• 3747 Citations
  • 36 h-Index
1974 …2020

Research output per year

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Research Output

2007

Development of risk profiles for systemic lupus erythematosus

Olsen, N. J., Wandstrat, A. E. & Karp, D. R., Oct 1 2007, In : Future Rheumatology. 2, 5, p. 507-514 8 p.

Research output: Contribution to journalReview article

Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes

Li, Q. Z., Zhou, J., Wandstrat, A. E., Carr-Johnson, F., Branch, V., Karp, D. R., Mohan, C., Wakeland, E. K. & Olsen, N. J., Jan 1 2007, In : Clinical and Experimental Immunology. 147, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

143 Scopus citations
2006

Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus

Wandstrat, A. E., Carr-Johnson, F., Branch, V., Gray, H., Fairhurst, A. M., Reimold, A., Karp, D., Wakeland, E. K. & Olsen, N. J., Nov 1 2006, In : Journal of Autoimmunity. 27, 3, p. 153-160 8 p.

Research output: Contribution to journalArticle

113 Scopus citations

Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype

King, M. R., Ismail, A. S., Davis, L. S. & Karp, D. R., Mar 1 2006, In : Journal of Immunology. 176, 5, p. 2765-2772 8 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations
2005

Complement and systemic lupus erythematosus

Karp, D. R., Sep 1 2005, In : Current Opinion in Rheumatology. 17, 5, p. 538-542 5 p.

Research output: Contribution to journalReview article

25 Scopus citations

Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement

Lee, Y., Haas, K. M., Gor, D. O., Ding, X., Karp, D. R., Greenspan, N. S., Poe, J. C. & Tedder, T. F., Dec 15 2005, In : Journal of Immunology. 175, 12, p. 8011-8023 13 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo, C., Gormley, A. K., Yuhanna, I. S., Osborne-Lawrence, S., Gibson, L. L., Hahner, L., Shohet, R. V., Black, S., Salmon, J. E., Samols, D., Karp, D. R., Thomas, G. D. & Shaul, P. W., Nov 1 2005, In : Circulation research. 97, 11, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Increased prevalence of activated CD70+CD4+ T cells in the periphery of patients with systemic lupus erythematosus

Han, B. K., White, A. M., Dao, K. H., Karp, D. R., Wakeland, E. K. & Davis, L. S., Sep 22 2005, In : Lupus. 14, 8, p. 598-606 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004

Cutting Edge: C3d Functions as a Molecular Adjuvant in the Absence of CD21/35 Expression

Haas, K. M., Toapanta, F. R., Oliver, J. A., Poe, J. C., Weis, J. H., Karp, D. R., Bower, J. F., Ross, T. M. & Tedder, T. F., May 15 2004, In : Journal of Immunology. 172, 10, p. 5833-5837 5 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations
2003

A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel

Gamerdinger, K., Moulon, C., Karp, D. R., Van Bergen, J., Koning, F., Wild, D., Pflugfelder, U. & Weltzien, H. U., May 19 2003, In : Journal of Experimental Medicine. 197, 10, p. 1345-1353 9 p.

Research output: Contribution to journalArticle

109 Scopus citations

γ-Glutamyl transpeptidase activity alters the T cell response to oxidative stress and Fas-induced apoptosis

Carlisle, M. L., King, M. R. & Karp, D. R., Jan 1 2003, In : International Immunology. 15, 1, p. 17-27 11 p.

Research output: Contribution to journalReview article

21 Scopus citations
2002

Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses

Haas, K. M., Hasegawa, M., Steeber, D. A., Poe, J. C., Zabel, M. D., Bock, C. B., Karp, D. R., Briles, D. E., Weis, J. H. & Tedder, T. F., Dec 1 2002, In : Immunity. 17, 6, p. 713-723 11 p.

Research output: Contribution to journalArticle

118 Scopus citations
2001

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

Boackle, S. A., Holers, V. M., Chen, X., Szakonyi, G., Karp, D. R., Wakeland, E. K. & Morel, L., Jan 1 2001, In : Immunity. 15, 5, p. 775-785 11 p.

