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Research Output 1982 2019

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Review article
2019
2 Citations (Scopus)

Challenges for the Clinical Development of PI3K Inhibitors: Strategies to Improve Their Impact in Solid Tumors

Hanker, A. B., Kaklamani, V. & Arteaga, C. L., Apr 1 2019, In : Cancer discovery. 9, 4, p. 482-491 10 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinases
Neoplasms
Drug-Related Side Effects and Adverse Reactions
Patient Selection
Cell Survival

Erratum: Triple-negative breast cancers with amplication of JAK2 at the 9p24 locus demonstrate JAK2-specic dependence (Science Translational Medicine (2019) 11, 476, (eaaw6162), 10.1126/scitranslmed.aaw6162)

Balko, J. M., Schwarz, L. J., Luo, N., Estrada, M. V., Giltnane, J. M., Dávila-González, D., Wang, K., Sánchez, V., Dean, P. T., Combs, S. E., Hicks, D., Pinto, J. A., Landis, M. D., Doimi, F. D., Yelensky, R., Miller, V. A., Stephens, P. J., Rimm, D. L., Gómez, H., Chang, J. C. & 3 others, Sanders, M. E., Cook, R. S. & Arteaga, C. L., Jan 23 2019, In : Science Translational Medicine. 11, 476, eaaw6162.

Research output: Contribution to journalReview article

Triple Negative Breast Neoplasms
Translational Medical Research
Research
2017
9 Citations (Scopus)

Neoadjuvant trials in ER+ breast cancer: A tool for acceleration of drug development and discovery

Guerrero-Zotano, A. L. & Arteaga, C. L., Jan 1 2017, In : Cancer Discovery. 7, 6, p. 561-574 14 p.

Research output: Contribution to journalReview article

Neoadjuvant Therapy
Drug Discovery
Biomarkers
Breast Neoplasms
Investigational Drugs
2015
45 Citations (Scopus)

Cardio-oncology: How new targeted cancer therapies and precision medicine can inform cardiovascular discovery

Bellinger, A. M., Arteaga, C. L., Force, T., Humphreys, B. D., Demetri, G. D., Druker, B. J. & Moslehi, J. J., Dec 8 2015, In : Circulation. 132, 23, p. 2248-2258 11 p.

Research output: Contribution to journalReview article

Precision Medicine
Phosphotransferases
Neoplasms
Clinical Trials
Therapeutics
7 Citations (Scopus)

NCCN Oncology Research Program's Investigator Steering Committee and NCCN Best Practices Committee molecular profiling surveys

Kurzrock, R., Colevas, A. D., Olszanski, A., Akerley, W., Arteaga, C. L., Carson, W. E., Clark, J. W., DiPersio, J. F., Ettinger, D. S., Morgan, R. J., Schwartzberg, L. S., Venook, A. P., Gocke, C. D., Tait, J. & Stewart, F. M., Jan 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 11, p. 1337-1346 10 p.

Research output: Contribution to journalReview article

Practice Guidelines
Molecular Pathology
Research Personnel
Patient Care
Research
10 Citations (Scopus)

Pitfalls in RECIST Data Extraction for Clinical Trials: Beyond the Basics

Abramson, R. G., McGhee, C. R., Lakomkin, N. & Arteaga, C. L., Jan 1 2015, In : Academic Radiology. 22, 6, p. 779-786 8 p.

Research output: Contribution to journalReview article

Clinical Trials
Workflow
Quality Improvement
Response Evaluation Criteria in Solid Tumors
Therapeutics
2014
372 Citations (Scopus)

ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics

Arteaga, C. L. & Engelman, J. A., Mar 17 2014, In : Cancer Cell. 25, 3, p. 282-303 22 p.

Research output: Contribution to journalReview article

Oncogenes
Neoplasms
Research Personnel
Therapeutics
Drug Resistance
2013
41 Citations (Scopus)

Optimal targeting of HER2-PI3K signaling in breast cancer: Mechanistic insights and clinical implications

Rexer, B. N. & Arteaga, C. L., Jul 1 2013, In : Cancer Research. 73, 13, p. 3817-3820 4 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Trastuzumab
7 Citations (Scopus)

Progress in breast cancer: Overview

Arteaga, C. L., Dec 1 2013, In : Clinical Cancer Research. 19, 23, p. 6353-6359 7 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Research
Translational Medical Research
Genomics
Direction compound
11 Citations (Scopus)

Role of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer

Ciruelos, E., Cortes-Funes, H., Ghanem, I., Manso, L. & Arteaga, C., Sep 1 2013, In : Anti-Cancer Drugs. 24, 8, p. 769-780 12 p.

