Galvin H Swift

  • 2488 Citations
  • 27 h-Index
1981 …2016
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1981 2016

  • 2488 Citations
  • 27 h-Index
  • 40 Article
  • 1 Chapter
Filter
Article
2016
9 Citations (Scopus)

Isolated pancreatic aplasia due to a hypomorphic PTF1A mutation

Houghton, J. A. L., Swift, G. H., Shaw-Smith, C., Flanagan, S. E., De Franco, E., Caswell, R., Hussain, K., Mohamed, S., Abdulrasoul, M., Hattersley, A. T., MacDonald, R. J. & Ellard, S., Sep 1 2016, In : Diabetes. 65, 9, p. 2810-2815 6 p.

Research output: Contribution to journalArticle

Mutation
Siblings
Exocrine Pancreatic Insufficiency
Phenotype
Missense Mutation
13 Citations (Scopus)

MIST1 and PTF1 collaborate in feed-forward regulatory loops that maintain the pancreatic acinar phenotype in adult mice

Jiang, M., Azevedo-Pouly, A. C., Deering, T. G., Hoang, C. Q., DiRenzo, D., Hess, D. A., Konieczny, S. F., Swift, G. H. & MacDonald, R. J., 2016, In : Molecular and Cellular Biology. 36, 23, p. 2945-2955 11 p.

Research output: Contribution to journalArticle

Acinar Cells
Basic Helix-Loop-Helix Transcription Factors
Phenotype
Transcription Factors
Secretory Pathway
22 Citations (Scopus)

Transcriptional maintenance of pancreatic acinar identity, differentiation, and homeostasis by PTF1A

Hoang, C. Q., Hale, M. A., Azevedo-Pouly, A. C., Elsässer, H. P., Deering, T. G., Willet, S. G., Pan, F. C., Magnuson, M. A., Wright, C. V. E., Swift, G. H. & MacDonald, R. J., 2016, In : Molecular and Cellular Biology. 36, 24, p. 3033-3047 15 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Homeostasis
Acinar Cells
Maintenance
Phenotype
2015
7 Citations (Scopus)

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ocal, O., Pashkov, V., Kollipara, R. K., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A. B., Christie, A. L., Tsoulfas, P., Lorens, J. B., Swift, G. H., Brekken, R. A. & Wilkie, T. M., Oct 1 2015, In : DMM Disease Models and Mechanisms. 8, 10, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

Tumors
Adenocarcinoma
Neoplasms
gemcitabine
G-Protein-Coupled Receptors
55 Citations (Scopus)

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

Krah, N. M., De La O., J. P., Swift, G. H., Hoang, C. Q., Willet, S. G., Pan, F. C., Cash, G. M., Bronner, M. P., Wright, C. V. E., MacDonald, R. J. & Murtaugh, L. C., Jul 7 2015, In : eLife. 4, JULY2015

Research output: Contribution to journalArticle

Gene expression
Tumors
Adenocarcinoma
Acinar Cells
Metaplasia
2014
35 Citations (Scopus)

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis

Hale, M. A., Swift, G. H., Hoang, C. Q., Deering, T. G., Masui, T., Lee, Y. K., Xue, J. & MacDonald, R. J., 2014, In : Development (Cambridge). 141, 16, p. 3123-3133 11 p.

Research output: Contribution to journalArticle

Organogenesis
Acinar Cells
Cytoplasmic and Nuclear Receptors
Stem Cells
Pancreas
2013
17 Citations (Scopus)

Program specificity for ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility

Meredith, D. M., Borromeo, M. D., Deering, T. G., Casey, B. H., Savage, T. K., Mayer, P. R., Hoang, C., Tung, K. C., Kumar, M., Shen, C., Swift, G. H., MacDonald, R. J. & Johnsona, J. E., 2013, In : Molecular and Cellular Biology. 33, 16, p. 3166-3179 14 p.

