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2020

Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis

West, K. L., Sivakolundu, D. K., Zuppichini, M. D., Turner, M. P., Spence, J. S., Lu, H., Okuda, D. T. & Rypma, B., Jan 1 2020, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

1 Scopus citations

Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre+ITGA4fl/fl mice

Manouchehri, N., Hussain, R. Z., Cravens, P. D., Doelger, R., Greenberg, B. M., Okuda, D. T., Forsthuber, T. G., Eagar, T. N. & Stüve, O., Jul 15 2020, In : Journal of Neuroimmunology. 344, 577245.

Research output: Contribution to journalArticle

The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

Sivakolundu, D. K., West, K. L., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Spence, J. S., Lu, H., Okuda, D. T. & Rypma, B., Jul 15 2020, In : NeuroImage. 215, 116812.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Cerebellar volume loss in radiologically isolated syndrome

George, I. C., El Mendili, M. M., Inglese, M., Azevedo, C. J., Kantarci, O., Lebrun, C., Siva, A., Okuda, D. T. & Pelletier, D., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Thouvenot, E., Hinsinger, G., Demattei, C., Uygunoglu, U., Castelnovo, G., Pittion-Vouyovitch, S., Okuda, D., Kantarci, O., Pelletier, D., Lehmann, S., Marin, P., Siva, A. & Lebrun, C., Apr 1 2019, In : Multiple Sclerosis Journal. 25, 5, p. 669-677 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Sivakolundu, D. K., West, K. L., Maruthy, G. B., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Nguyen, D., Spence, J. S., Lu, H., Okuda, D. & Rypma, B., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

4 Scopus citations

Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Sivakolundu, D. K., Hansen, M. R., West, K. L., Wang, Y., Stanley, T., Wilson, A., McCreary, M., Turner, M. P., Pinho, M. C., Newton, B. D., Guo, X., Rypma, B. & Okuda, D. T., Sep 1 2019, In : Journal of Neuroimaging. 29, 5, p. 605-614 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

Hussain, R. Z., Cravens, P. D., Miller-Little, W. A., Doelger, R., Granados, V., Herndon, E., Okuda, D. T., Eagar, T. N. & Stüve, O., Jul 1 2019, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 4, e563.

Research output: Contribution to journalArticle

Open Access
2018

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Mowry, E. M., Azevedo, C. J., McCulloch, C. E., Okuda, D., Lincoln, R. R., Waubant, E., Hauser, S. L. & Pelletier, D., Dec 11 2018, In : Neurology. 91, 24, p. e2256-e2264

Research output: Contribution to journalArticle

19 Scopus citations

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan, B., Gu, X., Atkinson, E. J., Keegan, B. M., Weinshenker, B. G., Tillema, J. M., Pelletier, D., Azevedo, C. J., Lebrun-Frenay, C., Siva, A., Okuda, D. T., Kantarci, K. & Kantarci, O. H., Mar 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 2, e435.

Research output: Contribution to journalArticle

25 Scopus citations

Leveraging technology to identify subclinical deficits in radiologically isolated syndrome

Okuda, D., Jan 1 2018, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. i

Research output: Contribution to journalArticle

Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

Hansen, M. R., Pan, E., Wilson, A., McCreary, M., Wang, Y., Stanley, T., Pinho, M. C., Guo, X. & Okuda, D. T., Jun 7 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Precision medicine for multiple sclerosis promotes preventative medicine

Hansen, M. R. & Okuda, D. T., May 1 2018, In : Annals of the New York Academy of Sciences. 1420, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

TLR3 agonism re-establishes CNS immune competence during α4-integrin deficiency

Hussain, R. Z., Cravens, P. C., Doelger, R., Dentel, B., Herndon, E., Loof, N., Tsai, P., Okuda, D., Racke, M. K. & Stuve, O., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

2017

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Hubbard, N. A., Turner, M. P., Ouyang, M., Himes, L., Thomas, B. P., Hutchison, J. L., Faghihahmadabadi, S., Davis, S. L., Strain, J. F., Spence, J., Krawczyk, D., Huang, H., Lu, H., Hart, J., Frohman, T. C., Frohman, E., Okuda, D. & Rypma, B., Nov 2017, In : Human Brain Mapping. 38, 11, p. 5375-5390 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis

Hubbard, N. A., Araujo, Y. S., Caballero, C., Ouyang, M., Turner, M. P., Himes, L., Faghihahmadabadi, S., Thomas, B. P., Hart, J., Huang, H., Okuda, D. & Rypma, B., Jun 11 2017, In : Brain Sciences. 7, 6, 64.

