Christopher T Chen

2017

A Biomechanical Analysis of Interference Screw Versus Bone Tunnel Fixation of Flexor Hallucis Longus Tendon Transfers to the Calcaneus

Liu, G. T., Balldin, B. C., Zide, J. R. & Chen, C. T., Jul 1 2017, In: Journal of Foot and Ankle Surgery. 56, 4, p. 813-816 4 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression

Rutkowski, J. M., Pastor, J., Sun, K., Park, S. K., Bobulescu, I. A., Chen, C. T., Moe, O. W. & Scherer, P. E., Feb 1 2017, In: Kidney international. 91, 2, p. 324-337 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

CHAPTER 1: Introduction to Cartilage

Xia, Y., Momot, K. I., Chen, Z., Chen, C. T., Kahn, D. & Badar, F., 2017, Biophysics and Biochemistry of Cartilage by NMR and MRI. Xia, Y. & Momot, K. I. (eds.). 8 ed. Royal Society of Chemistry, p. 3-43 41 p. (New Developments in NMR; vol. 2017-January, no. 8).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

2016

Type 2 Diabetes and Metformin Influence on Fracture Healing in an Experimental Rat Model

La Fontaine, J., Chen, C., Hunt, N., Jude, E. & Lavery, L., Sep 1 2016, In: Journal of Foot and Ankle Surgery. 55, 5, p. 955-960 6 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2015

In vitro cartilage explant injury models

Chen, C. T. & Torzilli, P. A., Jan 1 2015, Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management. Springer US, p. 29-40 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Relationship between serum uric acid and bone mineral density in the general population and in rats with experimental hyperuricemia

Zhang, D., Bobulescu, I. A., Maalouf, N. M., Adams-Huet, B., Poindexter, J., Park, S., Wei, F., Chen, C., Moe, O. W. & Sakhaee, K., Jun 1 2015, In: Journal of Bone and Mineral Research. 30, 6, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

2014

Topographical variations of the strain-dependent zonal properties of tibial articular cartilage by microscopic MRI

Lee, J. H., Badar, F., Kahn, D., Matyas, J., Qu, X., Chen, C. T. & Xia, Y., Jun 2014, In: Connective Tissue Research. 55, 3, p. 205-216 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2013

Biomechanical cadaveric analysis of biotenodesis screw versus bone tunnel fixation methods in flexor hallucis longus transfers

Balldin, B. C., Zide, J. R., Liu, G. T. & Chen, C. T., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

NF-κB mediates cartilage degradation induced by trauma injury and interleukin-1

Kashyap, M., Carter, K. T., Sauer, B. C. & Chen, C. T., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Posttraumatic Chondrocyte Apoptosis in the Murine Xiphoid

Davis, C. G., Eisner, E., McGlynn, M., Shelton, J. M., Richardson, J., Borrelli, J. & Chen, C. C. T., Oct 2013, In: Cartilage. 4, 4, p. 345-353 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2012

A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14

Zhang, X., Chen, C. T., Bhargava, M. & Torzilli, P. A., Jul 2012, In: Cartilage. 3, 3, p. 267-277 11 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons

Robertson, C. M., Chen, C. T., Shindle, M. K., Cordasco, F. A., Rodeo, S. A. & Warren, R. F., Sep 2012, In: American Journal of Sports Medicine. 40, 9, p. 1993-2001 9 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

2011

Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears

Shindle, M. K., Chen, C. C. T., Robertson, C., DiTullio, A. E., Paulus, M. C., Clinton, C. M., Cordasco, F. A., Rodeo, S. A. & Warren, R. F., Sep 2011, In: Journal of Shoulder and Elbow Surgery. 20, 6, p. 917-927 11 p.