Research output: Contribution to journalArticle

Neural Tube
Chromatin
Pancreas
Basic Helix-Loop-Helix Transcription Factors
Developmental Biology
2011
60 Citations (Scopus)

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

Holmstrom, S. R., Deering, T., Swift, G. H., Poelwijk, F. J., Mangelsdorf, D. J., Kliewer, S. A. & Macdonald, R. J., Aug 15 2011, In : Genes and Development. 25, 16, p. 1674-1679 6 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Gene Regulatory Networks
Pancreas
Transcription Factors
Liver
2010
53 Citations (Scopus)

Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells

Masui, T., Swift, G. H., Deering, T., Shen, C., Coats, W. S., Long, Q., Elsässer, H. P., Magnuson, M. A. & MacDonald, R. J., Jul 2010, In : Gastroenterology. 139, 1, p. 270-280 11 p.

Research output: Contribution to journalArticle

Acinar Cells
Genes
Pancreas
Enzymes
Developmental Genes
28 Citations (Scopus)

Transcriptional control of acinar development and homeostasis

MacDonald, R. J., Swift, G. H. & Real, F. X., 2010, In : Progress in Molecular Biology and Translational Science. 97, C, p. 1-40 40 p.

Research output: Contribution to journalArticle

Acinar Cells
Homeostasis
Stem Cells
Endocrine Cells
Islets of Langerhans
2009
30 Citations (Scopus)

Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex

Meredith, D. M., Masui, T., Swift, G. H., MacDonald, R. J. & Johnson, J. E., Sep 9 2009, In : Journal of Neuroscience. 29, 36, p. 11139-11148 10 p.

Research output: Contribution to journalArticle

Nervous System
Transgenic Mice
Homeostasis
Nucleic Acid Regulatory Sequences
Reporter Genes
2008
67 Citations (Scopus)

Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood

Masui, T., Swift, G. H., Hale, M. A., Meredith, D. M., Johnson, J. E. & MacDonald, R. J., Sep 2008, In : Molecular and Cellular Biology. 28, 17, p. 5458-5468 11 p.

Research output: Contribution to journalArticle

Acinar Cells
Homeostasis
Pancreas
Embryonic Development
Epithelium
2006
11 Citations (Scopus)

A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs

Kong, Y. M., MacDonald, R. J., Wen, X., Yang, P., Barbera, V. M. & Swift, G. H., Oct 2006, In : Gene Expression Patterns. 6, 7, p. 678-686 9 p.

Research output: Contribution to journalArticle

Transcription Factors
Gene Expression
DNA
Maintenance
RNA
154 Citations (Scopus)

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian suppressor of hairless (RBP-J) or its paralogue, RBP-L

Beres, T. M., Masui, T., Swift, G. H., Shi, L., Michael Henke, R. & MacDonald, R. J., Jan 2006, In : Molecular and Cellular Biology. 26, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

Pancreas
Transcription Factors
L Forms
Exocrine Pancreas
Inborn Genetic Diseases
2003
72 Citations (Scopus)

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

Annicotte, J. S., Fayard, E., Swift, G. H., Selander, L., Edlund, H., Tanaka, T., Kodama, T., Schoonjans, K. & Auwerx, J., Oct 2003, In : Molecular and Cellular Biology. 23, 19, p. 6713-6724 12 p.

Research output: Contribution to journalArticle

Homeobox Genes
Pancreas
Liver
Chromatin Immunoprecipitation
Nucleic Acid Regulatory Sequences
2001
51 Citations (Scopus)
Private telephone exchanges
Homeodomain Proteins
Acinar Cells
HeLa Cells
Transcriptional Activation
82 Citations (Scopus)

The Role of PTF1-P48 in Pancreatic Acinar Gene Expression

Rose, S. D., Swift, G. H., Peyton, M. J., Hammer, R. E. & MacDonald, R. J., Nov 23 2001, In : Journal of Biological Chemistry. 276, 47, p. 44018-44026 9 p.

Research output: Contribution to journalArticle

Acinar Cells
Gene expression
Genes
Gene Expression
5' Flanking Region
2000
2 Citations (Scopus)

A binary mechanism for the selective action of a pancreatic β-cell transcriptional silencer

Viswanath, R. L., Rose, S. D., Swift, G. H. & MacDonald, R. J., Dec 22 2000, In : Journal of Biological Chemistry. 275, 51, p. 40273-40281 9 p.

