• 2523 Citations
  • 19 h-Index
20072019
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Research Output 2007 2019

  • 2523 Citations
  • 19 h-Index
  • 30 Article
  • 6 Comment/debate
  • 1 Review article
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Article
2019
3 Citations (Scopus)

Identification and characterization of an alternative cancer-derived PD-L1 splice variant

Hassounah, N. B., Malladi, V. S., Huang, Y., Freeman, S. S., Beauchamp, E. M., Koyama, S., Souders, N., Martin, S., Dranoff, G., Wong, K. K., Pedamallu, C. S., Hammerman, P. S. & Akbay, E. A., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 407-420 14 p.

Research output: Contribution to journalArticle

Neoplasms
Exons
T-Lymphocytes
Cell Line
Immune Evasion
3 Citations (Scopus)

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

Choi, H., Deng, J., Li, S., Silk, T., Dong, L., Brea, E. J., Houghton, S., Redmond, D., Zhong, H., Boiarsky, J., Akbay, E., Smith, P. D., Merghoub, T., Wong, K. K. & Wolchok, J. D., Apr 16 2019, In : Cell Reports. 27, 3, p. 806-819.e5

Research output: Contribution to journalArticle

Open Access
T-cells
Mitogen-Activated Protein Kinase Kinases
Non-Small Cell Lung Carcinoma
Refractory materials
Tumors
5 Citations (Scopus)

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Miret, J. J., Kirschmeier, P., Koyama, S., Zhu, M., Li, Y. Y., Naito, Y., Wu, M., Malladi, V. S., Huang, W., Walker, W., Palakurthi, S., Dranoff, G., Hammerman, P. S., Pecot, C. V., Wong, K. K. & Akbay, E. A., Feb 6 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 504.

Research output: Contribution to journalArticle

Open Access
Arginase
Myeloid Cells
Immunity
Neoplasms
Arginine
2018
7 Citations (Scopus)

Assessing therapeutic efficacy of MEK inhibition in a KrasG12C-driven mouse model of lung cancer

Li, S., Liu, S., Deng, J., Akbay, E. A., Hai, J., Ambrogio, C., Zhang, L., Zhou, F., Jenkins, R. W., Adeegbe, D. O., Gao, P., Wang, X., Paweletz, C. P., Herter-Sprie, G. S., Chen, T., Gutierrez-Quiceno, L., Zhang, Y., Merlino, A. A., Quinn, M. M., Zeng, Y. & 7 others, Yu, X., Liu, Y., Fan, L., Aguirre, A. J., Barbie, D. A., Yi, X. & Wong, K. K., Oct 1 2018, In : Clinical Cancer Research. 24, 19, p. 4854-4864 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Lung Neoplasms
Neoplasms
Mutation
Lung
12 Citations (Scopus)

Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients

Osa, A., Uenami, T., Koyama, S., Fujimoto, K., Okuzaki, D., Takimoto, T., Hirata, H., Yano, Y., Yokota, S., Kinehara, Y., Naito, Y., Otsuka, T., Kanazu, M., Kuroyama, M., Hamaguchi, M., Koba, T., Futami, Y., Ishijima, M., Suga, Y., Akazawa, Y. & 13 others, Machiyama, H., Iwahori, K., Takamatsu, H., Nagatomo, I., Takeda, Y., Kida, H., Akbay, E., Hammerman, P. S., Wong, K. K., Dranoff, G., Mori, M., Kijima, T. & Kumanogoh, A., Oct 4 2018, In : JCI insight. 3, 19

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
T-Lymphocytes
nivolumab
Japan
Blocking Antibodies
16 Citations (Scopus)

