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1988 …2019
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Research Output 1988 2019

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Article
2018
2 Citations (Scopus)

CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice

Abe, H., Alavattam, K. G., Kato, Y., Castrillon, D. H., Pang, Q., Andreassen, P. R. & Namekawa, S. H., Apr 1 2018, In : Human Molecular Genetics. 27, 7, p. 1136-1149 14 p.

Research output: Contribution to journalArticle

DNA Damage
Spermatogonia
Sex Chromosomes
Histones
Serine

Foxo3 promotes apoptosis of B cell receptor-stimulated immature B cells, thus limiting the window for receptor editing

Ottens, K., Hinman, R. M., Barrios, E., Skaug, B., Davis, L. S., Li, Q. Z., Castrillon, D. H. & Satterthwaite, A. B., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 940-949 10 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
B-Lymphocytes
Apoptosis
Systemic Lupus Erythematosus
Autoantibodies
6 Citations (Scopus)
Hereditary Nonpolyposis Colorectal Neoplasms
DNA Mismatch Repair
Hyperplasia
Endometrial Neoplasms
Neoplasms
4 Citations (Scopus)

PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia

Strickland, A. L., Rivera, G., Lucas, E., John, G., Cuevas, I. & Castrillon, D. H., Jan 1 2018, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Catenins
Endometrium
Neoplasms
DNA Mismatch Repair
7 Citations (Scopus)

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

Li, H. D., Cuevas, I., Zhang, M., Lu, C., Alam, M. M., Fu, Y. X., You, M. J., Akbay, E. A., Zhang, H. & Castrillon, D. H., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 4179-4191 13 p.

Research output: Contribution to journalArticle

Neoplasms
Phenotype
DNA-Directed DNA Polymerase
Amino Acid Substitution
DNA Replication
2017
6 Citations (Scopus)

A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas

Thu, K. L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V. D., Zhang, Y. A., Castro, I. B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D. H., Davidson, H. L., Reynolds, C. P., Lam, W. L., Lea, J. & Gazdar, A. F., Feb 7 2017, In : Oncotarget. 8, 31, p. 50489-50499 11 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Cell Line
Heterografts
Neoplasms
54 Citations (Scopus)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
Ligases
Lung Neoplasms
DNA
Ammonia
20 Citations (Scopus)

Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma

Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., Ren, X., Ding, K. & Brekken, R. A., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2473-2485 13 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Collagen
Fibrillar Collagens
Pancreatic Neoplasms
Focal Adhesion Kinase 1
2016
21 Citations (Scopus)

Control of Oocyte Reawakening by Kit

Saatcioglu, H. D., Cuevas, I. & Castrillon, D. H., Aug 1 2016, In : PLoS Genetics. 12, 8, e1006215.

Research output: Contribution to journalArticle

Oocytes
phenotype
allele
oocytes
sterility
2015
18 Citations (Scopus)

Fibulin-5 blocks microenvironmental ROS in pancreatic cancer

Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D. A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D. H. & Brekken, R. A., Dec 1 2015, In : Cancer Research. 75, 23, p. 5058-5069 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Reactive Oxygen Species
Integrins
Adenocarcinoma
Neoplasms
31 Citations (Scopus)

FOXO1/3 and PTEN depletion in granulosa cells promotes ovarian granulosa cell tumor development

Liu, Z., Ren, Y. A., Pangas, S. A., Adams, J., Zhou, W., Castrillon, D. H., Wilhelm, D. & Richards, J. S., Jul 1 2015, In : Molecular Endocrinology. 29, 7, p. 1006-1024 19 p.

Research output: Contribution to journalArticle

Granulosa Cell Tumor
Granulosa Cells
Phosphoric Monoester Hydrolases
Activins
GATA4 Transcription Factor
35 Citations (Scopus)

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

Peña, C. G., Nakada, Y., Saatcioglu, H. D., Aloisio, G. M., Cuevas, I., Zhang, S., Miller, D. S., Lea, J. S., Wong, K. K., DeBerardinis, R. J., Amelio, A. L., Brekken, R. A. & Castrillon, D. H., Nov 2 2015, In : Journal of Clinical Investigation. 125, 11, p. 4063-4076 14 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Macrophages
Ligands
Neoplasms
Tumor Microenvironment
12 Citations (Scopus)

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Caserta, E., Egriboz, O., Wang, H., Martin, C., Koivisto, C., Pecót, T., Kladney, R. D., Shen, C., Shim, K. S., Pham, T., Karikomi, M. K., Mauntel, M. J., Majumder, S., Cuitino, M. C., Tang, X., Srivastava, A., Yu, L., Wallace, J., Mo, X., Park, M. & 17 others, Fernandez, S. A., Pilarski, R., La Perle, K. M. D., Rosol, T. J., Coppola, V., Castrillon, D. H., Timmers, C., Cohn, D. E., O’Malley, D. M., Backes, F., Suarez, A. A., Goodfellow, P., Chamberlin, H. M., Macrae, E. R., Shapiro, C. L., Ostrowski, M. C. & Leone, G., Aug 15 2015, In : Genes and Development. 29, 16, p. 1707-1720 14 p.