Research output: Contribution to journalArticle

Transcription
Acinar Cells
Pancreatic Elastase
Genes
Switches
24 Citations (Scopus)

Assessment of RNA quality by semi-quantitative RT-PCR of multiple regions of a long ubiquitous mRNA

Swift, G. H., Peyton, M. J. & MacDonald, R. J., 2000, In : BioTechniques. 28, 3, p. 524-531 8 p.

Research output: Contribution to journalArticle

RNA
Polymerase Chain Reaction
Messenger RNA
Transcription
Reverse Transcription
1998
12 Citations (Scopus)

Analysis of transcriptional regulatory regions in vivo

Macdonald, R. J. & Swift, G. H., 1998, In : International Journal of Developmental Biology. 42, 7, p. 983-994 12 p.

Research output: Contribution to journalArticle

Nucleic Acid Regulatory Sequences
Genes
Gene Transfer Techniques
Pancreatic Elastase
Pancreas
141 Citations (Scopus)

An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)

Swift, G. H., Liu, Y., Rose, S. D., Bischof, L. J., Steelman, S., Buchberg, A. M., Wright, C. V. E. & Macdonald, R. J., 1998, In : Molecular and Cellular Biology. 18, 9, p. 5109-5120 12 p.

Research output: Contribution to journalArticle

Homeodomain Proteins
Acinar Cells
Cell Line
Endocrine Cells
Pancreatic Elastase
1995
33 Citations (Scopus)

Cooperation between elements of an organ-specific transcriptional enhancer in animals

Kruse, F., Rose, S. D., Swift, G. H., Hammer, R. E. & MacDonald, R. J., 1995, In : Molecular and Cellular Biology. 15, 8, p. 4385-4394 10 p.

Research output: Contribution to journalArticle

Acinar Cells
Pancreatic Elastase
Genetically Modified Animals
Islets of Langerhans
Transgenic Mice
1994
13 Citations (Scopus)

An element of the elastase I enhancer is an overlapping bipartite binding site activated by a heteromeric factor

Swift, G. H., Rose, S. D. & MacDonald, R. J., Apr 29 1994, In : Journal of Biological Chemistry. 269, 17, p. 12809-12815 7 p.

Research output: Contribution to journalArticle

Acinar Cells
Pancreatic Elastase
Methylation
Binding Sites
Cells
30 Citations (Scopus)
Human Growth Hormone
Acinar Cells
Pancreatic Elastase
Pancreas
Transgenes
1993
34 Citations (Scopus)

An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer

Kruse, F., Rose, S. D., Swift, G. H., Hammer, R. E. & MacDonald, R. J., 1993, In : Genes and Development. 7, 5, p. 774-786 13 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Acinar Cells
Islets of Langerhans
Pancreatic Elastase
Cell Lineage
1989
43 Citations (Scopus)
Acinar Cells
Pancreatic Elastase
Transgenic Mice
Cell Culture Techniques
Pancreas
1987
3 Citations (Scopus)

Chapter 1 Targeted expression of cloned genes in transgenic mice

MacDonald, R. J., Swift, G. H., Hammer, R. E., Ornitz, D. M., Davis, B. P., Brinster, R. L. & Palmiter, R. D., 1987, In : Progress in Brain Research. 71, C, p. 3-12 10 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Genetic Transcription
Endopeptidases
Pancreatic Elastase
Molecular Cloning
51 Citations (Scopus)

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

Hammer, R. E., Swift, G. H., Ornitz, D. M., Quaife, C. J., Palmiter, R. D., Brinster, R. L. & MacDonald, R. J., Aug 1987, In : Molecular and Cellular Biology. 7, 8, p. 2956-2967 12 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Transgenic Mice
Human Growth Hormone
Genes
Exocrine Pancreas
1986
14 Citations (Scopus)

Tissue-specific expression of pancreatic genes in transgenic mice.