Research output: Contribution to journalReview article

Sirolimus
Hormones
Breast Neoplasms
exemestane
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

The genomic map of breast cancer: Which roads lead to better targeted therapies?

Balko, J. M., Stricker, T. P. & Arteaga, C. L., Jul 31 2013, In : Breast Cancer Research. 15, 4, 209.

Research output: Contribution to journalReview article

Genome
Breast Neoplasms
Technology
RNA Sequence Analysis
High-Throughput Nucleotide Sequencing
2012
168 Citations (Scopus)
erbB-2 Genes
Breast Neoplasms
Proto-Oncogenes
Protein-Tyrosine Kinases
Neoplasms
1 Citation (Scopus)

Molecular signatures of lung cancer: Defining new diagnostic and therapeutic paradigms

Balko, J. M. & Arteaga, C. L., Mar 2 2012, In : Molecular Diagnosis and Therapy. 16, 1, p. 1-6 6 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Patient Care
Therapeutics
Technology
465 Citations (Scopus)

Treatment of HER2-positive breast cancer: Current status and future perspectives

Arteaga, C. L., Sliwkowski, M. X., Osborne, C. K., Perez, E. A., Puglisi, F. & Gianni, L., Jan 1 2012, In : Nature Reviews Clinical Oncology. 9, 1, p. 16-32 17 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Therapeutics
Translational Medical Research
Phosphatidylinositol 3-Kinases
Protein-Tyrosine Kinases
2011
221 Citations (Scopus)

Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer

Miller, T. W., Rexer, B. N., Garrett, J. T. & Arteaga, C. L., Nov 1 2011, In : Breast Cancer Research. 13, 6, 224.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinase
Breast Neoplasms
Mutation
Estrogen Receptors
Neoplasms
50 Citations (Scopus)

New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available

Abramson, V. & Arteaga, C. L., Mar 1 2011, In : Clinical Cancer Research. 17, 5, p. 952-958 7 p.

Research output: Contribution to journalReview article

Drug Combinations
Breast Neoplasms
Natural History
Drug Resistance
Drug Therapy
235 Citations (Scopus)

Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer

Miller, T. W., Balko, J. M. & Arteaga, C. L., Nov 20 2011, In : Journal of Clinical Oncology. 29, 33, p. 4452-4461 10 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinase
Estrogen Receptor Modulators
Breast Neoplasms
Estrogen Receptors
Estrogens
117 Citations (Scopus)

Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: Mechanisms and clinical implications

Garrett, J. T. & Arteaga, C. L., May 1 2011, In : Cancer Biology and Therapy. 11, 9, p. 793-800 8 p.

Research output: Contribution to journalReview article

Protein-Tyrosine Kinases
Phosphatidylinositol 3-Kinase
Antibodies
Breast Neoplasms
Receptor Protein-Tyrosine Kinases
36 Citations (Scopus)

When tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene

Chow, A., Arteaga, C. L. & Wang, S. E., Jun 1 2011, In : Journal of Mammary Gland Biology and Neoplasia. 16, 2, p. 81-88 8 p.

Research output: Contribution to journalReview article

Oncogenes
Breast Neoplasms
Neoplasms
Neoplasm Metastasis
erbB-2 Genes
2009
58 Citations (Scopus)

Overcoming resistance to tyrosine kinase inhibitors: Lessons learned from cancer cells treated with EGFR antagonists

Rexer, B. N., Engelman, J. A. & Arteaga, C. L., Jan 1 2009, In : Cell Cycle. 8, 1, p. 18-22 5 p.