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

McKenney, A. S., Lau, A. N., Hanasoge Somasundara, A. V., Spitzer, B., Intlekofer, A. M., Ahn, J., Shank, K., Rapaport, F. T., Patel, M. A., Papalexi, E., Shih, A. H., Chiu, A., Freinkman, E., Akbay, E. A., Steadman, M., Nagaraja, R., Yen, K., Teruya-Feldstein, J., Wong, K. K., Rampal, R. & 3 others, Vander Heiden, M. G., Thompson, C. B. & Levine, R. L., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 789-804 16 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Stem Cells
Neoplasms
Mutation
Acute Myeloid Leukemia
7 Citations (Scopus)

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

Li, H. D., Cuevas, I., Zhang, M., Lu, C., Alam, M. M., Fu, Y. X., You, M. J., Akbay, E. A., Zhang, H. & Castrillon, D. H., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 4179-4191 13 p.

Research output: Contribution to journalArticle

Neoplasms
Phenotype
DNA-Directed DNA Polymerase
Amino Acid Substitution
DNA Replication
2017
3 Citations (Scopus)

Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib

Nishino, M., Sacher, A. G., Gandhi, L., Chen, Z., Akbay, E., Fedorov, A., Westin, C. F., Hatabu, H., Johnson, B. E., Hammerman, P. & Wong, K. K., Mar 1 2017, In : European Journal of Radiology. 88, p. 15-20 6 p.

Research output: Contribution to journalArticle

Tumor Burden
Non-Small Cell Lung Carcinoma
Therapeutics
Spiders
crizotinib
43 Citations (Scopus)

Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade

Akbay, E. A., Koyama, S., Liu, Y., Dries, R., Bufe, L. E., Silkes, M., Alam, MD. M., Magee, D. M., Jones, R., Jinushi, M., Kulkarni, M., Carretero, J., Wang, X., Warner-Hatten, T., Cavanaugh, J. D., Osa, A., Kumanogoh, A., Freeman, G. J., Awad, M. M., Christiani, D. C. & 4 others, Bueno, R., Hammerman, P. S., Dranoff, G. & Wong, K. K., Aug 1 2017, In : Journal of Thoracic Oncology. 12, 8, p. 1268-1279 12 p.

Research output: Contribution to journalArticle

Interleukin-17
Neutrophils
Cell Death
Lung
Neoplasms
19 Citations (Scopus)

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Zhang, H., Brainson, C. F., Koyama, S., Redig, A. J., Chen, T., Li, S., Gupta, M., Garcia-De-Alba, C., Paschini, M., Herter-Sprie, G. S., Lu, G., Zhang, X., Marsh, B. P., Tuminello, S. J., Xu, C., Chen, Z., Wang, X., Akbay, E. A., Zheng, M., Palakurthi, S. & 14 others, Sholl, L. M., Rustgi, A. K., Kwiatkowski, D. J., DIehl, J. A., Bass, A. J., Sharpless, N. E., Dranoff, G., Hammerman, P. S., Ji, H., Bardeesy, N., Saur, DI., Watanabe, H., Kim, C. F. & Wong, K. K., Apr 7 2017, In : Nature Communications. 8, 14922.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
deactivation
lungs
Squamous Cell Carcinoma
Lung Neoplasms
2016
418 Citations (Scopus)

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Koyama, S., Akbay, E. A., Li, Y. Y., Herter-Sprie, G. S., Buczkowski, K. A., Richards, W. G., Gandhi, L., Redig, A. J., Rodig, S. J., Asahina, H., Jones, R. E., Kulkarni, M. M., Kuraguchi, M., Palakurthi, S., Fecci, P. E., Johnson, B. E., Janne, P. A., Engelman, J. A., Gangadharan, S. P., Costa, D. B. & 6 others, Freeman, G. J., Bueno, R., Hodi, F. S., Dranoff, G., Wong, K. K. & Hammerman, P. S., Feb 17 2016, In : Nature Communications. 7, 10501.

