• 11575 Citations
  • 49 h-Index
1989 …2018

Research output per year

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Research Output

2018

Inactivation of NMDA receptors in the ventral tegmental area during cocaine self-administration prevents GluA1 upregulation but with paradoxical increases in cocaine-seeking behavior

Guzman, D., Carreira, M. B., Friedman, A. K., Adachi, M., Neve, R. L., Monteggia, L. M., Han, M. H., Cowan, C. W. & Self, D. W., Jan 17 2018, In : Journal of Neuroscience. 38, 3, p. 575-585 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety

Anderson, E. M., Sun, H., Guzman, D., Taniguchi, M., Cowan, C. W., Maze, I., Nestler, E. J. & Self, D. W., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

4 Scopus citations

Overexpression of the histone dimethyltransferase G9a in nucleus accumbens shell increases cocaine self-administration, stress-induced reinstatement, and anxiety

Anderson, E. M., Larson, E. B., Guzman, D., Wissman, A. M., Neve, R. L., Nestler, E. J. & Self, D. W., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 803-813 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors

Anderson, E. M., Wissman, A. M., Chemplanikal, J., Buzin, N., Guzman, D., Larson, E. B., Neve, R. L., Nestler, E. J., Cowan, C. W. & Self, D. W., Aug 29 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 35, p. 9469-9474 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors

Taniguchi, M., Carreira, M. B., Cooper, Y. A., Bobadilla, A. C., Heinsbroek, J. A., Koike, N., Larson, E. B., Balmuth, E. A., Hughes, B. W., Penrod, R. D., Kumar, J., Smith, L. N., Guzman, D., Takahashi, J. S., Kim, T. K., Kalivas, P. W., Self, D. W., Lin, Y. & Cowan, C. W., Sep 27 2017, In : Neuron. 96, 1, p. 130-144 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Incubation of cue-induced reinstatement of cocaine, but not sucrose, seeking in C57BL/6J mice

Nugent, A. L., Anderson, E. M., Larson, E. B. & Self, D. W., Aug 1 2017, In : Pharmacology Biochemistry and Behavior. 159, p. 12-17 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

It's only a matter of time: longevity of cocaine-induced changes in dendritic spine density in the nucleus accumbens

Anderson, E. M. & Self, D. W., Feb 1 2017, In : Current Opinion in Behavioral Sciences. 13, p. 117-123 7 p.

Research output: Contribution to journalReview article

7 Scopus citations
2015

Direct regulation of diurnal drd3 expression and cocaine reward by npas2

Ozburn, A. R., Falcon, E., Twaddle, A., Nugent, A. L., Gillman, A. G., Spencer, S. M., Arey, R. N., Mukherjee, S., Lyons-Weiler, J., Self, D. W. & McClung, C. A., Mar 1 2015, In : Biological Psychiatry. 77, 5, p. 425-433 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Optogenetic stimulation of accumbens shell or shell projections to lateral hypothalamus produce differential effects on the motivation for cocaine

Larson, E. B., Wissman, A. M., Loriaux, A. L., Kourrich, S. & Self, D. W., Jan 1 2015, In : Journal of Neuroscience. 35, 8, p. 3537-3543 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Diminished role for dopamine D1 receptors in cocaine addiction?

Self, D. W., Jul 1 2014, In : Biological Psychiatry. 76, 1, p. 2-3 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations
2013

Adenosine A 1 and dopamine D 1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior

Hobson, B. D., O'Neill, C. E., Levis, S. C., Monteggia, L. M., Neve, R. L., Self, D. W. & Bachtell, R. K., Sep 1 2013, In : Neuropsychopharmacology. 38, 10, p. 1974-1983 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli

Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., Riberio, E., Rabkin, J., Mouzon, E., Cachope, R., Cheer, J. F., Han, M. H., Dietz, D. M., Self, D. W., Hurd, Y. L., Vialou, V. & 1 others, Nestler, E. J., Nov 22 2013, In : Journal of Neuroscience. 33, 47, p. 18381-18395 15 p.

Research output: Contribution to journalArticle

124 Scopus citations
2012

Cocaine self-administration behaviors in ClockΔ19 mice

Ozburn, A. R., Larson, E. B., Self, D. W. & McClung, C. A., Sep 1 2012, In : Psychopharmacology. 223, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Emergence of context-associated GluR 1 and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration

Edwards, S., Bachtell, R. K., Guzman, D., Whisler, K. N. & Self, D. W., Jul 1 2011, In : Addiction Biology. 16, 3, p. 450-457 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats

Larson, E. B., Graham, D. L., Arzaga, R. R., Buzin, N., Webb, J., Green, T. A., Bass, C. E., Neve, R. L., Terwilliger, E. F., Nestler, E. J. & Self, D. W., Nov 9 2011, In : Journal of Neuroscience. 31, 45, p. 16447-16457 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine

Choi, K. H., Edwards, S., Graham, D. L., Larson, E. B., Whisler, K. N., Simmons, D., Friedman, A. K., Walsh, J. J., Rahman, Z., Monteggia, L. M., Eisch, A. J., Neve, R. L., Nestler, E. J., Han, M. H. & Self, D. W., May 25 2011, In : Journal of Neuroscience. 31, 21, p. 7927-7937 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Striatal signal transduction and drug addiction

Philibin, S. D., Hernandez, A., Self, D. W. & Bibb, J. A., Dec 1 2011, In : Frontiers in Neuroanatomy. SEP

Research output: Contribution to journalReview article

23 Scopus citations
2010

Integrating behavioral and molecular approaches in mouse: Self-administration studies

Graham, D. L. & Self, D. W., Jan 1 2010, Advances in the Neuroscience of Addiction. CRC Press, p. 163-192 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Stress-related receptor targets for cocaine addiction

Self, D. W., Aug 1 2010, In : Biological Psychiatry. 68, 3, p. 217-218 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Striatal regulation of ΔfosB, FosB, and cFos during cocaine self-administration and withdrawal

Larson, E. B., Akkentli, F., Edwards, S., Graham, D. L., Simmons, D. L., Alibhai, I. N., Nestler, E. J. & Self, D. W., Oct 1 2010, In : Journal of Neurochemistry. 115, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats

Bachtell, R. K. & Self, D. W., Jul 30 2009, In : Psychopharmacology. 206, 3, p. 469-478 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Increased impulsivity during withdrawal from cocaine self-administration: Role for ΔFosB in the orbitofrontal cortex

Winstanley, C. A., Bachtell, R. K., Theobald, D. E. H., Laali, S., Green, T. A., Kumar, A., Chakravarty, S., Self, D. W. & Nestler, E. J., Feb 1 2009, In : Cerebral Cortex. 19, 2, p. 435-444 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration

Edwards, S., Graham, D. L., Whisler, K. N. & Self, D. W., Mar 2009, In : Synapse. 63, 3, p. 224-235 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of Mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior

Simmons, D. & Self, D. W., Jul 1 2009, In : Neuropsychopharmacology. 34, 8, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Tropomyosin-Related Kinase B in the Mesolimbic Dopamine System: Region-Specific Effects on Cocaine Reward

Graham, D. L., Krishnan, V., Larson, E. B., Graham, A., Edwards, S., Bachtell, R. K., Simmons, D., Gent, L. M., Berton, O., Bolanos, C. A., DiLeone, R. J., Parada, L. F., Nestler, E. J. & Self, D. W., Apr 15 2009, In : Biological Psychiatry. 65, 8, p. 696-701 6 p.

Research output: Contribution to journalArticle

87 Scopus citations
2008

Distinct patterns of ΔFosB induction in brain by drugs of abuse

Perrotti, L. I., Weaver, R. R., Robison, B., Renthal, W., Maze, I., Yazdani, S., Elmore, R. G., Knapp, D. J., Selley, D. E., Martin, B. R., Sim-Selley, L., Bachtell, R. K., Self, D. W. & Nestler, E. J., May 1 2008, In : Synapse. 62, 5, p. 358-369 12 p.

Research output: Contribution to journalArticle

135 Scopus citations

Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior

Bachtell, R. K. & Self, D. W., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12808-12814 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior

Bachtell, R. K., Choi, K. H., Simmons, D. L., Falcon, E., Monteggia, L. M., Neve, R. L. & Self, D. W., May 1 2008, In : European Journal of Neuroscience. 27, 9, p. 2229-2240 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neurons

Noonan, M. A., Choi, K. H., Self, D. W. & Eisch, A. J., Mar 5 2008, In : Journal of Neuroscience. 28, 10, p. 2516-2526 11 p.

Research output: Contribution to journalArticle

84 Scopus citations
2007

Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration

Edwards, S., Whisler, K. N., Fuller, D. C., Orsulak, P. J. & Self, D. W., Feb 1 2007, In : Neuropsychopharmacology. 32, 2, p. 354-366 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Differential ability of D1 and D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats

Graham, D. L., Hoppenot, R., Hendryx, A. & Self, D. W., Apr 1 2007, In : Psychopharmacology. 191, 3, p. 719-730 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse

Graham, D. L., Edwards, S., Bachtell, R. K., DiLeone, R. J., Rios, M. & Self, D. W., Aug 1 2007, In : Nature neuroscience. 10, 8, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

292 Scopus citations

IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates

Russo, S. J., Bolanos, C. A., Theobald, D. E., DeCarolis, N. A., Renthal, W., Kumar, A., Winstanley, C. A., Renthal, N. E., Wiley, M. D., Self, D. W., Russell, D. S., Neve, R. L., Eisch, A. J. & Nestler, E. J., Jan 1 2007, In : Nature neuroscience. 10, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M. H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., Ghose, S., Reister, R., Tannous, P., Green, T. A., Neve, R. L., Chakravarty, S., Kumar, A., Eisch, A. J., Self, D. W., Lee, F. S. & 4 others, Tamminga, C. A., Cooper, D. C., Gershenfeld, H. K. & Nestler, E. J., Oct 19 2007, In : Cell. 131, 2, p. 391-404 14 p.

