• 11985 Citations
  • 59 h-Index
1981 …2020

Research output per year

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Research Output

2020

Advances in stable isotope tracer methodology part 1: Hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling

Diniz Behn, C., Jin, E. S., Bubar, K., Malloy, C., Parks, E. J. & Cree-Green, M., Jan 1 2020, In : Journal of Investigative Medicine. 68, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Does Tumor FDG-PET Avidity Represent Enhanced Glycolytic Metabolism in Non-Small Cell Lung Cancer?

Kernstine, K. H., Faubert, B., Do, Q. N., Rogers, T. J., Hensley, C. T., Cai, L., Torrealba, J., Oliver, D., Wachsmann, J. W., Lenkinski, R. E., Malloy, C. R. & Deberardinis, R. J., Apr 2020, In : Annals of Thoracic Surgery. 109, 4, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

Effects of Empagliflozin Treatment on Glycerol-Derived Hepatic Gluconeogenesis in Adults with Obesity: A Randomized Clinical Trial

Neeland, I. J., de Albuquerque Rocha, N., Hughes, C., Ayers, C. R., Malloy, C. R. & Jin, E. S., Jul 1 2020, In : Obesity. 28, 7, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

Open Access

Energetic adaptations and stress reserve in the obese heart

Borlaug, B. A. & Malloy, C. R., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1164-1167 4 p.

Research output: Contribution to journalReview article

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso, A. C., Lam, N. T., Savla, J. J., Nakada, Y., Pereira, A. H. M., Elnwasany, A., Menendez-Montes, I., Ensley, E. L., Bezan Petric, U., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Kinter, M. T., Tan, W. L. W., Anene-Nzelu, C. G., Foo, R. S. Y., Nguyen, N. U. N., Li, S., Ahmed, M. S. & 14 others, Elhelaly, W. M., Abdisalaam, S., Asaithamby, A., Xing, C., Kanchwala, M., Vale, G., Eckert, K. M., Mitsche, M. A., McDonald, J. G., Hill, J. A., Huang, L., Shaul, P. W., Szweda, L. I. & Sadek, H. A., Feb 1 2020, In : Nature Metabolism. 2, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019
1 Scopus citations

A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents

Carreau, A. M., Jin, E. S., Garcia-Reyes, Y., Rahat, H., Nadeau, K. J., Malloy, C. R. & Cree-Green, M., Jan 1 2019, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 317, 1, p. R134-R142

Research output: Contribution to journalArticle

1 Scopus citations

Assessing the pentose phosphate pathway using [2, 3-13C2]glucose

Lee, M. H., Malloy, C. R., Corbin, I. R., Li, J. & Jin, E. S., Jun 2019, In : NMR in biomedicine. 32, 6, e4096.

Research output: Contribution to journalArticle

3 Scopus citations

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Jakkamsetti, V., Marin-Valencia, I., Ma, Q., Good, L. B., Terrill, T., Rajasekaran, K., Pichumani, K., Khemtong, C., Hooshyar, M. A., Sundarrajan, C., Patel, M. S., Bachoo, R. M., Malloy, C. R. & Pascual, J. M., Jan 1 2019, In : Science Translational Medicine. 11, 480, aan0457.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of deuteration on transamination and oxidation of hyperpolarized 13 C-Pyruvate in the isolated heart

Funk, A. M., Wen, X., Hever, T., Maptue, N. R., Khemtong, C., Sherry, A. D. & Malloy, C. R., Apr 2019, In : Journal of Magnetic Resonance. 301, p. 102-108 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

Kurhanewicz, J., Vigneron, D. B., Ardenkjaer-Larsen, J. H., Bankson, J. A., Brindle, K., Cunningham, C. H., Gallagher, F. A., Keshari, K. R., Kjaer, A., Laustsen, C., Mankoff, D. A., Merritt, M. E., Nelson, S. J., Pauly, J. M., Lee, P., Ronen, S., Tyler, D. J., Rajan, S. S., Spielman, D. M., Wald, L. & 3 others, Zhang, X., Malloy, C. R. & Rizi, R., Jan 2019, In : Neoplasia (United States). 21, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

51 Scopus citations

Metabolism of hyperpolarized 13C-acetoacetate to β-hydroxybutyrate detects real-time mitochondrial redox state and dysfunction in heart tissue

Chen, W., Sharma, G., Jiang, W., Maptue, N. R., Malloy, C. R., Sherry, A. D. & Khemtong, C., Jun 2019, In : NMR in biomedicine. 32, 6, e4091.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations
Open Access

Remodeling of substrate consumption in the murine sTAC model of heart failure

Turer, A., Altamirano, F., Schiattarella, G. G., May, H., Gillette, T. G., Malloy, C. R. & Merritt, M. E., Sep 2019, In : Journal of Molecular and Cellular Cardiology. 134, p. 144-153 10 p.