Research output: Contribution to journalArticle

T-cells
Mucin-3
death
Up-Regulation
Immunoglobulins
110 Citations (Scopus)

STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment

Koyama, S., Akbay, E. A., Li, Y. Y., Aref, A. R., Skoulidis, F., Herter-Sprie, G. S., Buczkowski, K. A., Liu, Y., Awad, M. M., Denning, W. L., Diao, L., Wang, J., Parra-Cuentas, E. R., Wistuba, I. I., Soucheray, M., Thai, T., Asahina, H., Kitajima, S., Altabef, A., Cavanaugh, J. D. & 13 others, Rhee, K., Gao, P., Zhang, H., Fecci, P. E., Shimamura, T., Hellmann, M. D., Heymach, J. V., Hodi, F. S., Freeman, G. J., Barbie, D. A., Dranoff, G., Hammerman, P. S. & Wong, K. K., Mar 1 2016, In : Cancer Research. 76, 5, p. 999-1008 10 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Neutrophil Infiltration
Cytokines
T-Lymphocytes
Lung
4 Citations (Scopus)

The impact of the MYB-NFIB fusion protooncogene in vivo

Mikse, O. R., Tchaicha, J. H., Akbay, E. A., Chen, L., Bronson, R. T., Hammerman, P. S. & Wong, K. K., May 31 2016, In : Oncotarget. 7, 22, p. 31681-31688 8 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Adenoid Cystic Carcinoma
Breast
Oncogenes
Transcription Factors
2015
48 Citations (Scopus)

Development of Selective Covalent Janus Kinase 3 Inhibitors

Tan, L., Akahane, K., McNally, R., Reyskens, K. M. S. E., Ficarro, S. B., Liu, S., Herter-Sprie, G. S., Koyama, S., Pattison, M. J., Labella, K., Johannessen, L., Akbay, E. A., Wong, K. K., Frank, D. A., Marto, J. A., Look, T. A., Arthur, J. S. C., Eck, M. J. & Gray, N. S., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6589-6606 18 p.

Research output: Contribution to journalArticle

Janus Kinase 3
Janus Kinases
STAT Transcription Factors
Pyrimidines
Immune System Diseases
2014
40 Citations (Scopus)

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

Chen, Z., Akbay, E., Mikse, O., Tupper, T., Cheng, K., Wang, Y., Tan, X., Altabef, A., Woo, S. A., Chen, L., Reibel, J. B., Janne, P. A., Sharpless, N. E., Engelman, J. A., Shapiro, G. I., Kung, A. L. & Wong, K. K., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1204-1211 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Clinical Trials
Drug Therapy
docetaxel
Pemetrexed
34 Citations (Scopus)

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

Akbay, E. A., Moslehi, J., Christensen, C. L., Saha, S., Tchaicha, J. H., Ramkissoon, S. H., Stewart, K. M., Carretero, J., Kikuchi, E., Zhang, H., Cohoon, T. J., Murray, S., Liu, W., Uno, K., Fisch, S., Jones, K., Gurumurthy, S., Gliser, C., Choe, S., Keenan, M. & 17 others, Son, J., Stanley, I., Losman, J. A., Padera, R., Bronson, R. T., Asara, J. M., Abdel-Wahab, O., Amrein, P. C., Fathi, A. T., Danial, N. N., Kimmelman, A. C., Kung, A. L., Ligon, K. L., Yen, K. E., Kaelin, W. G., Bardeesy, N. & Wong, K. K., Mar 1 2014, In : Genes and Development. 28, 5, p. 479-490 12 p.

Research output: Contribution to journalArticle

Glycogen
Cardiomyopathies
Isocitrate Dehydrogenase
Acids
Muscular Dystrophies
22 Citations (Scopus)

Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

Herter-Sprie, G. S., Korideck, H., Christensen, C. L., Herter, J. M., Rhee, K., Berbeco, R. I., Bennett, D. G., Akbay, E. A., Kozono, D., Mak, R. H., Mike Makrigiorgos, G., Kimmelman, A. C. & Wong, K. K., Jan 1 2014, In : Nature Communications. 5, 5870.

