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Research Output

2020

African Americans experience disproportionate neurodegenerative changes in the medulla and upper cervical spinal cord in early multiple sclerosis

Moog, T. M., McCreary, M., Stanley, T., Wilson, A., Santoyo, J., Wright, K., Winkler, M. D., Wang, Y., Yu, F., Newton, B. D., Zeydan, B., Kantarci, O., Guo, X. & Okuda, D. T., Oct 2020, In : Multiple Sclerosis and Related Disorders. 45, 102429.

Research output: Contribution to journalArticle

Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis

West, K. L., Sivakolundu, D. K., Zuppichini, M. D., Turner, M. P., Spence, J. S., Lu, H., Okuda, D. T. & Rypma, B., Jan 1 2020, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

1 Scopus citations

Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients

West, K., Sivakolundu, D., Maruthy, G., Zuppichini, M., Liu, P., Thomas, B., Spence, J., Lu, H., Okuda, D. & Rypma, B., 2020, In : NeuroImage: Clinical. 27, 102281.

Research output: Contribution to journalArticle

Open Access

BOLD signal within and around white matter lesions distinguishes multiple sclerosis and non-specific white matter disease: a three-dimensional approach

Sivakolundu, D. K., West, K. L., Zuppichini, M. D., Wilson, A., Moog, T. M., Blinn, A. P., Newton, B. D., Wang, Y., Stanley, T., Guo, X., Rypma, B. & Okuda, D. T., 2020, (Accepted/In press) In : Journal of neurology.

Research output: Contribution to journalArticle

Handedness and potential implications for neurorehabilitation in multiple sclerosis

Shirani, A. & Okuda, D. T., Jan 2020, In : Multiple Sclerosis and Related Disorders. 37, 101405.

Research output: Contribution to journalLetter

Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre+ITGA4fl/fl mice

Manouchehri, N., Hussain, R. Z., Cravens, P. D., Doelger, R., Greenberg, B. M., Okuda, D. T., Forsthuber, T. G., Eagar, T. N. & Stüve, O., Jul 15 2020, In : Journal of Neuroimmunology. 344, 577245.

Research output: Contribution to journalArticle

Radiologically Isolated Syndrome: 10-Year Risk Estimate of a Clinical Event

Lebrun-Frenay, C., Kantarci, O., Siva, A., Sormani, M. P., Pelletier, D., Okuda, D. T., Azevedo, C., Amato, M. P., Bensa, C., Berger, E., Brochet, B., Ciron, J., Cohen, M., Inglese, M., Keegan, B. M., Labauge, P., Laplaud, D. A., Le Page, E., Louapre, C., Makhani, N. & 13 others, Mathey, G., Mondot, L., Montalban, X., Pelletier, J., de Seze, J., deStefano, N., Thouvenot, E., Tintore, M., Tutuncuoglu, M., Uygunoglu, U., Vermersch, P., Weinshenker, B. & Zeydan, B., Aug 1 2020, In : Annals of Neurology. 88, 2, p. 407-417 11 p.

Research output: Contribution to journalArticle

Real-World Safety and Effectiveness of Dimethyl Fumarate in Black or African American Patients with Multiple Sclerosis: 3-Year Results from ESTEEM

Williams, M. J., Amezcua, L., Okai, A., Okuda, D. T., Cohan, S., Su, R., Parks, B., Mendoza, J. P., Lewin, J. B. & Jones, C. C., 2020, (Accepted/In press) In : Neurology and Therapy.

Research output: Contribution to journalArticle

Open Access

State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis

Sá, M. J., Soares dos Reis, R., Altintas, A., Celius, E. G., Chien, C., Comi, G., Graus, F., Hillert, J., Hobart, J., Khan, G., Kissani, N., Langdon, D., Leite, M. I., Okuda, D. T., Palace, J., Papais-Alvarenga, R. M., Mendes-Pinto, I. & Shi, F. D., 2020, (Accepted/In press) In : Neurology and Therapy.

Research output: Contribution to journalReview article

Open Access

The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Sivakolundu, D. K., West, K. L., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Spence, J. S., Lu, H., Okuda, D. T. & Rypma, B., Jul 15 2020, In : NeuroImage. 215, 116812.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Cerebellar volume loss in radiologically isolated syndrome

George, I. C., El Mendili, M. M., Inglese, M., Azevedo, C. J., Kantarci, O., Lebrun, C., Siva, A., Okuda, D. T. & Pelletier, D., 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

2 Scopus citations

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Thouvenot, E., Hinsinger, G., Demattei, C., Uygunoglu, U., Castelnovo, G., Pittion-Vouyovitch, S., Okuda, D., Kantarci, O., Pelletier, D., Lehmann, S., Marin, P., Siva, A. & Lebrun, C., Apr 1 2019, In : Multiple Sclerosis Journal. 25, 5, p. 669-677 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Preserved canonicality of the BOLD hemodynamic response reflects healthy cognition: Insights into the healthy brain through the window of Multiple Sclerosis

Turner, M. P., Hubbard, N. A., Sivakolundu, D. K., Himes, L. M., Hutchison, J. L., Hart, J., Spence, J. S., Frohman, E., Frohman, T. C., Okuda, D. & Rypma, B., Apr 15 2019, In : NeuroImage. 190, p. 46-55 10 p.

