• 11506 Citations
  • 50 h-Index
1988 …2020

Research output per year

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Research Output

2020

PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Different Types of Tubo-Ovarian Carcinoma and Their Prognostic Value in High-grade Serous Carcinoma

Chen, H., Molberg, K. H., Strickland, A. L., Castrillon, D. H., Carrick, K. S., Jiang, Q., Niu, S., Rivera-Colon, G., Gwin, K., Hinson, S. A., Lea, J. S., Miller, D. S., Zheng, W. & Lucas, E., 2020, (Accepted/In press) In : American Journal of Surgical Pathology. 00001.

Research output: Contribution to journalArticle

2019

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & DeBerardinis, R. J., May 16 2019, In : Nature. 569, 7756, p. E4

Research output: Contribution to journalComment/debate

Open Access

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

Cuevas, I. C., Sahoo, S. S., Kumar, A., Zhang, H., Westcott, J., Aguilar, M., Cortez, J. D., Sullivan, S. A., Xing, C., Neil Hayes, D., Brekken, R. A., Bae-Jump, V. L. & Castrillon, D. H., Dec 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 25880-25890 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
6 Scopus citations
2018

CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice

Abe, H., Alavattam, K. G., Kato, Y., Castrillon, D. H., Pang, Q., Andreassen, P. R. & Namekawa, S. H., Apr 1 2018, In : Human Molecular Genetics. 27, 7, p. 1136-1149 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Foxo3 promotes apoptosis of B cell receptor-stimulated immature B cells, thus limiting the window for receptor editing

Ottens, K., Hinman, R. M., Barrios, E., Skaug, B., Davis, L. S., Li, Q. Z., Castrillon, D. H. & Satterthwaite, A. B., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 940-949 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia

Strickland, A. L., Rivera, G., Lucas, E., John, G., Cuevas, I. & Castrillon, D. H., Jan 1 2018, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

5 Scopus citations

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

Li, H. D., Cuevas, I., Zhang, M., Lu, C., Alam, M. M., Fu, Y. X., You, M. J., Akbay, E. A., Zhang, H. & Castrillon, D. H., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 4179-4191 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas

Thu, K. L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V. D., Zhang, Y. A., Castro, I. B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D. H., Davidson, H. L., Reynolds, C. P., Lam, W. L., Lea, J. & Gazdar, A. F., Feb 7 2017, In : Oncotarget. 8, 31, p. 50489-50499 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., Ren, X., Ding, K. & Brekken, R. A., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

LKB1 as a tumor suppressor in uterine cancer: Mouse models and translational studies

Peña, C. G. & Castrillón, D. H., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 943. p. 211-241 31 p. (Advances in Experimental Medicine and Biology; vol. 943).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Visualization and lineage tracing of pax7+ spermatogonial stem cells in the mouse

Aloisio, G. M., Cuevas, I., Nakada, Y., Peña, C. G. & Castrillon, D. H., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1463. p. 139-154 16 p. (Methods in Molecular Biology; vol. 1463).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2016

Control of Oocyte Reawakening by Kit

Saatcioglu, H. D., Cuevas, I. & Castrillon, D. H., Aug 2016, In : PLoS genetics. 12, 8, e1006215.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Fibulin-5 blocks microenvironmental ROS in pancreatic cancer

Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D. A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D. H. & Brekken, R. A., Dec 1 2015, In : Cancer Research. 75, 23, p. 5058-5069 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

FOXO1/3 and PTEN depletion in granulosa cells promotes ovarian granulosa cell tumor development

Liu, Z., Ren, Y. A., Pangas, S. A., Adams, J., Zhou, W., Castrillon, D. H., Wilhelm, D. & Richards, J. S., Jul 1 2015, In : Molecular Endocrinology. 29, 7, p. 1006-1024 19 p.

Research output: Contribution to journalArticle

35 Scopus citations

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

Peña, C. G., Nakada, Y., Saatcioglu, H. D., Aloisio, G. M., Cuevas, I., Zhang, S., Miller, D. S., Lea, J. S., Wong, K. K., DeBerardinis, R. J., Amelio, A. L., Brekken, R. A. & Castrillon, D. H., Nov 2 2015, In : Journal of Clinical Investigation. 125, 11, p. 4063-4076 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Caserta, E., Egriboz, O., Wang, H., Martin, C., Koivisto, C., Pecót, T., Kladney, R. D., Shen, C., Shim, K. S., Pham, T., Karikomi, M. K., Mauntel, M. J., Majumder, S., Cuitino, M. C., Tang, X., Srivastava, A., Yu, L., Wallace, J., Mo, X., Park, M. & 17 others, Fernandez, S. A., Pilarski, R., La Perle, K. M. D., Rosol, T. J., Coppola, V., Castrillon, D. H., Timmers, C., Cohn, D. E., O’Malley, D. M., Backes, F., Suarez, A. A., Goodfellow, P., Chamberlin, H. M., Macrae, E. R., Shapiro, C. L., Ostrowski, M. C. & Leone, G., Aug 15 2015, In : Genes and Development. 29, 16, p. 1707-1720 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary

Ezzati, M. M., Baker, M. D., Saatcioglu, H. D., Aloisio, G. M., Pena, C. G., Nakada, Y., Cuevas, I., Carr, B. R. & Castrillon, D. H., Dec 1 2015, In : Journal of Assisted Reproduction and Genetics. 32, 12, p. 1741-1747 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma

Aguilera, K. Y., Rivera, L. B., Hur, H., Carbon, J. G., Toombs, J. E., Goldstein, C. D., Dellinger, M. T., Castrillon, D. H. & Brekken, R. A., Feb 15 2014, In : Cancer Research. 74, 4, p. 1032-1044 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Loss of lkb1 and pten leads to lung squamous cell carcinoma with elevated pd-l1 expression

Xu, C., Fillmore, C. M., Koyama, S., Wu, H., Zhao, Y., Chen, Z., Herter-Sprie, G. S., Akbay, E. A., Tchaicha, J. H., Altabef, A., Reibel, J. B., Walton, Z., Ji, H., Watanabe, H., Jänne, P. A., Castrillon, D. H., Rustgi, A. K., Bass, A. J., Freeman, G. J., Padera, R. F. & 4 others, Dranoff, G., Hammerman, P. S., Kim, C. F. & Wong, K. K., May 12 2014, In : Cancer Cell. 25, 5, p. 590-604 15 p.

Research output: Contribution to journalArticle

214 Scopus citations

PAX7 expression defines germline stem cells in the adult testis

Aloisio, G. M., Nakada, Y., Saatcioglu, H. D., Peña, C. G., Baker, M. D., Tarnawa, E. D., Mukherjee, J., Manjunath, H., Bugde, A., Sengupta, A. L., Amatruda, J. F., Cuevas, I., Hamra, F. K. & Castrillon, D. H., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3929-3944 16 p.

Research output: Contribution to journalArticle

93 Scopus citations

The small GTPase Rheb is required for spermatogenesis but not oogenesis

Baker, M. D., Ezzati, M., Aloisio, G. M., Tarnawa, E. D., Cuevas, I., Nakada, Y. & Castrillon, D. H., May 2014, In : Reproduction. 147, 5, p. 615-625 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis

Akbay, E. A., Peña, C. G., Ruder, D., Michel, J. A., Nakada, Y., Pathak, S., Multani, A. S., Chang, S. & Castrillon, D. H., Jan 1 2013, In : Oncogene. 32, 17, p. 2211-2219 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH

Liu, Z., Castrillon, D. H., Zhou, W. & Richards, J. S., Feb 2013, In : Molecular Endocrinology. 27, 2, p. 238-252 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Gonadal expression of Foxo1, but not Foxo3, is conserved in diverse Mammalian species.

Tarnawa, E. D., Baker, M. D., Aloisio, G. M., Carr, B. R. & Castrillon, D. H., Apr 2013, In : Unknown Journal. 88, 4

Research output: Contribution to journalArticle

30 Scopus citations

Monitoring tumorigenesis and senescence in vivo with a p16 INK4a-luciferase model

Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H. & Sharpless, N. E., Jan 7 2013, In : Cell. 152, 1-2, p. 340-351 12 p.

Research output: Contribution to journalArticle

169 Scopus citations

Screening and familial characterization of copy-number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure

Harrison, S. M., Campbell, I. M., Keays, M., Granberg, C. F., Villanueva, C., Tannin, G., Zinn, A. R., Castrillon, D. H., Shaw, C. A., Stankiewicz, P. & Baker, L. A., Oct 1 2013, In : American Journal of Medical Genetics, Part A. 161, 10, p. 2487-2494 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

Nakada, Y., Stewart, T. G., Peña, C. G., Zhang, S., Zhao, N., Bardeesy, N., Sharpless, N. E., Wong, K. K., Hayes, D. N. & Castrillon, D. H., Sep 25 2013, In : PloS one. 8, 9, e73449.

Research output: Contribution to journalArticle

13 Scopus citations
2012

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Chen, Z., Cheng, K., Walton, Z., Wang, Y., Ebi, H., Shimamura, T., Liu, Y., Tupper, T., Ouyang, J., Li, J., Gao, P., Woo, M. S., Xu, C., Yanagita, M., Altabef, A., Wang, S., Lee, C., Nakada, Y., Peña, C. G., Sun, Y. & 23 others, Franchetti, Y., Yao, C., Saur, A., Cameron, M. D., Nishino, M., Hayes, D. N., Wilkerson, M. D., Roberts, P. J., Lee, C. B., Bardeesy, N., Butaney, M., Chirieac, L. R., Costa, D. B., Jackman, D., Sharpless, N. E., Castrillon, D. H., Demetri, G. D., Jänne, P. A., Pandolfi, P. P., Cantley, L. C., Kung, A. L., Engelman, J. A. & Wong, K. K., Mar 29 2012, In : Nature. 483, 7391, p. 613-617 5 p.