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Mechanical loading of articular cartilage reduces IL-1-induced enzyme expression

Torzilli, P. A., Bhargava, M. & Chen, C. T., Oct 2011, In: Cartilage. 2, 4, p. 364-373 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2010

Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage

Torzilli, P. A., Bhargava, M., Park, S. & Chen, C. T. C., Jan 2010, In: Osteoarthritis and Cartilage. 18, 1, p. 97-105 9 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

2009

Chondrocyte death and cartilage degradation after autologous osteochondral transplantation surgery in a rabbit model

Gulotta, L. V., Rudzki, J. R., Kovacevic, D., Chen, C. C. T., Milentijevic, D. & Williams, R. J., 2009, In: American Journal of Sports Medicine. 37, 7, p. 1324-1333 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Cyclic compression of chondrocytes counteracts pro-inflammatory tissue remodeling induced by interleukin-1

DiTullio, A. E., Park, S., Torzilli, P. A. & Chen, C. T., 2009, Proceedings of the ASME Summer Bioengineering Conference, SBC2008. PART A ed. p. 93-94 2 p. (Proceedings of the ASME Summer Bioengineering Conference, SBC2008; no. PART A).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Inhibitory effect of mechanical load on IL-1 induced cartilage degradation is mediated by interferon-gamma and IL-1 receptor 1

Chen, C. T., Park, S., Bhargava, M. & Torzilli, P. A., 2009, Proceedings of the ASME Summer Bioengineering Conference, SBC2008. PART B ed. p. 713-714 2 p. (Proceedings of the ASME Summer Bioengineering Conference, SBC2008; no. PART B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Musculoskeletal effects of obesity

Chan, G. & Chen, C. T., Feb 2009, In: Current opinion in pediatrics. 21, 1, p. 65-70 6 p.

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

2008

Material properties of fresh cold-stored allografts for osteochondral defects at 1 year

Ranawat, A. S., Vidal, A. F., Chen, C. T., Zelken, J. A., Turner, A. S. & Williams, R. J., Aug 2008, In: Clinical orthopaedics and related research. 466, 8, p. 1826-1836 11 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

2007

Gelatinase B (MMP-9) modulates joint inflammation and cartilage degradation after overload injury

Chen, C. T. C., DiTullio, A. & Deng, X., 2007, Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007. American Society of Mechanical Engineers (ASME), p. 813-814 2 p. (Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Load down-regulates TNF-α induced cartilage degradation in part through NF-κB and P38 pathways

Wolfe, V. M., Park, S., Tomic, M., Torzilli, P. A. & Chen, C. T. C., 2007, Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007. p. 819-820 2 p. (Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2005

Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine model

Strauss, E. J., Goodrich, L. R., Chen, C. T., Hidaka, C. & Nixon, A. J., Nov 2005, In: American Journal of Sports Medicine. 33, 11, p. 1647-1653 7 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Daily cyclic compression increases collagen cleavage in load-injured cartilage

Narayanan, S., Song, M., Torzilli, P. A. & Chen, C. T. C., 2005, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 956-957 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Effect of tissue maturity on cell viability in load-injured articular cartilage explants

Levin, A. S., Chen, C. T. C. & Torzilli, P. A., Jun 2005, In: Osteoarthritis and Cartilage. 13, 6, p. 488-496 9 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation

West, P. A., Torzilli, P. A., Chen, C., Lin, P. & Camacho, N. P., Jan 2005, In: Journal of biomedical optics. 10, 1, 014015.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Preventing matrix degradation and maintaining cell population in load-induced cartilage using TIMP-1 and a synthetic MMP inhibitor

Chen, C. T. C., Deng, X., Nikmanesh, M. & Torzilli, P. A., 2005, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 479-480 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2004

Chondrocyte Survival and Material Properties of Hypothermically Stored Cartilage: An Evaluation of Tissue Used for Osteochondral Allograft Transplantation

Williams, R. J., Dreese, J. C. & Chen, C. T., Jan 2004, In: American Journal of Sports Medicine. 32, 1, p. 132-139 8 p.

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage

Lin, P. M., Chen, C. T. C. & Torzilli, P. A., Jun 2004, In: Osteoarthritis and Cartilage. 12, 6, p. 485-496 12 p.

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

2003

Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7

Hidaka, C., Goodrich, L. R., Chen, C. T., Warren, R. F., Crystal, R. G. & Nixon, A. J., 2003, In: Journal of Orthopaedic Research. 21, 4, p. 573-583 11 p.