Research output: Contribution to journalReview article

7 Scopus citations

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Sivakolundu, D. K., West, K. L., Maruthy, G. B., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Nguyen, D., Spence, J. S., Lu, H., Okuda, D. T. & Rypma, B., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

5 Scopus citations

Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Sivakolundu, D. K., Hansen, M. R., West, K. L., Wang, Y., Stanley, T., Wilson, A., McCreary, M., Turner, M. P., Pinho, M. C., Newton, B. D., Guo, X., Rypma, B. & Okuda, D. T., Sep 1 2019, In : Journal of Neuroimaging. 29, 5, p. 605-614 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

Hussain, R. Z., Cravens, P. D., Miller-Little, W. A., Doelger, R., Granados, V., Herndon, E., Okuda, D. T., Eagar, T. N. & Stüve, O., Jul 1 2019, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 4, e563.

Research output: Contribution to journalArticle

Open Access
2018

Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

RISConsortium, Feb 2018, In : Neurologic Clinics. 36, 1, p. 59-68 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Mowry, E. M., Azevedo, C. J., McCulloch, C. E., Okuda, D., Lincoln, R. R., Waubant, E., Hauser, S. L. & Pelletier, D., Dec 11 2018, In : Neurology. 91, 24, p. e2256-e2264

Research output: Contribution to journalArticle

20 Scopus citations

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan, B., Gu, X., Atkinson, E. J., Keegan, B. M., Weinshenker, B. G., Tillema, J. M., Pelletier, D., Azevedo, C. J., Lebrun-Frenay, C., Siva, A., Okuda, D. T., Kantarci, K. & Kantarci, O. H., Mar 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 2, e435.

Research output: Contribution to journalArticle

28 Scopus citations

Classification of multiple sclerosis and non-specific white matter lesions using spherical harmonics descriptors

Wang, Y., Hansen, M., Okuda, D., Wilson, A. & Guo, X., Apr 12 2018, Proceedings of the 3rd International Workshop on Interactive and Spatial Computing, IWISC 2018. Association for Computing Machinery, p. 97-102 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Contemporary Topics in Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. xiii-xiv

Research output: Contribution to journalEditorial

Leveraging technology to identify subclinical deficits in radiologically isolated syndrome

Okuda, D., Jan 1 2018, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. i

Research output: Contribution to journalArticle

Multiple Sclerosis in the Contemporary Age: Understanding the Millennial Patient with Multiple Sclerosis to Create Next-Generation Care

Hansen, M. R. & Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. 219-230 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

Hansen, M. R., Pan, E., Wilson, A., McCreary, M., Wang, Y., Stanley, T., Pinho, M. C., Guo, X. & Okuda, D. T., Jun 7 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Precision medicine for multiple sclerosis promotes preventative medicine

Hansen, M. R. & Okuda, D. T., May 1 2018, In : Annals of the New York Academy of Sciences. 1420, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

TLR3 agonism re-establishes CNS immune competence during α4-integrin deficiency

Hussain, R. Z., Cravens, P. C., Doelger, R., Dentel, B., Herndon, E., Loof, N., Tsai, P., Okuda, D., Racke, M. K. & Stuve, O., Dec 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1543-1561 19 p.

Research output: Contribution to journalArticle

2017

Are miRNAs appropriate biomarkers for radiologic measures of tissue injury in multiple sclerosis?

Okuda, D. T., Mar 1 2017, In : JAMA Neurology. 74, 3, p. 260-261 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Hubbard, N. A., Turner, M. P., Ouyang, M., Himes, L., Thomas, B. P., Hutchison, J. L., Faghihahmadabadi, S., Davis, S. L., Strain, J. F., Spence, J., Krawczyk, D., Huang, H., Lu, H., Hart, J., Frohman, T. C., Frohman, E., Okuda, D. & Rypma, B., Nov 2017, In : Human Brain Mapping. 38, 11, p. 5375-5390 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis

Hubbard, N. A., Araujo, Y. S., Caballero, C., Ouyang, M., Turner, M. P., Himes, L., Faghihahmadabadi, S., Thomas, B. P., Hart, J., Huang, H., Okuda, D. & Rypma, B., Jun 11 2017, In : Brain Sciences. 7, 6, 64.

Research output: Contribution to journalArticle

1 Scopus citations

Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions

Shirani, A., Newton, B. D. & Okuda, D. T., Mar 21 2017, In : BMC Neurology. 17, 1, 55.

Research output: Contribution to journalArticle

8 Scopus citations

Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation

Wright, K., Winkler, M. D., Newton, B. D., Sormani, M. P. & Okuda, D. T., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e397.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Radiologically isolated syndrome in children

Makhani, N., Lebrun, C., Siva, A., Brassat, D., Carra Dallière, C., De Seze, J., Du, W., Durand Dubief, F., Kantarci, O., Langille, M., Narula, S., Pelletier, J., Rojas, J. I., Shapiro, E. D., Stone, R. T., Tintoré, M., Uygunoglu, U., Vermersch, P., Wassmer, E., Okuda, D. T. & 1 others, Pelletier, D., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e395.

