• 9684 Citations
  • 17 h-Index
19992019
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Research Output 1999 2019

  • 9684 Citations
  • 17 h-Index
  • 26 Article
  • 4 Chapter
  • 1 Conference contribution
  • 1 Short survey
2019
3 Citations (Scopus)

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific Reports. 9, 1, 382.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Libraries
Yeasts
Acyl Carrier Protein
Antigens

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris

Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Jan 1 2019, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

Open Access
Pichia
Isoleucine
Labeling
Proteins
Costs and Cost Analysis
2 Citations (Scopus)

Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics

Dikiy, I., Clark, L. D., Gardner, K. H. & Rosenbaum, D. M., Jan 1 2019, Methods in Enzymology. Wand, A. J. (ed.). Academic Press Inc., p. 37-65 29 p. (Methods in Enzymology; vol. 614).

Research output: Chapter in Book/Report/Conference proceedingChapter

Labeling
Membrane Proteins
Nuclear magnetic resonance
G-Protein-Coupled Receptors
Adenosine A2A Receptors
1 Citation (Scopus)

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Shao, Z., Yan, W., Chapman, K., Ramesh, K., Ferrell, A. J., Yin, J., Wang, X., Xu, Q. & Rosenbaum, D. M., Dec 1 2019, In : Nature chemical biology. 15, 12, p. 1199-1205 7 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Cannabinoids
G-Protein-Coupled Receptors
Pharmaceutical Preparations
Seizures
2018
4 Citations (Scopus)

Crystal structure of the human NK1 tachykinin receptor

Yin, J., Chapman, K., Clark, L. D., Shao, Z., Borek, D., Xu, Q., Wang, J. & Rosenbaum, D. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13264-13269 6 p.

Research output: Contribution to journalArticle

Tachykinin Receptors
aprepitant
L 760735
Vomiting
Depression
17 Citations (Scopus)

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Suno, R., Kimura, K. T., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Horita, S., Tsujimoto, H., Tawaramoto, M. S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M. & 4 others, Rosenbaum, D. M., Iwata, S., Shimamura, T. & Kobayashi, T., Jan 2 2018, In : Structure. 26, 1, p. 7-19.e5

Research output: Contribution to journalArticle

Orexin Receptors
Synchrotrons
Molecular Dynamics Simulation
Dissociative Disorders
Crystallography
6 Citations (Scopus)

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies

Clark, L., Dikiy, I., Rosenbaum, D. M. & Gardner, K. H., Aug 1 2018, In : Journal of Biomolecular NMR. 71, 4, p. 203-211 9 p.

Research output: Contribution to journalArticle

Pichia
G-Protein-Coupled Receptors
Labeling
Membrane Proteins
Nuclear magnetic resonance
2017
25 Citations (Scopus)

Ligand modulation of sidechain dynamics in a wild-type human GPCR

Clark, L. D., Dikiy, I., Chapman, K., Rödström, K. E. J., Aramini, J., LeVine, M. V., Khelashvili, G., Rasmussen, S. G. F., Gardner, K. H. & Rosenbaum, D. M., Oct 6 2017, In : eLife. 6, e28505.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Modulation
Ligands
Adenosine-5'-(N-ethylcarboxamide)
Isoleucine
1 Citation (Scopus)

The Human Orexin/Hypocretin receptor crystal structures

Yin, J. & Rosenbaum, D. M., 2017, Current Topics in Behavioral Neurosciences. Springer Verlag, Vol. 33. p. 1-16 16 p. (Current Topics in Behavioral Neurosciences; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

Orexin Receptors
G-Protein-Coupled Receptors
Neuropeptides
Lateral Hypothalamic Area
Drug Discovery
6 Citations (Scopus)

Transporters Revealed

Lee, J. Y. & Rosenbaum, D. M., Mar 9 2017, In : Cell. 168, 6, p. 951-953 3 p.

Research output: Contribution to journalShort survey

ATP-Binding Cassette Transporters
Cryoelectron Microscopy
Multiple Drug Resistance
Electron microscopy
Ions
2016
104 Citations (Scopus)

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

Sterols
ATP-Binding Cassette Transporters
Nucleotides
Mutation
Lipid Bilayers
7 Citations (Scopus)

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

Homeostasis
Demonstrations
Cholesterol
Endoplasmic Reticulum
Protein Transport

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. K. & Rosenbaum, D. M., Feb 19 2016, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1 1 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

High-resolution crystal structure of the human CB1 cannabinoid receptor

Shao, Z., Yin, J., Chapman, K., Grzemska, M., Clark, L., Wang, J. & Rosenbaum, D. M., Dec 22 2016, In : Nature. 540, 7634, p. 602-606 5 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
G-Protein-Coupled Receptors
Cannabinoid Receptors
Endocannabinoids
Dronabinol
57 Citations (Scopus)

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, J., Babaoglu, K., Brautigam, C. A., Clark, L., Shao, Z., Scheuermann, T. H., Harrell, C. M., Gotter, A. L., Roecker, A. J., Winrow, C. J., Renger, J. J., Coleman, P. J. & Rosenbaum, D. M., Mar 7 2016, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

Orexin Receptors
Ligands
Neuropeptides
Mammals
Sleep
2015
115 Citations (Scopus)

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Yin, J., Mobarec, J. C., Kolb, P. & Rosenbaum, D. M., Mar 12 2015, In : Nature. 519, 7542, p. 247-250 4 p.

