• 11575 Citations
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1985 …2020

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2020

Progress towards drug discovery for Friedreich's Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein

Shen, X., Wong, J., Prakash, T. P., Rigo, F., Li, Y., Napierala, M. & Corey, D. R., Jun 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 11, 115472.

Research output: Contribution to journalArticle

2019

Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy

Hu, J., Shen, X., Rigo, F., Prakash, T. P., Mootha, V. V. & Corey, D. R., Apr 2019, In : Nucleic Acid Therapeutics. 29, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficient electroporation of neuronal cells using synthetic oligonucleotides: Identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression

Shen, X., Beasley, S., Putman, J. N., Li, Y., Prakash, T. P., Rigo, F., Napierala, M. & Corey, D. R., Jan 1 2019, In : RNA. 25, 9, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes

Liu, Z., Johnson, S. T., Zhang, Z. & Corey, D. R., Dec 2019, In : Nucleic Acid Therapeutics. 29, 6, p. 323-334 12 p.

Research output: Contribution to journalArticle

Open Access

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs

Gagnon, K. T. & Corey, D. R., Jun 2019, In : Nucleic Acid Therapeutics. 29, 3, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
1 Scopus citations
2018

Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion

Shen, X., Kilikevicius, A., O'Reilly, D., Prakash, T. P., Damha, M. J., Rigo, F. & Corey, D. R., Sep 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 17, p. 2850-2855 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Activation of frataxin protein expression by antisense oligonucleotides targeting the mutant expanded repeat

Li, L., Shen, X., Liu, Z., Norrbom, M., Prakash, T. P., O'Reilly, D., Sharma, V. K., Damha, M. J., Watts, J. K., Rigo, F. & Corey, D. R., Feb 1 2018, In : Nucleic Acid Therapeutics. 28, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Shen, X. & Corey, D. R., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1584-1600 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy

Hu, J., Rong, Z., Gong, X., Zhou, Z., Sharma, V. K., Xing, C., Watts, J. K., Corey, D. R. & Mootha, V., Mar 15 2018, In : Human molecular genetics. 27, 6, p. 1015-1026 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing

Liu, J., Liu, Z. & Corey, D. R., Sep 4 2018, In : Biochemistry. 57, 35, p. 5247-5256 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA

Liu, J., Hu, J., Ludlow, A. T., Pham, J. T., Shay, J. W., Rothstein, J. D. & Corey, D. R., Feb 16 2017, In : Cell Chemical Biology. 24, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Hicks, J. A., Li, L., Matsui, M., Chu, Y., Volkov, O., Johnson, K. C. & Corey, D. R., Aug 15 2017, In : Cell Reports. 20, 7, p. 1543-1552 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy

Corey, D. R., Feb 13 2017, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

81 Scopus citations

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Hu, J., Rigo, F., Prakash, T. P. & Corey, D. R., Apr 1 2017, In : Nucleic Acid Therapeutics. 27, 2, p. 87-94 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Activating frataxin expression by repeat-targeted nucleic acids

Li, L., Matsui, M. & Corey, D. R., Feb 4 2016, In : Nature communications. 7, 10606.

Research output: Contribution to journalArticle

45 Scopus citations

Argonaute 2-dependent regulation of gene expression by single-stranded miRNA mimics

Matsui, M., Prakash, T. P. & Corey, D. R., May 1 2016, In : Molecular Therapy. 24, 5, p. 946-955 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Liu, H., Liang, C., Kollipara, R. K., Matsui, M., Ke, X., Jeong, B. C., Wang, Z., Yoo, K. S., Yadav, G. P., Kinch, L. N., Grishin, N. V., Nam, Y., Corey, D. R., Kittler, R. & Liu, Q., Aug 4 2016, In : Molecular cell. 63, 3, p. 420-432 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Non-coding RNAs as drug targets

Matsui, M. & Corey, D. R., Jul 22 2016, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

210 Scopus citations

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

Dodd, D. W., Tomchick, D. R., Corey, D. R. & Gagnon, K. T., Mar 8 2016, In : Biochemistry. 55, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of mammalian transcription and splicing by Nuclear RNAi

Kalantari, R., Chiang, C. M. & Corey, D. R., Jan 29 2016, In : Nucleic acids research. 44, 2, p. 524-537 14 p.

Research output: Contribution to journalArticle

49 Scopus citations
2015

Design and bioinformatics analysis of genome-wide CLIP experiments

Wang, T., Xiao, G., Chu, Y., Zhang, M. Q., Corey, D. R. & Xie, Y., Apr 23 2015, In : Nucleic Acids Research. 43, 11, p. 5263-5274 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus

Hu, J., Liu, J., Li, L., Gagnon, K. T. & Corey, D. R., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification and validation of miRNA target sites within nontraditional miRNA targets

Younger, S. T. & Corey, D. R., 2015, In : Methods in Molecular Biology. 1206, p. 53-67 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Modulation of Splicing by Single-Stranded Silencing RNAs

Liu, J., Hu, J., Hicks, J. A., Prakash, T. P. & Corey, D. R., Jun 1 2015, In : Nucleic Acid Therapeutics. 25, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors

Matsui, M., Li, L., Janowski, B. A. & Corey, D. R., Aug 5 2015, In : Scientific Reports. 5, 12855.

