• 12584 Citations
  • 56 h-Index
1969 …2018
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Research Output 1969 2018

  • 12584 Citations
  • 56 h-Index
  • 186 Article
  • 4 Chapter
  • 2 Conference contribution
  • 1 Book
2018
1 Citation (Scopus)

High school science fair: Student opinions regarding whether participation should be required or optional and why

Grinnell, F., Dalley, S., Shepherd, K. & Reisch, J., Aug 1 2018, In : PLoS One. 13, 8, e0202320.

Research output: Contribution to journalArticle

high schools
students
Students
high school students
engineering

Research integrity and everyday practice of science

Grinnell, F. L., Jul 23 2018, Getting to Good: Research Integrity in the Biomedical Sciences. Springer International Publishing, p. 23-40 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Research
Intuition
Noise
Research Personnel
Education
2017
risk research
Committee Membership
research ethics
Research Ethics Committees
Decision Making
2 Citations (Scopus)

Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices

Ozcelikkale, A., Dutton, J. C., Grinnell, F. & Han, B., Oct 1 2017, In : Journal of the Royal Society Interface. 14, 135, 20170287.

Research output: Contribution to journalArticle

Fibroblasts
Collagen
Cell Communication
Cell Movement
Physiological Phenomena
2 Citations (Scopus)

High school science fair and research integrity

Grinnell, F., Dalley, S., Shepherd, K. & Reisch, J., Mar 1 2017, In : PLoS One. 12, 3, e0174252.

Research output: Contribution to journalArticle

high school students
high schools
Students
students
Research
2 Citations (Scopus)
Vascular Diseases
Smooth Muscle
Actins
Fibroblasts
Mutation
2015
2 Citations (Scopus)

PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2

Da Rocha-Azevedo, B., Ho, C. H. & Grinnell, F., Mar 15 2015, In : Molecular Biology of the Cell. 26, 6, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Fibronectins
Collagen
Matrix Metalloproteinases
Cluster Analysis
8 Citations (Scopus)

Preservation of tissue microstructure and functionality during freezing by modulation of cytoskeletal structure

Park, S., Seawright, A., Park, S., Dutton, J. C., Grinnell, F. & Han, B., May 1 2015, In : Journal of the Mechanical Behavior of Biomedical Materials. 45, p. 32-44 13 p.

Research output: Contribution to journalArticle

Cryoprotective Agents
Freezing
Modulation
Tissue
Microstructure
6 Citations (Scopus)

Rethink our approach to assessing risk

Grinnell, F., Jun 17 2015, In : Nature. 522, 7556, p. 257 1 p.

Research output: Contribution to journalArticle

Human Experimentation
Uncertainty
2014
10 Citations (Scopus)

The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts

Liu, Z., Ho, C. H. & Grinnell, F., Aug 15 2014, In : Experimental Cell Research. 326, 2, p. 295-306 12 p.

Research output: Contribution to journalArticle

Nonmuscle Myosin Type IIB
Nonmuscle Myosin Type IIA
Collagen
Fibroblasts
Stress Fibers
2013
61 Citations (Scopus)

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

Velasquez, L. S., Sutherland, L. B., Liu, Z., Grinnell, F., Kamm, K. E., Schneider, J. W., Olson, E. N. & Small, E. M., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16850-16855 6 p.

Research output: Contribution to journalArticle

Myofibroblasts
Wound Healing
Transcription Factors
Gene Expression
Serum Response Factor
19 Citations (Scopus)

Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization

da Rocha-Azevedo, B., Ho, C. H. & Grinnell, F., Feb 15 2013, In : Experimental Cell Research. 319, 4, p. 546-555 10 p.

Research output: Contribution to journalArticle

Fibronectins
Collagen
Fibroblasts
Cluster Analysis
Platelet-Derived Growth Factor
21 Citations (Scopus)

Fibroblast morphogenesis on 3D collagen matrices: The balance between cell clustering and cell migration

da Rocha-Azevedo, B. & Grinnell, F., Oct 1 2013, In : Experimental Cell Research. 319, 16, p. 2440-2446 7 p.

Research output: Contribution to journalArticle

Morphogenesis
Cell Movement
Cluster Analysis
Collagen
Fibroblasts
2 Citations (Scopus)

It is time to update US biomedical funding

Grinnell, F., 2013, In : Nature. 501, 7466, p. 137 1 p.

Research output: Contribution to journalArticle

Journal Impact Factor
Federal Government
Salaries and Fringe Benefits
National Institutes of Health (U.S.)
Budgets
8 Citations (Scopus)

Research Integrity and Everyday Practice of Science

Grinnell, F., Sep 2013, In : Science and Engineering Ethics. 19, 3, p. 685-701 17 p.