Research output: Contribution to journalArticle

1 Scopus citations

Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions

Shirani, A., Newton, B. D. & Okuda, D. T., Mar 21 2017, In : BMC Neurology. 17, 1, 55.

Research output: Contribution to journalArticle

7 Scopus citations

Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation

Wright, K., Winkler, M. D., Newton, B. D., Sormani, M. P. & Okuda, D. T., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e397.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Radiologically isolated syndrome in children

Makhani, N., Lebrun, C., Siva, A., Brassat, D., Carra Dallière, C., De Seze, J., Du, W., Durand Dubief, F., Kantarci, O., Langille, M., Narula, S., Pelletier, J., Rojas, J. I., Shapiro, E. D., Stone, R. T., Tintoré, M., Uygunoglu, U., Vermersch, P., Wassmer, E., Okuda, D. T. & 1 others, Pelletier, D., Oct 23 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 6, e395.

Research output: Contribution to journalArticle

12 Scopus citations

Three-Dimensional Shape and Surface Features Distinguish Multiple Sclerosis Lesions from Nonspecific White Matter Disease

Newton, B. D., Wright, K., Winkler, M. D., Bovis, F., Takahashi, M., Dimitrov, I. E., Sormani, M. P., Pinho, M. C. & Okuda, D. T., 2017, (Accepted/In press) In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Extended interval dosing of natalizumab in multiple sclerosis

Zhovtis Ryerson, L., Frohman, T. C., Foley, J., Kister, I., Weinstock-Guttman, B., Tornatore, C., Pandey, K., Donnelly, S., Pawate, S., Bomprezzi, R., Smith, D., Kolb, C., Qureshi, S., Okuda, D., Kalina, J., Rimler, Z., Green, R., Monson, N. L., Hoyt, T., Bradshaw, M. & 8 others, Fallon, J., Chamot, E., Bucello, M., Beh, S. C., Cutter, G., Major, E., Herbert, J. & Frohman, E., Feb 25 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

52 Scopus citations

Interleukin 17 alone is not a discriminant biomarker in early demyelinating spectrum disorders

Lebrun, C., Cohen, M., Pignolet, B., Seitz-Polski, B., Bucciarelli, F., Benzaken, S., Kantarci, O., Siva, A., Okuda, D., Pelletier, D. & Brassat, D., Sep 15 2016, In : Journal of the Neurological Sciences. 368, p. 334-336 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Long-term evolution of multiple sclerosis disability in the treatment era

University of California, San Francisco MS-EPIC Team:, Oct 1 2016, In : Annals of Neurology. 80, 4, p. 499-510 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Primary Progressive Multiple Sclerosis Evolving from Radiologically Isolated Syndrome

Kantarci, O. H., Lebrun, C., Siva, A., Keegan, M. B., Azevedo, C. J., Inglese, M., Tintoré, M., Newton, B. D., Durand-Dubief, F., Amato, M. P., De Stefano, N., Sormani, M. P., Pelletier, D. & Okuda, D. T., Feb 1 2016, In : Annals of Neurology. 79, 2, p. 288-294 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Shirani, A., Okuda, D. T. & Stüve, O., Jan 1 2016, In : Neurotherapeutics. 13, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

49 Scopus citations
2015

Aquatic training in MS: Neurotherapeutic impact upon quality of life

Frohman, A. N., Okuda, D., Beh, S. C., Treadaway, K., Mooi, C., Davis, S. L., Shah, A., Frohman, T. C. & Frohman, E., Aug 1 2015, In : Annals of Clinical and Translational Neurology. 2, 8, p. 864-872 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Early CNS neurodegeneration in radiologically isolated syndrome