Research output: Contribution to journalArticle

2018

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

Wu, C. Y., Satapati, S., Gui, W., Max Wynn, R., Sharma, G., Lou, M., Qi, X., Burgess, S. C., Malloy, C., Khemtong, C., Dean Sherry, A., Chuang, D. T. & Merritt, M. E., Jun 22 2018, In : Journal of Biological Chemistry. 293, 25, p. 9604-9613 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Esterase-Catalyzed Production of Hyperpolarized 13C-Enriched Carbon Dioxide in Tissues for Measuring pH

Maptue, N., Jiang, W., Harrison, C., Funk, A. M., Sharma, G., Malloy, C. R., Sherry, D. & Khemtong, C., Nov 26 2018, In : ACS Sensors. 3, 11, p. 2232-2236 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans

Jin, E. S., Browning, J. D., Murphy, R. E. & Malloy, C. R., Jan 1 2018, In : Journal of Lipid Research. 59, 9, p. 1685-1694 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

Courtney, K. D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy, V., Funk, A. M., Wimberly, J., McNeil, S. S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J. A., Pedrosa, I., DeBerardinis, R. J., Malloy, C. R., Bachoo, R. & Maher, E. A., Nov 6 2018, In : Cell Metabolism. 28, 5, p. 793-800.e2

Research output: Contribution to journalArticle

42 Scopus citations

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

Makarewich, C. A., Baskin, K. K., Munir, A. Z., Bezprozvannaya, S., Sharma, G., Khemtong, C., Shah, A. M., McAnally, J. R., Malloy, C. R., Szweda, L. I., Bassel-Duby, R. & Olson, E. N., Jun 26 2018, In : Cell Reports. 23, 13, p. 3701-3709 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
7 Scopus citations
2017

An adjustable-length Dipole Using Forced-Current Excitation For 7T MR

Cui, J., Dimitrov, I. E., Cheshkov, S., Gu, M., Malloy, C. R. & Wright, S. M., Dec 30 2017, (Accepted/In press) In : IEEE Transactions on Biomedical Engineering.

Research output: Contribution to journalArticle

Effects of visceral adiposity on glycerol pathways in gluconeogenesis

Neeland, I. J., Hughes, C., Ayers, C. R., Malloy, C. R. & Jin, E. S., Feb 1 2017, In : Metabolism: Clinical and Experimental. 67, p. 80-89 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Hyperpolarized δ-[1-13C]gluconolactone as a probe of the pentose phosphate pathway

Moreno, K. X., Harrison, C. E., Merritt, M. E., Kovacs, Z., Malloy, C. R. & Dean Sherry, A., 2017, (Accepted/In press) In : NMR in Biomedicine.

Research output: Contribution to journalArticle

7 Scopus citations

Imaging myocardial metabolism

Gropler, R. J. & Malloy, C. R., Sep 25 2017, Imaging and Metabolism. Springer International Publishing, p. 243-279 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Intramyocellular lipid excess in the mitochondrial disorder MELAS

Golla, S., Ren, J., Malloy, C. R. & Pascual, J. M., Jul 1 2017, In : Neurology: Genetics. 3, 3, e160.

Research output: Contribution to journalArticle

3 Scopus citations

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R. E., Malloy, C. R. & 4 others, Wachsmann, J. W., Young, J. D., Kernstine, K. & DeBerardinis, R. J., Oct 5 2017, In : Cell. 171, 2, p. 358-371.e9

Research output: Contribution to journalArticle

250 Scopus citations

Measurement of 13C turnover into glutamate and glutamine pools in brain tumor patients

Pichumani, K., Mashimo, T., Vemireddy, V., Ijare, O. B., Mickey, B. E., Malloy, C. R., Marin-Valencia, I., Baskin, D. S., Bachoo, R. M. & Maher, E. A., Nov 1 2017, In : FEBS Letters. 591, 21, p. 3548-3554 7 p.

