• 3484 Citations
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19962020

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Article
56 Scopus citations

Chemical activity of cholesterol in membranes

Radhakrishnan, A. & McConnell, H. M., Jul 18 2000, In : Biochemistry. 39, 28, p. 8119-8124 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In : eLife. 8, e50051.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
12 Scopus citations

Cholesterol - Phospholipid complexes in membranes

Radhakrishnan, A. & McConnell, H. M., Jan 20 1999, In : Journal of the American Chemical Society. 121, 2, p. 486-487 2 p.

Research output: Contribution to journalArticle

97 Scopus citations

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., Infante, R. E., Radhakrishnan, A., Covey, D. F., Guan, K. L., Buck, J., Levin, L. R., Tontonoz, P., Schwabe, R. F. & Tabas, I., May 5 2020, In : Cell Metabolism. 31, 5, p. 969-986.e7

Research output: Contribution to journalArticle

Composition fluctuations, chemical exchange, and nuclear relaxation in membranes containing cholesterol

Radhakrishnan, A. & McConnell, H., May 18 2007, In : Journal of Chemical Physics. 126, 18, 185101.

Research output: Contribution to journalArticle

23 Scopus citations

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

Radhakrishnan, A., Anderson, T. G. & McConnell, H. M., Nov 7 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12422-12427 6 p.

Research output: Contribution to journalArticle

209 Scopus citations

Condensed complexes in vesicles containing cholesterol and phospholipids

Radhakrishnan, A. & McConnell, H., Sep 6 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 36, p. 12662-12666 5 p.

Research output: Contribution to journalArticle

120 Scopus citations

Condensed complexes of cholesterol and phospholipids

Radhakrishnan, A. & McConnell, H. M., Sep 1999, In : Biophysical journal. 77, 3, p. 1507-1517 11 p.

Research output: Contribution to journalArticle

Open Access
200 Scopus citations
39 Scopus citations

Critical points in charged membranes containing cholesterol

Radhakrishnan, A. & McConnell, H. M., Oct 15 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 21, p. 13391-13396 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

Ren, R., Zhou, X., He, Y., Ke, M., Wu, J., Liu, X., Yan, C., Wu, Y., Gong, X., Lei, X., Yan, S. F., Radhakrishnan, A. & Yan, N., Jul 10 2015, In : Science. 349, 6244, p. 187-191 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
107 Scopus citations

Direct binding of cholesterol to the purified membrane region of SCAP: Mechanism for a sterol-sensing domain

Radhakrishnan, A., Sun, L. P., Kwon, H. J., Brown, M. S. & Goldstein, J. L., Jul 23 2004, In : Molecular cell. 15, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

221 Scopus citations

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

DNA sequencing using a four-color confocal fluorescence capillary array scanner

Kheterpal, I., Scherer, J. R., Clark, S. M., Radhakrishnan, A., Ju, J., Ginther, C. L., Sensabaugh, G. F. & Mathies, R. A., Jan 1 1996, In : ELECTROPHORESIS. 17, 12, p. 1852-1859 8 p.

Research output: Contribution to journalArticle

105 Scopus citations

Electric field effect on cholesterol-phospholipid complexes

Radhakrishnan, A. & McConnell, H. M., Feb 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 3, p. 1073-1078 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
27 Scopus citations

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R. & Radhakrishnan, A., Feb 21 2019, In : Cell. 176, 5, p. 1040-1053.e17

Research output: Contribution to journalArticle

20 Scopus citations

Molecular motion at the critical point in lipid membranes

McConnell, H. & Radhakrishnan, A., Jul 15 2008, In : Biophysical journal. 95, 2, p. L22-L24

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations
252 Scopus citations

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum

Johnson, K. A., Endapally, S., Vazquez, D. C., Infante, R. E. & Radhakrishnan, A., Nov 15 2019, In : Journal of Biological Chemistry. 294, 46, p. 17289-17300 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jan 1 2020, (Accepted/In press) In : Nature microbiology.

Research output: Contribution to journalArticle

Phase separations in binary and ternary cholesterol-phospholipid mixtures

Radhakrishnan, A., May 5 2010, In : Biophysical journal. 98, 9, p. L41-L43

Research output: Contribution to journalArticle

7 Scopus citations

Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein

Infante, R. E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J. D., Brown, M. S. & Goldstein, J. L., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1052-1063 12 p.

Research output: Contribution to journalArticle

151 Scopus citations

Purified NPC1 protein II. Localization of sterol binding to a 240-amino acid soluble luminal loop

Infante, R. E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L. N., Wang, M. L., Grishin, N. V., Goldstein, J. L. & Brown, M. S., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 1064-1075 12 p.

Research output: Contribution to journalArticle

163 Scopus citations

Saturated phospholipids with high melting temperatures form complexes with cholesterol in monolayers

Keller, S. L., Radhakrishnan, A. & McConnell, H. M., Aug 10 2000, In : Journal of Physical Chemistry B. 104, 31, p. 7522-7527 6 p.

Research output: Contribution to journalArticle

64 Scopus citations
339 Scopus citations

Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Radhakrishnan, A., Li, X. M., Brown, R. E. & McConnell, H. M., Mar 9 2001, In : Biochimica et Biophysica Acta - Biomembranes. 1511, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

58 Scopus citations
277 Scopus citations

Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes

Gay, A., Rye, D. & Radhakrishnan, A., Mar 24 2015, In : Biophysical journal. 108, 6, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Theory of the deuterium NMR of sterol-phospholipid membranes

McConnell, H. & Radhakrishnan, A., Jan 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1184-1189 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Thermal dissociation of condensed complexes of cholesterol and phospholipid

Radhakrishnan, A. & McConnell, H. M., May 9 2002, In : Journal of Physical Chemistry B. 106, 18, p. 4755-4762 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A., Jun 11 2014, In : eLife. 2014, 3, e02882.

Research output: Contribution to journalArticle

104 Scopus citations

Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Okonogi, T. M., Radhakrishnan, A. & McConnell, H. M., Aug 19 2002, In : Biochimica et Biophysica Acta - Biomembranes. 1564, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ultra-high throughout rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis

Scherer, J. R., Kheterpal, I., Radhakrishnan, A., Ja, W. W. & Mathies, R. A., Jul 8 1999, In : ELECTROPHORESIS. 20, 7, p. 1508-1517 10 p.

Research output: Contribution to journalArticle

58 Scopus citations
56 Scopus citations

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

Chakrabarti, R. S., Ingham, S. A., Kozlitina, J., Gay, A., Cohen, J. C., Radhakrishnan, A. & Hobbs, H. H., Feb 8 2017, In : eLife. 6, e23355.

Research output: Contribution to journalArticle

13 Scopus citations