Research output: Contribution to journalArticle

Image-Guided Radiotherapy
nodules
Radiotherapy
lungs
mice
25 Citations (Scopus)

Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC

Tchaicha, J. H., Akbay, E. A., Altabef, A., Mikse, O. R., Kikuchi, E., Rhee, K., Liao, R. G., Bronson, R. T., Sholl, L. M., Meyerson, M., Hammerman, P. S. & Wong, K. K., Sep 1 2014, In : Cancer Research. 74, 17, p. 4676-4684 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Phosphotransferases
Mutation
Lung Neoplasms
Lung
192 Citations (Scopus)

Loss of lkb1 and pten leads to lung squamous cell carcinoma with elevated pd-l1 expression

Xu, C., Fillmore, C. M., Koyama, S., Wu, H., Zhao, Y., Chen, Z., Herter-Sprie, G. S., Akbay, E. A., Tchaicha, J. H., Altabef, A., Reibel, J. B., Walton, Z., Ji, H., Watanabe, H., Jänne, P. A., Castrillon, D. H., Rustgi, A. K., Bass, A. J., Freeman, G. J., Padera, R. F. & 4 others, Dranoff, G., Hammerman, P. S., Kim, C. F. & Wong, K. K., May 12 2014, In : Cancer Cell. 25, 5, p. 590-604 15 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Lung
Neoplasms
Tumor Escape
Spinocerebellar Ataxias
179 Citations (Scopus)

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

Saha, S. K., Parachoniak, C. A., Ghanta, K. S., Fitamant, J., Ross, K. N., Najem, M. S., Gurumurthy, S., Akbay, E. A., Sia, D., Cornella, H., Miltiadous, O., Walesky, C., Deshpande, V., Zhu, A. X., Heze, A. F., Yen, K. E., Straley, K. S., Travins, J., Popovici-Muller, J., Gliser, C. & 6 others, Ferrone, C. R., Apte, U., Llovet, J. M., Wong, K. K., Ramaswamy, S. & Bardeesy, N., Sep 1 2014, In : Nature. 513, 7516, p. 110-152 43 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Hepatocytes
Liver
Cholangiocarcinoma
Mutation
161 Citations (Scopus)

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

Christensen, C. L., Kwiatkowski, N., Abraham, B. J., Carretero, J., Al-Shahrour, F., Zhang, T., Chipumuro, E., Herter-Sprie, G. S., Akbay, E. A., Altabef, A., Zhang, J., Shimamura, T., Capelletti, M., Reibel, J. B., Cavanaugh, J. D., Gao, P., Liu, Y., Michaelsen, S. R., Poulsen, H. S., Aref, A. R. & 6 others, Barbie, D. A., Bradner, J. E., George, R. E., Gray, N. S., Young, R. A. & Wong, K. K., Jan 1 2014, In : Cancer Cell. 26, 6, p. 909-922 14 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Transcription Factors
Small Molecule Libraries
Proto-Oncogenes
Cyclin-Dependent Kinases
2013
593 Citations (Scopus)

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

Akbay, E. A., Koyama, S., Carretero, J., Altabef, A., Tchaicha, J. H., Christensen, C. L., Mikse, O. R., Cherniack, A. D., Beauchamp, E. M., Pugh, T. J., Wilkerson, M. D., Fecci, P. E., Butaney, M., Reibel, J. B., Soucheray, M., Cohoon, T. J., Janne, P. A., Meyerson, M., Neil Hayes, D., Shapiro, G. I. & 7 others, Shimamura, T., Sholl, L. M., Rodig, S. J., Freeman, G. J., Hammerman, P. S., Dranoff, G. & Wong, K. K., Dec 1 2013, In : Cancer Discovery. 3, 12, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung
Neoplasms
Cytokines
T-Lymphocytes
16 Citations (Scopus)

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis

Akbay, E. A., Peña, C. G., Ruder, D., Michel, J. A., Nakada, Y., Pathak, S., Multani, A. S., Chang, S. & Castrillon, D. H., 2013, In : Oncogene. 32, 17, p. 2211-2219 9 p.