Azevedo, C. J., Overton, E., Khadka, S., Buckley, J., Liu, S., Sampat, M., Kantarci, O., Frenay, C. L., Siva, A., Okuda, D. T. & Pelletier, D., Jun 1 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e102

Research output: Contribution to journalArticle

89 Scopus citations

Pontine myelinolysis following excessive consumption of commercial energy drinks

Newton, B. D. & Okuda, D. T., Jun 1 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e91

Research output: Contribution to journalArticle

3 Scopus citations

Thoracic spinal cord lesions are influenced by the degree of cervical spine involvement in multiple sclerosis

Hua, L. H., Donlon, S. L., Sobhanian, M. J., Portner, S. M. & Okuda, D. T., Jul 11 2015, In : Spinal Cord. 53, 7, p. 520-525 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

A case of Susac syndrome with cervical spinal cord involvement on MRI

Hua, L. H., Donlon, S. L. & Okuda, D. T., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 228-231 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Central neuropathic pain in MS is due to distinct thoracic spinal cord lesions

Okuda, D. T., Melmed, K., Matsuwaki, T., Blomqvist, A. & Craig, A. D. B., Aug 1 2014, In : Annals of Clinical and Translational Neurology. 1, 8, p. 554-561 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immunosuppressive treatments in multiple sclerosis

Okuda, D. T., 2014, In : Handbook of Clinical Neurology. 122, p. 503-511 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

In vivo evidence of glutamate toxicity in multiple sclerosis

Azevedo, C. J., Kornak, J., Chu, P., Sampat, M., Okuda, D. T., Cree, B. A., Nelson, S. J., Hauser, S. L. & Pelletier, D., Aug 2014, In : Annals of Neurology. 76, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Radiologically isolated syndrome: 5-year risk for an initial clinical event

Okuda, D. T., Siva, A., Kantarci, O., Inglese, M., Katz, I., Tutuncu, M., Keegan, B. M., Donlon, S., Hua, L. H., Vidal-Jordana, A., Montalban, X., Rovira, A., Tintoré, M., Amato, M. P., Brochet, B., De Seze, J., Brassat, D., Vermersch, P., De Stefano, N., Sormani, M. P. & 2 others, Pelletier, D. & Lebrun, C., Mar 5 2014, In : PloS one. 9, 3, e90509.

Research output: Contribution to journalArticle

146 Scopus citations
2012

From injection therapies to natalizumab: Views on the treatment of multiple sclerosis

Bomprezzi, R., Okuda, D., Alderazi, Y. J., Stüve, O. & Frohman, E., Mar 2012, In : Therapeutic Advances in Neurological Disorders. 5, 2, p. 97-104 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort

Lebrun, C., Le Page, E., Kantarci, O., Siva, A., Pelletier, D. & Okuda, D. T., Sep 2012, In : Multiple Sclerosis Journal. 18, 9, p. 1297-1302 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis

Mowry, E. M., Waubant, E., McCulloch, C. E., Okuda, D. T., Evangelista, A. A., Lincoln, R. R., Gourraud, P. A., Brenneman, D., Owen, M. C., Qualley, P., Bucci, M., Hauser, S. L. & Pelletier, D., Aug 1 2012, In : Annals of Neurology. 72, 2, p. 234-240 7 p.

Research output: Contribution to journalArticle

175 Scopus citations
2011

Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome

Okuda, D. T., Mowry, E. M., Cree, B. A. C., Crabtree, E. C., Goodin, D. S., Waubant, E. & Pelletier, D., Feb 22 2011, In : Neurology. 76, 8, p. 686-692 7 p.

Research output: Contribution to journalArticle

154 Scopus citations

Switching multiple sclerosis patients with breakthrough disease to second-line therapy

Castillo-Trivino, T., Mowry, E. M., Gajofatto, A., Chabas, D., Crabtree-Hartman, E., Cree, B. A., Goodin, D. S., Green, A. J., Okuda, D. T., Pelletier, D., Zamvil, S. S., Vittinghoff, E. & Waubant, E., Feb 14 2011, In : PloS one. 6, 2, e16664.