Research output: Contribution to journalArticle

Missense Mutation
Carcinoma
Neoplasms
PTEN Phosphohydrolase
Chromosomes, Human, Pair 10
7 Citations (Scopus)

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary

Ezzati, M. M., Baker, M. D., Saatcioglu, H. D., Aloisio, G. M., Pena, C. G., Nakada, Y., Cuevas, I., Carr, B. R. & Castrillon, D. H., Dec 1 2015, In : Journal of Assisted Reproduction and Genetics. 32, 12, p. 1741-1747 7 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Ovary
Oocytes
Laboratory Animals
Phosphatidylinositol 3-Kinases
2014
40 Citations (Scopus)

Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma

Aguilera, K. Y., Rivera, L. B., Hur, H., Carbon, J. G., Toombs, J. E., Goldstein, C. D., Dellinger, M. T., Castrillon, D. H. & Brekken, R. A., Feb 15 2014, In : Cancer Research. 74, 4, p. 1032-1044 13 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Adenocarcinoma
Collagen
Neoplasms
Therapeutics
192 Citations (Scopus)

Loss of lkb1 and pten leads to lung squamous cell carcinoma with elevated pd-l1 expression

Xu, C., Fillmore, C. M., Koyama, S., Wu, H., Zhao, Y., Chen, Z., Herter-Sprie, G. S., Akbay, E. A., Tchaicha, J. H., Altabef, A., Reibel, J. B., Walton, Z., Ji, H., Watanabe, H., Jänne, P. A., Castrillon, D. H., Rustgi, A. K., Bass, A. J., Freeman, G. J., Padera, R. F. & 4 others, Dranoff, G., Hammerman, P. S., Kim, C. F. & Wong, K. K., May 12 2014, In : Cancer Cell. 25, 5, p. 590-604 15 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Lung
Neoplasms
Tumor Escape
Spinocerebellar Ataxias
84 Citations (Scopus)

PAX7 expression defines germline stem cells in the adult testis

Aloisio, G. M., Nakada, Y., Saatcioglu, H. D., Peña, C. G., Baker, M. D., Tarnawa, E. D., Mukherjee, J., Manjunath, H., Bugde, A., Sengupta, A. L., Amatruda, J. F., Cuevas, I., Hamra, F. K. & Castrillon, D. H., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3929-3944 16 p.

Research output: Contribution to journalArticle

Spermatogonia
Testis
Spermatogenesis
Stem Cells
PAX7 Transcription Factor
10 Citations (Scopus)

The small GTPase Rheb is required for spermatogenesis but not oogenesis

Baker, M. D., Ezzati, M., Aloisio, G. M., Tarnawa, E. D., Cuevas, I., Nakada, Y. & Castrillon, D. H., 2014, In : Reproduction. 147, 5, p. 615-625 11 p.

Research output: Contribution to journalArticle

Oogenesis
Monomeric GTP-Binding Proteins
Spermatogenesis
Germ Cells
Gametogenesis
2013
16 Citations (Scopus)

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis

Akbay, E. A., Peña, C. G., Ruder, D., Michel, J. A., Nakada, Y., Pathak, S., Multani, A. S., Chang, S. & Castrillon, D. H., 2013, In : Oncogene. 32, 17, p. 2211-2219 9 p.

Research output: Contribution to journalArticle

Telomere
Endometrial Neoplasms
Carcinogenesis
Adenocarcinoma
Tetraploidy
44 Citations (Scopus)

FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH

Liu, Z., Castrillon, D. H., Zhou, W. & Richards, J. S., Feb 2013, In : Molecular Endocrinology. 27, 2, p. 238-252 15 p.

Research output: Contribution to journalArticle

Granulosa Cells
Activins
Growth
Apoptosis
Forkhead Transcription Factors
29 Citations (Scopus)

Gonadal expression of Foxo1, but not Foxo3, is conserved in diverse Mammalian species.

