• 4479 Citations
  • 25 h-Index
20052020

Research output per year

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Research Output

  • 4479 Citations
  • 25 h-Index
  • 38 Article
  • 6 Review article
  • 3 Comment/debate
2020

A novel model of diabetic complications: Adipocyte mitochondrial dysfunction triggers massive β-cell hyperplasia

Kusminski, C. M., Ghaben, A. L., Morley, T. S., Samms, R. J., Adams, A. C., An, Y., Johnson, J. A., Joffin, N., Onodera, T., Crewe, C., Holland, W. L., Gordillo, R. & Scherer, P. E., Mar 1 2020, In : Diabetes. 69, 3, p. 313-330 18 p.

Research output: Contribution to journalArticle

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In : Molecular Metabolism. 37, 100995.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Suppressing adipocyte inflammation promotes insulin resistance in mice

Zhu, Q., An, Y. A., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M. & Scherer, P. E., Sep 2020, In : Molecular Metabolism. 39, 101010.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhang, Z., Shao, M., Hepler, C., Zi, Z., Zhao, S., An, Y. A., Zhu, Y., Ghaben, A. L., May-Yun, W., Li, N., Onodera, T., Joffin, N., Crewe, C., Zhu, Q., Vishvanath, L., Kumar, A., Xing, C., Wang, Q. A., Gautron, L., Deng, Y. & 5 others, Gordillo, R., Kruglikov, I., Kusminski, C. M., Gupta, R. K. & Scherer, P. E., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5327-5342 16 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

An, Y. A., Crewe, C., Asterholm, I. W., Sun, K., Chen, S., Zhang, F., Shao, M., Funcke, J. B., Zhang, Z., Straub, L., Yoshino, J., Klein, S., Kusminski, C. M. & Scherer, P. E., Dec 1 2019, In : Nature Metabolism. 1, 12, p. 1243-1257 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human endotrophin as a driver of malignant tumor growth

Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X. Z., Lønning, P. E., Halberg, N., Rios, A., Chang, Y., Gonzalez, A., Zhang, N., An, Z. & Scherer, P. E., 2019, In : JCI Insight. 4, 9, e125094.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Lowering ceramides to overcome diabetes

Kusminski, C. & Scherer, P. E., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 319-320 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., Zhang, N. & 5 others, Kusminski, C. M., Elmquist, J. K., Williams, K. W., An, Z. & Scherer, P. E., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 706-719.e6

Research output: Contribution to journalArticle

23 Scopus citations

β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis

Ye, R., Onodera, T., Blanchard, P. G., Kusminski, C. M., Esser, V., Brekken, R. A. & Scherer, P. E., Apr 2019, In : American Journal of Pathology. 189, 4, p. 813-825 13 p.

Research output: Contribution to journalArticle

2018

An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

Zhang, F., Hao, G., Shao, M., Nham, K., An, Y., Wang, Q., Zhu, Y., Kusminski, C., Hassan, G., Gupta, R. K., Zhai, Q., Sun, X., Scherer, P. E. & Oz, O. K., Jan 9 2018, In : Cell Metabolism. 27, 1, p. 252-262.e3

Research output: Contribution to journalArticle

40 Scopus citations

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy

Wilson, R. J., Drake, J. C., Cui, D., Zhang, M., Perry, H. M., Kashatus, J. A., Kusminski, C. M., Scherer, P. E., Kashatus, D. F., Okusa, M. D. & Yan, Z., Jan 1 2018, (Accepted/In press) In : Mitochondrion.

Research output: Contribution to journalArticle

13 Scopus citations

New zoning laws enforced by glucagon

Kusminski, C. M. & Scherer, P. E., Apr 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. 4308-4310 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2017

Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice

Xia, J. Y., Sun, K., Hepler, C., Ghaben, A. L., Gupta, R. K., An, Y. A., Holland, W. L., Morley, T. S., Adams, A. C., Gordillo, R., Kusminski, C. & Scherer, P. E., Dec 9 2017, (Accepted/In press) In : Diabetologia. p. 1-10 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

An, Y. A., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M. & Scherer, P. E., Mar 29 2017, In : eLife. 6, e24071.