Research output: Contribution to journalArticle

175 Scopus citations

Expression of γ-Glutamyl Transpeptidase Protects Ramos B Cells from Oxidation-induced Cell Death

Karp, D. R., Shimooku, K. & Lipsky, P. E., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 3798-3804 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function

Henson, S. E., Smith, D., Boackle, S. A., Holers, V. M. & Karp, D. R., Dec 1 2001, In : Journal of Immunological Methods. 258, 1-2, p. 97-109 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

Reanalysis of the involvement of γ-glutamyl transpeptidase in the cell activation process

Antczak, C., Karp, D. R., London, R. E. & Bauvois, B., Nov 16 2001, In : FEBS Letters. 508, 2, p. 226-230 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg

Guthridge, J. M., Rakstang, J. K., Young, K. A., Hinshelwood, J., Aslam, M., Robertson, A., Gipson, M. G., Sarrias, M. R., Moore, W. T., Meagher, M., Karp, D., Lambris, J. D., Perkins, S. J. & Holers, V. M., May 22 2001, In : Biochemistry. 40, 20, p. 5931-5941 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
1999

The ectoenzyme γ-glutamyl transpeptidase regulates antiproliferative effects of S-nitrosoglutathione on human T and B lymphocytes

Henson, S. E., Nichols, T. C., Holers, V. M. & Karp, D. R., Aug 15 1999, In : Journal of Immunology. 163, 4, p. 1845-1852 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

γ-glutamyl transpeptidase is up-regulated on memory T lymphocytes

Karp, D. R., Carlisle, M. L., Mobley, A. B., Nichols, T. C., Oppenheimer-Marks, N., Brezinschek, R. I. & Holers, V. M., Nov 24 1999, In : International Immunology. 11, 11, p. 1791-1800 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
1998

Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells

Boackle, S. A., Morris, M. A., Holers, V. M. & Karp, D. R., Dec 15 1998, In : Journal of Immunology. 161, 12, p. 6537-6543 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

γ-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes

Nichols, T. C., Guthridge, J. M., Karp, D. R., Molina, H., Fletcher, D. R. & Holers, V. M., Dec 1998, In : European Journal of Immunology. 28, 12, p. 4123-4129 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
1997

CD21 augments antigen presentation in immune individuals

Boackle, S. A., Holers, V. M. & Karp, D. R., Jan 1 1997, In : European Journal of Immunology. 27, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
1996

CD21 augments antigen presentation in immune individuals

Boadde, S. A., Michael Holers, V. & Karp, D. R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1212

Research output: Contribution to journalArticle

Functional activity of staphylococcal enterotoxin A requires interactions with both the alpha and beta chains of HLA-DR

Dowd, J. E., Karr, R. W. & Karp, D. R., Nov 1 1996, In : Molecular Immunology. 33, 16, p. 1267-1274 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Staphylococcal enterotoxin D functions as a human B cell superantigen by rescuing VH4-expressing B cells from apoptosis

Domiati-Saad, R., Attrep, J. F., Brezinschek, H. P., Cherrie, A. H., Karp, D. R. & Lipsky, P. E., May 15 1996, In : Journal of Immunology. 156, 10, p. 3608-3620 13 p.

Research output: Contribution to journalArticle

58 Scopus citations
1995

Inhibition of antigen-specific T cell activation by staphylococcal enterotoxins

Dowd, J. E., Jenkins, R. N. & Karp, D. R., Jan 1 1995, In : Journal of Immunology. 154, 3, p. 1024-1031 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
1994

Wegener's granulomatosis presenting as lower back pain with prostatitis and ureteral obstruction

Middleton, G., Karp, D., Lee, E. & Cush, J., Jan 1 1994, In : Journal of Rheumatology. 21, 3, p. 566-569 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
1993

49th Forum in Immunology: Discussion

Labrecque, N., Thibodeau, J., Sekaly, R. P., Karp, D. R., Gascoigne, N. R. J., Fraser, J. D., Hudson, K. R., Simpson, E., Acha-Orbea, H., Woodland, D. L., Blackman, M. A., Huber, B. T. & Lafon, M., Jan 1 1993, In : Research in Immunology. 144, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

Analyses of the staphylococcal toxin binding sites on MHC class II molecules

Karp, D. R., 1993, In : Research in Immunology. 144, 3, p. 181-184 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mhc-independent presentation of mycobacteria to human t cells

Holoshitz, J., Romzek, N. C., Jia, Y., Wagner, L., Vila, L. M., Chen, S. J., Wilson, J. M. & Karp, D. R., Nov 1993, In : International Immunology. 5, 11, p. 1437-1443 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
1992

Distinct binding sites on HLA-DR for invariant chain and staphylococcal enterotoxins

Karp, D. R., Jenkins, R. N. & Long, E. O., Oct 15 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 20, p. 9657-9661 5 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Identification of HLA-DR1 β chain residues critical for binding staphylococcal enterotoxins A and E

Karp, D. R. & Long, E. O., Feb 1 1992, In : Journal of Experimental Medicine. 175, 2, p. 415-424 10 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations

Sequences in both class ii major histocompatibility complex α and β chains contribute to the binding of the superantigen toxic shock syndrome toxin 1

Braunstein, N. S., Weber, D. A., Wang, X. C., Long, E. O. & Karp, D., May 1 1992, In : Journal of Experimental Medicine. 175, 5, p. 1301-1305 5 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR

Roche, P. A., Teletski, C. L., Karp, D. R., Pinet, V., Bakke, O. & Long, E. O., Jan 1 1992, In : EMBO Journal. 11, 8, p. 2841-2847 7 p.

