• 4916 Citations
  • 33 h-Index
19982019
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Research Output 1998 2019

  • 4916 Citations
  • 33 h-Index
  • 63 Article
  • 1 Chapter
  • 1 Review article
2019

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C. & Lum, L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6273-6282 10 p.

Research output: Contribution to journalArticle

Porcupines
Acylation
Animals
Acyltransferases
Proteins

Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation

Wang, S., Han, L., Han, J., Li, P., Ding, Q., Zhang, Q. J., Liu, Z. P., Chen, C. & Yu, Y., Dec 1 2019, In : Nature chemical biology. 15, 12, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Adenosine Diphosphate
Muscle Cells
DNA Damage
Cell Death
2018

A synthetic combinatorial approach to disabling deviant Hedgehog signaling

Fan, C. W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C. & Lum, L., Dec 1 2018, In : Scientific Reports. 8, 1, 1133.

Research output: Contribution to journalArticle

Histone Deacetylases
Medulloblastoma
Critical Pathways
Basal Cell Carcinoma
DNA-Binding Proteins
1 Citation (Scopus)

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Catenins
Acute Myeloid Leukemia
Neoplasms
Proteins
Genetic Translocation
2 Citations (Scopus)

Natural Products as Inspiration for the Development of New Synthetic Methods

Ma, Z. & Chen, C., Jan 1 2018, In : Journal of the Chinese Chemical Society. 65, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

Biological Products
Biosynthesis
Organic Chemistry
2017
94 Citations (Scopus)

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Cross-Priming
Interferon Type I
Experimental Melanomas
Antibodies
10 Citations (Scopus)

Ketone-catalyzed photochemical C(sp3)–H chlorination

Han, L., Xia, J. B., You, L. & Chen, C., Jun 29 2017, In : Tetrahedron. 73, 26, p. 3696-3701 6 p.

Research output: Contribution to journalArticle

Chlorination
Halogenation
Ketones
Fluorescent lamps
Free Radicals
2 Citations (Scopus)
Pyrroles
Ketones
Alkaloids
Skeleton
Coordination Complexes

Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter

Ma, Z., You, L. & Chen, C., Jan 6 2017, In : Journal of Organic Chemistry. 82, 1, p. 731-736 6 p.

Research output: Contribution to journalArticle

Pyrroles
Alkaloids
Oxidation
Molecules
massadine
2016
13 Citations (Scopus)

Asymmetric Synthesis of Axinellamines A and B

Ma, Z., Wang, X., Ma, Y. & Chen, C., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Alkaloids
Pyrroles
Chlorination
Metabolites
axinellamine A
7 Citations (Scopus)

Development of a triazole class of highly potent Porcn inhibitors

You, L., Zhang, C., Yarravarapu, N., Morlock, L., Wang, X., Zhang, L., Williams, N. S., Lum, L. & Chen, C., Dec 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5891-5895 5 p.

Research output: Contribution to journalArticle

Porcupines
Triazoles
Scaffolds
Wnt Proteins
Acyltransferases
4 Citations (Scopus)

Palladium-catalyzed C-H arylation of 1,2,3-triazoles

Zhang, C., You, L. & Chen, C., Oct 1 2016, In : Molecules. 21, 10, 1268.

Research output: Contribution to journalArticle

Triazoles
Palladium
palladium
acetates
palladium(II) acetate
17 Citations (Scopus)

The past, present, and future of the Yang reaction

Chen, C., 2016, In : Organic and Biomolecular Chemistry. 14, 37, p. 8641-8647 7 p.