MacDonald, R. J., Hammer, R. E., Swift, G. H., Ornitz, D. M., Davis, B. P., Palmiter, R. D. & Brinster, R. L., 1986, In : Annals of the New York Academy of Sciences. 478, p. 131-146 16 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Gene expression regulation
Endopeptidases
Recombinant DNA
Pancreatic Elastase
5 Citations (Scopus)

Transgenic progeny inherit tissue-specific expression of rat elastase I genes

MacDonald, R. J., Hammer, R. E., Swift, G. H., Davis, B. P. & Brinster, R. L., 1986, In : DNA. 5, 5, p. 393-401 9 p.

Research output: Contribution to journalArticle

Gene expression regulation
Pancreatic Elastase
Rats
Animals
Genes
1985
110 Citations (Scopus)

Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

Ornitz, D. M., Palmiter, R. D., Hammer, R. E., Brinster, R. L., Swift, G. H. & MacDonald, R. J., 1985, In : Nature. 313, 6003, p. 600-602 3 p.

Research output: Contribution to journalArticle

Human Growth Hormone
Acinar Cells
Pancreatic Elastase
Gene Fusion
Transgenic Mice

Targeted expression of cloned genes to the pancreas of transgenic mice

MacDonald, R. J., Swift, G. H. & Ornitz, D. M., 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

Transgenic Mice
Pancreas
Gene Expression
1984
66 Citations (Scopus)

Structure of the two related elastase genes expressed in the rat pancreas

Swift, G. H., Craik, C. S., Stary, S. J., Quinto, C., Lahaie, R. G., Rutter, W. J. & MacDonald, R. J., 1984, In : Journal of Biological Chemistry. 259, 22, p. 14271-14278 8 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Rats
Pancreas
Genes
Introns
123 Citations (Scopus)

Structure of two related rat pancreatic trypsin genes

Craik, C. S., Choo, Q. L., Swift, G. H., Quinto, C., MacDonald, R. J. & Rutter, W. J., 1984, In : Journal of Biological Chemistry. 259, 22, p. 14255-14264 10 p.

Research output: Contribution to journalArticle

Trypsin
Rats
Genes
Introns
Sequence Homology
113 Citations (Scopus)

Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice

Swift, G. H., Hammer, R. E., MacDonald, R. J. & Brinster, R. L., 1984, In : Cell. 38, 3, p. 639-646 8 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Transgenic Mice
Rats
Genes
Tissue
1982
89 Citations (Scopus)

Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences

MacDonald, R. J., Swift, G. H., Quinto, C., Swain, W., Pictet, R. L., Nikovits, W. & Rutter, W. J., 1982, In : Biochemistry. 21, 6, p. 1453-1463 11 p.

Research output: Contribution to journalArticle

Pancreatic Elastase
Sequence Analysis
Rats
RNA
Amino Acids
101 Citations (Scopus)

Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.

Swift, G. H., Dagorn, J. C., Ashley, P. L., Cummings, S. W. & MacDonald, R. J., Dec 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 23, p. 7263-7267 5 p.

Research output: Contribution to journalArticle

Tissue Kallikreins
Amino Acid Sequence
Kallikreins
Submandibular Gland
Messenger RNA
30 Citations (Scopus)
Pancreatic Ribonuclease
Rats
Amino Acid Sequence
Nucleotides
Amino Acids
121 Citations (Scopus)

Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide sequences of the cloned cDNAs.

MacDonald, R. J., Stary, S. J. & Swift, G. H., Aug 25 1982, In : Journal of Biological Chemistry. 257, 16, p. 9724-9732 9 p.

Research output: Contribution to journalArticle

Trypsinogen
Rats
Nucleotides
Complementary DNA
Messenger RNA
1981
56 Citations (Scopus)

DNA sequence of a plasmid-encoded dihydrofolate reductase

Swift, G., McCarthy, B. J. & Heffron, F., May 1981, In : MGG Molecular & General Genetics. 181, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Plasmids
Methotrexate
R388
Genes