• 4390 Citations
  • 12 h-Index
20022017

Research output per year

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Research Output

  • 4390 Citations
  • 12 h-Index
  • 18 Article
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Article
2002

Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NFκB activation

Yeh, P. Y., Chuang, S. E., Yeh, K. H., Song, Y. C., Ea, C. K. & Cheng, A. L., Apr 15 2002, In : Biochemical Pharmacology. 63, 8, p. 1423-1430 8 p.

Research output: Contribution to journalArticle

119 Scopus citations
2004

TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains

Kanayama, A., Seth, R. B., Sun, L., Ea, C. K., Hong, M., Shaito, A., Chiu, Y. H., Deng, L. & Chen, Z. J., Aug 27 2004, In : Molecular cell. 15, 4, p. 535-548 14 p.

Research output: Contribution to journalArticle

609 Scopus citations

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Sun, L., Deng, L., Ea, C. K., Xia, Z. P. & Chen, Z. J., May 7 2004, In : Molecular cell. 14, 3, p. 289-301 13 p.

Research output: Contribution to journalArticle

514 Scopus citations

TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6

Ea, C. K., Sun, L., Inoue, J. I. & Chen, Z. J., Oct 26 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 43, p. 15318-15323 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
2005

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J., Sep 9 2005, In : Cell. 122, 5, p. 669-682 14 p.

Research output: Contribution to journalArticle

1901 Scopus citations
2006

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. & Chen, Z. J., Apr 21 2006, In : Molecular cell. 22, 2, p. 245-257 13 p.

Research output: Contribution to journalArticle

677 Scopus citations
2007

Ubiquitination and TRAF signaling

Pineda, G., Ea, C. K. & Chen, Z. J., 2007, In : Advances in Experimental Medicine and Biology. 597, p. 80-92 13 p.

Research output: Contribution to journalArticle

46 Scopus citations
2009

Regulation of NF-κB activity through lysine monomethylation of p65

Ea, C. K. & Baltimore, D., Nov 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 45, p. 18972-18977 6 p.

Research output: Contribution to journalArticle

151 Scopus citations
2012

EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression

Ea, C. K., Hao, S. L., Yeo, K. S. & Baltimore, D., Sep 7 2012, In : Journal of Biological Chemistry. 287, 37, p. 31207-31217 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

miR-146a controls the resolution of T cell responses in mice

Yang, L., Boldin, M. P., Yu, Y., Liu, C. S., Ea, C. K., Ramakrishnan, P., Taganov, K. D., Zhao, J. L. & Baltimore, D., Aug 1 2012, In : Journal of Experimental Medicine. 209, 9, p. 1655-1670 16 p.

Research output: Contribution to journalArticle

177 Scopus citations
2014

Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment

Loh, S. W., Ng, W. L., Yeo, K. S., Lim, Y. Y. & Ea, C. K., Jul 31 2014, In : PloS one. 9, 7, e103915.

Research output: Contribution to journalArticle

5 Scopus citations

Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation

Shawish, H. B., Wong, W. Y., Wong, Y. L., Loh, S. W., Looi, C. Y., Hassandarvish, P., Phan, A. Y. L., Wong, W. F., Wang, H., Paterson, I. C., Ea, C. K., Mustafa, M. R. & Maah, M. J., Jun 30 2014, In : PloS one. 9, 6, e100933.

Research output: Contribution to journalArticle

30 Scopus citations
2015

A cell-based screening system for anti-influenza A virus agents

Wong, W. Y., Loh, S. W., Ng, W. L., Tan, M. C., Yeo, K. S., Looi, C. Y., Maah, M. J. & Ea, C. K., 2015, In : Scientific reports. 5, 8672.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

Ng, W. L., Marinov, G. K., Liau, E. S., Lam, Y. L., Lim, Y. Y. & Ea, C. K., Sep 1 2016, In : RNA Biology. 13, 9, p. 861-871 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

JMJD8 is a positive regulator of TNF-induced NF-κB signaling

Yeo, K. S., Tan, M. C., Wong, W. Y., Loh, S. W., Lam, Y. L., Tan, C. L., Lim, Y. Y. & Ea, C. K., Sep 27 2016, In : Scientific Reports. 6, 34125.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Identification of 5-methoxy-2-(diformylmethylidene)-3,3-dimethylindole as an anti-influenza a virus agent

Tan, M. C., Wong, W. Y., Ng, W. L., Yeo, K. S., Begam, T., Mohidin, M., Lim, Y. Y., Lafta, F., Ali, H. M. & Ea, C. K., Jan 1 2017, In : PLoS One. 12, 1, e0170352.

Research output: Contribution to journalArticle

3 Scopus citations

JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain

Yeo, K. S., Tan, M. C., Lim, Y. Y. & Ea, C. K., Dec 1 2017, In : Scientific Reports. 7, 1, 15407.

Research output: Contribution to journalArticle

3 Scopus citations

Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway

Ng, W. L., Marinov, G. K., Chin, Y. M., Lim, Y. Y. & Ea, C. K., Dec 1 2017, In : Scientific Reports. 7, 1, 12227.

Research output: Contribution to journalArticle

6 Scopus citations