Research output: Contribution to journalArticle

14 Scopus citations

Radiologically isolated syndrome should be treated with disease-modifying therapy – Yes

Okuda, D. T., Dec 1 2017, In : Multiple Sclerosis. 23, 14, p. 1818-1819 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Three-Dimensional Shape and Surface Features Distinguish Multiple Sclerosis Lesions from Nonspecific White Matter Disease

Newton, B. D., Wright, K., Winkler, M. D., Bovis, F., Takahashi, M., Dimitrov, I. E., Sormani, M. P., Pinho, M. C. & Okuda, D. T., 2017, (Accepted/In press) In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Extended interval dosing of natalizumab in multiple sclerosis

Zhovtis Ryerson, L., Frohman, T. C., Foley, J., Kister, I., Weinstock-Guttman, B., Tornatore, C., Pandey, K., Donnelly, S., Pawate, S., Bomprezzi, R., Smith, D., Kolb, C., Qureshi, S., Okuda, D., Kalina, J., Rimler, Z., Green, R., Monson, N. L., Hoyt, T., Bradshaw, M. & 8 others, Fallon, J., Chamot, E., Bucello, M., Beh, S. C., Cutter, G., Major, E., Herbert, J. & Frohman, E., Feb 25 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

57 Scopus citations

Incidental Lesions Suggesting Multiple Sclerosis

Okuda, D. T., Jun 1 2016, In : CONTINUUM Lifelong Learning in Neurology. 22, 3, p. 730-743 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

Interleukin 17 alone is not a discriminant biomarker in early demyelinating spectrum disorders

Lebrun, C., Cohen, M., Pignolet, B., Seitz-Polski, B., Bucciarelli, F., Benzaken, S., Kantarci, O., Siva, A., Okuda, D., Pelletier, D. & Brassat, D., Sep 15 2016, In : Journal of the Neurological Sciences. 368, p. 334-336 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Long-term evolution of multiple sclerosis disability in the treatment era

University of California, San Francisco MS-EPIC Team:, Oct 1 2016, In : Annals of Neurology. 80, 4, p. 499-510 12 p.

Research output: Contribution to journalArticle

135 Scopus citations

Primary Progressive Multiple Sclerosis Evolving from Radiologically Isolated Syndrome

Kantarci, O. H., Lebrun, C., Siva, A., Keegan, M. B., Azevedo, C. J., Inglese, M., Tintoré, M., Newton, B. D., Durand-Dubief, F., Amato, M. P., De Stefano, N., Sormani, M. P., Pelletier, D. & Okuda, D. T., Feb 1 2016, In : Annals of Neurology. 79, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Shirani, A., Okuda, D. T. & Stüve, O., Jan 1 2016, In : Neurotherapeutics. 13, 1, p. 58-69 12 p.

Research output: Contribution to journalReview article

49 Scopus citations
2015

Aquatic training in MS: Neurotherapeutic impact upon quality of life

Frohman, A. N., Okuda, D., Beh, S. C., Treadaway, K., Mooi, C., Davis, S. L., Shah, A., Frohman, T. C. & Frohman, E., Aug 1 2015, In : Annals of Clinical and Translational Neurology. 2, 8, p. 864-872 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Early CNS neurodegeneration in radiologically isolated syndrome

Azevedo, C. J., Overton, E., Khadka, S., Buckley, J., Liu, S., Sampat, M., Kantarci, O., Frenay, C. L., Siva, A., Okuda, D. T. & Pelletier, D., Jun 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e102

Research output: Contribution to journalArticle

94 Scopus citations

Pontine myelinolysis following excessive consumption of commercial energy drinks

Newton, B. D. & Okuda, D. T., Jun 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e91

Research output: Contribution to journalArticle

3 Scopus citations

Thoracic spinal cord lesions are influenced by the degree of cervical spine involvement in multiple sclerosis

Hua, L. H., Donlon, S. L., Sobhanian, M. J., Portner, S. M. & Okuda, D. T., Jul 11 2015, In : Spinal Cord. 53, 7, p. 520-525 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

A case of Susac syndrome with cervical spinal cord involvement on MRI

Hua, L. H., Donlon, S. L. & Okuda, D. T., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 228-231 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Central neuropathic pain in MS is due to distinct thoracic spinal cord lesions

Okuda, D. T., Melmed, K., Matsuwaki, T., Blomqvist, A. & Craig, A. D. B., Aug 1 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 554-561 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immunosuppressive treatments in multiple sclerosis

Okuda, D. T., 2014, In : Handbook of Clinical Neurology. 122, p. 503-511 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

In vivo evidence of glutamate toxicity in multiple sclerosis

Azevedo, C. J., Kornak, J., Chu, P., Sampat, M., Okuda, D. T., Cree, B. A., Nelson, S. J., Hauser, S. L. & Pelletier, D., Aug 2014, In : Annals of Neurology. 76, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

44 Scopus citations