Diana R Tomchick

  • 7821 Citations
  • 44 h-Index
1988 …2019

Research output per year

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Research Output

  • 7821 Citations
  • 44 h-Index
  • 101 Article
  • 4 Comment/debate
2019

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

3 Scopus citations

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

Padavannil, A., Sarkar, P., Kim, S. J., Cagatay, T., Jiou, J., Brautigam, C. A., Tomchick, D. R., Sali, A., D’Arcy, S. & Chook, Y. M., Mar 2019, In : eLife. 8, e43630.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R. & Radhakrishnan, A., Feb 21 2019, In : Cell. 176, 5, p. 1040-1053.e17

Research output: Contribution to journalArticle

20 Scopus citations
2018

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

5 Scopus citations

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

21 Scopus citations

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

Afanador, G. A., Tomchick, D. R. & Phillips, M. A., Nov 6 2018, In : Structure. 26, 11, p. 1499-1512.e5

Research output: Contribution to journalArticle

3 Scopus citations
2017
11 Scopus citations

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum

Brautigam, C. A., Deka, R. K., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., Apr 1 2017, In : Protein Science. 26, 4, p. 847-856 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

Xu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y. Z., Ma, C., Tomchick, D. R., Rosenmund, C. & Rizo-Rey, J., Feb 8 2017, In : eLife. 6, e22567.

Research output: Contribution to journalArticle

37 Scopus citations

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

Bae, S. J., Ni, L., Osinski, A., Tomchick, D. R., Brautigam, C. A. & Luo, X., Oct 24 2017, In : eLife. 6, e30278.

Research output: Contribution to journalArticle

26 Scopus citations
2016

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Phillips, M. A., White, K. L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D. M., Chiu, F. C. K., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 16 others, Martinez, M. S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman, A. M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J. N., Waterson, D., Palmer, M. J., Rathod, P. K. & Charman, S. A., Dec 9 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

18 Scopus citations
30 Scopus citations
12 Scopus citations

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

Dodd, D. W., Tomchick, D. R., Corey, D. R. & Gagnon, K. T., Mar 8 2016, In : Biochemistry. 55, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphorylation of spore coat proteins by a family of atypical protein kinases

Nguyen, K. B., Sreelatha, A., Durrant, E. S., Lopez-Garrido, J., Muszewska, A., Dudkiewicz, M., Grynberg, M., Yee, S., Pogliano, K., Tomchick, D. R., Pawłowski, K., Dixon, J. E. & Tagliabracci, V. S., Jun 21 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 25, p. E3482-E3491

Research output: Contribution to journalArticle

17 Scopus citations

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Volkov, O. A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D. R., Chen, Z. & Phillips, M. A., Dec 15 2016, In : eLife. 5, DECEMBER2016, e20198.

Research output: Contribution to journalArticle

12 Scopus citations

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Kokkonda, S., Deng, X., White, K. L., Coteron, J. M., Marco, M., De Las Heras, L., White, J., El Mazouni, F., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Chen, G., Morizzi, J., Ryan, E., Kaminsky, W., Leroy, D., Martínez-Martínez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 6 others, Waterson, D., Burrows, J. N., Matthews, D., Charman, S. A., Phillips, M. A. & Rathod, P. K., Jun 9 2016, In : Journal of Medicinal Chemistry. 59, 11, p. 5416-5431 16 p.

Research output: Contribution to journalArticle

31 Scopus citations
2015

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. J. G. & 33 others, Alonso, L. M. S., Martinez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M. J., Rathod, P. K., Burrows, J. N. & Charman, S. A., Jul 15 2015, In : Science Translational Medicine. 7, 296, aaa6645.

Research output: Contribution to journalArticle

124 Scopus citations

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

Guo, Y., Scheuermann, T. H., Partch, C. L., Tomchick, D. R. & Gardner, K. H., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7707-7721 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Häussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Südhof, T. C. & Rizo-Rey, J., Jul 9 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555-564 10 p.

Research output: Contribution to journalArticle

73 Scopus citations
16 Scopus citations

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

Ouyang, Z., Zheng, G., Tomchick, D. R., Luo, X. & Yu, H., Nov 16 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

54 Scopus citations
2014

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

Rivera-Cancel, G., Ko, W. H., Tomchick, D. R., Correa, F. & Gardner, K. H., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17839-17844 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection

Fortune, D. E., Lin, Y. P., Deka, R. K., Groshong, A. M., Moore, B. P., Hagman, K. E., Leong, J. M., Tomchick, D. R. & Blevins, J. S., 2014, In : Infection and immunity. 82, 8, p. 3186-3198 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Re-examining how complexin inhibits neurotransmitter release: SNARE complex insertion or electrostatic hindrance?

