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Research Output

2019

Cerebellar volume loss in radiologically isolated syndrome

George, I. C., El Mendili, M. M., Inglese, M., Azevedo, C. J., Kantarci, O., Lebrun, C., Siva, A., Okuda, D. T. & Pelletier, D., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Sivakolundu, D. K., West, K. L., Maruthy, G. B., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Nguyen, D., Spence, J. S., Lu, H., Okuda, D. & Rypma, B., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

1 Scopus citations

Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Sivakolundu, D. K., Hansen, M. R., West, K. L., Wang, Y., Stanley, T., Wilson, A., McCreary, M., Turner, M. P., Pinho, M. C., Newton, B. D., Guo, X., Rypma, B. & Okuda, D. T., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

1 Scopus citations

α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

Hussain, R. Z., Cravens, P. D., Miller-Little, W. A., Doelger, R., Granados, V., Herndon, E., Okuda, D. T., Eagar, T. N. & Stüve, O., Jul 1 2019, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 4, e563.

Research output: Contribution to journalArticle

Open Access
2018

Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome

RISConsortium, Feb 1 2018, In : Neurologic Clinics. 36, 1, p. 59-68 10 p.

Research output: Contribution to journalReview article

4 Scopus citations

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Mowry, E. M., Azevedo, C. J., McCulloch, C. E., Okuda, D., Lincoln, R. R., Waubant, E., Hauser, S. L. & Pelletier, D., Dec 11 2018, In : Neurology. 91, 24, p. e2256-e2264

Research output: Contribution to journalArticle

16 Scopus citations

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Thouvenot, E., Hinsinger, G., Demattei, C., Uygunoglu, U., Castelnovo, G., Pittion-Vouyovitch, S., Okuda, D., Kantarci, O., Pelletier, D., Lehmann, S., Marin, P., Siva, A. & Lebrun, C., Mar 1 2018, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

4 Scopus citations

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan, B., Gu, X., Atkinson, E. J., Keegan, B. M., Weinshenker, B. G., Tillema, J. M., Pelletier, D., Azevedo, C. J., Lebrun-Frenay, C., Siva, A., Okuda, D. T., Kantarci, K. & Kantarci, O. H., Mar 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 2, e435.

Research output: Contribution to journalArticle

22 Scopus citations

Classification of multiple sclerosis and non-specific white matter lesions using spherical harmonics descriptors

Wang, Y., Hansen, M., Okuda, D., Wilson, A. & Guo, X., Apr 12 2018, Proceedings of the 3rd International Workshop on Interactive and Spatial Computing, IWISC 2018. Association for Computing Machinery, p. 97-102 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Contemporary Topics in Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. xiii-xiv

Research output: Contribution to journalEditorial

Leveraging technology to identify subclinical deficits in radiologically isolated syndrome

Okuda, D., Jan 1 2018, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. i

Research output: Contribution to journalArticle

Multiple Sclerosis in the Contemporary Age: Understanding the Millennial Patient with Multiple Sclerosis to Create Next-Generation Care

Hansen, M. R. & Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. 219-230 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

Hansen, M. R., Pan, E., Wilson, A., McCreary, M., Wang, Y., Stanley, T., Pinho, M. C., Guo, X. & Okuda, D. T., Jun 7 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Precision medicine for multiple sclerosis promotes preventative medicine

Hansen, M. R. & Okuda, D. T., May 1 2018, In : Annals of the New York Academy of Sciences. 1420, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

Preserved canonicality of the BOLD hemodynamic response reflects healthy cognition: Insights into the healthy brain through the window of Multiple Sclerosis

Turner, M. P., Hubbard, N. A., Sivakolundu, D. K., Himes, L. M., Hutchison, J. L., Hart, J., Spence, J. S., Frohman, E., Frohman, T. C., Okuda, D. & Rypma, B., Jan 1 2018, (Accepted/In press) In : NeuroImage.

Research output: Contribution to journalArticle

6 Scopus citations

TLR3 agonism re-establishes CNS immune competence during α4-integrin deficiency

Hussain, R. Z., Cravens, P. C., Doelger, R., Dentel, B., Herndon, E., Loof, N., Tsai, P., Okuda, D., Racke, M. K. & Stuve, O., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

2017

Are miRNAs appropriate biomarkers for radiologic measures of tissue injury in multiple sclerosis?

Okuda, D. T., Mar 1 2017, In : JAMA Neurology. 74, 3, p. 260-261 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Hubbard, N. A., Turner, M. P., Ouyang, M., Himes, L., Thomas, B. P., Hutchison, J. L., Faghihahmadabadi, S., Davis, S. L., Strain, J. F., Spence, J., Krawczyk, D., Huang, H., Lu, H., Hart, J., Frohman, T. C., Frohman, E., Okuda, D. & Rypma, B., Nov 1 2017, In : Human Brain Mapping. 38, 11, p. 5375-5390 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis

Hubbard, N. A., Araujo, Y. S., Caballero, C., Ouyang, M., Turner, M. P., Himes, L., Faghihahmadabadi, S., Thomas, B. P., Hart, J., Huang, H., Okuda, D. & Rypma, B., Jun 11 2017, In : Brain Sciences. 7, 6, 64.