Research output: Contribution to journalArticle

Telomere
Endometrial Neoplasms
Carcinogenesis
Adenocarcinoma
Tetraploidy
116 Citations (Scopus)

Efficacy of BET bromodomain inhibition in KRAS-mutant non-small cell lung cancer

Shimamura, T., Chen, Z., Soucheray, M., Carretero, J., Kikuchi, E., Tchaicha, J. H., Gao, Y., Cheng, K. A., Cohoon, T. J., Qi, J., Akbay, E., Kimmelman, A. C., Kung, A. L., Bradner, J. E. & Wong, K. K., Nov 15 2013, In : Clinical Cancer Research. 19, 22, p. 6183-6192 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Hematologic Neoplasms
Drug Resistance
2010
74 Citations (Scopus)

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

Contreras, C. M., Akbay, E. A., Gallardo, T. D., Haynie, J. M., Sharma, S., Tagao, O., Bardeesy, N., Takahashi, M., Settleman, J., Wong, K. K. & Castrillon, D. H., Mar 2010, In : DMM Disease Models and Mechanisms. 3, 3-4, p. 181-193 13 p.

Research output: Contribution to journalArticle

Sirolimus
Endometrial Neoplasms
Tumors
Neoplasms
Genes
31 Citations (Scopus)

Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex

Gonzalez, M. D., Akbay, E. A., Boyd, D. & Beckwith, J., Jun 1 2010, In : Journal of Bacteriology. 192, 11, p. 2757-2768 12 p.

Research output: Contribution to journalArticle

Cell Division
Proteins
Bacteria
Escherichia coli Proteins
Computational Biology
2009
184 Citations (Scopus)

Somatic LKB1 mutations promote cervical cancer progression

Wingo, S. N., Gallardo, T. D., Akbay, E. A., Liang, M. C., Contreras, C. M., Boren, T., Shimamura, T., Miller, D. S., Sharpless, N. E., Bardeesy, N., Kwiatkowski, D. J., Schorge, J. O., Wong, K. K. & Castrillon, D. H., Apr 2 2009, In : PLoS One. 4, 4, e5137.

Research output: Contribution to journalArticle

somatic mutation
uterine cervical neoplasms
Uterine Cervical Neoplasms
Tumors
Papillomaviridae
2008
19 Citations (Scopus)

Differential roles of telomere attrition in type I and II endometrial carcinogenesis

Akbay, E. A., Contreras, C. M., Perera, S. A., Sullivan, J. P., Broaddus, R. R., Schorge, J. O., Ashfaq, R., Saboorian, H., Wong, K. K. & Castrillon, D. H., Aug 2008, In : American Journal of Pathology. 173, 2, p. 536-544 9 p.

Research output: Contribution to journalArticle

Telomere
Carcinogenesis
Endometrial Neoplasms
Telomere Shortening
Neoplasms
77 Citations (Scopus)

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas

Contreras, C. M., Gurumurthy, S., Haynie, J. M., Shirley, L. J., Akbay, E. A., Wingo, S. N., Schorge, J. O., Broaddus, R. R., Wong, K. K., Bardeesy, N. & Castrillon, D. H., Feb 1 2008, In : Cancer Research. 68, 3, p. 759-766 8 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Adenocarcinoma
Cell Polarity
Alleles
Peutz-Jeghers Syndrome
2007
57 Citations (Scopus)

Genomewide discovery and classification of candidate ovarian fertility genes in the mouse

Gallardo, T. D., John, G. B., Shirley, L., Contreras, C. M., Akbay, E. A., Haynie, J. M., Ward, S. E., Shidler, M. J. & Castrillon, D. H., Sep 2007, In : Genetics. 177, 1, p. 179-194 16 p.

Research output: Contribution to journalArticle

Female Infertility
Fertility
Ovarian Follicle
Genes
Oogenesis