• 11660 Citations
  • 61 h-Index
1985 …2020

Research output per year

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Research Output

2020

Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease

Chu, Y., Hu, J., Liang, H., Kanchwala, M., Xing, C., Beebe, W., Bowman, C. B., Gong, X., Corey, D. R. & Mootha, V., Jul 9 2020, In : Nucleic acids research. 48, 12, p. 6740-6758 19 p.

Research output: Contribution to journalArticle

Open Access

Argonaute binding within 3'-untranslated regions poorly predicts gene repression

Chu, Y., Kilikevicius, A., Liu, J., Johnson, K. C., Yokota, S. & Corey, D. R., Jul 27 2020, In : Nucleic acids research. 48, 13, p. 7439-7453 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Progress towards drug discovery for Friedreich's Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein

Shen, X., Wong, J., Prakash, T. P., Rigo, F., Li, Y., Napierala, M. & Corey, D. R., Jun 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 11, 115472.

Research output: Contribution to journalArticle

The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy

Aartsma-Rus, A. & Corey, D. R., Apr 2020, In : Nucleic Acid Therapeutics. 30, 2, p. 67-70 4 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations
2019

CHAPTER 2: Mechanisms of Antisense Oligonucleotides

Liu, Z. & Corey, D. R., Jan 1 2019, Therapies for Retinal Degeneration: Targeting Common Processes. Agrawal, S. & Gait, M. J. (eds.). 68 ed. Royal Society of Chemistry, p. 22-31 10 p. (RSC Drug Discovery Series; vol. 2019-January, no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy

Hu, J., Shen, X., Rigo, F., Prakash, T. P., Mootha, V. V. & Corey, D. R., Apr 2019, In : Nucleic Acid Therapeutics. 29, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficient electroporation of neuronal cells using synthetic oligonucleotides: Identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression

Shen, X., Beasley, S., Putman, J. N., Li, Y., Prakash, T. P., Rigo, F., Napierala, M. & Corey, D. R., Jan 1 2019, In : RNA. 25, 9, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes

Liu, Z., Johnson, S. T., Zhang, Z. & Corey, D. R., Dec 2019, In : Nucleic Acid Therapeutics. 29, 6, p. 323-334 12 p.

Research output: Contribution to journalArticle

Open Access

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs

Gagnon, K. T. & Corey, D. R., Jun 2019, In : Nucleic Acid Therapeutics. 29, 3, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
1 Scopus citations
2018

Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion

Shen, X., Kilikevicius, A., O'Reilly, D., Prakash, T. P., Damha, M. J., Rigo, F. & Corey, D. R., Sep 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 17, p. 2850-2855 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Activation of frataxin protein expression by antisense oligonucleotides targeting the mutant expanded repeat

Li, L., Shen, X., Liu, Z., Norrbom, M., Prakash, T. P., O'Reilly, D., Sharma, V. K., Damha, M. J., Watts, J. K., Rigo, F. & Corey, D. R., Feb 1 2018, In : Nucleic Acid Therapeutics. 28, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Shen, X. & Corey, D. R., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1584-1600 17 p.

Research output: Contribution to journalArticle

159 Scopus citations

Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics

Stoddard, B. L., Khvorova, A., Corey, D. R., Dynan, W. S. & Fox, K. R., Feb 28 2018, In : Nucleic acids research. 46, 4, p. 1563-1564 2 p.

Research output: Contribution to journalEditorial

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy

Hu, J., Rong, Z., Gong, X., Zhou, Z., Sharma, V. K., Xing, C., Watts, J. K., Corey, D. R. & Mootha, V., Mar 15 2018, In : Human molecular genetics. 27, 6, p. 1015-1026 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing

Liu, J., Liu, Z. & Corey, D. R., Sep 4 2018, In : Biochemistry. 57, 35, p. 5247-5256 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA

Liu, J., Hu, J., Ludlow, A. T., Pham, J. T., Shay, J. W., Rothstein, J. D. & Corey, D. R., Feb 16 2017, In : Cell Chemical Biology. 24, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Hicks, J. A., Li, L., Matsui, M., Chu, Y., Volkov, O., Johnson, K. C. & Corey, D. R., Aug 15 2017, In : Cell Reports. 20, 7, p. 1543-1552 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy

Corey, D. R., Feb 13 2017, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

85 Scopus citations

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Hu, J., Rigo, F., Prakash, T. P. & Corey, D. R., Apr 1 2017, In : Nucleic Acid Therapeutics. 27, 2, p. 87-94 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

RNA-mediated gene activation: Identifying a candidate RNA for preclinical development

Corey, D. R., 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 983. p. 161-171 11 p. (Advances in Experimental Medicine and Biology; vol. 983).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2016

Activating frataxin expression by repeat-targeted nucleic acids

Li, L., Matsui, M. & Corey, D. R., Feb 4 2016, In : Nature communications. 7, 10606.

Research output: Contribution to journalArticle

45 Scopus citations

Argonaute 2-dependent regulation of gene expression by single-stranded miRNA mimics

Matsui, M., Prakash, T. P. & Corey, D. R., May 1 2016, In : Molecular Therapy. 24, 5, p. 946-955 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Doubts about therapy for neurological diseases with antisense oligonucleotides-reply

Corey, D. R., 2016, In : JAMA Neurology. 73, 12, p. 1502-1503 2 p.

