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2019

Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice

Lackey, D. E., Reis, F. C. G., Isaac, R., Zapata, R. C., El Ouarrat, D., Lee, Y. S., Bandyopadhyay, G., Ofrecio, J. M., Oh, D. Y. & Osborn, O., Dec 1 2019, In : Scientific reports. 9, 1, 14779.

Research output: Contribution to journalArticle

Open Access

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
2017

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D., Li, P., Osborn, O. & Olefsky, J. M., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 1019-1030 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
2016

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

Li, P., Liu, S., Lu, M., Bandyopadhyay, G., Oh, D., Imamura, T., Johnson, A. M. F., Sears, D., Shen, Z., Cui, B., Kong, L., Hou, S., Liang, X., Iovino, S., Watkins, S. M., Ying, W., Osborn, O., Wollam, J., Brenner, M. & Olefsky, J. M., Nov 3 2016, In : Cell. 167, 4, p. 973-984.e12

Research output: Contribution to journalArticle

77 Scopus citations
2015

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh, D., Izquierdo, C. L., Chung, H., Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D. & Olefsky, J. M., Jan 1 2015, In : Molecular Metabolism. 4, 5, p. 378-391 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice

Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A. R., Chi, T. J., Chung, H., Bogner-Strauss, J. G., Evans, R. M., Olefsky, J. M. & Oh, D., Apr 1 2015, In : Diabetes. 64, 4, p. 1120-1130 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Dual actions of a novel bifunctional compound to lower glucose in mice with diet-induced insulin resistance

Chen, K., Jih, A., Kavaler, S. T., Lagakos, W. S., Oh, D., Watkins, S. M. & Kim, J. J., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 3, p. E293-E301

Research output: Contribution to journalArticle

2 Scopus citations

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Li, P., Oh, D., Bandyopadhyay, G., Lagakos, W. S., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., Ofrecio, J. M., Taguchi, S., Lu, M. & Olefsky, J. M., Jan 1 2015, In : Nature Medicine. 21, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer

Chung, H., Lee, Y. S., Mayoral, R., Oh, D., Siu, J. T., Webster, N. J., Sears, D. D., Olefsky, J. M. & Ellies, L. G., Jul 1 2015, In : Oncogene. 34, 27, p. 3504-3513 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Oh, D., Walenta, E., Akiyama, T. E., Lagakos, W. S., Lackey, D., Pessentheiner, A. R., Sasik, R., Hah, N., Chi, T. J., Cox, J. M., Powels, M. A., Di Salvo, J., Sinz, C., Watkins, S. M., Armando, A. M., Chung, H., Evans, R. M., Quehenberger, O., McNelis, J., Bogner-Strauss, J. G. & 1 others, Olefsky, J. M., Jan 1 2014, In : Nature Medicine. 20, 8, p. 942-947 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

Lee, Y. S., Kim, J. W., Osborne, O., Oh, D., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., Quehenberger, O., Johnson, R. S. & Olefsky, J. M., Jun 5 2014, In : Cell. 157, 6, p. 1339-1352 14 p.

Research output: Contribution to journalArticle

164 Scopus citations
2013

An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice

Reilly, S. M., Chiang, S. H., Decker, S. J., Chang, L., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J., White, N. M., Hochberg, I., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Oh, D., Li, P., Olefsky, J. M. & Saltiel, A. R., Mar 1 2013, In : Nature Medicine. 19, 3, p. 313-321 9 p.

Research output: Contribution to journalArticle

215 Scopus citations

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

Li, P., Spann, N. J., Kaikkonen, M. U., Lu, M., Oh, D., Fox, J. N., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W. S., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E. A., Watkins, S. M., Auwerx, J., Glass, C. K. & Olefsky, J. M., Sep 26 2013, In : Cell. 155, 1, p. 200-214 15 p.

Research output: Contribution to journalArticle

77 Scopus citations

α/β-hydrolase domain containing protein 15 (abhd15) - An adipogenic protein protecting from apoptosis

Walenta, E., Pessentheiner, A. R., Pelzmann, H. J., Deutsch, A., Goeritzer, M., Kratky, D., Hackl, H., Oh, D., Prokesch, A. & Bogner-Strauss, J. G., Nov 13 2013, In : PLoS One. 8, 11, e79134.