Research output: Contribution to journalArticle

1 Scopus citations

Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions

Shirani, A., Newton, B. D. & Okuda, D. T., Mar 21 2017, In : BMC Neurology. 17, 1, 55.

Research output: Contribution to journalArticle

6 Scopus citations

Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation

Wright, K., Winkler, M. D., Newton, B. D., Sormani, M. P. & Okuda, D. T., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e397.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Radiologically isolated syndrome in children

Makhani, N., Lebrun, C., Siva, A., Brassat, D., Carra Dallière, C., De Seze, J., Du, W., Durand Dubief, F., Kantarci, O., Langille, M., Narula, S., Pelletier, J., Rojas, J. I., Shapiro, E. D., Stone, R. T., Tintoré, M., Uygunoglu, U., Vermersch, P., Wassmer, E., Okuda, D. T. & 1 others, Pelletier, D., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e395.

Research output: Contribution to journalArticle

12 Scopus citations

Radiologically isolated syndrome should be treated with disease-modifying therapy – Yes

Okuda, D. T., Dec 1 2017, In : Multiple Sclerosis. 23, 14, p. 1818-1819 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Three-Dimensional Shape and Surface Features Distinguish Multiple Sclerosis Lesions from Nonspecific White Matter Disease

Newton, B. D., Wright, K., Winkler, M. D., Bovis, F., Takahashi, M., Dimitrov, I. E., Sormani, M. P., Pinho, M. C. & Okuda, D. T., 2017, (Accepted/In press) In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Extended interval dosing of natalizumab in multiple sclerosis

Zhovtis Ryerson, L., Frohman, T. C., Foley, J., Kister, I., Weinstock-Guttman, B., Tornatore, C., Pandey, K., Donnelly, S., Pawate, S., Bomprezzi, R., Smith, D., Kolb, C., Qureshi, S., Okuda, D., Kalina, J., Rimler, Z., Green, R., Monson, N. L., Hoyt, T., Bradshaw, M. & 8 others, Fallon, J., Chamot, E., Bucello, M., Beh, S. C., Cutter, G., Major, E., Herbert, J. & Frohman, E., Feb 25 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

49 Scopus citations

Incidental Lesions Suggesting Multiple Sclerosis

Okuda, D. T., Jun 1 2016, In : CONTINUUM Lifelong Learning in Neurology. 22, 3, p. 730-743 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

Interleukin 17 alone is not a discriminant biomarker in early demyelinating spectrum disorders

Lebrun, C., Cohen, M., Pignolet, B., Seitz-Polski, B., Bucciarelli, F., Benzaken, S., Kantarci, O., Siva, A., Okuda, D., Pelletier, D. & Brassat, D., Sep 15 2016, In : Journal of the Neurological Sciences. 368, p. 334-336 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Long-term evolution of multiple sclerosis disability in the treatment era

University of California, San Francisco MS-EPIC Team:, Oct 1 2016, In : Annals of Neurology. 80, 4, p. 499-510 12 p.

Research output: Contribution to journalArticle

111 Scopus citations

Primary Progressive Multiple Sclerosis Evolving from Radiologically Isolated Syndrome

Kantarci, O. H., Lebrun, C., Siva, A., Keegan, M. B., Azevedo, C. J., Inglese, M., Tintoré, M., Newton, B. D., Durand-Dubief, F., Amato, M. P., De Stefano, N., Sormani, M. P., Pelletier, D. & Okuda, D. T., Feb 1 2016, In : Annals of Neurology. 79, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Shirani, A., Okuda, D. T. & Stüve, O., Jan 1 2016, In : Neurotherapeutics. 13, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2015

Aquatic training in MS: Neurotherapeutic impact upon quality of life

Frohman, A. N., Okuda, D., Beh, S. C., Treadaway, K., Mooi, C., Davis, S. L., Shah, A., Frohman, T. C. & Frohman, E., Aug 1 2015, In : Annals of Clinical and Translational Neurology. 2, 8, p. 864-872 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Early CNS neurodegeneration in radiologically isolated syndrome

Azevedo, C. J., Overton, E., Khadka, S., Buckley, J., Liu, S., Sampat, M., Kantarci, O., Frenay, C. L., Siva, A., Okuda, D. T. & Pelletier, D., Jun 1 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e102

Research output: Contribution to journalArticle

85 Scopus citations

Pontine myelinolysis following excessive consumption of commercial energy drinks

Newton, B. D. & Okuda, D. T., Jun 1 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e91