Research output: Contribution to journalLetter

3 Scopus citations

Oxidation of [U-13C]glucose in the human brain at 7T under steady state conditions

Cheshkov, S., Dimitrov, I. E., Jakkamsetti, V., Good, L., Kelly, D., Rajasekaran, K., Deberardinis, R. J., Pascual, J. M., Sherry, A. D. & Malloy, C. R., 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

12 Scopus citations

The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose

Funk, A. M., Anderson, B. L., Wen, X., Hever, T., Khemtong, C., Kovacs, Z., Sherry, A. D. & Malloy, C. R., Nov 1 2017, In : Journal of Magnetic Resonance. 284, p. 86-93 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Accelerated chemical shift imaging of hyperpolarized 13C metabolites

Wang, J. X., Merritt, M. E., Sherry, A. D. & Malloy, C. R., Oct 1 2016, In : Magnetic Resonance in Medicine. 76, 4, p. 1033-1038 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

A general chemical shift decomposition method for hyperpolarized 13C metabolite magnetic resonance imaging

Wang, J. X., Merritt, M. E., Sherry, D. & Malloy, C. R., Aug 1 2016, In : Magnetic Resonance in Chemistry. p. 665-673 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
8 Scopus citations
6 Scopus citations

Assessing Cardiac Metabolism

Taegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V., Des Rosiers, C., Gerszten, R., Glatz, J. F., Griffin, J. L., Gropler, R. J., Holzhuetter, H. G., Kizer, J. R., Lewandowski, E. D., Malloy, C. R., Neubauer, S., Peterson, L. R., Portman, M. A., Recchia, F. A., Van Eyk, J. E. & 1 others, Wang, T. J., May 13 2016, In : Circulation Research. 118, 10, p. 1659-1701 43 p.

Research output: Contribution to journalArticle

84 Scopus citations
3 Scopus citations

Biochemical Specificity in Human Cardiac Imaging by 13C Magnetic Resonance Imaging

Malloy, C. R. & Sherry, A. D., Nov 11 2016, In : Circulation Research. 119, 11, p. 1146-1148 3 p.

Research output: Contribution to journalReview article

1 Scopus citations
6 Scopus citations

Erratum: Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver (American Society for Clinical Investigation (2015) 125:12 (4447-4462) DOI: 10.1172/JCI82204)

Satapati, S., Kucejova, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., Merritt, M. E., Sherry, A. D., Malloy, C. R., Shelton, J. M., Lambert, J., Parks, E. J., Corbin, I., Magnuson, M. A., Browning, J. D. & Burgess, S. C., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1605 1 p.

Research output: Contribution to journalArticle

17 Scopus citations

Hepatic gluconeogenesis influences 13C enrichment in lactate in human brain tumors during metabolism of [1,2-13C]acetate

Pichumani, K., Mashimo, T., Vemireddy, V., Kovacs, Z., Ratnakar, J., Mickey, B., Malloy, C. R., DeBerardinis, R. J., Bachoo, R. M. & Maher, E. A., Feb 17 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolic Heterogeneity in Human Lung Tumors

Hensley, C. T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., Wodzak, M., Klimko, C., McMillan, E., Butt, Y., Ni, M., Oliver, D., Torrealba, J., Malloy, C. R., Kernstine, K., Lenkinski, R. E. & 1 others, DeBerardinis, R. J., Feb 11 2016, In : Cell. 164, 4, p. 681-694 14 p.

Research output: Contribution to journalArticle

344 Scopus citations

Metabolism of hyperpolarized [1-13C]pyruvate through alternate pathways in rat liver

Jin, E. S., Moreno, K. X., Wang, J. X., Fidelino, L., Merritt, M. E., Sherry, A. D. & Malloy, C. R., Apr 1 2016, In : NMR in biomedicine. 29, 4, p. 466-474 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

10 Scopus citations
75 Scopus citations

Trap design and construction for high-power multinuclear magnetic resonance experiments

Rispoli, J. V., Dimitrov, I. E., Cheshkov, S., Malloy, C., Wright, S. M. & Mcdougall, M. P., 2016, (Accepted/In press) In : Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering.

Research output: Contribution to journalArticle

3 Scopus citations
2015
34 Scopus citations
12 Scopus citations