• 560 Citations
  • 13 h-Index
20032019
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Research Output 2003 2019

  • 560 Citations
  • 13 h-Index
  • 26 Article
  • 5 Conference contribution
  • 1 Comment/debate
  • 1 Letter
2019

An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

Murali, V. S., Chang, B. J., Fiolka, R., Danuser, G., Cobanoglu, M. C. & Welf, E., May 28 2019, In : BMC Cancer. 19, 1, 502.

Research output: Contribution to journalArticle

Open Access
Pharmaceutical Preparations
Melanoma
Mitogen-Activated Protein Kinase Kinases
Cultured Cells
Cell Survival

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1 P29S Melanoma Cells

Mohan, A. S., Dean, K. M., Isogai, T., Kasitinon, S. Y., Murali, V. S., Roudot, P., Groisman, A., Reed, D. K., Welf, E. S., Han, S. J., Noh, J. & Danuser, G., May 6 2019, In : Developmental Cell. 49, 3, p. 444-460.e9

Research output: Contribution to journalArticle

Pseudopodia
Actins
Melanoma
Growth
Mutation
11 Citations (Scopus)

Nuclear positioning facilitates amoeboid migration along the path of least resistance

Renkawitz, J., Kopf, A., Stopp, J., de Vries, I., Driscoll, M. K., Merrin, J., Hauschild, R., Welf, E. S., Danuser, G., Fiolka, R. & Sixt, M., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

Microtubule-Organizing Center
Locomotion
Microtubules
Leukocytes
Proteolysis
1 Citation (Scopus)

Robust and automated detection of subcellular morphological motifs in 3D microscopy images

Driscoll, M. K., Welf, E. S., Jamieson, A. R., Dean, K. M., Isogai, T., Fiolka, R. & Danuser, G., Oct 1 2019, In : Nature methods. 16, 10, p. 1037-1044 8 p.

Research output: Contribution to journalArticle

Blister
Microscopy
Microscopic examination
Pseudopodia
Morphogenesis
6 Citations (Scopus)

Universal light-sheet generation with field synthesis

Chang, B. J., Kittisopikul, M., Dean, K. M., Roudot, P., Welf, E. S. & Fiolka, R., Mar 1 2019, In : Nature methods. 16, 3, p. 235-238 4 p.

Research output: Contribution to journalArticle

Light
Microscopy
Microscopic examination
Photobleaching
Lighting
2018

A sparse-to-dense method for 3D optical flow estimation in 3D light-microscopy image sequences

Manandhar, S., Bouthemy, P., Welf, E., Roudot, P. & Kervrann, C., May 23 2018, 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. IEEE Computer Society, Vol. 2018-April. p. 952-956 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optical flows
Optical microscopy
Microscopy
Interpolation
Light
2017
15 Citations (Scopus)

Imaging subcellular dynamics with fast and lightefficient volumetrically parallelized microscopy

Dean, K. M., Roudot, P., Welf, E. S., Pohlkamp, T., Garrelts, G., Herz, J. & Fiolka, R., Feb 20 2017, In : Optica. 4, 2, p. 263-271 9 p.

Research output: Contribution to journalArticle

Microscopic examination
microscopy
Imaging techniques
Fluorescence microscopy
cells
2016
73 Citations (Scopus)

A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo

Chu, J., Oh, Y., Sens, A., Ataie, N., Dana, H., Macklin, J. J., Laviv, T., Welf, E. S., Dean, K. M., Zhang, F., Kim, B. B., Tang, C. T., Hu, M., Baird, M. A., Davidson, M. W., Kay, M. A., Fiolka, R., Yasuda, R., Kim, D. S., Ng, H. L. & 1 others, Lin, M. Z., Jul 1 2016, In : Nature Biotechnology. 34, 7, p. 760-767 8 p.

Research output: Contribution to journalArticle

Bioluminescence
Microscopy
Microscopic examination
Tissue
Proteins
17 Citations (Scopus)

Diagonally Scanned Light-Sheet Microscopy for Fast Volumetric Imaging of Adherent Cells

Dean, K. M., Roudot, P., Reis, C. R., Welf, E. S., Mettlen, M. & Fiolka, R., Mar 29 2016, In : Biophysical Journal. 110, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

Microscopy
Light
Clathrin
Glass
Transport Vesicles
32 Citations (Scopus)

Quantitative Multiscale Cell Imaging in Controlled 3D Microenvironments

Welf, E. S., Driscoll, M. K., Dean, K. M., Schäfer, C., Chu, J., Davidson, M. W., Lin, M. Z., Danuser, G. & Fiolka, R., Feb 22 2016, In : Developmental Cell. 36, 4, p. 462-475 14 p.

Research output: Contribution to journalArticle

Actins
Microscopic examination
Collagen
Lighting
Phosphatidylinositol 3-Kinase
13 Citations (Scopus)

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases

Bendris, N., Williams, K. C., Reis, C. R., Welf, E. S., Chen, P. H., Lemmers, B., Hahne, M., Leong, H. S. & Schmid, S. L., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

Sorting Nexins
Neoplasm Metastasis
Neoplasms
Breast Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
2015
46 Citations (Scopus)

Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy

Dean, K. M., Roudot, P., Welf, E. S., Danuser, G. & Fiolka, R., Jun 18 2015, In : Biophysical Journal. 108, 12, p. 2807-2815 9 p.