Research output: Contribution to journalArticle

313 Scopus citations

Chromatin associated Sin3A is essential for male germ cell lineage in the mouse

Pellegrino, J., Castrillon, D. H. & David, G., Sep 15 2012, In : Developmental Biology. 369, 2, p. 349-355 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Liu, W., Monahan, K. B., Pfefferle, A. D., Shimamura, T., Sorrentino, J., Chan, K. T., Roadcap, D. W., Ollila, D. W., Thomas, N. E., Castrillon, D. H., Miller, C. R., Perou, C. M., Wong, K. K., Bear, J. E. & Sharpless, N. E., Jun 12 2012, In : Cancer Cell. 21, 6, p. 751-764 14 p.

Research output: Contribution to journalArticle

84 Scopus citations
2 Scopus citations

Preface

Friedberg, E. C., Castrillon, D. H., Galindo, R. L. & Wharton, K. A., Jan 1 2012, New-Opathies: An Emerging Molecular Reclassification of Human Disease. World Scientific Publishing Co., p. 7-9 3 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

2011

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

Wolff, N. C., Vega-Rubin-de-Celis, S., Xie, X. J., Castrillon, D. H., Kabbani, W. & Brugarolas, J., May 2011, In : Molecular and cellular biology. 31, 9, p. 1870-1884 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

Goertz, M. J., Wu, Z., Gallardo, T. D., Hamra, F. K. & Castrillon, D. H., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3456-3466 11 p.

Research output: Contribution to journalArticle

141 Scopus citations

GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis

Strauss, T. J., Castrillon, D. H. & Hammes, S. R., Feb 1 2011, In : Reproduction. 141, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Insights into primary ovarian insufficiency through genetically engineered mouse models

Sullivan, S. D. & Castrillon, D. H., Oct 14 2011, In : Seminars in reproductive medicine. 29, 4, p. 283-298 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death

Srisuttee, R., Koh, S. S., Park, E. H., Cho, I. R., Min, H. J., Jhun, B. H., Yu, D. Y., Park, S., Park, D. Y., Lee, M. O., Castrillon, D. H., Johnston, R. N. & Chung, Y. H., Aug 1 2011, In : International journal of molecular medicine. 28, 2, p. 255-260 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

Lynn, K. D., Udugamasooriya, D. G., Roland, C. L., Castrillon, D. H., Kodadek, T. J. & Brekken, R. A., Jul 30 2010, In : BMC Cancer. 10, 397.

Research output: Contribution to journalArticle

22 Scopus citations

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Carretero, J., Shimamura, T., Rikova, K., Jackson, A. L., Wilkerson, M. D., Borgman, C. L., Buttarazzi, M. S., Sanofsky, B. A., McNamara, K. L., Brandstetter, K. A., Walton, Z. E., Gu, T. L., Silva, J. C., Crosby, K., Shapiro, G. I., Maira, S. M., Ji, H., Castrillon, D. H., Kim, C. F., García-Echeverría, C. & 6 others, Bardeesy, N., Sharpless, N. E., Hayes, N. D., Kim, W. Y., Engelman, J. A. & Wong, K. K., Jun 15 2010, In : Cancer Cell. 17, 6, p. 547-559 13 p.

Research output: Contribution to journalArticle

176 Scopus citations

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Arnold, S. A., Rivera, L. B., Miller, A. F., Carbon, J. G., Dineen, S. P., Xie, Y., Castrillon, D. H., Sage, E. H., Puolakkainen, P., Bradshaw, A. D. & Brekken, R. A., Jan 2010, In : DMM Disease Models and Mechanisms. 3, 1-2, p. 57-72 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

Contreras, C. M., Akbay, E. A., Gallardo, T. D., Haynie, J. M., Sharma, S., Tagao, O., Bardeesy, N., Takahashi, M., Settleman, J., Wong, K. K. & Castrillon, D. H., Mar 2010, In : DMM Disease Models and Mechanisms. 3, 3-4, p. 181-193 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Mouse models of uterine corpus tumors: Clinical significance and utility

Friel, A. M., Growdon, W. B., McCann, C. K., Olawaiye, A. B., Munro, E. G., Schorge, J. O., Castrillon, D. H., Broaddus, R. R. & Rueda, B. R., Jun 1 2010, In : Frontiers in Bioscience - Elite. 2 E, 3, p. 882-895 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pathology Quiz Case 2

Fishero, B. A., Sailors, J. L., Castrillon, D. H. & Myers, L. L., May 2010, In : Archives of Otolaryngology - Head and Neck Surgery. 136, 5, p. 523+525+526

Research output: Contribution to journalArticle

2009

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillon, D. H., DePinho, R. A. & Hedrick, S. M., Jan 12 2009, In : Nature Immunology. 10, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

335 Scopus citations

Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution

Hinman, R. M., Nichols, W. A., Diaz, T. M., Gallardo, T. D., Castrillon, D. H. & Satterthwaite, A. B., Jul 10 2009, In : International Immunology. 21, 7, p. 831-842 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

Zhou, W., Cao, Q., Peng, Y., Zhang, Q. J., Castrillon, D. H., DePinho, R. A. & Liu, Z. P., Oct 2009, In : Gastroenterology. 137, 4, p. 1403-1414 12 p.

Research output: Contribution to journalArticle

81 Scopus citations