Research output: Contribution to journalReview article

Ketones
ketones
Atoms
Hydrocarbons
Hydrogen
2015
72 Citations (Scopus)

2-hydroxyglutarate inhibits ATP synthase and mTOR Signaling

Fu, X., Chin, R. M., Vergnes, L., Hwang, H., Deng, G., Xing, Y., Pai, M. Y., Li, S., Ta, L., Fazlollahi, F., Chen, C., Prins, R. M., Teitell, M. A., Nathanson, D. A., Lai, A., Faull, K. F., Jiang, M., Clarke, S. G., Cloughesy, T. F., Graeber, T. G. & 5 others, Braas, D., Christofk, H. R., Jung, M. E., Reue, K. & Huang, J., Sep 1 2015, In : Cell Metabolism. 22, 3, p. 508-515 8 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Isocitrate Dehydrogenase
Glucose
Ketone Bodies
Glioblastoma
12 Citations (Scopus)

An approach for the synthesis of nakamuric acid

Wang, X. & Chen, C., Jun 3 2015, In : Tetrahedron. 71, 22, p. 3690-3693 4 p.

Research output: Contribution to journalArticle

Pyrroles
Cycloaddition
Cycloaddition Reaction
Alkaloids
Electrons
13 Citations (Scopus)
Regenerative Medicine
Decision Making
Decision making
Molecules
Wnt Proteins
9 Citations (Scopus)

Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F

Shi, H., De, S., Wang, Q., Gao, S., Wang, X. & Chen, C., May 25 2015, In : Tetrahedron Letters. 56, 23, p. 3225-3227 3 p.

Research output: Contribution to journalArticle

Palladium
Alkenes
Skeleton
lancifodilactone F
32 Citations (Scopus)

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Telomere Homeostasis
Telomere
Porcupines

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification and characterization of β-sitosterol target proteins

Lomenick, B., Shi, H., Huang, J. & Chen, C., Feb 11 2015, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Harpagophytum
Phytosterols
Proteins
Traditional Medicine
Nutrition
21 Citations (Scopus)
Ligands
Proteins
Protein Conformation
Entropy
Second Messenger Systems
3 Citations (Scopus)

Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S. & Chen, C., Jul 10 2015, In : Science. 349, 6244, p. 149c

Research output: Contribution to journalArticle

Pyrroles
Biological Products
imidazole
sceptrin
massadine
37 Citations (Scopus)

Syntheses of cyclic guanidine-containing natural products

Ma, Y., De, S. & Chen, C., Feb 25 2015, In : Tetrahedron. 71, 8, p. 1145-1173 29 p.

Research output: Contribution to journalArticle

Guanidine
Biological Products
Alkaloids
9 Citations (Scopus)

Syntheses of sceptrins and nakamuric acid and insights into the biosyntheses of pyrrole-imidazole dimers

Wang, X., Gao, Y., Ma, Z., Rodriguez, R. A., Yu, Z. X. & Chen, C., Aug 1 2015, In : Organic Chemistry Frontiers. 2, 8, p. 978-984 7 p.

Research output: Contribution to journalArticle

Pyrroles
Cycloaddition
Biosynthesis
Dimers
Cyclobutanes
2014
15 Citations (Scopus)

A simple method for the electrophilic cyanation of secondary amines

Chen, C., Zhu, C. & Xia, J. B., Jan 3 2014, In : Organic Letters. 16, 1, p. 247-249 3 p.

Research output: Contribution to journalArticle

Amines
amines
Cyanamide
cyanamides
cyanogen
64 Citations (Scopus)

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S. & Chen, C., Oct 10 2014, In : Science. 346, 6206, p. 219-224 6 p.

Research output: Contribution to journalArticle

Cycloaddition Reaction
Porifera
Pyrroles
Biological Products
Alkaloids
38 Citations (Scopus)

Dimeric pyrrole-imidazole alkaloids: Synthetic approaches and biosynthetic hypotheses

Wang, X., Ma, Z., Wang, X., De, S., Ma, Y. & Chen, C., Aug 14 2014, In : Chemical Communications. 50, 63, p. 8628-8639 12 p.

Research output: Contribution to journalArticle

Alkaloids
Pyrroles
Metabolites
Biological Products
Dimers
12 Citations (Scopus)

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

Cilia
Phosphatidylinositol-4-Phosphate 3-Kinase
Hedgehog Proteins
Chemical activation
Cell membranes
56 Citations (Scopus)

Vanadium-catalyzed C(sp<sup>3</sup>)-H fluorination reactions

Xia, J. B., Ma, Y. & Chen, C., Jul 1 2014, In : Organic Chemistry Frontiers. 1, 5, p. 468-472 5 p.

