• 10043 Citations
  • 18 h-Index
19992020

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Article
2020

Structure-based development of a subtype-selective orexin 1 receptor antagonist

Hellmann, J., Drabek, M., Yin, J., Gunera, J., Pröll, T., Kraus, F., Langmead, C. J., Hübner, H., Weikert, D., Kolb, P., Rosenbaum, D. M. & Gmeiner, P., Jul 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 18059-18067 9 p.

Research output: Contribution to journalArticle

Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

Yin, J., Chen, K. Y. M., Clark, M. J., Hijazi, M., Kumari, P., Bai, X. C., Sunahara, R. K., Barth, P. & Rosenbaum, D. M., Aug 6 2020, In : Nature. 584, 7819, p. 125-129 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific reports. 9, 1, 382.

Research output: Contribution to journalArticle

7 Scopus citations

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris

Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In : Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Shao, Z., Yan, W., Chapman, K., Ramesh, K., Ferrell, A. J., Yin, J., Wang, X., Xu, Q. & Rosenbaum, D. M., Dec 1 2019, In : Nature chemical biology. 15, 12, p. 1199-1205 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Crystal structure of the human NK 1 tachykinin receptor

Yin, J., Chapman, K., Clark, L. D., Shao, Z., Borek, D., Xu, Q., Wang, J. & Rosenbaum, D. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13264-13269 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA

Suno, R., Kimura, K. T., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Horita, S., Tsujimoto, H., Tawaramoto, M. S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M. & 4 others, Rosenbaum, D. M., Iwata, S., Shimamura, T. & Kobayashi, T., Jan 2 2018, In : Structure. 26, 1, p. 7-19.e5

Research output: Contribution to journalArticle

23 Scopus citations

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies

Clark, L., Dikiy, I., Rosenbaum, D. M. & Gardner, K. H., Aug 1 2018, In : Journal of biomolecular NMR. 71, 4, p. 203-211 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Ligand modulation of sidechain dynamics in a wild-type human GPCR

Clark, L. D., Dikiy, I., Chapman, K., Rödström, K. E. J., Aramini, J., LeVine, M. V., Khelashvili, G., Rasmussen, S. G. F., Gardner, K. H. & Rosenbaum, D. M., Oct 6 2017, In : eLife. 6, e28505.

Research output: Contribution to journalArticle

34 Scopus citations
2016

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

114 Scopus citations

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. K. & Rosenbaum, D. M., Feb 19 2016, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1 1 p.

Research output: Contribution to journalArticle

High-resolution crystal structure of the human CB1 cannabinoid receptor

Shao, Z., Yin, J., Chapman, K., Grzemska, M., Clark, L., Wang, J. & Rosenbaum, D. M., Dec 22 2016, In : Nature. 540, 7634, p. 602-606 5 p.

Research output: Contribution to journalArticle

159 Scopus citations

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

Yin, J., Babaoglu, K., Brautigam, C. A., Clark, L., Shao, Z., Scheuermann, T. H., Harrell, C. M., Gotter, A. L., Roecker, A. J., Winrow, C. J., Renger, J. J., Coleman, P. J. & Rosenbaum, D. M., Mar 7 2016, (Accepted/In press) In : Nature Structural and Molecular Biology.

Research output: Contribution to journalArticle

64 Scopus citations
2015

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Yin, J., Mobarec, J. C., Kolb, P. & Rosenbaum, D. M., Mar 12 2015, In : Nature. 519, 7542, p. 247-250 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

Clark, L., Zahm, J. A., Ali, R., Kukula, M., Bian, L., Patrie, S. M., Gardner, K. H., Rosen, M. & Rosenbaum, D. M., May 30 2015, (Accepted/In press) In : Journal of Biomolecular NMR.

Research output: Contribution to journalArticle

30 Scopus citations
2012

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Kruse, A. C., Hu, J., Pan, A. C., Arlow, D. H., Rosenbaum, D. M., Rosemond, E., Green, H. F., Liu, T., Chae, P. S., Dror, R. O., Shaw, D. E., Weis, W. I., Wess, J. & Kobilka, B. K., Feb 23 2012, In : Nature. 482, 7386, p. 552-556 5 p.

Research output: Contribution to journalArticle

557 Scopus citations
2011

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, S. G. F., Choi, H. J., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 236-242 7 p.

Research output: Contribution to journalArticle

591 Scopus citations

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Rasmussen, S. G. F., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 175-181 7 p.

Research output: Contribution to journalArticle

1115 Scopus citations
2010

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Bokoch, M. P., Zou, Y., Rasmussen, S. G. F., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., Jan 7 2010, In : Nature. 463, 7277, p. 108-112 5 p.

Research output: Contribution to journalArticle

361 Scopus citations
2009

Structure-based discovery of β 2 -adrenergic receptor ligands

Kolb, P., Rosenbaum, D. M., Irwin, J. J., Fung, J. J., Kobilka, B. K. & Shoichet, B. K., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6843-6848 6 p.

Research output: Contribution to journalArticle

250 Scopus citations
2007

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Rasmussen, S. G. F., Choi, H. J., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., Schertler, G. F. X., Weis, W. I. & Kobilka, B. K., Nov 15 2007, In : Nature. 450, 7168, p. 383-387 5 p.

Research output: Contribution to journalArticle

1547 Scopus citations

GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Yao, X. J., Weis, W. I., Stevens, R. C. & Kobilka, B. K., Nov 23 2007, In : Science. 318, 5854, p. 1266-1273 8 p.

Research output: Contribution to journalArticle

1084 Scopus citations

High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Foon, S. T., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K. & Stevens, R. C., Nov 23 2007, In : Science. 318, 5854, p. 1258-1265 8 p.

Research output: Contribution to journalArticle

2510 Scopus citations
2006
8 Scopus citations
2003

Efficient and Sequence-Specific DNA-Templated Polymerization of Peptide Nucleic Acid Aldehydes

Rosenbaum, D. M. & Liu, D. R., Nov 19 2003, In : Journal of the American Chemical Society. 125, 46, p. 13924-13925 2 p.

Research output: Contribution to journalArticle

112 Scopus citations
1999

Screening combinatorial libraries of de Novo proteins by hydrogen- deuterium exchange and electrospray mass spectrometry

Rosenbaum, D. M., Roy, S. & Hecht, M. H., Oct 20 1999, In : Journal of the American Chemical Society. 121, 41, p. 9509-9513 5 p.

Research output: Contribution to journalArticle

33 Scopus citations