Research output: Contribution to journalArticle

5 Scopus citations
2012

GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity

Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., Lazarowski, E., Olefsky, J. M. & Kim, J. J., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1992-1999 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

Osborn, O., Oh, D., McNelis, J., Sanchez-Alavez, M., Talukdar, S., Lu, M., Li, P. P., Thiede, L., Morinaga, H., Kim, J. J., Heinrichsdorff, J., Nalbandian, S., Ofrecio, J. M., Scadeng, M., Schenk, S., Hadcock, J., Bartfai, T. & Olefsky, J. M., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2444-2453 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Increased macrophage migration into adipose tissue in obese mice

Oh, D., Morinaga, H., Talukdar, S., Bae, E. J. & Olefsky, J. M., Feb 1 2012, In : Diabetes. 61, 2, p. 346-354 9 p.

Research output: Contribution to journalArticle

213 Scopus citations

Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance

Bae, E. J., Xu, J., Oh, D., Bandyopadhyay, G., Lagakos, W. S., Keshwani, M. & Olefsky, J. M., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 18769-18780 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Talukdar, S., Oh, D., Bandyopadhyay, G., Li, D., Xu, J., McNelis, J., Lu, M., Li, P., Yan, Q., Zhu, Y., Ofrecio, J., Lin, M., Brenner, M. B. & Olefsky, J. M., Sep 1 2012, In : Nature Medicine. 18, 9, p. 1407-1412 6 p.

Research output: Contribution to journalArticle

423 Scopus citations

Omega 3 fatty acids and GPR120

Oh, D. & Olefsky, J. M., May 2 2012, In : Cell Metabolism. 15, 5, p. 564-565 2 p.

Research output: Contribution to journalArticle

56 Scopus citations

Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages

Nguyen, M. T. A., Chen, A., Lu, W. J., Fan, W. Q., Li, P. P., Oh, D. & Patsouris, D., Apr 17 2012, In : PLoS One. 7, 4, e34976.

Research output: Contribution to journalArticle

33 Scopus citations
2011

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity

Li, P., Fan, W., Xu, J., Lu, M., Yamamoto, H., Auwerx, J., Sears, D. D., Talukdar, S., Oh, D., Chen, A., Bandyopadhyay, G., Scadeng, M., Ofrecio, J. M., Nalbandian, S. & Olefsky, J. M., Nov 11 2011, In : Cell. 147, 4, p. 815-826 12 p.

Research output: Contribution to journalArticle

174 Scopus citations
2010

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

Oh, D., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W. Q., Li, P., Lu, W. J., Watkins, S. M. & Olefsky, J. M., Sep 3 2010, In : Cell. 142, 5, p. 687-698 12 p.

Research output: Contribution to journalArticle

1304 Scopus citations

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

Yoshizaki, T., Schenk, S., Imamura, T., Babendure, J. L., Sonoda, N., Bae, E. J., Oh, D., Lu, M., Milne, J. C., Westphal, C., Bandyopadhyay, G. & Olefsky, J. M., Mar 1 2010, In : American Journal of Physiology - Endocrinology and Metabolism. 298, 3

Research output: Contribution to journalArticle

226 Scopus citations
2009

Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin

Moon, J. S., Lee, Y. R., Oh, D., Hwang, J. I., Lee, J. Y., Kim, J. I., Vaudry, H., Kwon, H. B. & Seong, J. Y., Jan 1 2009, In : Peptides. 30, 1, p. 171-179 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

Oh, D. Y., Jung, M. Y., Mi, J. M., Jong-Ik, H., Han, C., Ju, Y. L., Jae, I. K., Sunoh, K., Hyewhon, R., David, K. O. D., Michael, J. W., Heung, S. N., Min, G. L., Hyuk, B. K., Kyungjin, K. & Jae, Y. S., Jul 25 2008, In : Journal of Biological Chemistry. 283, 30, p. 21054-21064 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Involvement of amino acids flanking Glu7.32 of the Gonadotropin-releasing hormone receptor in the selectivity of antagonists