Trimbuch, T., Xu, J., Flaherty, D., Tomchick, D. R., Rizo-Rey, J. & Rosenmund, C., May 8 2014, In : eLife. 2014, 3, e02391.

Research output: Contribution to journalArticle

41 Scopus citations

Structure and Ca2+-binding properties of the tandem C 2 Domains of E-Syt2

Xu, J., Bacaj, T., Zhou, A., Tomchick, D. R., Südhof, T. C. & Rizo-Rey, J., Feb 4 2014, In : Structure. 22, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

Hara, K., Zheng, G., Qu, Q., Liu, H., Ouyang, Z., Chen, Z., Tomchick, D. R. & Yu, H., Jan 1 2014, In : Nature Structural and Molecular Biology. 21, 10, p. 864-870 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

Lin, Z., Jia, L., Tomchick, D. R., Luo, X. & Yu, H., Nov 4 2014, In : Structure. 22, 11, p. 1616-1627 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Structure of the human cohesin inhibitor Wapl

Ouyang, Z., Zheng, G., Song, J., Borek, D., Otwinowski, Z., Brautigam, C. A., Tomchick, D. R., Rankin, S. & Yu, H., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11355-11360 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

The bacterial effector VopL organizes actin into filament-like structures

Zahm, J. A., Padrick, S. B., Chen, Z., Pak, C. W., Yunus, A. A., Henry, L., Tomchick, D. R., Chen, Z. & Rosen, M. K., Oct 10 2013, In : Cell. 155, 2, p. 423-434 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
15 Scopus citations
2012

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

Matos, M. F., Xu, Y., Dulubova, I., Otwinowski, Z., Richardson, J. M., Tomchick, D. R., Rizo-Rey, J. & Ho, A., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3802-3807 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Biophysical and bioinformatic analyses implicate the treponema pallidum tp34 lipoprotein (tp0971) in transition metal homeostasis

Brautigam, C. A., Deka, R. K., Ouyang, Z., Machius, M., Knutsen, G., Tomchick, D. R. & Norgard, M. V., Oct 1 2012, In : Journal of bacteriology. 194, 24, p. 6771-6781 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural, bioinformatic, and in vivo analyses of two treponema pallidum Lipoproteins reveal a unique TRAP transporter

Deka, R. K., Brautigam, C. A., Goldberg, M., Schuck, P., Tomchick, D. R. & Norgard, M. V., Mar 9 2012, In : Journal of Molecular Biology. 416, 5, p. 678-696 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

Tian, W., Li, B., Warrington, R., Tomchick, D. R., Yu, H. & Luo, X., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18419-18424 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
17 Scopus citations
68 Scopus citations
2011

A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation

Haines, D. C., Hegde, A., Chen, B., Zhao, W., Bondlela, M., Humphreys, J. M., Mullin, D. A., Tomchick, D. R., MacHius, M. & Peterson, J. A., Oct 4 2011, In : Biochemistry. 50, 39, p. 8333-8341 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanism of actin filament nucleation by the bacterial effector VopL

Yu, B., Cheng, H. C., Brautigam, C. A., Tomchick, D. R. & Rosen, M. K., Sep 1 2011, In : Nature Structural and Molecular Biology. 18, 9, p. 1068-1074 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold

Selyunin, A. S., Sutton, S. E., Weigele, B. A., Reddick, L. E., Orchard, R. C., Bresson, S. M., Tomchick, D. R. & Alto, N. M., Jan 6 2011, In : Nature. 469, 7328, p. 107-113 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors

Li, W., Ma, C., Guan, R., Xu, Y., Tomchick, D. R. & Rizo-Rey, J., Oct 12 2011, In : Structure. 19, 10, p. 1443-1455 13 p.

Research output: Contribution to journalArticle

59 Scopus citations
2010

Crystal structure of the formin mDIA1 in autoinhibited conformation

Otomo, T., Tomchick, D. R., Otomo, C., Machius, M. & Rosen, M. K., Nov 1 2010, In : PloS one. 5, 9, p. 1-13 13 p., e12896.

Research output: Contribution to journalArticle

29 Scopus citations
17 Scopus citations

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

Luong, P., Kinch, L. N., Brautigam, C. A., Grishin, N. V., Tomchick, D. R. & Orth, K. A., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20155-20163 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Munc13 C 2 B domain is an activity-dependent Ca 2+ regulator of synaptic exocytosis

Shin, O. H., Lu, J., Rhee, J. S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., MacHius, M., Rizo-Rey, J., Rosenmund, C. & Südhof, T. C., Mar 1 2010, In : Nature Structural and Molecular Biology. 17, 3, p. 280-288 9 p.

Research output: Contribution to journalArticle

120 Scopus citations