Research output: Contribution to journalReview article

Protein-Tyrosine Kinases
Neoplasms
Phosphatidylinositol 3-Kinases
Up-Regulation
Cell Line
2006
100 Citations (Scopus)

Inhibition of TGFβ signaling in cancer therapy

Arteaga, C. L., Feb 1 2006, In : Current Opinion in Genetics and Development. 16, 1, p. 30-37 8 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Oncogenes
Cell Movement
Immune System
Neoplasms
58 Citations (Scopus)
Biological Models
Tumor Suppressor Genes
Transforming Growth Factor beta
Antineoplastic Agents
Signal Transduction
2005
616 Citations (Scopus)

Critical update and emerging trends in epidermal growth factor receptor targeting in cancer

Baselga, J. & Arteaga, C. L., Dec 1 2005, In : Journal of Clinical Oncology. 23, 11, p. 2445-2459 15 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Neoplasms
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
erbB-1 Genes
2004
32 Citations (Scopus)

Challenges in the Development of Anti-Epidermal Growth Factor Receptor Therapies in Breast Cancer

Arteaga, C. L. & Truica, C. I., Feb 1 2004, In : Seminars in Oncology. 31, 1 SUPPL. 3, p. 3-8 6 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Breast Neoplasms
Therapeutics
Neoplasms
Clinical Trials
39 Citations (Scopus)

Modeling the cancer patient with genetically engineered mice: Prediction of toxicity from molecule-targeted therapies

Roberts, R. B., Arteaga, C. L. & Threadgill, D. W., Feb 1 2004, In : Cancer Cell. 5, 2, p. 115-120 6 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
Molecular Biology
Clinical Trials
Proteins
85 Citations (Scopus)

Tyrosine kinase inhibitors: Why does the current process of clinical development not apply to them?

Arteaga, C. L. & Baselga, J., Jun 1 2004, In : Cancer Cell. 5, 6, p. 525-531 7 p.

Research output: Contribution to journalReview article

Protein-Tyrosine Kinases
Gastrointestinal Stromal Tumors
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Epidermal Growth Factor Receptor
Patient Selection
2003
188 Citations (Scopus)

ErbB-targeted therapeutic approaches in human cancer

Arteaga, C. L., Mar 10 2003, In : Experimental Cell Research. 284, 1, p. 122-130 9 p.

Research output: Contribution to journalReview article

Ligands
Antibodies, Monoclonal, Humanized
Neoplasms
Endocytosis
Epidermal Growth Factor Receptor
24 Citations (Scopus)

Inhibiting tyrosine kinases: successes and limitations.

Arteaga, C. L., Jul 1 2003, In : Cancer biology & therapy. 2, 4 Suppl 1

Research output: Contribution to journalReview article

Protein-Tyrosine Kinases
Gastrointestinal Stromal Tumors
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Natural History
Epidermal Growth Factor Receptor
190 Citations (Scopus)

Targeting the TGFβ signaling network in human neoplasia

Dumont, N. & Arteaga, C. L., Jun 1 2003, In : Cancer Cell. 3, 6, p. 531-536 6 p.

Research output: Contribution to journalReview article

Neoplasms
153 Citations (Scopus)

The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors

Ritter, C. A. & Arteaga, C. L., Feb 1 2003, In : Seminars in Oncology. 30, 1 SUPPL. 1, p. 3-11 9 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Neoplasms
Ligands
Therapeutics
48 Citations (Scopus)

Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancer

Arteaga, C. L., Apr 1 2003, In : Breast Cancer Research. 5, 2, p. 96-100 5 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Proto-Oncogenes
Therapeutics
Combination Drug Therapy
Immunoglobulin G
2002
383 Citations (Scopus)

Epidermal growth factor receptor dependence in human tumors: More than just expression?

Arteaga, C. L., Sep 14 2002, In : Oncologist. 7, SUPPL. 4, p. 31-39 9 p.

Research output: Contribution to journalReview article

Epidermal Growth Factor Receptor
Neoplasms
Protein-Tyrosine Kinases
Cell Movement
36 Citations (Scopus)

Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer

Arteaga, C. L., Khuri, F., Krystal, G. & Sebti, S., Mar 25 2002, In : Seminars in Oncology. 29, 1 SUPPL. 4, p. 15-26 12 p.