Tarnawa, E. D., Baker, M. D., Aloisio, G. M., Carr, B. R. & Castrillon, D. H., Apr 2013, In : Biology of Reproduction. 88, 4, 103.

Research output: Contribution to journalArticle

Oocytes
Maintenance
Oogenesis
Spermatogonia
Gene Duplication
153 Citations (Scopus)

Monitoring tumorigenesis and senescence in vivo with a p16 INK4a-luciferase model

Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H. & Sharpless, N. E., Jan 7 2013, In : Cell. 152, 1-2, p. 340-351 12 p.

Research output: Contribution to journalArticle

Luciferases
Carcinogenesis
Aging of materials
Tumors
Monitoring
18 Citations (Scopus)

Screening and familial characterization of copy-number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure

Harrison, S. M., Campbell, I. M., Keays, M., Granberg, C. F., Villanueva, C., Tannin, G., Zinn, A. R., Castrillon, D. H., Shaw, C. A., Stankiewicz, P. & Baker, L. A., Oct 2013, In : American Journal of Medical Genetics, Part A. 161, 10, p. 2487-2494 8 p.

Research output: Contribution to journalArticle

XY Disorders of Sex Development 46
Primary Ovarian Insufficiency
Disorders of Sex Development
Hypospadias
Multiplex Polymerase Chain Reaction
13 Citations (Scopus)

The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

Nakada, Y., Stewart, T. G., Peña, C. G., Zhang, S., Zhao, N., Bardeesy, N., Sharpless, N. E., Wong, K. K., Hayes, D. N. & Castrillon, D. H., Sep 25 2013, In : PLoS One. 8, 9, e73449.

Research output: Contribution to journalArticle

Biomarkers
Tumors
Assays
biomarkers
Tissue
2012
304 Citations (Scopus)

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Chen, Z., Cheng, K., Walton, Z., Wang, Y., Ebi, H., Shimamura, T., Liu, Y., Tupper, T., Ouyang, J., Li, J., Gao, P., Woo, M. S., Xu, C., Yanagita, M., Altabef, A., Wang, S., Lee, C., Nakada, Y., Peña, C. G., Sun, Y. & 23 others, Franchetti, Y., Yao, C., Saur, A., Cameron, M. D., Nishino, M., Hayes, D. N., Wilkerson, M. D., Roberts, P. J., Lee, C. B., Bardeesy, N., Butaney, M., Chirieac, L. R., Costa, D. B., Jackman, D., Sharpless, N. E., Castrillon, D. H., Demetri, G. D., Jänne, P. A., Pandolfi, P. P., Cantley, L. C., Kung, A. L., Engelman, J. A. & Wong, K. K., Mar 29 2012, In : Nature. 483, 7391, p. 613-617 5 p.

Research output: Contribution to journalArticle

docetaxel
Lung Neoplasms
Clinical Trials
Mutation
Neoplasms
13 Citations (Scopus)

Chromatin associated Sin3A is essential for male germ cell lineage in the mouse

Pellegrino, J., Castrillon, D. H. & David, G., Sep 15 2012, In : Developmental Biology. 369, 2, p. 349-355 7 p.

Research output: Contribution to journalArticle

Cell Lineage
Germ Cells
Chromatin
Sertoli Cells
Gene Expression Profiling
83 Citations (Scopus)

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Liu, W., Monahan, K. B., Pfefferle, A. D., Shimamura, T., Sorrentino, J., Chan, K. T., Roadcap, D. W., Ollila, D. W., Thomas, N. E., Castrillon, D. H., Miller, C. R., Perou, C. M., Wong, K. K., Bear, J. E. & Sharpless, N. E., Jun 12 2012, In : Cancer Cell. 21, 6, p. 751-764 14 p.

Research output: Contribution to journalArticle

Melanoma
Phosphotransferases
Peutz-Jeghers Syndrome
Penetrance
Germ-Line Mutation
2011
47 Citations (Scopus)

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

Wolff, N. C., Vega-Rubin-de-Celis, S., Xie, X. J., Castrillon, D. H., Kabbani, W. & Brugarolas, J., May 2011, In : Molecular and Cellular Biology. 31, 9, p. 1870-1884 15 p.

Research output: Contribution to journalArticle

Raptors
AMP-Activated Protein Kinases
Neoplasms
Hepatocytes
Phosphorylation
133 Citations (Scopus)

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

Goertz, M. J., Wu, Z., Gallardo, T. D., Hamra, F. K. & Castrillon, D. H., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3456-3466 11 p.