Research output: Contribution to journalArticle

1134 Scopus citations

Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration

Edwards, S., Graham, D. L., Bachtell, R. K. & Self, D. W., Apr 1 2007, In : European Journal of Neuroscience. 25, 7, p. 2201-2213 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

ΔFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction

Winstanley, C. A., LaPlant, Q., Theobald, D. E. H., Green, T. A., Bachtell, R. K., Perrotti, L. I., DiLeone, R. J., Russo, S. J., Garth, W. J., Self, D. W. & Nestler, E. J., Sep 26 2007, In : Journal of Neuroscience. 27, 39, p. 10497-10507 11 p.

Research output: Contribution to journalArticle

105 Scopus citations
2006

Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement

Choi, K. H., Whisler, K., Graham, D. L. & Self, D. W., Jan 9 2006, In : Neuroscience. 137, 2, p. 373-383 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Enhanced acquisition of cocaine self-administration by increasing percentages of C57BL/6J genes in mice with a nonpreferring outbred background

Ruiz-Durántez, E., Hall, S. K., Steffen, C. & Self, D. W., Jul 1 2006, In : Psychopharmacology. 186, 4, p. 553-560 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., Monteggia, L. M., Self, D. W. & Nestler, E. J., Feb 10 2006, In : Science. 311, 5762, p. 864-868 5 p.

Research output: Contribution to journalArticle

1344 Scopus citations

Monogamy: Dopamine ties the knot

Edwards, S. & Self, D. W., Jan 1 2006, In : Nature neuroscience. 9, 1, p. 7-8 2 p.

Research output: Contribution to journalShort survey

19 Scopus citations
2005

A paradigm to investigate the self-regulation of cocaine administration in humans

Sughondhabirom, A., Jain, D., Gueorguieva, R., Coric, V., Berman, R., Lynch, W. J., Self, D., Jatlow, P. & Malison, R. T., Jul 1 2005, In : Psychopharmacology. 180, 3, p. 436-446 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum

Kumar, A., Choi, K. H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H. T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., Neve, R. L., Self, D. W. & Nestler, E. J., Oct 20 2005, In : Neuron. 48, 2, p. 303-314 12 p.

Research output: Contribution to journalArticle

573 Scopus citations

Effects of dopamine D2 receptor (DRD2) and transporter (SLC6A3) polymorphisms on smoking cue-induced cigarette craving among African-American smokers

Erblich, J., Lerman, C., Self, D. W., Diaz, G. A. & Bovbjerg, D. H., Apr 1 2005, In : Molecular psychiatry. 10, 4, p. 407-414 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Effects of intranucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat

Bachtell, R. K., Whisler, K., Karanian, D. & Self, D. W., Nov 1 2005, In : Psychopharmacology. 183, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

124 Scopus citations

Molecular and genetic approaches for behavioral analysis of protein function

Self, D. W., Jun 15 2005, In : Biological Psychiatry. 57, 12, p. 1479-1484 6 p.

Research output: Contribution to journalReview article

4 Scopus citations

Regulation of drug reward by cAMP response element-binding protein: Evidence for two functionally distinct subregions of the ventral tegmental area

Olson, V. G., Zabetian, C. P., Bolanos, C. A., Edwards, S., Barrot, M., Eisch, A. J., Hughes, T., Self, D. W., Neve, R. L. & Nestler, E. J., Jun 8 2005, In : Journal of Neuroscience. 25, 23, p. 5553-5562 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment

Perrotti, L. I., Bolaños, C. A., Choi, K. H., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J. & Barrot, M., May 1 2005, In : European Journal of Neuroscience. 21, 10, p. 2817-2824 8 p.

Research output: Contribution to journalArticle

131 Scopus citations
2004

Applications of a rat multiple tissue gene expression data set

Walker, J. R., Su, A. I., Self, D. W., Hogenesch, J. B., Lapp, H., Maier, R., Hoyer, D. & Bilbe, G., Apr 1 2004, In : Genome Research. 14, 4, p. 742-749 8 p.

Research output: Contribution to journalArticle

73 Scopus citations

Drug Dependence and Addiction: Neural Substrates

Self, D. & Tamminga, C. A., Feb 1 2004, In : American Journal of Psychiatry. 161, 2, 1 p.

Research output: Contribution to journalArticle

12 Scopus citations