Research output: Contribution to journalLetter

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Liu, H., Liang, C., Kollipara, R. K., Matsui, M., Ke, X., Jeong, B. C., Wang, Z., Yoo, K. S., Yadav, G. P., Kinch, L. N., Grishin, N. V., Nam, Y., Corey, D. R., Kittler, R. & Liu, Q., Aug 4 2016, In : Molecular cell. 63, 3, p. 420-432 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Non-coding RNAs as drug targets

Matsui, M. & Corey, D. R., Jul 22 2016, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

218 Scopus citations

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

Dodd, D. W., Tomchick, D. R., Corey, D. R. & Gagnon, K. T., Mar 8 2016, In : Biochemistry. 55, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of mammalian transcription and splicing by Nuclear RNAi

Kalantari, R., Chiang, C. M. & Corey, D. R., Jan 29 2016, In : Nucleic acids research. 44, 2, p. 524-537 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

Synthetic nucleic acids and treatment of neurological diseases

Corey, D. R., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1238-1242 5 p.

Research output: Contribution to journalReview article

8 Scopus citations
2015

Design and bioinformatics analysis of genome-wide CLIP experiments

Wang, T., Xiao, G., Chu, Y., Zhang, M. Q., Corey, D. R. & Xie, Y., Apr 23 2015, In : Nucleic Acids Research. 43, 11, p. 5263-5274 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus

Hu, J., Liu, J., Li, L., Gagnon, K. T. & Corey, D. R., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification and validation of miRNA target sites within nontraditional miRNA targets

Younger, S. T. & Corey, D. R., 2015, In : Methods in Molecular Biology. 1206, p. 53-67 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Modulation of Splicing by Single-Stranded Silencing RNAs

Liu, J., Hu, J., Hicks, J. A., Prakash, T. P. & Corey, D. R., Jun 1 2015, In : Nucleic Acid Therapeutics. 25, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors

Matsui, M., Li, L., Janowski, B. A. & Corey, D. R., Aug 5 2015, In : Scientific Reports. 5, 12855.

Research output: Contribution to journalArticle

15 Scopus citations

Stepping toward therapeutic CRISPR

Gagnon, K. T. & Corey, D. R., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. 15536-15537 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs

Hu, J., Liu, J., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Swayze, E. E., Lima, W. F., Prakash, T. P., Xiang, Q., Martinez, C. & Corey, D. R., Jul 22 2014, In : Biochemistry. 53, 28, p. 4510-4518 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

Gagnon, K. T., Li, L., Janowski, B. A. & Corey, D. R., Sep 2014, In : Nature Protocols. 9, 9, p. 2045-2060 16 p.

Research output: Contribution to journalReview article

68 Scopus citations

Breakthrough Articles: Putting science first

Corey, D. R., Wise, J. A., Fox, K. R. & Stoddard, B. L., Oct 13 2014, In : Nucleic acids research. 42, 18, p. 11273-11274 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells

Matsui, M., Threlfall, R. N., Caruthers, M. H. & Corey, D. R., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e1146391

Research output: Contribution to journalArticle

1 Scopus citations

Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs

Hu, J., Liu, J., Yu, D., Aiba, Y., Lee, S., Pendergraff, H., Boubaker, J., Artates, J. W., Lagier-Tourenne, C., Lima, W. F., Swayze, E. E., Prakash, T. P. & Corey, D. R., Jun 1 2014, In : Nucleic Acid Therapeutics. 24, 3, p. 199-209 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification and validation of miRNA target sites within nontraditional miRNA targets

Younger, S. T. & Corey, D. R., Sep 20 2014, Regulatory Non-Coding RNAs: Methods and Protocols. Springer New York, p. 53-67 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

RNAi factors are present and active in human cell nuclei

Gagnon, K., Li, L., Chu, Y., Janowski, B. & Corey, D., Jan 3 2014, In : Cell Reports. 6, 1, p. 211-221 11 p.

Research output: Contribution to journalArticle

188 Scopus citations
2013

Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions

Aiba, Y., Hu, J., Liu, J., Xiang, Q., Martinez, C. & Corey, D. R., Dec 23 2013, In : Biochemistry. 52, 51, p. 9329-9338 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Digital quantitation of potential therapeutic target RNAs

Dodd, D. W., Gagnon, K. T. & Corey, D. R., Jun 1 2013, In : Nucleic Acid Therapeutics. 23, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Matsui, M., Chu, Y., Zhang, H., Gagnon, K. T., Shaikh, S., Kuchimanchi, S., Corey, D. R. & Janowski, B. A., Dec 1 2013, In : Nucleic acids research. 41, 22, p. 10086-10109 24 p.

Research output: Contribution to journalArticle

97 Scopus citations

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression

Liu, J., Pendergraff, H., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Hu, J. & Corey, D. R., Oct 2013, In : Nucleic acids research. 41, 18, p. 8788-8801 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ss-siRNAs allele selectively inhibit ataxin-3 expression: Multiple mechanisms for an alternative gene silencing strategy

Liu, J., Yu, D., Aiba, Y., Pendergraff, H., Swayze, E. E., Lima, W. F., Hu, J., Prakash, T. P. & Corey, D. R., Nov 2013, In : Nucleic acids research. 41, 20, p. 9570-9583 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Transcriptional silencing by single-stranded RNAs targeting a noncoding rna that overlaps a gene promoter

Matsui, M., Prakash, T. P. & Corey, D. R., Jan 18 2013, In : ACS chemical biology. 8, 1, p. 122-126 5 p.

Research output: Contribution to journalArticle

18 Scopus citations