• 3167 Citations
  • 24 h-Index
19972019
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Research Output 1997 2019

  • 3167 Citations
  • 24 h-Index
  • 52 Article
  • 3 Review article
  • 1 Letter
2019

Beyond bulk: a review of single cell transcriptomics methodologies and applications

Kulkarni, A., Anderson, A. G., Merullo, D. P. & Konopka, G., Aug 1 2019, In : Current Opinion in Biotechnology. 58, p. 129-136 8 p.

Research output: Contribution to journalReview article

Neurology
RNA
Brain
RNA Sequence Analysis
Gene expression
1 Citation (Scopus)

Cell type-specific epigenetic links to schizophrenia risk in the brain

Mendizabal, I., Berto, S., Usui, N., Toriumi, K., Chatterjee, P., Douglas, C., Huh, I., Jeong, H., Layman, T., Tamminga, C. A., Preuss, T. M., Konopka, G. & Yi, S. V., Jul 9 2019, In : Genome Biology. 20, 1, 135.

Research output: Contribution to journalArticle

Open Access
Epigenomics
epigenetics
brain
Schizophrenia
methylation

Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes

Hickey, S. L., Berto, S. & Konopka, G., May 7 2019, In : Cell Reports. 27, 6, p. 1699-1711.e9

Research output: Contribution to journalArticle

Open Access
Neurons
Chromatin
Genes
Brain
Aptitude
1 Citation (Scopus)

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities

Shimada, I. S., Somatilaka, B. N., Hwang, S. H., Anderson, A. G., Shelton, J. M., Rajaram, V., Konopka, G. & Mukhopadhyay, S., Jun 1 2019, In : Developmental Biology. 450, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

Hedgehogs
Prosencephalon
Neuroglia
Periventricular Nodular Heterotopia
Neuroepithelial Cells
2 Citations (Scopus)

Regulatory genes and pathways disrupted in autism spectrum disorders

Ayhan, F. & Konopka, G., Mar 8 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 89, p. 57-64 8 p.

Research output: Contribution to journalReview article

Regulator Genes
Inborn Genetic Diseases
Chromatin Assembly and Disassembly
Autism Spectrum Disorder
Alternative Splicing

The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue

Onder, Y., Laothamatas, I., Berto, S., Sewart, K., Kilaru, G., Bordieanu, B., Stubblefield, J. J., Konopka, G., Mishra, P. & Green, C. B., Sep 27 2019, In : iScience. 19, p. 83-92 10 p.

Research output: Contribution to journalArticle

Open Access
Brown Adipose Tissue
Proteins
Exonucleases
Messenger RNA
Metabolomics
2018
12 Citations (Scopus)

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

Richardson, R. B., Ohlson, M. B., Eitson, J. L., Kumar, A., McDougal, M. B., Boys, I. N., Mar, K. B., De La Cruz-Rivera, P. C., Douglas, C., Konopka, G., Xing, C. & Schoggins, J. W., Nov 1 2018, In : Nature Microbiology. 3, 11, p. 1214-1223 10 p.

Research output: Contribution to journalLetter

Clustered Regularly Interspaced Short Palindromic Repeats
Flavivirus
Endoplasmic Reticulum
Interferons
Proteins
2 Citations (Scopus)

Genomics of autism spectrum disorder: approach to therapy

Ayhan, F. & Konopka, G., Jan 1 2018, In : F1000Research. 7

Research output: Contribution to journalReview article

Open Access
Genomics
Genes
Alternative Splicing
Therapeutics
Brain
2 Citations (Scopus)

Human Genomic Signatures of Brain Oscillations During Memory Encoding

Berto, S., Wang, G. Z., Germi, J., Lega, B. C. & Konopka, G., May 1 2018, In : Cerebral cortex (New York, N.Y. : 1991). 28, 5, p. 1733-1748 16 p.

Research output: Contribution to journalArticle

Brain
Genes
Gene Expression
Episodic Memory
Neocortex
2017
10 Citations (Scopus)

Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity

Araujo, D. J., Toriumi, K., Escamilla, C. O., Kulkarni, A., Anderson, A. G., Harper, M., Usui, N., Ellegood, J., Lerch, J. P., Birnbaum, S. G., Tucker, H. O., Powell, C. M. & Konopka, G., Nov 8 2017, In : Journal of Neuroscience. 37, 45, p. 10917-10931 15 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Pyramidal Cells
Prosencephalon
Intellectual Disability
Hippocampus
11 Citations (Scopus)

Foxp1 regulation of neonatal vocalizations via cortical development

Usui, N., Araujo, D. J., Kulkarni, A., Co, M., Ellegood, J., Harper, M., Toriumi, K., Lerch, J. P. & Konopka, G., Oct 15 2017, In : Genes and Development. 31, 20, p. 2039-2055 17 p.