Research output: Contribution to journalArticle

Spermatogenesis
Stem Cells
Maintenance
Phosphatidylinositol 3-Kinases
3-Phosphoinositide-Dependent Protein Kinases
9 Citations (Scopus)

GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis

Strauss, T. J., Castrillon, D. H. & Hammes, S. R., Feb 2011, In : Reproduction. 141, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

Oogenesis
Germ Cells
Embryonic Development
Proteins
Gonads
21 Citations (Scopus)

Insights into primary ovarian insufficiency through genetically engineered mouse models

Sullivan, S. D. & Castrillon, D. H., 2011, In : Seminars in Reproductive Medicine. 29, 4, p. 283-298 16 p.

Research output: Contribution to journalArticle

Primary Ovarian Insufficiency
Oocytes
Apoptosis
Hypogonadism
Genetic Models
Primary Ovarian Insufficiency
Reproductive Medicine
28 Citations (Scopus)

Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death

Srisuttee, R., Koh, S. S., Park, E. H., Cho, I. R., Min, H. J., Jhun, B. H., Yu, D. Y., Park, S., Park, D. Y., Lee, M. O., Castrillon, D. H., Johnston, R. N. & Chung, Y. H., Aug 2011, In : International Journal of Molecular Medicine. 28, 2, p. 255-260 6 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Oxidative Stress
Cell Death
Up-Regulation
Reactive Oxygen Species
2010
20 Citations (Scopus)

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

Lynn, K. D., Udugamasooriya, D. G., Roland, C. L., Castrillon, D. H., Kodadek, T. J. & Brekken, R. A., Jul 30 2010, In : BMC Cancer. 10, 397.

Research output: Contribution to journalArticle

Peptoids
Doxorubicin
Breast Neoplasms
Neoplasms
Vascular Endothelial Growth Factor A
173 Citations (Scopus)

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Carretero, J., Shimamura, T., Rikova, K., Jackson, A. L., Wilkerson, M. D., Borgman, C. L., Buttarazzi, M. S., Sanofsky, B. A., McNamara, K. L., Brandstetter, K. A., Walton, Z. E., Gu, T. L., Silva, J. C., Crosby, K., Shapiro, G. I., Maira, S. M., Ji, H., Castrillon, D. H., Kim, C. F., García-Echeverría, C. & 6 others, Bardeesy, N., Sharpless, N. E., Hayes, N. D., Kim, W. Y., Engelman, J. A. & Wong, K. K., Jun 15 2010, In : Cancer Cell. 17, 6, p. 547-559 13 p.

Research output: Contribution to journalArticle

Proteomics
Lung
Neoplasms
Penetrance
Phosphoproteins
66 Citations (Scopus)

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Arnold, S. A., Rivera, L. B., Miller, A. F., Carbon, J. G., Dineen, S. P., Xie, Y., Castrillon, D. H., Sage, E. H., Puolakkainen, P., Bradshaw, A. D. & Brekken, R. A., Jan 2010, In : DMM Disease Models and Mechanisms. 3, 1-2, p. 57-72 16 p.

Research output: Contribution to journalArticle

Cysteine
Blood Vessels
Tumors
Neoplasms
Proteins
74 Citations (Scopus)

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

Contreras, C. M., Akbay, E. A., Gallardo, T. D., Haynie, J. M., Sharma, S., Tagao, O., Bardeesy, N., Takahashi, M., Settleman, J., Wong, K. K. & Castrillon, D. H., Mar 2010, In : DMM Disease Models and Mechanisms. 3, 3-4, p. 181-193 13 p.

Research output: Contribution to journalArticle

Sirolimus
Endometrial Neoplasms
Tumors
Neoplasms
Genes
11 Citations (Scopus)

Mouse models of uterine corpus tumors: Clinical significance and utility

Friel, A. M., Growdon, W. B., McCann, C. K., Olawaiye, A. B., Munro, E. G., Schorge, J. O., Castrillon, D. H., Broaddus, R. R. & Rueda, B. R., Jun 1 2010, In : Frontiers in Bioscience - Elite. 2 E, 3, p. 882-895 14 p.