Research output: Contribution to journalArticle

Integrity
integrity
Logic
Science Education
Linear Process
18 Citations (Scopus)

The effect of growth factor environment on fibroblast morphological response to substrate stiffness

Grinnell, F. & Ho, C. H., Jan 2013, In : Biomaterials. 34, 4, p. 965-974 10 p.

Research output: Contribution to journalArticle

Fibroblasts
Intercellular Signaling Peptides and Proteins
Stiffness
Substrates
Adhesion
7 Citations (Scopus)

Thermomechanical analysis of freezing-induced cell-fluid-matrix interactions in engineered tissues

Han, B., Teo, K. Y., Ghosh, S., Dutton, J. C. & Grinnell, F., Feb 2013, In : Journal of the Mechanical Behavior of Biomedical Materials. 18, p. 67-80 14 p.

Research output: Contribution to journalArticle

Freezing
Tissue
Fluids
Dimethyl Sulfoxide
Cryoprotective Agents
2011

Effects of freezing-induced cell-fluid-matrix interactions on cells and extracellular matrix of engineered tissues

Teo, K. Y., Dutton, J. C., Grinnell, F. & Han, B., 2011, ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. p. 133-134 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Freezing
Tissue
Fluids
32 Citations (Scopus)

Effects of freezing-induced cell-fluid-matrix interactions on the cells and extracellular matrix of engineered tissues

Teo, K. Y., DeHoyos, T. O., Dutton, J. C., Grinnell, F. & Han, B., Aug 2011, In : Biomaterials. 32, 23, p. 5380-5390 11 p.

Research output: Contribution to journalArticle

Freezing
Cell Communication
Extracellular Matrix
Tissue
Fluids

The evolution of credibility

Grinnell, F., Feb 1 2011, In : Scientist. 25, 2, p. 76 1 p.

Research output: Contribution to journalArticle

2010
206 Citations (Scopus)

Cell motility and mechanics in three-dimensional collagen matrices

Grinnell, F. & Petroll, W. M., Nov 10 2010, In : Annual Review of Cell and Developmental Biology. 26, p. 335-361 27 p.

Research output: Contribution to journalArticle

Mechanics
Cell Movement
Collagen
Connective Tissue
Fibroblasts
20 Citations (Scopus)

Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis

Rhee, S., Ho, C. H. & Grinnell, F., Jan 15 2010, In : Experimental Cell Research. 316, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

Morphogenesis
Intercellular Signaling Peptides and Proteins
Fibroblasts
Platelet-Derived Growth Factor
Serum
138 Citations (Scopus)

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., Sep 2010, In : Biomaterials. 31, 25, p. 6425-6435 11 p.

Research output: Contribution to journalArticle

Porosity
Stiffness matrix
Collagen
Cells
Cell Movement
2009
2 Citations (Scopus)

Discovery in the lab: Plato's paradox and Delbrück's principle of limited sloppiness

Grinnell, F., Jan 2009, In : FASEB Journal. 23, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

20th Century History
Ancient History
Research
27 Citations (Scopus)
Intuition
Religion and Science
Research
Research Ethics
Conflict of Interest
2008
55 Citations (Scopus)

Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices

Miron-Mendoza, M., Seemann, J. & Grinnell, F., May 2008, In : Molecular Biology of the Cell. 19, 5, p. 2051-2058 8 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Cell Movement
Skin
Microscopy
38 Citations (Scopus)

Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices

Jiang, H., Rhee, S., Ho, C. H. & Grinnell, F., Jul 2008, In : FASEB Journal. 22, 7, p. 2151-2160 10 p.

Research output: Contribution to journalArticle

Fibroblasts
sphingosine
growth factors
Sphingosine
fibroblasts
33 Citations (Scopus)

Fibroblast mechanics in three-dimensional collagen matrices

Grinnell, F., Jul 2008, In : Journal of Bodywork and Movement Therapies. 12, 3, p. 191-193 3 p.

Research output: Contribution to journalArticle

Fascia
Mechanics
Collagen
Fibroblasts
Collagen Type I
18 Citations (Scopus)

Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices

Menezes, G. C., Miron-Mendoza, M., Ho, C. H., Jiang, H. & Grinnell, F., Oct 1 2008, In : Experimental Cell Research. 314, 16, p. 3081-3091 11 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Cell Movement
Intercellular Signaling Peptides and Proteins
Contact Inhibition
2007
122 Citations (Scopus)

Fibroblast mechanics in 3D collagen matrices

Rhee, S. & Grinnell, F., Nov 10 2007, In : Advanced Drug Delivery Reviews. 59, 13, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

Mechanics
Collagen
Fibroblasts
Microtubules
Connective Tissue Cells
101 Citations (Scopus)
Cell Communication
Microtubules
Stress Fibers
Fibroblasts
Focal Adhesions
2006

Intelligent design: Fallacy recapitulates ontogeny

Grinnell, F., Mar 2006, In : FASEB Journal. 20, 3, p. 410-411 2 p.