Research output: Contribution to journalArticle

49 Scopus citations
2010

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

Baranzini, S. E., Srinivasan, R., Khankhanian, P., Okuda, D. T., Nelson, S. J., Matthews, P. M., Hauser, S. L., Oksenberg, J. R. & Pelletier, D., Sep 2010, In : Brain. 133, 9, p. 2603-2611 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

High-resolution phased-array MRI of the human brain at 7 tesla: Initial experience in multiple sclerosis patients

Metcalf, M., Xu, D., Okuda, D. T., Carvajal, L., Srinivasan, R., Kelley, D. A. C., Mukherjee, P., Nelson, S. J., Vigneron, D. B. & Pelletier, D., Apr 2010, In : Journal of Neuroimaging. 20, 2, p. 141-147 7 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Connecting white matter injury and thalamic atrophy in clinically isolated syndromes

Henry, R. G., Shieh, M., Amirbekian, B., Chung, S., Okuda, D. T. & Pelletier, D., Jul 15 2009, In : Journal of the Neurological Sciences. 282, 1-2, p. 61-66 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults

Waubant, E., Chabas, D., Okuda, D. T., Glenn, O., Mowry, E., Henry, R. G., Strober, J. B., Soares, B., Wintermark, M. & Pelletier, D., Aug 1 2009, In : Archives of neurology. 66, 8, p. 967-971 5 p.

Research output: Contribution to journalArticle

104 Scopus citations

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Baranzini, S. E., Wang, J., Gibson, R. A., Galwey, N., Naegelin, Y., Barkhof, F., Radue, E. W., Lindberg, R. L. P., Uitdehaag, B. M. G., Johnson, M. R., Angelakopoulou, A., Hall, L., Richardson, J. C., Prinjha, R. K., Gass, A., Geurts, J. J. G., Kragt, J., Sombekke, M., Vrenken, H., Qualley, P. & 17 others, Lincoln, R. R., Gomez, R., Caillier, S. J., George, M. F., Mousavi, H., Guerrero, R., Okuda, D. T., Cree, B. A. C., Green, A. J., Waubant, E., Goodin, D. S., Pelletier, D., Matthews, P. M., Hauser, S. L., Kappos, L., Polman, C. H. & Oksenberg, J. R., Feb 3 2009, In : Human molecular genetics. 18, 4, p. 767-778 12 p.

Research output: Contribution to journalArticle

338 Scopus citations

Genotype-phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures

Okuda, D. T., Srinivasan, R., Oksenberg, J. R., Goodin, D. S., Baranzini, S. E., Beheshtian, A., Waubant, E., Zamvil, S. S., Leppert, D., Qualley, P., Lincoln, R., Gomez, R., Caillier, S., George, M., Wang, J., Nelson, S. J., Cree, B. A. C., Hauser, S. L. & Pelletier, D., Jan 2009, In : Brain. 132, 1, p. 250-259 10 p.

Research output: Contribution to journalArticle

122 Scopus citations

Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome

Okuda, D. T., Mowry, E. M., Beheshtian, A., Waubant, E., Baranzini, S. E., Goodin, D. S., Hauser, S. L. & Pelletier, D., Mar 3 2009, In : Neurology. 72, 9, p. 800-805 6 p.

Research output: Contribution to journalArticle

310 Scopus citations

Quality of life in multiple sclerosis is associated with lesion burden and brain volume measures

Mowry, E. M., Beheshtian, A., Waubant, E., Goodin, D. S., Cree, B. A., Qualley, P., Lincoln, R., George, M. F., Gomez, R., Hauser, S. L., Okuda, D. T. & Pelletier, D., May 19 2009, In : Neurology. 72, 20, p. 1760-1765 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

Recurrent asymptomatic demyelinating disease following 13-cis-retinoic acid exposure

Okuda, D. T. & Prados, M. D., Sep 8 2009, In : BMJ Case Reports.

Research output: Contribution to journalArticle

1 Scopus citations