Research output: Contribution to journalArticle

Microscopy
Fluorescence
Time-Lapse Imaging
Light
Clathrin
10 Citations (Scopus)

Linking morphodynamics and directional persistence of T lymphocyte migration

Liu, X., Welf, E. S. & Haugh, J. M., May 6 2015, In : Journal of the Royal Society Interface. 12, 106, 20141412.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Actins
Myosin Type II
Chemokine CXCL12
30 Citations (Scopus)

Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration

Zaritsky, A., Welf, E. S., Tseng, Y. Y., Angeles Rabadán, M., Serra-Picamal, X., Trepat, X. & Danuser, G., Dec 15 2015, In : Biophysical Journal. 109, 12, p. 2492-2600 109 p.

Research output: Contribution to journalArticle

Cell Movement
Seeds
Mechanical Stress
Cell Communication
2014
8 Citations (Scopus)
Causality
2013
13 Citations (Scopus)

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

Welf, E. S., Johnson, H. E. & Haugh, J. M., Dec 15 2013, In : Molecular Biology of the Cell. 24, 24, p. 3945-3955 11 p.

Research output: Contribution to journalArticle

Actomyosin
Mechanics
Integrins
Actins
Animal Migration
2012
33 Citations (Scopus)

A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding

Welf, E. S., Naik, U. P. & Ogunnaike, B. A., Sep 19 2012, In : Biophysical Journal. 103, 6, p. 1379-1389 11 p.

Research output: Contribution to journalArticle

Integrins
Cluster Analysis
Extracellular Matrix
Talin
Cell Movement
53 Citations (Scopus)

Migrating fibroblasts reorient directionality: By a metastable, PI3K-dependent mechanism

Welf, E. S., Ahmed, S., Johnson, H. E., Melvin, A. T. & Haugh, J. M., Apr 2 2012, In : Journal of Cell Biology. 197, 1, p. 105-114 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Fibroblasts
Cell Movement
Chemotactic Factors
Chemotaxis
4 Citations (Scopus)

Stochastic Models of Cell Protrusion Arising From Spatiotemporal Signaling and Adhesion Dynamics

Welf, E. S. & Haugh, J. M., Apr 9 2012, In : Methods in Cell Biology. 110, p. 223-241 19 p.

Research output: Contribution to journalArticle

Biochemical Phenomena
Physical Phenomena
Cell Adhesion
Cell Movement
Signal Transduction
2011
19 Citations (Scopus)

In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling

Melvin, A. T., Welf, E. S., Wang, Y., Irvine, D. J. & Haugh, J. M., Apr 20 2011, In : Biophysical Journal. 100, 8, p. 1893-1901 9 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Cell Movement
Fibroblasts
Platelet-Derived Growth Factor
Chemotaxis
9 Citations (Scopus)
Integrins
Cluster Analysis
Binding Sites
Adhesiveness
Proteins
49 Citations (Scopus)

Signaling pathways that control cell migration: models and analysis

Welf, E. S. & Haugh, J. M., Mar 1 2011, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 3, 2, p. 231-240 10 p.

Research output: Contribution to journalArticle

Cell Movement
Cellular Microenvironment
Focal Adhesions
Eukaryotic Cells
Actin Cytoskeleton
2010
32 Citations (Scopus)

Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling

Weiger, M. C., Ahmed, S., Welf, E. S. & Haugh, J. M., Jan 6 2010, In : Biophysical Journal. 98, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Cell Movement
1-Phosphatidylinositol 4-Kinase
Transducers
Cues
Microscopy
9 Citations (Scopus)

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells

Welf, E. S. & Haugh, J. M., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Stochastic Dynamics
Adhesion
Extracellular Matrix
Pathway
Membrane
38 Citations (Scopus)

Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells

Cirit, M., Krajcovic, M., Choi, C. K., Welf, E. S., Horwitz, A. F. & Haugh, J. M., Feb 1 2010, In : PLoS Computational Biology. 6, 2, e1000688.

Research output: Contribution to journalArticle

Integrin
integrins
Stochastic models
Adhesion
adhesion
2009
7 Citations (Scopus)

Quantitative statistical description of integrin clusters in adherent cells

Welf, E. S., Ogunnaike, B. A. & Naik, U. P., Oct 2 2009, In : IET Systems Biology. 3, 5, p. 307-316 10 p.

Research output: Contribution to journalArticle

Integrin
Integrins
Proteins
Cell signaling
Cell
2008

A control engineering model for hemostasis following blood vessel injury

Welf, E. S., Naik, U. P. & Ogunnaike, B. A., Dec 1 2008, AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blood vessels

Computational investigation of how integrin clustering affects cell adhesion and migration

Welf, E. S., Naik, U. P. & Ogunnaike, B. A., Dec 1 2008, AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell adhesion
Integrins

Experimental investigation of the relationship between integrin clustering and focal adhesion kinase phosphorylation

Welf, E. S., Ogunnaike, B. A. & Naik, U. P., Dec 1 2008, AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Focal Adhesion Protein-Tyrosine Kinases
Phosphorylation
Integrins
Adhesion
2005

A diffusion-reaction model for integrin clustering in response to cell adhesion

Welf, E. S., Naik, U. P. & Ogunnaike, B. A., Dec 1 2005, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. p. 8487-8494 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell adhesion
31 Citations (Scopus)
Papermaking
water retention
Cellulose
swelling
Swelling
2003
1 Citation (Scopus)

Pulping Wax Containing Old Corrugated Containers with Hardwood Chips in a Kraft Pulping Operation

Welf, E. S., Venditti, R. A., Jameel, H. & Renard, J. J., Feb 1 2003, In : Progress in Paper Recycling. 12, 2, p. 13-18 6 p.

Research output: Contribution to journalArticle

Corrugated containers
Kraft process
Waxes
Hardwoods
wax