Research output: Contribution to journalArticle

3 Scopus citations

Thoracic spinal cord lesions are influenced by the degree of cervical spine involvement in multiple sclerosis

Hua, L. H., Donlon, S. L., Sobhanian, M. J., Portner, S. M. & Okuda, D. T., Jul 11 2015, In : Spinal Cord. 53, 7, p. 520-525 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

A case of Susac syndrome with cervical spinal cord involvement on MRI

Hua, L. H., Donlon, S. L. & Okuda, D. T., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 228-231 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Central neuropathic pain in MS is due to distinct thoracic spinal cord lesions

Okuda, D. T., Melmed, K., Matsuwaki, T., Blomqvist, A. & Craig, A. D. B., Aug 1 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 554-561 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immunosuppressive treatments in multiple sclerosis

Okuda, D. T., 2014, In : Handbook of Clinical Neurology. 122, p. 503-511 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

In vivo evidence of glutamate toxicity in multiple sclerosis

Azevedo, C. J., Kornak, J., Chu, P., Sampat, M., Okuda, D. T., Cree, B. A., Nelson, S. J., Hauser, S. L. & Pelletier, D., Aug 2014, In : Annals of Neurology. 76, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Radiologically isolated syndrome: 5-year risk for an initial clinical event

Okuda, D. T., Siva, A., Kantarci, O., Inglese, M., Katz, I., Tutuncu, M., Keegan, B. M., Donlon, S., Hua, L. H., Vidal-Jordana, A., Montalban, X., Rovira, A., Tintoré, M., Amato, M. P., Brochet, B., De Seze, J., Brassat, D., Vermersch, P., De Stefano, N., Sormani, M. P. & 2 others, Pelletier, D. & Lebrun, C., Mar 5 2014, In : PloS one. 9, 3, e90509.

Research output: Contribution to journalArticle

142 Scopus citations
2013

Metabolite changes in radiologically isolated syndrome: More pathology than meets the eye?

Okuda, D. T. & Vrenken, H., Jun 4 2013, In : Neurology. 80, 23, p. 2084-2085 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2012

From injection therapies to natalizumab: Views on the treatment of multiple sclerosis

Bomprezzi, R., Okuda, D., Alderazi, Y. J., Stüve, O. & Frohman, E., Mar 2012, In : Therapeutic Advances in Neurological Disorders. 5, 2, p. 97-104 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort

Lebrun, C., Le Page, E., Kantarci, O., Siva, A., Pelletier, D. & Okuda, D. T., Sep 2012, In : Multiple Sclerosis Journal. 18, 9, p. 1297-1302 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis

Mowry, E. M., Waubant, E., McCulloch, C. E., Okuda, D. T., Evangelista, A. A., Lincoln, R. R., Gourraud, P. A., Brenneman, D., Owen, M. C., Qualley, P., Bucci, M., Hauser, S. L. & Pelletier, D., Aug 1 2012, In : Annals of Neurology. 72, 2, p. 234-240 7 p.

Research output: Contribution to journalArticle

173 Scopus citations
2011

Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome

Okuda, D. T., Mowry, E. M., Cree, B. A. C., Crabtree, E. C., Goodin, D. S., Waubant, E. & Pelletier, D., Feb 22 2011, In : Neurology. 76, 8, p. 686-692 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Switching multiple sclerosis patients with breakthrough disease to second-line therapy

Castillo-Trivino, T., Mowry, E. M., Gajofatto, A., Chabas, D., Crabtree-Hartman, E., Cree, B. A., Goodin, D. S., Green, A. J., Okuda, D. T., Pelletier, D., Zamvil, S. S., Vittinghoff, E. & Waubant, E., Feb 14 2011, In : PloS one. 6, 2, e16664.

Research output: Contribution to journalArticle

49 Scopus citations
2010

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

Baranzini, S. E., Srinivasan, R., Khankhanian, P., Okuda, D. T., Nelson, S. J., Matthews, P. M., Hauser, S. L., Oksenberg, J. R. & Pelletier, D., Sep 2010, In : Brain. 133, 9, p. 2603-2611 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

High-resolution phased-array MRI of the human brain at 7 tesla: Initial experience in multiple sclerosis patients

Metcalf, M., Xu, D., Okuda, D. T., Carvajal, L., Srinivasan, R., Kelley, D. A. C., Mukherjee, P., Nelson, S. J., Vigneron, D. B. & Pelletier, D., Apr 2010, In : Journal of Neuroimaging. 20, 2, p. 141-147 7 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Connecting white matter injury and thalamic atrophy in clinically isolated syndromes

Henry, R. G., Shieh, M., Amirbekian, B., Chung, S., Okuda, D. T. & Pelletier, D., Jul 15 2009, In : Journal of the Neurological Sciences. 282, 1-2, p. 61-66 6 p.

Research output: Contribution to journalArticle

87 Scopus citations