Research output: Contribution to journalArticle

Neocortex
Sumoylation
Brain
Prosencephalon
Mi-2 Nucleosome Remodeling and Deacetylase Complex
24 Citations (Scopus)

Kctd13 deletion reduces synaptic transmission via increased RhoA

Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z. X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S. B., López-García, I. A., Mendoza, D. B., Usui, N., Ellegood, J., Eisch, A. J., Konopka, G., Lerch, J. P., Schier, A. F., Speed, H. E. & Powell, C. M., Nov 9 2017, In : Nature. 551, 7679, p. 227-231 5 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Neurogenesis
Brain
Chromosomes, Human, Pair 16
ras Genes
7 Citations (Scopus)

Novel transcriptional networks regulated by clock in human neurons

Fontenot, M. R., Berto, S., Liu, Y., Werthmann, G., Douglas, C., Usu, N., Gleason, K., Tamminga, C. A., Takahashi, J. S. & Konopka, G., Nov 1 2017, In : Genes and Development. 31, 21, p. 2121-2135 15 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Neurons
RNA Sequence Analysis
Chromatin Immunoprecipitation
Neocortex
2016
13 Citations (Scopus)

Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution

Mendizabal, I., Shi, L., Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T. F., Hu, E., Zhang, Z., Su, B. & Yi, S. V., Nov 1 2016, In : Molecular Biology and Evolution. 33, 11, p. 2947-2959 13 p.

Research output: Contribution to journalArticle

Epigenomics
epigenetics
brain
loci
Brain
12 Citations (Scopus)

ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism

Berto, S., Usui, N., Konopka, G. & Fogel, B. L., Jun 15 2016, In : Human Molecular Genetics. 25, 12, p. 2451-2464 14 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Autistic Disorder
Neurons
RNA-Binding Proteins
Genes
29 Citations (Scopus)

Insights into the Neural and Genetic Basis of Vocal Communication

Konopka, G. & Roberts, T. F., Mar 10 2016, In : Cell. 164, 6, p. 1269-1276 8 p.

Research output: Contribution to journalArticle

Communication
Vertebrates
Networks (circuits)
Gene Regulatory Networks
Basal Ganglia
30 Citations (Scopus)

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

Harrington, A. J., Raissi, A., Rajkovich, K., Berto, S., Kumar, J., Molinaro, G., Raduazzo, J., Guo, Y., Loerwald, K., Konopka, G., Huber, K. M. & Cowan, C. W., Oct 25 2016, In : eLife. 5, OCTOBER2016, e20059.

Research output: Contribution to journalArticle

Autistic Disorder
Intellectual Disability
Synapses
Neurons
Schizophrenia
64 Citations (Scopus)

Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects

Hanners, N. W., Eitson, J. L., Usui, N., Richardson, R. B., Wexler, E. M., Konopka, G. & Schoggins, J. W., Jun 14 2016, In : Cell Reports. 15, 11, p. 2315-2322 8 p.

Research output: Contribution to journalArticle

Viruses
Pathology
Flavivirus
Microcephaly
Virus Replication
2015
13 Citations (Scopus)
Psychiatry
Animal Models
Communication
Neuronal Plasticity
Language
38 Citations (Scopus)

Correspondence between Resting-State Activity and Brain Gene Expression

Wang, G. Z., Belgard, T. G., Mao, D., Chen, L., Berto, S., Preuss, T. M., Lu, H., Geschwind, D. H. & Konopka, G., Nov 18 2015, In : Neuron. 88, 4, p. 659-666 8 p.

Research output: Contribution to journalArticle

Gene Expression
Brain
Genes
Magnetic Resonance Imaging
RNA
32 Citations (Scopus)

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H. C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R. & Konopka, G., Oct 15 2015, In : Genes and Development. 29, 20, p. 2081-2096 16 p.

Research output: Contribution to journalArticle

Corpus Striatum
Autistic Disorder
Forkhead Transcription Factors
Gene Expression
Neurons
9 Citations (Scopus)

Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development

Usui, N., Co, M., Harper, M., Rieger, M. A., Dougherty, J. D. & Konopka, G., Aug 11 2015, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Sumoylation
Purkinje Cells
Communication
Cerebellum
Language
2014
17 Citations (Scopus)

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

Wang, G. Z., Hickey, S. L., Shi, L., Huang, H. C., Nakashe, P., Koike, N., Tu, B. P., Takahashi, J. S. & Konopka, G., Dec 18 2014, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Energy utilization
Genes
Genome
Gene expression
3 Citations (Scopus)

Decoding the molecular evolution of human cognition using comparative genomics

Usui, N., Co, M. & Konopka, G., Nov 7 2014, In : Brain, Behavior and Evolution. 84, 2, p. 103-116 14 p.