Research output: Contribution to journalArticle

84 Scopus citations
1991

Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells

Long, E. O., Rosen-Bronson, S., Karp, D. R., Malnati, M., Sekaly, R. P. & Jaraquemada, D., Aug 1991, In : Human Immunology. 31, 4, p. 229-235 7 p.

Research output: Contribution to journalArticle

122 Scopus citations
1990

Structural requirements for pairing of α and β chains in HLA-DR and HLA-DP molecules

Karp, D. R., Teletski, C. L., Jaraquemada, D., Maloy, W. L., Coligan, J. E. & Long, E. O., Mar 1 1990, In : Journal of Experimental Medicine. 171, 3, p. 615-628 14 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

The α1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1

Karp, D. R., Teletski, C. L., Scholl, P., Geha, R. & Long, E. O., Jan 1 1990, In : Nature. 346, 6283, p. 474-476 3 p.

Research output: Contribution to journalArticle

93 Scopus citations
1989

Class II MHC molecules and the HIV gp120 envelope protein interact with functionally distinct regions of the CD4 molecule

Lamarre, D., Capon, D. J., Karp, D. R., Gregory, T., Long, E. O. & Sekaly, R. P., Jan 1 1989, In : EMBO Journal. 8, 11, p. 3271-3277 7 p.

Research output: Contribution to journalArticle

62 Scopus citations
1988

Origin of the fourth component of complement related Chido and Rodgers blood group antigens

Atkinson, J. P., Chan, A. C., Karp, D. R., Killion, C. C., Brown, R., Spinella, D., Shreffler, D. C. & Levine, R. P., 1988, In : Complement. 5, 2, p. 65-76 12 p.

Research output: Contribution to journalReview article

21 Scopus citations

Successful management of catastrophic gastrointestinal involvement in polyarteritis nodosa

Karp, D. R., Kantor, O. S., Halverson, J. D. & Atkinson, J. P., May 1988, In : Arthritis & Rheumatism. 31, 5, p. 683-687 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
1984

The 20 faces of the fourth component of complement

Chan, A. C., Karp, D. R., Shreffler, D. C. & Atkinson, J. P., Jul 1984, In : Immunology Today. 5, 7, p. 200-203 4 p.

Research output: Contribution to journalReview article

10 Scopus citations

The C4 and Slp genes of the complement region of the murine H-2 major histocompatibility complex.

Shreffler, D. C., Atkinson, J. P., Chan, A. C., Karp, D. R., Killion, C. C., Ogata, R. T. & Rosa, P. A., Sep 6 1984, In : Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 306, 1129, p. 395-403 9 p.

Research output: Contribution to journalReview article

Open Access
19 Scopus citations
1983
Open Access
22 Scopus citations

Post-translational modification of the fourth component of complement. Sulfation of the α-chain

Karp, D. R., Dec 1 1983, In : Journal of Biological Chemistry. 258, 21, p. 12745-12748 4 p.

Research output: Contribution to journalArticle

24 Scopus citations
15 Scopus citations
8 Scopus citations
1982

Amino acid sequence homologies and glycosylation differences between the fourth component of murine complement and sex-limited protein

Karp, D. R., Parker, K. L., Shreffler, D. C., Slaughter, C. & Capra, J. D., 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 20 I, p. 6347-6349 3 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
9 Scopus citations

Genetic variation in glycosylation of the fourth component of murine complement. Association with hemolytic activity

Karp, D. R., Atkinson, J. P. & Shreffler, D. C., Dec 1 1982, In : Journal of Biological Chemistry. 257, 13, p. 7330-7335 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: A compilation

Atkinson, J. P., Karp, D. R., Seeskin, E. P., Killion, C. C., Rosa, P. A., Newell, S. L. & Shreffler, D. C., Dec 1982, In : Immunogenetics. 16, 6, p. 617-623 7 p.

Research output: Contribution to journalArticle

16 Scopus citations