Research output: Contribution to journalArticle

25 Scopus citations

Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK–LKB1 signaling axis

Casimiro, M. C., Di Sante, G., Di Rocco, A., Loro, E., Pupo, C., Pestell, T. G., Bisetto, S., Velasco-Velázquez, M. A., Jiao, X., Li, Z., Kusminski, C. M., Seifert, E. L., Wang, C., Ly, D., Zheng, B., Shen, C. H., Scherer, P. E. & Pestell, R. G., Jul 1 2017, In : Cancer research. 77, 13, p. 3391-3405 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

MicroRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Hajarnis, S., Lakhia, R., Yheskel, M., Williams, D., Sorourian, M., Liu, X., Aboudehen, K., Zhang, S., Kersjes, K., Galasso, R., Li, J., Kaimal, V., Lockton, S., Davis, S., Flaten, A., Johnson, J. A., Holland, W. L., Kusminski, C. M., Scherer, P. E., Harris, P. C. & 6 others, Trudel, M., Wallace, D. P., Igarashi, P., Lee, E. C., Androsavich, J. R. & Patel, V., Feb 16 2017, In : Nature communications. 8, 14395.

Research output: Contribution to journalArticle

59 Scopus citations
2016

Metabolic endotoxaemia in childhood obesity

Varma, M. C., Kusminski, C. M., Azharian, S., Gilardini, L., Kumar, S., Invitti, C. & McTernan, P. G., 2016, In : BMC Obesity. 3, 1, 3.

Research output: Contribution to journalArticle

14 Scopus citations

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Gallardo-Montejano, V. I., Saxena, G., Kusminski, C. M., Yang, C., McAfee, J. L., Hahner, L., Hoch, K., Dubinsky, W., Narkar, V. A. & Bickel, P. E., Aug 24 2016, In : Nature communications. 7, 12723.

Research output: Contribution to journalArticle

40 Scopus citations

Pdgfrβ+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice

Vishvanath, L., Macpherson, K. A., Hepler, C., Wang, Q. A., Shao, M., Spurgin, S. B., Wang, M. Y., Kusminski, C. M., Morley, T. S. & Gupta, R. K., Feb 9 2016, In : Cell Metabolism. 23, 2, p. 350-359 10 p.

Research output: Contribution to journalArticle

114 Scopus citations

SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

Fujikawa, T., Castorena, C. M., Pearson, M., Kusminski, C., Ahmed, N., Battiprolu, P. K., Kim, K. W., Lee, S., Hill, J. A., Scherer, P. E., Holland, W. L. & Elmquist, J. K., Nov 22 2016, In : eLife. 5, NOVEMBER2016, e18206.

Research output: Contribution to journalArticle

16 Scopus citations
206 Scopus citations

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

Shao, M., Ishibashi, J., Kusminski, C., Wang, Q. A., Hepler, C., Vishvanath, L., MacPherson, K. A., Spurgin, S. B., Sun, K., Holland, W. L., Seale, P. & Gupta, R. K., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1167-1184 18 p.

Research output: Contribution to journalArticle

87 Scopus citations
2015

E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte

Kusminski, C. M., Gallardo-Montejano, V. I., Wang, Z. V., Hegde, V., Bickel, P. E., Dhurandhar, N. V. & Scherer, P. E., Oct 1 2015, In : Molecular Metabolism. 4, 10, p. 653-664 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Leptin beyond the lipostat: Key component of blood pressure regulation

Kusminski, C. M. & Scherer, P. E., Apr 10 2015, In : Circulation research. 116, 8, p. 1293-1295 3 p.

Research output: Contribution to journalReview article

4 Scopus citations

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A. L., Kusminski, C. M., Sun, K., Zhang, Y., Scherer, P. E., Mangelsdorf, D. J. & Elmquist, J. K., Jun 15 2015, In : eLife. 4, JUNE, e06667.

Research output: Contribution to journalArticle

12 Scopus citations

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R. & Scherer, P. E., Aug 4 2015, In : Cell Metabolism. 22, 2, p. 266-278 13 p.

Research output: Contribution to journalArticle

130 Scopus citations
2014

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

Sun, K., Kusminski, C. M., Luby-Phelps, K., Spurgin, S. B., An, Y. A., Wang, Q. A., Holland, W. L. & Scherer, P. E., Jul 2014, In : Molecular Metabolism. 3, 4, p. 474-483 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

Baskin, K. K., Grueter, C. E., Kusminski, C. M., Holland, W. L., Bookout, A. L., Satapati, S., Kong, Y. M., Burgess, S. C., Malloy, C. R., Scherer, P. E., Newgard, C. B., Bassel-Duby, R. & Olson, E. N., Dec 1 2014, In : EMBO Molecular Medicine. 6, 12, p. 1610-1621 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

MitoNEET-mediated effects on browning of white adipose tissue

Kusminski, C. M., Park, J. & Scherer, P. E., May 28 2014, In : Nature communications. 5, 3962.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Alterations in glucose homeostasis in a murine model of Chagas disease