Research output: Contribution to journalArticle

Molecular Evolution
Cognition Disorders
Genomics
Cognition
Gene Regulatory Networks
7 Citations (Scopus)

Influencing circadian and sleep-wake regulation for prevention and intervention in mood and anxiety disorders: What makes a good homeostat?

Frank, E., Benabou, M., Bentzley, B., Bianchi, M., Goldstein, T., Konopka, G., Maywood, E., Pritchett, D., Sheaves, B. & Thomas, J., Dec 1 2014, In : Annals of the New York Academy of Sciences. 1334, 1, p. 1-25 25 p.

Research output: Contribution to journalArticle

Anxiety Disorders
Mood Disorders
Sleep
Homeostasis
Tissue
4 Citations (Scopus)

Molecular networks and the evolution of human cognitive specializations

Fontenot, M. & Konopka, G., Dec 1 2014, In : Current Opinion in Genetics and Development. 29, p. 52-59 8 p.

Research output: Contribution to journalArticle

Molecular Evolution
Brain
Cognition
Primates
Gene Expression
21 Citations (Scopus)

Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2

Fogel, B. L., Cho, E., Wahnich, A., Gao, F., Becherel, O. J., Wang, X., Fike, F., Chen, L., Criscuolo, C., De Michele, G., Filla, A., Collins, A., Hahn, A. F., Gatti, R. A., Konopka, G., Perlman, S., Lavin, M. F., Geschwind, D. H. & Coppola, G., 2014, In : Human Molecular Genetics. 23, 18, p. 4758-4769 12 p., ddu190.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Mutation
Gene Expression
Fibroblasts
Genes
2013
6 Citations (Scopus)

Connecting signaling pathways underlying communication to ASD vulnerability

Lepp, S., Anderson, A. & Konopka, G., 2013, In : International Review of Neurobiology. 113, p. 97-133 37 p.

Research output: Contribution to journalArticle

Autistic Disorder
Language
Communication
Cognition
Genes
4 Citations (Scopus)

Decoding human gene expression signatures in the brain

Wang, G. Z. & Konopka, G., 2013, In : Transcription. 4, 3

Research output: Contribution to journalArticle

Transcriptome
Gene expression
Decoding
Brain
Molecular Evolution
1 Citation (Scopus)
Neurobiology
Autistic Disorder
Mental Disorders
Brain
2012
1 Citation (Scopus)

Differential functional constraints on the evolution of postsynaptic density proteins in neocortical laminae

Wang, G. Z. & Konopka, G., Jun 28 2012, In : PLoS One. 7, 6, e39686.

Research output: Contribution to journalArticle

laminae (animals)
Post-Synaptic Density
Genes
genes
proteins
95 Citations (Scopus)

Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution

Zeng, J., Konopka, G., Hunt, B. G., Preuss, T. M., Geschwind, D. & Yi, S. V., Sep 7 2012, In : American Journal of Human Genetics. 91, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

Pan troglodytes
Epigenomics
Methylation
DNA Methylation
Genome
133 Citations (Scopus)

Human-Specific Transcriptional Networks in the Brain

Konopka, G., Friedrich, T., Davis-Turak, J., Winden, K., Oldham, M. C., Gao, F., Chen, L., Wang, G. Z., Luo, R., Preuss, T. M. & Geschwind, D. H., Aug 23 2012, In : Neuron. 75, 4, p. 601-617 17 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Brain
Frontal Lobe
Genes
Telencephalon
53 Citations (Scopus)

Modeling the functional genomics of autism using human neurons

Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K. & Geschwind, D. H., Feb 2012, In : Molecular Psychiatry. 17, 2, p. 202-214 13 p.