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Matrix fixed-charge density as determined by magnetic resonance microscopy of bioreactor-derived hyaline cartilage correlates with biochemical and biomechanical properties

Chen, C. T., Fishbein, K. W., Torzilli, P. A., Hilger, A., Spencer, R. G. S. & Horton, W. E., Apr 1 2003, In: Arthritis and rheumatism. 48, 4, p. 1047-1056 10 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Stain is the major factor for chondrocyte death in articular cartilage under static load

Shah, A. K., Yuan, L. J., Torzilli, P. A. & Chen, C. T. C., 2003, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. American Society of Mechanical Engineers (ASME), Vol. 55. p. 331-332 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage

Chen, C. T., Bhargava, M., Lin, P. M. & Torzilli, P. A., 2003, In: Journal of Orthopaedic Research. 21, 5, p. 888-898 11 p.

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

2002

Chondrocyte death in articular cartilage due to excessive mechanical loading in the axial and transverse directions

Chen, C. T. & Torzilli, P. A., Jan 1 2002, Advances in Bioengineering. American Society of Mechanical Engineers (ASME), p. 51-52 2 p. (ASME International Mechanical Engineering Congress and Exposition, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

2001

Biomechanical properties of grown cartilage are decreased in the presence of retinoic acid, chondroitinase ABC and ibuprofen

Chen, C. T., Torzilli, P. A., Fishbein, K. W., Spencer, R. G. S. & Horton, W. E., 2001, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Lieber, B. B. (ed.). Vol. 51. p. 297-298 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cell death and matrix damage in cyclically loaded cartilage is time and depth dependent

Chen, C. T., Bhargava, M., Lin, P. & Torzilli, P. A., 2001, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Kamm, R. D., Schmid-Schoenbein, G. W., Atesian, G. A. & Hefzy, M. S. (eds.). Vol. 50. p. 713-714 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chondrocyte necrosis and apoptosis in impact damaged articular cartilage

Chen, C. T., Burton-Wurster, N., Borden, C., Hueffer, K., Bloom, S. E. & Lust, G., 2001, In: Journal of Orthopaedic Research. 19, 4, p. 703-711 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

189 Scopus citations

Intercellular signalling as a cause of cell death in cyclically impacted cartilage explants

Levine, A., Burton-Wurster, N., Chen, C. T. & Lust, G., Nov 2001, In: Osteoarthritis and Cartilage. 9, 8, p. 702-711 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2000

Transient and cyclic responses of strain-generated potential in rabbit patellar tendon are frequency and pH dependent

Chen, C. T., McCabe, R. P., Grodzinsky, A. J. & Vanderby R., J., 2000, In: Journal of Biomechanical Engineering. 122, 5, p. 465-470 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

1999

Compositional and metabolic changes in damaged cartilage are peak- stress, stress-rate, and loading-duration dependent

Chen, C. T., Burton-Wurster, N., Lust, G., Bank, R. A. & Tekoppele, J. M., 1999, In: Journal of Orthopaedic Research. 17, 6, p. 870-879 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

1998

A fiber matrix model for interstitial fluid flow and permeability in ligaments and tendons

Chen, C. T., Malkus, D. S. & Vanderby, R., 1998, In: Biorheology. 35, 2, p. 103-118 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

1997

A poroelastic model of streaming potential and interstitial fluid flow in ligament and tendon

Chen, C. T. & Vanderby, R., Dec 1 1997, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 36, p. 185-186 2 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

A POROELASTIC MODEL OF STREAMING POTENTIAL AND INTERSTITIAL FLUID FLOW IN LIGAMENT AND TENDON

Chen, C. T. & Vanderby, R., 1997, Advances in Bioengineering. American Society of Mechanical Engineers (ASME), p. 185-186 2 p. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); vol. 1997-H).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Interstitial fluid flow in tendons or ligaments: A porous medium finite element simulation

Butler, S. L., Kohles, S. S., Thielke, R. J., Chen, C. & Vanderby, R., 1997, In: Medical and Biological Engineering and Computing. 35, 6, p. 742-746 5 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

1996

Strain induced pressure and potential in ligament and tendon

Chen, C. T. & Vanderby, R., 1996, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 231-232 2 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

1995

Two electrokinetic phenomena in rabbit patellar tendon: pressure and voltage

Chen, C., McCabe, R. P. & Vanderby, R., 1995, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ASME, Vol. 29. p. 31-32 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Scopus citations

Christopher T Chen

Research output

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