Nagajyothi, F., Kuliawat, R., Kusminski, C. M., Machado, F. S., Desruisseaux, M. S., Zhao, D., Schwartz, G. J., Huang, H., Albanese, C., Lisanti, M. P., Singh, R., Li, F., Weiss, L. M., Factor, S. M., Pessin, J. E., Scherer, P. E. & Tanowitz, H. B., Mar 1 2013, In : American Journal of Pathology. 182, 3, p. 886-894 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice

Holland, W. L., Adams, A. C., Brozinick, J. T., Bui, H. H., Miyauchi, Y., Kusminski, C. M., Bauer, S. M., Wade, M., Singhal, E., Cheng, C. C., Volk, K., Kuo, M. S., Gordillo, R., Kharitonenkov, A. & Scherer, P. E., May 7 2013, In : Cell Metabolism. 17, 5, p. 790-797 8 p.

Research output: Contribution to journalArticle

281 Scopus citations
2012

Dichotomous effects of VEGF-A on adipose tissue dysfunction

Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A. & Scherer, P. E., Apr 10 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 15, p. 5874-5879 6 p.

Research output: Contribution to journalArticle

226 Scopus citations

Mitochondrial dysfunction in white adipose tissue

Kusminski, C. M. & Scherer, P. E., Sep 1 2012, In : Trends in Endocrinology and Metabolism. 23, 9, p. 435-443 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

Kusminski, C. M., Holland, W. L., Sun, K., Park, J., Spurgin, S. B., Lin, Y., Askew, G. R., Simcox, J. A., McClain, D. A., Li, C. & Scherer, P. E., Oct 2012, In : Nature medicine. 18, 10, p. 1539-1551 13 p.

Research output: Contribution to journalArticle

233 Scopus citations
2011

Adipose tissue remodeling and obesity

Sun, K., Kusminski, C. M. & Scherer, P. E., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2094-2101 8 p.

Research output: Contribution to journalReview article

893 Scopus citations

Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytes

McGee, K. C., Harte, A. L., da Silva, N. F., Al-Daghri, N., Creely, S. J., Kusminski, C. M., Tripathi, G., Levick, P. L., Khanolkar, M., Evans, M., Chittari, M. V., Patel, V., Kumar, S. & McTernan, P. G., 2011, In : PloS one. 6, 6, e20287.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo

Park, J., Kusminski, C. M., Chua, S. C. & Scherer, P. E., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3133-3144 12 p.

Research output: Contribution to journalArticle

53 Scopus citations
2009

Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies

Shetty, S., Kusminski, C. M. & Scherer, P. E., May 1 2009, In : Trends in Pharmacological Sciences. 30, 5, p. 234-239 6 p.

Research output: Contribution to journalReview article

167 Scopus citations

Diabetes and apoptosis: Lipotoxicity

Kusminski, C., Shetty, S., Orci, L., Unger, R. H. & Scherer, P. E., Dec 1 2009, In : Apoptosis. 14, 12, p. 1484-1495 12 p.

Research output: Contribution to journalReview article

176 Scopus citations
39 Scopus citations
2007

Adiponectin complexes in human cerebrospinal fluid: Distinct complex distribution from serum

Kusminski, C. M., McTernan, P. G., Schraw, T., Kos, K., O'Hare, J. P., Ahima, R., Kumar, S. & Scherer, P. E., Mar 1 2007, In : Diabetologia. 50, 3, p. 634-642 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

Creely, S. J., McTernan, P. G., Kusminski, C. M., Fisher, F. M., Da Silva, N. F., Khanolkar, M., Evans, M., Harte, A. L. & Kumar, S., Mar 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 3, p. E740-E747

Research output: Contribution to journalArticle

628 Scopus citations

The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes

Kusminski, C. M., Da Silva, N. F., Creely, S. J., Fisher, F. M., Harte, A. L., Baker, A. R., Kumar, S. & McTernan, P. G., Jan 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 1, p. 270-276 7 p.

Research output: Contribution to journalArticle

62 Scopus citations
2006

Resistin

McTernan, P. G., Kusminski, C. M. & Kumar, S., Apr 2006, In : Current opinion in lipidology. 17, 2, p. 170-175 6 p.

Research output: Contribution to journalReview article

144 Scopus citations
2005

Role of resistin in obesity, insulin resistance and Type II diabetes

Kusminski, C. M., McTernan, P. G. & Kumar, S., Sep 2005, In : Clinical science. 109, 3, p. 243-256 14 p.

Research output: Contribution to journalReview article

214 Scopus citations