Research output: Contribution to journalArticle

Religion and Science
Religious Philosophies
Biological Models
Dissent and Disputes
Embryonic Development
80 Citations (Scopus)

Nested collagen matrices: A new model to study migration of human fibroblast populations in three dimensions

Grinnell, F., B. Rocha, L., Iucu, C., Rhee, S. & Jiang, H., Jan 1 2006, In : Experimental Cell Research. 312, 1, p. 86-94 9 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Population
Cell Movement
Skin
54 Citations (Scopus)

P21-activated kinase 1: Convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human broblasts

Rhee, S. & Grinnell, F., Jan 30 2006, In : Journal of Cell Biology. 172, 3, p. 423-432 10 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Platelet-Derived Growth Factor
Collagen
Cell Surface Extensions
Fibroblasts
2005
70 Citations (Scopus)

Cell-matrix entanglement and mechanical anchorage of fibroblasts in three-dimensional collagen matrices

Jiang, H. & Grinnell, F., Nov 2005, In : Molecular Biology of the Cell. 16, 11, p. 5070-5076 7 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Fibronectins
Integrins
Phagocytes

Ethical decision making [3]

Grinnell, F., Aug 11 2005, In : Nature. 436, 7052, p. 776 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Misconduct: acceptable practices differ by field.

Grinnell, F., Aug 11 2005, In : Nature. 436, 7052, p. 776 1 p.

Research output: Contribution to journalArticle

Scientific Misconduct
Biomedical Research
Research Design
2004
3 Citations (Scopus)

Human embryo research: From moral uncertainty to death

Grinnell, F., 2004, In : American Journal of Bioethics. 4, 1, p. 12-13 2 p.

Research output: Contribution to journalArticle

Medical Journalism
Beginning of Human Life
Embryo Research
Moral Obligations
Embryo Loss
9 Citations (Scopus)

Subject vulnerability: The precautionary principle of human research

Grinnell, F., 2004, In : American Journal of Bioethics. 4, 3, p. 72-74 3 p.

Research output: Contribution to journalArticle

precautionary principle
vulnerability
2003
5 Citations (Scopus)

Defining embryo death would permit important research

Grinnell, F., May 16 2003, In : Chronicle of Higher Education. 49, 36 SEC.2

Research output: Contribution to journalArticle

Stem cells
Embryo
Federal funds

Defining embryo death would permit important research.

Grinnell, F., May 16 2003, In : The Chronicle of higher education. 49, 36

Research output: Contribution to journalArticle

Beginning of Human Life
Embryo Research
Embryo Loss
Value of Life
Fertilization in Vitro
159 Citations (Scopus)

Dendritic fibroblasts in three-dimensional collagen matrices

Grinnell, F., Ho, C. H., Tamariz, E., Lee, D. J. & Skuta, G., Feb 1 2003, In : Molecular Biology of the Cell. 14, 2, p. 384-395 12 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
rho-Associated Kinases
Growth Cones
Platelet-Derived Growth Factor
47 Citations (Scopus)
Platelet-Derived Growth Factor
Collagen
Myosin Type II
rho-Associated Kinases
Fibroblasts
587 Citations (Scopus)

Fibroblast biology in three-dimensional collagen matrices

Grinnell, F., May 1 2003, In : Trends in Cell Biology. 13, 5, p. 264-269 6 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Morphogenesis
Connective Tissue
Intercellular Signaling Peptides and Proteins
39 Citations (Scopus)

Fibroblast quiescence in floating collagen matrices. Decrease in serum activation of MEK and Raf but not Ras

Fringer, J. & Grinnell, F., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20612-20617 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Fibroblasts
Collagen
Chemical activation
Serum
25 Citations (Scopus)
rho-Associated Kinases
Collagen
Fibroblasts
Platelet-Derived Growth Factor
Connective Tissue
2002
6 Citations (Scopus)

Bioethical pluralism and complementarity

Grinnell, F., Bishop, J. P. & McCullough, L. B., 2002, In : Perspectives in Biology and Medicine. 45, 3, p. 338-349 12 p.

Research output: Contribution to journalArticle

multicultural diversity
Cultural Diversity
bioethics
Bioethics
Physics
180 Citations (Scopus)

Modulation of fibroblast morphology and adhesion during collagen matrix remodeling

Tamariz, E. & Grinnell, F., Nov 1 2002, In : Molecular Biology of the Cell. 13, 11, p. 3915-3929 15 p.

Research output: Contribution to journalArticle

Collagen
Fibroblasts
Focal Adhesions
Cell Communication
rho-Associated Kinases
1 Citation (Scopus)

Moral hypotheses

Grinnell, F., Oct 4 2002, In : Chronicle of Higher Education. 49, 6 SEC. 2

Research output: Contribution to journalArticle

93 Citations (Scopus)
Transforming Growth Factors
Collagen
Fibroblasts
Myofibroblasts
Actin Cytoskeleton