Research output: Contribution to journalReview article

Meta-Analysis
Proto-Oncogene Proteins
Signal Transduction
Lung Neoplasms
Receptor Protein-Tyrosine Kinases
31 Citations (Scopus)

The tumor microenvironment: A potential arbitrator of the tumor suppressive and promoting actions of TGFβ

Dumont, N. & Arteaga, C. L., Jan 1 2002, In : Differentiation. 70, 9-10, p. 574-582 9 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Transforming Growth Factors
Neoplasms
Carcinogenesis
CD36 Antigens
2001
23 Citations (Scopus)

Inhibitors of HER2/neu (erbB-2) signal transduction

Arteaga, C. L., Chinratanalab, W. & Carter, M. B., Dec 1 2001, In : Seminars in Oncology. 28, 6 SUPPL. 18, p. 30-35 6 p.

Research output: Contribution to journalReview article

Signal Transduction
Proto-Oncogenes
Oncogene Proteins
Neoplasms
Cell Survival
2000
128 Citations (Scopus)

Transforming growth factor-β and breast cancer: Tumor promoting effects of transforming growth factor-β

Dumont, N. & Arteaga, C. L., Dec 1 2000, In : Breast Cancer Research. 2, 2, p. 125-132 8 p.

Research output: Contribution to journalReview article

Transforming Growth Factors
Breast Neoplasms
Neoplasms
Epithelial Cells
Growth Inhibitors
1999

Foundations of molecular therapies in breast carcinoma.

Arteaga, C. L., Oct 1 1999, In : Journal of Mammary Gland Biology and Neoplasia. 4, 4, p. 333-335 3 p.

Research output: Contribution to journalReview article

Experimental Mammary Neoplasms
Breast Neoplasms
Therapeutics
1997

Growth factors and cytokines in health and disease. Breast cancer

Arteaga, C. L., Dec 1 1997, In : Growth Factors and Cytokines in Health and Disease. 3, C, p. 293-330 38 p.

Research output: Contribution to journalReview article

Tumors
Intercellular Signaling Peptides and Proteins
Cells
Health
Breast Neoplasms
1996
27 Citations (Scopus)

Complex role of tumor cell transforming growth factor (TGF)-beta s on breast carcinoma progression.

Koli, K. M. & Arteaga, C. L., Oct 1 1996, In : Journal of Mammary Gland Biology and Neoplasia. 1, 4, p. 373-380 8 p.

Research output: Contribution to journalReview article

Transforming Growth Factor beta
Breast Neoplasms
Breast
Growth
Neoplasms
1994
21 Citations (Scopus)

TGF beta regulation of cell proliferation.

Moses, H. L., Arteaga, C. L., Alexandrow, M. G., Dagnino, L., Kawabata, M., Pierce, D. F. & Serra, R., Dec 1 1994, In : Princess Takamatsu symposia. 24, p. 250-263 14 p.

Research output: Contribution to journalReview article

Transforming Growth Factor beta1
Transforming Growth Factor beta
Cell Proliferation
Breast
Epithelium
1991
34 Citations (Scopus)

Growth factors as mediators of estrogen/antiestrogen action in human breast cancer cells.

Arteaga, C. L. & Osborne, C. K., Jan 1 1991, In : Cancer Treatment and Research. 53, p. 289-304 16 p.

Research output: Contribution to journalReview article

Growth Substances
Cultured Tumor Cells
Estrogen Antagonists
Transforming Growth Factor alpha
Estrogen Receptor Modulators
1988
3 Citations (Scopus)

New anticancer agents.

Weiss, G. R., Arteaga, C. L., Brown, T. D., Craig, J. B., Harman, G. S., Havlin, K. A., Koeller, J. M., Kuhn, J. G. & Von Hoff, D. D., Dec 1 1988, In : Cancer chemotherapy and biological response modifiers. 10, p. 85-116 32 p.

Research output: Contribution to journalReview article

Menogaril
Nogalamycin
Vidarabine Phosphate
Echinomycin
Biphenyl Compounds
1987
3 Citations (Scopus)

New anticancer agents.

Weiss, G. R., Arteaga, C. L., Brown, T. D., Craig, J. B., Harman, G. S., Koeller, J. M., Kuhn, J. G. & Von Hoff, D. D., Dec 1 1987, In : Cancer chemotherapy and biological response modifiers. 9, p. 93-120 28 p.

Research output: Contribution to journalReview article

Antineoplastic Antimetabolites
Organoplatinum Compounds
Mitolactol
Vidarabine Phosphate
Acetamides