Research output: Contribution to journalArticle

Autistic Disorder
Genomics
Neurons
Gene Expression
Genes
12 Citations (Scopus)

Neuroscience: Genes and human brain evolution

Geschwind, D. H. & Konopka, G., Jun 28 2012, In : Nature. 486, 7404, p. 481-482 2 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development

Fogel, B. L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G. & Geschwind, D. H., Oct 2012, In : Human Molecular Genetics. 21, 19, p. 4171-4186 16 p., dds240.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Human Development
Alternative Splicing
RNA Splicing
RNA Sequence Analysis
17 Citations (Scopus)

STAT3-iNOS signaling mediates EGFRvIII-induced glial proliferation and transformation

Puram, S. V., Yeung, C. M., Jahani-Asl, A., Lin, C., de la Iglesia, N., Konopka, G., Jackson-Grusby, L. & Bonni, A., Jun 6 2012, In : Journal of Neuroscience. 32, 23, p. 7806-7818 13 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Nitric Oxide Synthase Type II
Epidermal Growth Factor Receptor
Neuroglia
Astrocytes
1 Citation (Scopus)

The fetal brain provides a raison d'être for the evolution of new human genes

Konopka, G., Jun 2012, In : Brain, Behavior and Evolution. 79, 4, p. 213-214 2 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Developmental Gene Expression Regulation
Biological Evolution
Species Specificity
Molecular Evolution
37 Citations (Scopus)

The role of the FOXP family of transcription factors in ASD

Bowers, J. M. & Konopka, G., 2012, In : Disease Markers. 33, 5, p. 251-260 10 p.

Research output: Contribution to journalArticle

Transcription Factors
Genes
Brain
Animals
Language
2011
8 Citations (Scopus)
Neurology
Systems Analysis
Genomics
Brain
Central Nervous System
116 Citations (Scopus)

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

DeLaForest, A., Nagaoka, M., Si-Tayeb, K., Noto, F. K., Konopka, G., Battle, M. A. & Duncan, S. A., Oct 1 2011, In : Development. 138, 19, p. 4143-4153 11 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Hepatocytes
Liver
Embryoid Bodies
Feeder Cells
56 Citations (Scopus)

Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk

Mukame, Z., Konopka, G., Wexler, E., Osborn, G. E., Dong, H., Bergman, M. Y., Levitt, P. & Geschwind, D. H., Aug 10 2011, In : Journal of Neuroscience. 31, 32, p. 11437-11442 6 p.

Research output: Contribution to journalArticle

Autistic Disorder
Temporal Lobe
Genes
Cerebral Cortex
Proto-Oncogene Proteins c-met
2010
22 Citations (Scopus)

Human brain evolution: Harnessing the genomics (R)evolution to link genes, cognition, and behavior

Konopka, G. & Geschwind, D. H., Oct 21 2010, In : Neuron. 68, 2, p. 231-244 14 p.

Research output: Contribution to journalArticle

Genomics
Cognition
Brain
Genes
Genomic Structural Variation
2009
246 Citations (Scopus)

Human-specific transcriptional regulation of CNS development genes by FOXP2

Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A. & Geschwind, D. H., Nov 12 2009, In : Nature. 462, 7270, p. 213-217 5 p.

Research output: Contribution to journalArticle

Central Nervous System
Genes
Amino Acids
Language Development
Language
132 Citations (Scopus)

Neuroscience in the era of functional genomics and systems biology

Geschwind, D. H. & Konopka, G., Oct 15 2009, In : Nature. 461, 7266, p. 908-915 8 p.

Research output: Contribution to journalArticle

Systems Biology
Neurosciences
Genomics
Data Mining
Nervous System
2008
111 Citations (Scopus)

Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness

De La Iglesia, N., Konopka, G., Lim, K. L., Nutt, C. L., Bromberg, J. F., Frank, D. A., Mischel, P. S., Louis, D. N. & Bonni, A., Jun 4 2008, In : Journal of Neuroscience. 28, 23, p. 5870-5878 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Glioblastoma
Interleukin-8
Cell Proliferation
Neoplasms
442 Citations (Scopus)

Functional organization of the transcriptome in human brain

Oldham, M. C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S. & Geschwind, D. H., Nov 2008, In : Nature Neuroscience. 11, 11, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

Transcriptome
Brain
Astrocytes
Program Development
Neural Stem Cells
234 Citations (Scopus)

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

De La Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J., Levy, D. E., DePinho, R. A. & Bonni, A., Feb 15 2008, In : Genes and Development. 22, 4, p. 449-462 14 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Glioblastoma
Neoplasms
Neuroglia
Astrocytes
2007
173 Citations (Scopus)

Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain

Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B. & Geschwind, D. H., 2007, In : American Journal of Human Genetics. 81, 6, p. 1144-1157 14 p.

Research output: Contribution to journalArticle

Language
Brain
Genes
Frontal Lobe
Basal Ganglia
35 Citations (Scopus)

Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells

Konopka, G., Tekiela, J., Iverson, M., Wells, C. & Duncan, S. A., Sep 21 2007, In : Journal of Biological Chemistry. 282, 38, p. 28137-28148 12 p.

Research output: Contribution to journalArticle

Junctional Adhesion Molecule A
Cadherins
Tight Junction Proteins
Hepatocytes
Adherens Junctions