Research output: Contribution to journalArticle

14 Scopus citations

Stepping toward therapeutic CRISPR

Gagnon, K. T. & Corey, D. R., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. 15536-15537 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs

Hu, J., Liu, J., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Swayze, E. E., Lima, W. F., Prakash, T. P., Xiang, Q., Martinez, C. & Corey, D. R., Jul 22 2014, In : Biochemistry. 53, 28, p. 4510-4518 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells

Matsui, M., Threlfall, R. N., Caruthers, M. H. & Corey, D. R., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e1146391

Research output: Contribution to journalArticle

1 Scopus citations

Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs

Hu, J., Liu, J., Yu, D., Aiba, Y., Lee, S., Pendergraff, H., Boubaker, J., Artates, J. W., Lagier-Tourenne, C., Lima, W. F., Swayze, E. E., Prakash, T. P. & Corey, D. R., Jun 1 2014, In : Nucleic Acid Therapeutics. 24, 3, p. 199-209 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

RNAi factors are present and active in human cell nuclei

Gagnon, K., Li, L., Chu, Y., Janowski, B. & Corey, D., Jan 3 2014, In : Cell Reports. 6, 1, p. 211-221 11 p.

Research output: Contribution to journalArticle

187 Scopus citations
2013

Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions

Aiba, Y., Hu, J., Liu, J., Xiang, Q., Martinez, C. & Corey, D. R., Dec 23 2013, In : Biochemistry. 52, 51, p. 9329-9338 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Digital quantitation of potential therapeutic target RNAs

Dodd, D. W., Gagnon, K. T. & Corey, D. R., Jun 1 2013, In : Nucleic Acid Therapeutics. 23, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Matsui, M., Chu, Y., Zhang, H., Gagnon, K. T., Shaikh, S., Kuchimanchi, S., Corey, D. R. & Janowski, B. A., Dec 1 2013, In : Nucleic acids research. 41, 22, p. 10086-10109 24 p.

Research output: Contribution to journalArticle

96 Scopus citations

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression

Liu, J., Pendergraff, H., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Hu, J. & Corey, D. R., Oct 2013, In : Nucleic acids research. 41, 18, p. 8788-8801 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ss-siRNAs allele selectively inhibit ataxin-3 expression: Multiple mechanisms for an alternative gene silencing strategy

Liu, J., Yu, D., Aiba, Y., Pendergraff, H., Swayze, E. E., Lima, W. F., Hu, J., Prakash, T. P. & Corey, D. R., Nov 2013, In : Nucleic acids research. 41, 20, p. 9570-9583 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Transcriptional silencing by single-stranded RNAs targeting a noncoding rna that overlaps a gene promoter

Matsui, M., Prakash, T. P. & Corey, D. R., Jan 18 2013, In : ACS chemical biology. 8, 1, p. 122-126 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Argonaute and the nuclear RNAs: New pathways for RNA-Mediated control of gene expression

Gagnon, K. T. & Corey, D. R., Feb 1 2012, In : Nucleic Acid Therapeutics. 22, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Expanding the action of duplex RNAs into the nucleus: Redirecting alternative splicing

Liu, J., Hu, J. & Corey, D. R., Feb 2012, In : Nucleic acids research. 40, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: Function through the RNAi pathway

Hu, J., Liu, J., Yu, D., Chu, Y. & Corey, D. R., Dec 1 2012, In : Nucleic acids research. 40, 22, p. 11270-11280 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Non-coding RNAs and cancer: An AACR Special Conference, Miami, FL, USA, January 8-11, 2012

Corey, D., 2012, In : Drugs of the Future. 37, 4, p. 297-299 3 p.

Research output: Contribution to journalArticle

RNA sequencing: Platform selection, experimental design, and data interpretation

Chu, Y. & Corey, D. R., Aug 1 2012, In : Nucleic Acid Therapeutics. 22, 4, p. 271-274 4 p.

Research output: Contribution to journalArticle

93 Scopus citations

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression

Yu, D., Pendergraff, H., Liu, J., Kordasiewicz, H. B., Cleveland, D. W., Swayze, E. E., Lima, W. F., Crooke, S. T., Prakash, T. P. & Corey, D. R., Aug 31 2012, In : Cell. 150, 5, p. 895-908 14 p.

Research output: Contribution to journalArticle

178 Scopus citations

Transcriptional silencing by hairpin RNAs complementary to a gene promoter

Chu, Y., Kalantari, R., Dodd, D. W. & Corey, D. R., Jun 1 2012, In : Nucleic Acid Therapeutics. 22, 3, p. 147-151 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs

Hu, J., Gagnon, K. T., Liu, J., Watts, J. K., Syeda-Nawaz, J., Bennett, C. F., Swayze, E. E., Randolph, J., Chattopadhyaya, J. & Corey, D. R., Apr 1 2011, In : Biological Chemistry. 392, 4, p. 315-325 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates

Gagnon, K. T., Watts, J. K., Pendergraff, H. M., Montaillier, C., Thai, D., Potier, P. & Corey, D. R., Jun 8 2011, In : Journal of the American Chemical Society. 133, 22, p. 8404-8407 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression

Yu, D., Sakurai, F. & Corey, D. R., Sep 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5202-5205 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of TFEB and V-ATPases by mTORC1

Peña-Llopis, S., Vega-Rubin-De-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X. J., Corey, D. R. & Brugarolas, J., Aug 17 2011, In : EMBO Journal. 30, 16, p. 3242-3258 17 p.

Research output: Contribution to journalArticle

255 Scopus citations