• 4953 Citations
  • 33 h-Index
19982019

Research output per year

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Research Output

  • 4953 Citations
  • 33 h-Index
  • 63 Article
  • 1 Chapter
  • 1 Review article
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Article
2019

Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN)

Tuladhar, R., Yarravarapu, N., Ma, Y., Zhang, C., Herbert, J., Kim, J., Chen, C. & Lum, L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6273-6282 10 p.

Research output: Contribution to journalArticle

Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation

Wang, S., Han, L., Han, J., Li, P., Ding, Q., Zhang, Q. J., Liu, Z. P., Chen, C. & Yu, Y., Dec 1 2019, In : Nature chemical biology. 15, 12, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A synthetic combinatorial approach to disabling deviant Hedgehog signaling

Fan, C. W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C. & Lum, L., Dec 1 2018, In : Scientific Reports. 8, 1, 1133.

Research output: Contribution to journalArticle

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

1 Scopus citations

Natural Products as Inspiration for the Development of New Synthetic Methods

Ma, Z. & Chen, C., Jan 1 2018, In : Journal of the Chinese Chemical Society. 65, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L. & Chen, Z. J., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Ketone-catalyzed photochemical C(sp3)–H chlorination

Han, L., Xia, J. B., You, L. & Chen, C., Jun 29 2017, In : Tetrahedron. 73, 26, p. 3696-3701 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2 Scopus citations

Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter

Ma, Z., You, L. & Chen, C., Jan 6 2017, In : Journal of Organic Chemistry. 82, 1, p. 731-736 6 p.

Research output: Contribution to journalArticle

2016

Asymmetric Synthesis of Axinellamines A and B

Ma, Z., Wang, X., Ma, Y. & Chen, C., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

13 Scopus citations

Development of a triazole class of highly potent Porcn inhibitors

You, L., Zhang, C., Yarravarapu, N., Morlock, L., Wang, X., Zhang, L., Williams, N. S., Lum, L. & Chen, C., Dec 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5891-5895 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Palladium-catalyzed C-H arylation of 1,2,3-triazoles

Zhang, C., You, L. & Chen, C., Oct 1 2016, In : Molecules. 21, 10, 1268.

Research output: Contribution to journalArticle

4 Scopus citations
2015

2-hydroxyglutarate inhibits ATP synthase and mTOR Signaling

Fu, X., Chin, R. M., Vergnes, L., Hwang, H., Deng, G., Xing, Y., Pai, M. Y., Li, S., Ta, L., Fazlollahi, F., Chen, C., Prins, R. M., Teitell, M. A., Nathanson, D. A., Lai, A., Faull, K. F., Jiang, M., Clarke, S. G., Cloughesy, T. F., Graeber, T. G. & 5 others, Braas, D., Christofk, H. R., Jung, M. E., Reue, K. & Huang, J., Sep 1 2015, In : Cell Metabolism. 22, 3, p. 508-515 8 p.

Research output: Contribution to journalArticle

73 Scopus citations

An approach for the synthesis of nakamuric acid

Wang, X. & Chen, C., Jun 3 2015, In : Tetrahedron. 71, 22, p. 3690-3693 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
13 Scopus citations

Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F

Shi, H., De, S., Wang, Q., Gao, S., Wang, X. & Chen, C., May 25 2015, In : Tetrahedron Letters. 56, 23, p. 3225-3227 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

Identification and characterization of β-sitosterol target proteins

Lomenick, B., Shi, H., Huang, J. & Chen, C., Feb 11 2015, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

7 Scopus citations
21 Scopus citations

Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S. & Chen, C., Jul 10 2015, In : Science. 349, 6244, p. 149c

Research output: Contribution to journalArticle

3 Scopus citations

Syntheses of cyclic guanidine-containing natural products

Ma, Y., De, S. & Chen, C., Feb 25 2015, In : Tetrahedron. 71, 8, p. 1145-1173 29 p.

Research output: Contribution to journalArticle

37 Scopus citations

Syntheses of sceptrins and nakamuric acid and insights into the biosyntheses of pyrrole-imidazole dimers

Wang, X., Gao, Y., Ma, Z., Rodriguez, R. A., Yu, Z. X. & Chen, C., Aug 1 2015, In : Organic Chemistry Frontiers. 2, 8, p. 978-984 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

A simple method for the electrophilic cyanation of secondary amines

Chen, C., Zhu, C. & Xia, J. B., Jan 3 2014, In : Organic Letters. 16, 1, p. 247-249 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence

Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S. & Chen, C., Oct 10 2014, In : Science. 346, 6206, p. 219-224 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Dimeric pyrrole-imidazole alkaloids: Synthetic approaches and biosynthetic hypotheses

Wang, X., Ma, Z., Wang, X., De, S., Ma, Y. & Chen, C., Aug 14 2014, In : Chemical Communications. 50, 63, p. 8628-8639 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Vanadium-catalyzed C(sp<sup>3</sup>)-H fluorination reactions

Xia, J. B., Ma, Y. & Chen, C., Jul 1 2014, In : Organic Chemistry Frontiers. 1, 5, p. 468-472 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation of para-methoxyphenyl (PMP)-protected primary amines

Chen, C., Zhu, C. & Xia, J. B., Jan 1 2014, In : Tetrahedron Letters. 55, 1, p. 232-234 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

Visible light-promoted metal-free sp<sup>3</sup>-C-H fluorination

Xia, J. B., Zhu, C. & Chen, C., Oct 11 2014, In : Chemical Communications. 50, 79, p. 11701-11704 4 p.

