., Willingham, M. & Frankel, A., Nov 1 1996, In : Bioconjugate Chemistry. 7, 6, p. 651-658 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Double-site ricin B chain mutants retain galactose binding

Frankel, A., Tagge, E., Chandler, J., Burbage, C. & Willingham, M., Apr 1 1996, In : Protein Engineering. 9, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Fibrin matrix for local delivery of a mitotoxin to inhibit vascular smooth muscle cell proliferation

Brothers, T. E., Boggs, J., Goldsmith, C., Frankel, A. E. & Willingham, M. C., Dec 1 1996, In : FASEB Journal. 10, 3, p. A621

Research output: Contribution to journalArticle

Interleukin 2 (IL-2) receptor expression and sensitivity to diphtheria fusion toxin DAB389IL-2 in cultured hematopoietic cells

Re, G. G., Waters, C., Poisson, L., Willingham, M. C., Sugamura, K. & Frankel, A. E., Jun 1 1996, In : Cancer Research. 56, 11, p. 2590-2595 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Laboratory preparation of a deglycosylated ricin toxin A chain containing immunotoxin directed against a CD7 T lineage differentiation antigen for phase I human clinical studies involving T cell malignancies

Vallera, D. A., Burns, L. J., Frankel, A. E., Sicheneder, A. R., Gunther, R., Gajl-Peczalska, K., Pennell, C. A. & Kersey, J. H., Oct 16 1996, In : Journal of Immunological Methods. 197, 1-2, p. 69-83 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Preproricin expressed in Nicotiana tabacum cells in vitro is fully processed and biologically active

Tagge, E. P., Chandler, J., Harris, B., Czako, M., Marton, L., Willingham, M. C., Burbage, C., Afrin, L. & Frankel, A. E., Aug 1996, In : Protein Expression and Purification. 8, 1, p. 109-118 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1α, 1β, and 2γ

Frankel, A. E., Burbage, C., Fu, T., Tagge, E., Chandler, J. & Willingham, M. C., Nov 26 1996, In : Biochemistry. 35, 47, p. 14749-14756 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Ricin toxin contains three lectin sites which contribute to its in vivo toxicity

Fu, T., Burbage, C., Tagge, E. P., Brothers, T., Willingham, M. C. & Frankel, A. E., Dec 1996, In : International Journal of Immunopharmacology. 18, 12, p. 685-689 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structure and activity of an active site substitution of ricin A chain

Day, P. J., Ernst, S. R., Frankel, A. E., Monzingo, A. F., Pascal, J. M., Molina-Svinth, M. C. & Robertus, J. D., Sep 22 1996, In : Biochemistry. 35, 34, p. 11098-11103 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
1995

Characterization of an Ovarian Cancer Activating Factor in Ascites From Ovarian Cancer Patients

Xu, Y., Gaudette, D. C., Boynton, J. D., Frankel, A., Fang, X. J., Sharma, A., Hurteau, J., Casey, G., Goodbody, A., Mellors, A., Holub, B. J. & Mills, G. B., Oct 1 1995, In : Clinical Cancer Research. 1, 10, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

284 Scopus citations

Clinical trials of targeted toxins

Frankel, A. E., Tagge, E. P. & Willingham, M. C., Jan 1 1995, In : Seminars in Cancer Biology. 6, 5, p. 307-317 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

IL2-Ricin Fusion Toxin is Selectively Cytotoxic in Vitro to IL2 Receptor-Bearing Tumor Cells

Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. & Willingham, M., Jan 1 1995, In : Bioconjugate Chemistry. 6, 6, p. 666-672 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Recombinant ricin B chain produced in Escherichia coli is biologically active

Tonevitsky, A. G., Toptygin Yu., A., Agapov, I. I., Rakhmanova, V. A., Shamshiev, A. T., Alekseev Yu., O., Pfuller, U. & Frankel, A., Jan 1 1995, In : Molekulyarnaya Biologiya. 29, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

Upregulation of b-fgf receptor expression after carotid bypass

Brothers, T. E., Robison, J. G., Elliott, B. M., Boggs, J. M., Frankel, A. E. & Willingham, M. C., Jan 1995, In : Journal of Surgical Research. 58, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

8 Scopus citations