• 3411 Citations
  • 25 h-Index
19962019
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Research Output 1996 2019

  • 3411 Citations
  • 25 h-Index
  • 39 Article
  • 1 Chapter
  • 1 Conference contribution
  • 1 Review article
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Article
2019

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In : eLife. 8, e50051.

Research output: Contribution to journalArticle

Open Access
Cholesterol
Membranes
Cilia
Ligands
Sphingomyelins
16 Citations (Scopus)

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R. & Radhakrishnan, A., Feb 21 2019, In : Cell. 176, 5, p. 1040-1053.e17

Research output: Contribution to journalArticle

Sphingomyelins
Cell membranes
Conformations
Cholesterol
Cell Membrane
2 Citations (Scopus)
Cholesterol
Endoplasmic Reticulum
Cell Membrane
cholesterol-binding protein
Membranes
2017
12 Citations (Scopus)
Cholesterol
Feedback
Proteins
Endoplasmic Reticulum
Membranes
33 Citations (Scopus)
Cell membranes
Endoplasmic Reticulum
Cholesterol
Cell Membrane
Anticholesteremic Agents
12 Citations (Scopus)

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

Chakrabarti, R. S., Ingham, S. A., Kozlitina, J., Gay, A., Cohen, J. C., Radhakrishnan, A. & Hobbs, H. H., Feb 8 2017, In : eLife. 6, e23355.

Research output: Contribution to journalArticle

Blood
Erythrocytes
Cholesterol
Cells
Cell membranes
2016
7 Citations (Scopus)

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

Homeostasis
Demonstrations
Cholesterol
Endoplasmic Reticulum
Protein Transport
2015
14 Citations (Scopus)

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

Ren, R., Zhou, X., He, Y., Ke, M., Wu, J., Liu, X., Yan, C., Wu, Y., Gong, X., Lei, X., Yan, S. F., Radhakrishnan, A. & Yan, N., Jul 10 2015, In : Science. 349, 6244, p. 187-191 5 p.

Research output: Contribution to journalArticle

Sterols
Sterol Regulatory Element Binding Proteins
Structural Models
Diglycerides
Protein Subunits
20 Citations (Scopus)

Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes

Gay, A., Rye, D. & Radhakrishnan, A., Mar 24 2015, In : Biophysical Journal. 108, 6, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Cholesterol
Membranes
Proteins
Bacterial Toxins
Lipids
2014
99 Citations (Scopus)

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A., Jun 11 2014, In : eLife. 2014, 3, e02882.

Research output: Contribution to journalArticle

Cell membranes
Homeostasis
Cholesterol
Cell Membrane
Sphingomyelin Phosphodiesterase
2013
53 Citations (Scopus)
Cholesterol
Cell Membrane
Lysosomes
Organelles
Membranes
2010
54 Citations (Scopus)
Endoplasmic Reticulum
Chemical activation
Cholesterol
Switches
Membranes
7 Citations (Scopus)

Phase separations in binary and ternary cholesterol-phospholipid mixtures

Radhakrishnan, A., May 5 2010, In : Biophysical Journal. 98, 9

Research output: Contribution to journalArticle

1,2-Dipalmitoylphosphatidylcholine
Phospholipids
Cholesterol
Phosphatidylcholines
Fluorescence Microscopy
2009
102 Citations (Scopus)
Cyclodextrins
Lysosomes
Endoplasmic Reticulum
Cholesterol
Esterification
2008
5 Citations (Scopus)

Molecular motion at the critical point in lipid membranes

McConnell, H. & Radhakrishnan, A., Jul 15 2008, In : Biophysical Journal. 95, 2

Research output: Contribution to journalArticle

Membrane Lipids
Temperature
Magnetic Resonance Spectroscopy
Deuterium
Phospholipids
247 Citations (Scopus)
Lipid Bilayers
Lysosomes
Cholesterol
Liposomes
Lysosome-Associated Membrane Glycoproteins
150 Citations (Scopus)

Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein

Infante, R. E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J. D., Brown, M. S. & Goldstein, J. L., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1052-1063 12 p.

Research output: Contribution to journalArticle

Membrane Proteins
Cholesterol
Amino Acids
Proteins
Hydroxyl Radical
161 Citations (Scopus)

Purified NPC1 protein II. Localization of sterol binding to a 240-amino acid soluble luminal loop

Infante, R. E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L. N., Wang, M. L., Grishin, N. V., Goldstein, J. L. & Brown, M. S., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1064-1075 12 p.

Research output: Contribution to journalArticle

Sterols
Protein C
Cholesterol
Amino Acids
Proteins
267 Citations (Scopus)
Endoplasmic Reticulum
Cholesterol
Lipids
Membrane Lipids
Cultured Cells
2007
23 Citations (Scopus)
nuclear relaxation
cholesterol
Phospholipids
Cholesterol
membranes
334 Citations (Scopus)
Sterol Regulatory Element Binding Proteins
Sterols
Endoplasmic Reticulum
Cholesterol
Proteins
2006
37 Citations (Scopus)

Theory of the deuterium NMR of sterol-phospholipid membranes

McConnell, H. & Radhakrishnan, A., Jan 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1184-1189 6 p.

Research output: Contribution to journalArticle

Deuterium
Sterols
Phospholipids
Membranes
Lipids
2005
120 Citations (Scopus)

Condensed complexes in vesicles containing cholesterol and phospholipids

Radhakrishnan, A. & McConnell, H., Sep 6 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 36, p. 12662-12666 5 p.