Research output: Contribution to journalArticle

Fluorination
Vanadium
Fluorine
Oxides
Byproducts
20 Citations (Scopus)

Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation of para-methoxyphenyl (PMP)-protected primary amines

Chen, C., Zhu, C. & Xia, J. B., Jan 1 2014, In : Tetrahedron Letters. 55, 1, p. 232-234 3 p.

Research output: Contribution to journalArticle

Vanadium
Amines
Bearings (structural)
Oxidants
Carbon
68 Citations (Scopus)

Visible light-promoted metal-free sp<sup>3</sup>-C-H fluorination

Xia, J. B., Zhu, C. & Chen, C., Oct 11 2014, In : Chemical Communications. 50, 79, p. 11701-11704 4 p.

Research output: Contribution to journalArticle

Light Metals
Light metals
Fluorination
Fluorescent lamps
Halogenation
2013
319 Citations (Scopus)

Cyclic GMP-AMP containing mixed Phosphodiester linkages is an endogenous high-affinity ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. & Chen, Z., Jul 25 2013, In : Molecular Cell. 51, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

Ligands
GMP synthase (glutamine-hydrolyzing)
Adenosine Monophosphate
Phosphates
Guanosine Monophosphate
709 Citations (Scopus)

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 826-830 5 p.

Research output: Contribution to journalArticle

Second Messenger Systems
DNA
Interferons
DNA Virus Infections
Interferon Type I
Pyrroles
Biomimetics
Alkaloids
imidazole
ageliferin
1 Citation (Scopus)

Erratum: Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation (Nature Cell Biology (2013) 15 (1035-1044))

Das, A., Tanigawa, S., Karner, C. M., Xin, M., Lum, L., Chen, C., Olson, E. N., Perantoni, A. O. & Carroll, T. J., Oct 2013, In : Nature Cell Biology. 15, 10, p. 1260 1 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation

Das, A., Tanigawa, S., Karner, C. M., Xin, M., Lum, L., Chen, C., Olson, E. N., Perantoni, A. O. & Carroll, T. J., Sep 2013, In : Nature Cell Biology. 15, 9, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
Stem Cells
Kidney
Nephrons
Cadherins
44 Citations (Scopus)

The development of highly potent inhibitors for porcupine

Wang, X., Moon, J., Dodge, M. E., Pan, X., Zhang, L., Hanson, J. M., Tuladhar, R., Ma, Z., Shi, H., Williams, N. S., Amatruda, J. F., Carroll, T. J., Lum, L. & Chen, C., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2700-2704 5 p.

Research output: Contribution to journalArticle

Porcupines
Wnt Proteins
Lipoylation
Kidney Tubules
Zebrafish
269 Citations (Scopus)

Visible light-promoted metal-free C-H activation: Diarylketone-catalyzed selective benzylic mono- and difluorination

Xia, J. B., Zhu, C. & Chen, C., Nov 20 2013, In : Journal of the American Chemical Society. 135, 46, p. 17494-17500 7 p.

Research output: Contribution to journalArticle

Light Metals
Light metals
Chemical activation
Gems
Light
2012
34 Citations (Scopus)

A biomimetic route for construction of the [4+2] and [3+2] core skeletons of dimeric pyrrole-imidazole alkaloids and asymmetric synthesis of ageliferins

Wang, X., Wang, X., Tan, X., Lu, J., Cormier, K. W., Ma, Z. & Chen, C., Nov 14 2012, In : Journal of the American Chemical Society. 134, 45, p. 18834-18842 9 p.

Research output: Contribution to journalArticle

Alkaloids
Biomimetics
Pyrroles
Biosynthesis
Skeleton
40 Citations (Scopus)

A highly selective vanadium catalyst for benzylic C-H oxidation

Xia, J. B., Cormier, K. W. & Chen, C., Jul 2012, In : Chemical Science. 3, 7, p. 2240-2245 6 p.