Research output: Contribution to journalArticle

Tumors
Steroid hormones
Neoplasms
Steroids
Hormones

Pathology Quiz Case 2

Fishero, B. A., Sailors, J. L., Castrillon, D. H. & Myers, L. L., May 2010, In : Archives of Otolaryngology - Head and Neck Surgery. 136, 5

Research output: Contribution to journalArticle

Parotid Neoplasms
Salivary Ducts
Mucinous Adenocarcinoma
Differential Diagnosis
Pathology
2009
325 Citations (Scopus)

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillon, D. H., DePinho, R. A. & Hedrick, S. M., 2009, In : Nature Immunology. 10, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
L-Selectin
Intercellular Signaling Peptides and Proteins
Transcription Factors
T-Lymphocytes
25 Citations (Scopus)

Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution

Hinman, R. M., Nichols, W. A., Diaz, T. M., Gallardo, T. D., Castrillon, D. H. & Satterthwaite, A. B., 2009, In : International Immunology. 21, 7, p. 831-842 12 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Demography
B-Cell Antigen Receptors
Cyclin G2
Down-Regulation
78 Citations (Scopus)

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

Zhou, W., Cao, Q., Peng, Y., Zhang, Q. J., Castrillon, D. H., DePinho, R. A. & Liu, Z. P., Oct 2009, In : Gastroenterology. 137, 4, p. 1403-1414 12 p.

Research output: Contribution to journalArticle

Trinitrobenzenes
Mucosal Immunity
Sulfonic Acids
Inflammatory Bowel Diseases
Inflammation
52 Citations (Scopus)

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation

John, G. B., Shidler, M. J., Besmer, P. & Castrillon, D. H., Jul 15 2009, In : Developmental Biology. 331, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Ovarian Follicle
Receptor Protein-Tyrosine Kinases
Growth
Mammals
184 Citations (Scopus)

Somatic LKB1 mutations promote cervical cancer progression

Wingo, S. N., Gallardo, T. D., Akbay, E. A., Liang, M. C., Contreras, C. M., Boren, T., Shimamura, T., Miller, D. S., Sharpless, N. E., Bardeesy, N., Kwiatkowski, D. J., Schorge, J. O., Wong, K. K. & Castrillon, D. H., Apr 2 2009, In : PLoS One. 4, 4, e5137.

Research output: Contribution to journalArticle

somatic mutation
uterine cervical neoplasms
Uterine Cervical Neoplasms
Tumors
Papillomaviridae
153 Citations (Scopus)

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

Dejean, A. S., Beisner, D. R., Ch'en, I. L., Kerdiles, Y. M., Babour, A., Arden, K. C., Castrillon, D. H., DePinho, R. A. & Hedrick, S. M., 2009, In : Nature Immunology. 10, 5, p. 504-513 10 p.

Research output: Contribution to journalArticle

Dendritic Cells
Transcription Factors
T-Lymphocytes
Cell Survival
Interleukin-6
2008
19 Citations (Scopus)

Differential roles of telomere attrition in type I and II endometrial carcinogenesis

Akbay, E. A., Contreras, C. M., Perera, S. A., Sullivan, J. P., Broaddus, R. R., Schorge, J. O., Ashfaq, R., Saboorian, H., Wong, K. K. & Castrillon, D. H., Aug 2008, In : American Journal of Pathology. 173, 2, p. 536-544 9 p.

Research output: Contribution to journalArticle

Telomere
Carcinogenesis
Endometrial Neoplasms
Telomere Shortening
Neoplasms
205 Citations (Scopus)

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

Dengler, H. S., Baracho, G. V., Omori, S. A., Bruckner, S., Arden, K. C., Castrillon, D. H., DePinho, R. A. & Rickert, R. C., 2008, In : Nature Immunology. 9, 12, p. 1388-1398 11 p.

Research output: Contribution to journalArticle

Cell Differentiation
B-Lymphocytes
Transcription Factors
B-Lymphoid Precursor Cells
Genetic Recombination
20 Citations (Scopus)

DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling

Lees-Murdock, D. J., Lau, H. T., Castrillon, D. H., De Felici, M. & Walsh, C. P., Sep 1 2008, In : Developmental Biology. 321, 1, p. 238-250 13 p.

Research output: Contribution to journalArticle

Methyltransferases
Methylation
Oocytes
DNA
Growth
189 Citations (Scopus)

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth

John, G. B., Gallardo, T. D., Shirley, L. J. & Castrillon, D. H., Sep 1 2008, In : Developmental Biology. 321, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Oocytes
Growth
Forkhead Transcription Factors
Cell Nucleus Active Transport
77 Citations (Scopus)

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas

Contreras, C. M., Gurumurthy, S., Haynie, J. M., Shirley, L. J., Akbay, E. A., Wingo, S. N., Schorge, J. O., Broaddus, R. R., Wong, K. K., Bardeesy, N. & Castrillon, D. H., Feb 1 2008, In : Cancer Research. 68, 3, p. 759-766 8 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Adenocarcinoma
Cell Polarity
Alleles
Peutz-Jeghers Syndrome