Research output: Contribution to journalArticle

Phospholipids
Cholesterol
Phosphatidylcholines
Physical Chemistry
Sphingomyelins
27 Citations (Scopus)
Aspartic Acid
Sterol Regulatory Element Binding Proteins
Cholesterol
Endoplasmic Reticulum
Proteins
2004
220 Citations (Scopus)

Direct binding of cholesterol to the purified membrane region of SCAP: Mechanism for a sterol-sensing domain

Radhakrishnan, A., Sun, L. P., Kwon, H. J., Brown, M. S. & Goldstein, J. L., Jul 23 2004, In : Molecular Cell. 15, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

Sterols
Cholesterol
Sterol Regulatory Element Binding Proteins
Membranes
Endoplasmic Reticulum
2003
317 Citations (Scopus)

Condensed complexes of cholesterol and phospholipids

McConnell, H. M. & Radhakrishnan, A., Mar 10 2003, In : Biochimica et Biophysica Acta - Biomembranes. 1610, 2, p. 159-173 15 p.

Research output: Contribution to journalArticle

Phospholipids
Cholesterol
Cell Membrane
Lipid Bilayers
Thermodynamics
2002
19 Citations (Scopus)

Critical points in charged membranes containing cholesterol

Radhakrishnan, A. & McConnell, H. M., Oct 15 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 21, p. 13391-13396 6 p.

Research output: Contribution to journalArticle

Cholestanol
Cholesterol
Pressure
Membranes
G(M1) Ganglioside
24 Citations (Scopus)

Thermal dissociation of condensed complexes of cholesterol and phospholipid

Radhakrishnan, A. & McConnell, H. M., May 9 2002, In : Journal of Physical Chemistry B. 106, 18, p. 4755-4762 8 p.

Research output: Contribution to journalArticle

thermal dissociation
Cholesterol
Phospholipids
cholesterol
solubility
17 Citations (Scopus)

Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Okonogi, T. M., Radhakrishnan, A. & McConnell, H. M., Aug 19 2002, In : Biochimica et Biophysica Acta - Biomembranes. 1564, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Cholestanol
Phospholipids
Fatty Acids
Cholesterol
Myristic Acid
2001

Erratum: (Biophysical Journal (1999) 77 (1507-1517))

Radhakrishnan, A. & McConnell, H. M., 2001, In : Biophysical Journal. 80, 4, p. 2037 1 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Radhakrishnan, A., Li, X. M., Brown, R. E. & McConnell, H. M., Mar 9 2001, In : Biochimica et Biophysica Acta - Biomembranes. 1511, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Sphingomyelins
Stoichiometry
Monolayers
Cholesterol
Binary mixtures
2000
129 Citations (Scopus)

Chemical activity of cholesterol in membranes

Radhakrishnan, A. & McConnell, H. M., Jul 18 2000, In : Biochemistry. 39, 28, p. 8119-8124 6 p.

Research output: Contribution to journalArticle

Cholesterol
Membranes
Stoichiometry
Monolayers
Phospholipids
209 Citations (Scopus)

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

Radhakrishnan, A., Anderson, T. G. & McConnell, H. M., Nov 7 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12422-12427 6 p.

Research output: Contribution to journalArticle

Cholesterol
Membranes
Phospholipids
G(M1) Ganglioside
Cholera Toxin
35 Citations (Scopus)

Electric field effect on cholesterol-phospholipid complexes

Radhakrishnan, A. & McConnell, H. M., Feb 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 3, p. 1073-1078 6 p.

Research output: Contribution to journalArticle

Phospholipids
Cholesterol
Cholestanol
Membranes
Thermodynamics
64 Citations (Scopus)

Saturated phospholipids with high melting temperatures form complexes with cholesterol in monolayers

Keller, S. L., Radhakrishnan, A. & McConnell, H. M., Aug 10 2000, In : Journal of Physical Chemistry B. 104, 31, p. 7522-7527 6 p.

Research output: Contribution to journalArticle

Cholesterol
Phospholipids
cholesterol
Melting point
Monolayers
1999
97 Citations (Scopus)

Cholesterol - Phospholipid complexes in membranes

Radhakrishnan, A. & McConnell, H. M., Jan 20 1999, In : Journal of the American Chemical Society. 121, 2, p. 486-487 2 p.

Research output: Contribution to journalArticle

Phospholipids
Cholesterol
Membranes
199 Citations (Scopus)

Condensed complexes of cholesterol and phospholipids

Radhakrishnan, A. & McConnell, H. M., Sep 1999, In : Biophysical Journal. 77, 3, p. 1507-1517 11 p.

Research output: Contribution to journalArticle

Cholestanol
Phospholipids
Cholesterol
Membranes
Terminology
58 Citations (Scopus)

Ultra-high throughout rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis

Scherer, J. R., Kheterpal, I., Radhakrishnan, A., Ja, W. W. & Mathies, R. A., 1999, In : Electrophoresis. 20, 7, p. 1508-1517 10 p.

Research output: Contribution to journalArticle

Capillary Electrophoresis
Electrophoresis
DNA Sequence Analysis
Fluorescence
Capillarity
1996
104 Citations (Scopus)

DNA sequencing casing a four-color confocal fluorescence capillary array scanner

Kheterpal, I., Scherer, J. R., Clark, S. M., Radhakrishnan, A., Ju, J., Ginther, C. L., Sensabaugh, G. F. & Mathies, R. A., 1996, In : Electrophoresis. 17, 12, p. 1852-1859 8 p.

Research output: Contribution to journalArticle

DNA Sequence Analysis
Color
Fluorescence
DNA
Sierra Leone