• 9951 Citations
  • 18 h-Index
19992020

Research output per year

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Research Output

2020

Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

Yin, J., Chen, K. Y. M., Clark, M. J., Hijazi, M., Kumari, P., Bai, X. C., Sunahara, R. K., Barth, P. & Rosenbaum, D. M., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

2019

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific reports. 9, 1, 382.

Research output: Contribution to journalArticle

5 Scopus citations

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris

Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In : Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics

Dikiy, I., Clark, L. D., Gardner, K. H. & Rosenbaum, D. M., Jan 1 2019, Methods in Enzymology. Wand, A. J. (ed.). Academic Press Inc., p. 37-65 29 p. (Methods in Enzymology; vol. 614).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Shao, Z., Yan, W., Chapman, K., Ramesh, K., Ferrell, A. J., Yin, J., Wang, X., Xu, Q. & Rosenbaum, D. M., Dec 1 2019, In : Nature chemical biology. 15, 12, p. 1199-1205 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Crystal structure of the human NK1 tachykinin receptor

Yin, J., Chapman, K., Clark, L. D., Shao, Z., Borek, D., Xu, Q., Wang, J. & Rosenbaum, D. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13264-13269 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Suno, R., Kimura, K. T., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Horita, S., Tsujimoto, H., Tawaramoto, M. S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M. & 4 others, Rosenbaum, D. M., Iwata, S., Shimamura, T. & Kobayashi, T., Jan 2 2018, In : Structure. 26, 1, p. 7-19.e5

Research output: Contribution to journalArticle

22 Scopus citations

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies

Clark, L., Dikiy, I., Rosenbaum, D. M. & Gardner, K. H., Aug 1 2018, In : Journal of biomolecular NMR. 71, 4, p. 203-211 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Ligand modulation of sidechain dynamics in a wild-type human GPCR

Clark, L. D., Dikiy, I., Chapman, K., Rödström, K. E. J., Aramini, J., LeVine, M. V., Khelashvili, G., Rasmussen, S. G. F., Gardner, K. H. & Rosenbaum, D. M., Oct 6 2017, In : eLife. 6, e28505.

Research output: Contribution to journalArticle

33 Scopus citations

The Human Orexin/Hypocretin receptor crystal structures

Yin, J. & Rosenbaum, D. M., 2017, Current Topics in Behavioral Neurosciences. Springer Verlag, Vol. 33. p. 1-16 16 p. (Current Topics in Behavioral Neurosciences; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Transporters Revealed

Lee, J. Y. & Rosenbaum, D. M., Mar 9 2017, In : Cell. 168, 6, p. 951-953 3 p.

Research output: Contribution to journalShort survey

8 Scopus citations
2016

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

112 Scopus citations

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. K. & Rosenbaum, D. M., Feb 19 2016, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1 1 p.

Research output: Contribution to journalArticle

High-resolution crystal structure of the human CB1 cannabinoid receptor

Shao, Z., Yin, J., Chapman, K., Grzemska, M., Clark, L., Wang, J. & Rosenbaum, D. M., Dec 22 2016, In : Nature. 540, 7634, p. 602-606 5 p.

Research output: Contribution to journalArticle

148 Scopus citations

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, J., Babaoglu, K., Brautigam, C. A., Clark, L., Shao, Z., Scheuermann, T. H., Harrell, C. M., Gotter, A. L., Roecker, A. J., Winrow, C. J., Renger, J. J., Coleman, P. J. & Rosenbaum, D. M., Mar 7 2016, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Yin, J., Mobarec, J. C., Kolb, P. & Rosenbaum, D. M., Mar 12 2015, In : Nature. 519, 7542, p. 247-250 4 p.

Research output: Contribution to journalArticle

126 Scopus citations

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Kruse, A. C., Hu, J., Pan, A. C., Arlow, D. H., Rosenbaum, D. M., Rosemond, E., Green, H. F., Liu, T., Chae, P. S., Dror, R. O., Shaw, D. E., Weis, W. I., Wess, J. & Kobilka, B. K., Feb 23 2012, In : Nature. 482, 7386, p. 552-556 5 p.