Wang, C., Oh, D., Maiti, K., Kwon, H. B., Cheon, J., Hwang, J. I. & Seong, J. Y., Feb 29 2008, In : Molecules and Cells. 25, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

2007

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13

Moon, M. J., Oh, D., Moon, J. S., Kim, D. K., Hwang, J. I., Lee, J. Y., Kim, J. I., Cho, S., Kwon, H. B. & Seong, J. Y., Oct 15 2007, In : Molecular and Cellular Endocrinology. 277, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Involvement of the Ser-Glu-Pro motif in ligand species-dependent desensitisation of the rat gonadotrophin-releasing hormone receptor

Song, J. A., Oh, D., Moon, J. S., Geum, D., Kwon, H. B. & Seong, J. Y., Oct 1 2006, In : Journal of Neuroendocrinology. 18, 10, p. 757-766 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2005

Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death

Kaushik, M., Oh, D., Jung, S. M., Sujata, A., Jian, H. L., Dong, G. B., Hee-Sae, P., Keesook, L., Young, C. L., Neon, C. J., Kyungjin, K., Hubert, V., Hyuk, B. K. & Jae, Y. S., Jul 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4287-4298 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs

Oh, D., Song, J. A., Moon, J. S., Moon, M. J., Kim, J. I., Kim, K., Kwon, H. B. & Seong, J. Y., Mar 1 2005, In : Molecular Endocrinology. 19, 3, p. 722-731 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin: Insights into molecular coevolution of V1a type receptors and their ligands

Acharjee, S., Do-Rego, J. L., Oh, D., Ahn, R. S., Choe, H., Vaudry, H., Kim, K., Seong, J. Y. & Kwon, H. B., Dec 24 2004, In : Journal of Biological Chemistry. 279, 52, p. 54445-54453 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee, S., Do-Rego, J. L., Oh, D., Moon, J. S., Ahn, R. S., Lee, K., Bai, D. G., Vaudry, H., Kwon, H. B. & Seong, J. Y., Aug 1 2004, In : Journal of Molecular Endocrinology. 33, 1, p. 293-313 21 p.

Research output: Contribution to journalArticle

47 Scopus citations

Molecular cloning and characterization of an amphibian progesterone receptor from Rana dybowskii

Wang, L., Sanyal, S., Oh, D., Kim, J. Y., Ju, J. W., Song, K. H., Kim, J. W., Kwon, H. B. & Choi, H. S., Jan 1 2004, In : General and Comparative Endocrinology. 135, 1, p. 142-149 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Position of Pro and Ser near Glu7.32 in the Extracellular Loop 3 of Mammalian and Nonmammalian Gonadotropin-Releasing Hormone (GnRH) Receptors Is a Critical Determinant for Differential Ligand Selectivity for Mammalian GnRH and Chicken GnRH-II

Wang, C., Yun, O., Maiti, K., Oh, D., Kim, K. K., Chae, C. H., Lee, C. J., Seong, J. Y. & Kwon, H. B., Jan 1 2004, In : Molecular Endocrinology. 18, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Ala/Thr201 in extracellular loop 2 and Leu/Phe290 in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction

Seong, J. Y., Wang, L., Oh, D., Yun, O., Maiti, K., Li, J. H., Soh, J. M., Choi, H. S., Kim, K., Vaudry, H. & Kwon, H. B., Feb 1 2003, In : Endocrinology. 144, 2, p. 454-466 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors

Oh, D., Wang, L., Ahn, R. S., Park, J. Y., Seong, J. Y. & Kwon, H. B., Jul 31 2003, In : Molecular and Cellular Endocrinology. 205, 1-2, p. 89-98 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Inhibitory activity of alternative splice variants of the bullfrog GnRH receptor-3 on wild-type receptor signaling

Wang, L., Oh, D., Bogerd, J., Choi, H. S., Ahn, R. S., Seong, J. Y. & Kwon, H. B., Sep 12 2001, In : Endocrinology. 142, 9, p. 4015-4025 11 p.

Research output: Contribution to journalArticle

38 Scopus citations