Research output: Contribution to journalArticle

Orexin Receptors
Sleep Initiation and Maintenance Disorders
G-Protein-Coupled Receptors
Pharmaceutical Preparations
Cataplexy
27 Citations (Scopus)

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

Biomolecular Nuclear Magnetic Resonance
Pichia
Eukaryota
Labeling
Nuclear magnetic resonance spectroscopy
2012
536 Citations (Scopus)

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Kruse, A. C., Hu, J., Pan, A. C., Arlow, D. H., Rosenbaum, D. M., Rosemond, E., Green, H. F., Liu, T., Chae, P. S., Dror, R. O., Shaw, D. E., Weis, W. I., Wess, J. & Kobilka, B. K., Feb 23 2012, In : Nature. 482, 7386, p. 552-556 5 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
G-Protein-Coupled Receptors
Ligands
GTP-Binding Proteins
Allosteric Site
2011
581 Citations (Scopus)

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, S. G. F., Choi, H. J., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 236-242 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Adrenergic Receptors
Adrenergic Agonists
Heterotrimeric GTP-Binding Proteins
Antibodies
1075 Citations (Scopus)

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Rasmussen, S. G. F., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 175-181 7 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
G-Protein-Coupled Receptors
Adrenergic Receptors
GTP-Binding Proteins
Opsins
2010
356 Citations (Scopus)

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Bokoch, M. P., Zou, Y., Rasmussen, S. G. F., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., Jan 7 2010, In : Nature. 463, 7277, p. 108-112 5 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
GTP-Binding Proteins
Binding Sites
Drug Delivery Systems

The γ2 adrenergic receptor as a model for g-protein-coupled receptor structure and activation by diffusible hormones

Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K., 2010, Handbook of Cell Signaling, 2/e. Elsevier Inc., Vol. 1. p. 163-169 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adrenergic Receptors
Chemical activation
G-Protein-Coupled Receptors
Hormones
Proteins
2009

Crystal structures of the β2-adrenergic receptor

Weis, W. I., Rosenbaum, D. M., Rasmussen, S. G. F., Choi, H. J., Thian, F. S., Kobilka, T. S., Yao, X. J., Day, P. W., Parnot, C., Fung, J. J., Ratnala, V. R. P., Kobilka, B. K., Cherezov, V., Hanson, M. A., Kuhn, P., Stevens, R. C., Edwards, P. C., Schertler, G. F. X., Burghammer, M., Sanishvili, R. & 3 others, Fischetti, R. F., Masood, A. & Rohrer, D. K., 2009, NATO Science for Peace and Security Series A: Chemistry and Biology. p. 217-230 14 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Adrenergic Receptors
G-Protein-Coupled Receptors
Crystal structure
Ligands
Proteins

Crystal structures of the β2-adrenergic receptor

Weis, W. I., Rosenbaum, D. M., Rasmussen, S. G. F., Choi, H. J., Thian, F. S., Kobilka, T. S., Yao, X. J., Day, P. W., Parnot, C., Fung, J. J., Ratnala, V. R. P., Kobilka, B. K., Cherezov, V., Hanson, M. A., Kuhn, P., Stevens, R. C., Edwards, P. C., Schertler, G. F. X., Burghammer, M., Sanishvili, R. & 3 others, Fischetti, R. F., Masood, A. & Rohrer, D. K., 2009, NATO Security through Science Series C: Environmental Security. p. 217-230 14 p. (NATO Security through Science Series C: Environmental Security).

Research output: Chapter in Book/Report/Conference proceedingChapter

crystal structure
ligand
protein
hormone
membrane
244 Citations (Scopus)

Structure-based discovery of β 2 -adrenergic receptor ligands

Kolb, P., Rosenbaum, D. M., Irwin, J. J., Fung, J. J., Kobilka, B. K. & Shoichet, B. K., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6843-6848 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Adrenergic Receptors
Ligands
Drug Discovery
X-Rays
1197 Citations (Scopus)

The structure and function of G-protein-coupled receptors

Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K., May 21 2009, In : Nature. 459, 7245, p. 356-363 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Neurotransmitter Agents
Membrane Proteins
Hormones
Pharmacology
2007
1519 Citations (Scopus)

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Rasmussen, S. G. F., Choi, H. J., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., Nov 15 2007, In : Nature. 450, 7168, p. 383-387 5 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Adrenergic Receptors
G-Protein-Coupled Receptors
Rhodopsin
Detergents
1062 Citations (Scopus)

GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Yao, X. J., Weis, W. I., Stevens, R. C. & Kobilka, B. K., Nov 23 2007, In : Science. 318, 5854, p. 1266-1273 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Adrenergic Receptors
Muramidase
CCR10 Receptors
Ligands
2459 Citations (Scopus)

High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., Nov 23 2007, In : Science. 318, 5854, p. 1258-1265 8 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Rhodopsin
G-Protein-Coupled Receptors
Ligands
Adrenergic Receptors
2006
8 Citations (Scopus)
Nuclear Receptor Coactivators
Peroxisome Proliferator-Activated Receptors
Firearms
Alanine
Scanning
2003
109 Citations (Scopus)

Efficient and Sequence-Specific DNA-Templated Polymerization of Peptide Nucleic Acid Aldehydes

Rosenbaum, D. M. & Liu, D. R., Nov 19 2003, In : Journal of the American Chemical Society. 125, 46, p. 13924-13925 2 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Aldehydes
Polymerization
DNA
Polymers
1999
33 Citations (Scopus)

Screening combinatorial libraries of de Novo proteins by hydrogen- deuterium exchange and electrospray mass spectrometry

Rosenbaum, D. M., Roy, S. & Hecht, M. H., Oct 20 1999, In : Journal of the American Chemical Society. 121, 41, p. 9509-9513 5 p.

Research output: Contribution to journalArticle

Deuterium
Mass spectrometry
Hydrogen
Mass Spectrometry
Screening