Research output: Contribution to journalArticle

553 Scopus citations
2011

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, S. G. F., Choi, H. J., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 236-242 7 p.

Research output: Contribution to journalArticle

588 Scopus citations

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Rasmussen, S. G. F., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 175-181 7 p.

Research output: Contribution to journalArticle

1108 Scopus citations
2010

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Bokoch, M. P., Zou, Y., Rasmussen, S. G. F., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., Jan 7 2010, In : Nature. 463, 7277, p. 108-112 5 p.

Research output: Contribution to journalArticle

361 Scopus citations

The γ2 adrenergic receptor as a model for g-protein-coupled receptor structure and activation by diffusible hormones

Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K., Dec 1 2010, Handbook of Cell Signaling, 2/e. Elsevier Inc., Vol. 1. p. 163-169 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2009

Crystal structures of the β2-adrenergic receptor

Weis, W. I., Rosenbaum, D. M., Rasmussen, S. G. F., Choi, H. J., Thian, F. S., Kobilka, T. S., Yao, X. J., Day, P. W., Parnot, C., Fung, J. J., Ratnala, V. R. P., Kobilka, B. K., Cherezov, V., Hanson, M. A., Kuhn, P., Stevens, R. C., Edwards, P. C., Schertler, G. F. X., Burghammer, M., Sanishvili, R. & 3 others, Fischetti, R. F., Masood, A. & Rohrer, D. K., May 4 2009, From Molecules to Medicines: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism. Sussman, J. (ed.). p. 217-230 14 p. (NATO Security through Science Series C: Environmental Security).

Research output: Chapter in Book/Report/Conference proceedingChapter

Crystal structures of the β2-adrenergic receptor

Weis, W. I., Rosenbaum, D. M., Rasmussen, S. G. F., Choi, H. J., Thian, F. S., Kobilka, T. S., Yao, X. J., Day, P. W., Parnot, C., Fung, J. J., Ratnala, V. R. P., Kobilka, B. K., Cherezov, V., Hanson, M. A., Kuhn, P., Stevens, R. C., Edwards, P. C., Schertler, G. F. X., Burghammer, M., Sanishvili, R. & 3 others, Fischetti, R. F., Masood, A. & Rohrer, D. K., Dec 1 2009, From Molecules to Medicines. p. 217-230 14 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Structure-based discovery of β 2 -adrenergic receptor ligands

Kolb, P., Rosenbaum, D. M., Irwin, J. J., Fung, J. J., Kobilka, B. K. & Shoichet, B. K., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6843-6848 6 p.

Research output: Contribution to journalArticle

250 Scopus citations

The structure and function of G-protein-coupled receptors

Rosenbaum, D. M., Rasmussen, S. G. F. & Kobilka, B. K., May 21 2009, In : Nature. 459, 7245, p. 356-363 8 p.

Research output: Contribution to journalReview article

1240 Scopus citations
2007

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Rasmussen, S. G. F., Choi, H. J., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., Nov 15 2007, In : Nature. 450, 7168, p. 383-387 5 p.

Research output: Contribution to journalArticle

1539 Scopus citations

GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Yao, X. J., Weis, W. I., Stevens, R. C. & Kobilka, B. K., Nov 23 2007, In : Science. 318, 5854, p. 1266-1273 8 p.

Research output: Contribution to journalArticle

1081 Scopus citations

High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., Nov 23 2007, In : Science. 318, 5854, p. 1258-1265 8 p.

Research output: Contribution to journalArticle

2500 Scopus citations
2006
8 Scopus citations
2003

Efficient and Sequence-Specific DNA-Templated Polymerization of Peptide Nucleic Acid Aldehydes

Rosenbaum, D. M. & Liu, D. R., Nov 19 2003, In : Journal of the American Chemical Society. 125, 46, p. 13924-13925 2 p.

Research output: Contribution to journalArticle

111 Scopus citations
1999

Screening combinatorial libraries of de Novo proteins by hydrogen- deuterium exchange and electrospray mass spectrometry

Rosenbaum, D. M., Roy, S. & Hecht, M. H., Oct 20 1999, In : Journal of the American Chemical Society. 121, 41, p. 9509-9513 5 p.

Research output: Contribution to journalArticle

33 Scopus citations