Research output: Contribution to journalArticle

Vanadium
Oxidation
Catalysts
Alkenes
Alcohols
54 Citations (Scopus)

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine

Dodge, M. E., Moon, J., Tuladhar, R., Lu, J., Jacob, L. S., Zhang, L. S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C. M., Carroll, T. J., Chen, C., Amatruda, J. F. & Lum, L., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 23246-23254 9 p.

Research output: Contribution to journalArticle

Porcupines
Wnt Proteins
Acyltransferases
Catenins
Scaffolds
110 Citations (Scopus)

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

Moro, E., Ozhan-Kizil, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R. M., Bournele, D., Domenichini, A., Valdivia, L. E., Lum, L., Chen, C., Amatruda, J. F., Tiso, N., Weidinger, G. & Argenton, F., Jun 15 2012, In : Developmental Biology. 366, 2, p. 327-340 14 p.

Research output: Contribution to journalArticle

Catenins
Biosensing Techniques
Fishes
Developmental Biology
Wnt Signaling Pathway
1 Citation (Scopus)

Nakiterpiosin

Gao, S. & Chen, C., Aug 1 2012, Total Synthesis of Natural Products: At the Frontiers of Organic Chemistry. Springer-Verlag Berlin Heidelberg, Vol. 9783642340659. p. 25-37 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Research laboratories
Agriculture
Defects
nakiterpiosin
5 Citations (Scopus)

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids

Gao, S., Wang, Q., Wang, G., Lomenick, B., Liu, J., Fan, C. W., Deng, L. W., Huang, J., Lum, L. & Chen, C., 2012, (Accepted/In press) In : Synlett. 23

Research output: Contribution to journalArticle

Homosteroids
Biomimetics
Biological Products
nakiterpiosin
2011
34 Citations (Scopus)

Asymmetric synthesis of ageliferin

Wang, X., Ma, Z., Lu, J., Tan, X. & Chen, C., Oct 5 2011, In : Journal of the American Chemical Society. 133, 39, p. 15350-15353 4 p.

Research output: Contribution to journalArticle

Pyrroles
Dimerization
Cyclization
Skeleton
Dimers
158 Citations (Scopus)

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

Karner, C. M., Das, A., Ma, Z., Self, M., Chen, C., Lum, L., Oliver, G. & Carroll, T. J., Apr 2011, In : Development. 138, 7, p. 1247-1257 11 p.

Research output: Contribution to journalArticle

Nephrons
Catenins
Cell Differentiation
Stem Cells
Kidney
33 Citations (Scopus)

Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine

Ma, Z., Lu, J., Wang, X. & Chen, C., Jan 7 2011, In : Chemical Communications. 47, 1, p. 427-429 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Amines
palau'amine
Biosynthetic Pathways
2010
47 Citations (Scopus)

Chemical and biological studies of nakiterpiosin and nakiterpiosinone

Gao, S., Wang, Q., Huang, L. J. S., Lum, L. & Chen, C., Jan 13 2010, In : Journal of the American Chemical Society. 132, 1, p. 371-383 13 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Signal transduction
Hedgehogs
Antineoplastic Agents
Homosteroids
33 Citations (Scopus)

Tankyrase is necessary for canonical Wnt signaling during kidney development

Karner, C. M., Merkel, C. E., Dodge, M., Ma, Z., Lu, J., Chen, C., Lum, L. & Carroll, T. J., 2010, In : Developmental Dynamics. 239, 7, p. 2014-2023 10 p.

Research output: Contribution to journalArticle

Tankyrases
Kidney
Wnt Signaling Pathway
Catenins
Zebrafish
2009
903 Citations (Scopus)

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C. & Lum, L., Feb 6 2009, In : Nature Chemical Biology. 5, 2, p. 100-107 8 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Regeneration
Wnt Proteins
Catenins
Axin Protein