Research output: Contribution to journalArticle

68 Scopus citations
2013

Cyclic GMP-AMP containing mixed Phosphodiester linkages is an endogenous high-affinity ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C. & Chen, Z., Jul 25 2013, In : Molecular Cell. 51, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

325 Scopus citations

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C. & Chen, Z. J., Feb 15 2013, In : Science. 339, 6121, p. 826-830 5 p.

Research output: Contribution to journalArticle

721 Scopus citations

Erratum: Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation (Nature Cell Biology (2013) 15 (1035-1044))

Das, A., Tanigawa, S., Karner, C. M., Xin, M., Lum, L., Chen, C., Olson, E. N., Perantoni, A. O. & Carroll, T. J., Oct 2013, In : Nature Cell Biology. 15, 10, p. 1260 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation

Das, A., Tanigawa, S., Karner, C. M., Xin, M., Lum, L., Chen, C., Olson, E. N., Perantoni, A. O. & Carroll, T. J., Sep 2013, In : Nature Cell Biology. 15, 9, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

127 Scopus citations

The development of highly potent inhibitors for porcupine

Wang, X., Moon, J., Dodge, M. E., Pan, X., Zhang, L., Hanson, J. M., Tuladhar, R., Ma, Z., Shi, H., Williams, N. S., Amatruda, J. F., Carroll, T. J., Lum, L. & Chen, C., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2700-2704 5 p.

Research output: Contribution to journalArticle

45 Scopus citations

Visible light-promoted metal-free C-H activation: Diarylketone-catalyzed selective benzylic mono- and difluorination

Xia, J. B., Zhu, C. & Chen, C., Nov 20 2013, In : Journal of the American Chemical Society. 135, 46, p. 17494-17500 7 p.

Research output: Contribution to journalArticle

275 Scopus citations
2012

A biomimetic route for construction of the [4+2] and [3+2] core skeletons of dimeric pyrrole-imidazole alkaloids and asymmetric synthesis of ageliferins

Wang, X., Wang, X., Tan, X., Lu, J., Cormier, K. W., Ma, Z. & Chen, C., Nov 14 2012, In : Journal of the American Chemical Society. 134, 45, p. 18834-18842 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

A highly selective vanadium catalyst for benzylic C-H oxidation

Xia, J. B., Cormier, K. W. & Chen, C., Jul 2012, In : Chemical Science. 3, 7, p. 2240-2245 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine

Dodge, M. E., Moon, J., Tuladhar, R., Lu, J., Jacob, L. S., Zhang, L. S., Shi, H., Wang, X., Moro, E., Mongera, A., Argenton, F., Karner, C. M., Carroll, T. J., Chen, C., Amatruda, J. F. & Lum, L., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 23246-23254 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

Moro, E., Ozhan-Kizil, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R. M., Bournele, D., Domenichini, A., Valdivia, L. E., Lum, L., Chen, C., Amatruda, J. F., Tiso, N., Weidinger, G. & Argenton, F., Jun 15 2012, In : Developmental Biology. 366, 2, p. 327-340 14 p.

Research output: Contribution to journalArticle

110 Scopus citations

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids

Gao, S., Wang, Q., Wang, G., Lomenick, B., Liu, J., Fan, C. W., Deng, L. W., Huang, J., Lum, L. & Chen, C., 2012, (Accepted/In press) In : Synlett. 23

Research output: Contribution to journalArticle

5 Scopus citations
2011

Asymmetric synthesis of ageliferin

Wang, X., Ma, Z., Lu, J., Tan, X. & Chen, C., Oct 5 2011, In : Journal of the American Chemical Society. 133, 39, p. 15350-15353 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

Karner, C. M., Das, A., Ma, Z., Self, M., Chen, C., Lum, L., Oliver, G. & Carroll, T. J., Apr 2011, In : Development. 138, 7, p. 1247-1257 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine

Ma, Z., Lu, J., Wang, X. & Chen, C., Jan 7 2011, In : Chemical Communications. 47, 1, p. 427-429 3 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Chemical and biological studies of nakiterpiosin and nakiterpiosinone

Gao, S., Wang, Q., Huang, L. J. S., Lum, L. & Chen, C., Jan 13 2010, In : Journal of the American Chemical Society. 132, 1, p. 371-383 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Tankyrase is necessary for canonical Wnt signaling during kidney development

Karner, C. M., Merkel, C. E., Dodge, M., Ma, Z., Lu, J., Chen, C., Lum, L. & Carroll, T. J., 2010, In : Developmental Dynamics. 239, 7, p. 2014-2023 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C. & Lum, L., Feb 6 2009, In : Nature Chemical Biology. 5, 2, p. 100-107 8 p.

Research output: Contribution to journalArticle

905 Scopus citations

Structure-activity relationship studies of small-molecule inhibitors of Wnt response

Lu, J., Ma, Z., Hsieh, J. C., Fan, C. W., Chen, B., Longgood, J. C., Williams, N. S., Amatruda, J. F., Lum, L. & Chen, C., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3825-3827 3 p.

Research output: Contribution to journalArticle

90 Scopus citations

Synthesis and structure revision of nakiterpiosin

Gao, S., Wang, Q. & Chen, C., Feb 4 2009, In : Journal of the American Chemical Society. 131, 4, p. 1410-1412 3 p.

Research output: Contribution to journalArticle

96 Scopus citations