• 3405 Citations
  • 26 h-Index
19972020

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Article
2020

Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression

Co, M., Hickey, S. L., Kulkarni, A., Harper, M. & Konopka, G., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1855-1870 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epigenetic inheritance of circadian period in clonal cells

Li, Y., Shan, Y., Kilaru, G., Berto, S., Wang, G. Z., Cox, K. H., Yoo, S. H., Yang, S., Konopka, G. & Takahashi, J. S., May 2020, In : eLife. 9, p. 1-36 36 p., e54186.

Research output: Contribution to journalArticle

Open Access

Hippocampal subfield transcriptome analysis in schizophrenia psychosis

Perez, J. M., Berto, S., Gleason, K., Ghose, S., Tan, C., Kim, T. K., Konopka, G. & Tamminga, C. A., Jan 1 2020, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome–like Behaviors in Mice

Harrington, A. J., Bridges, C. M., Berto, S., Blankenship, K., Cho, J. Y., Assali, A., Siemsen, B. M., Moore, H. W., Tsvetkov, E., Thielking, A., Konopka, G., Everman, D. B., Scofield, M. D., Skinner, S. A. & Cowan, C. W., 2020, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development

Anderson, A. G., Kulkarni, A., Harper, M. & Konopka, G., Mar 3 2020, In : Cell Reports. 30, 9, p. 3051-3066.e7

Research output: Contribution to journalArticle

Open Access
2019

Accelerated evolution of oligodendrocytes in the human brain

Berto, S., Mendizabal, I., Usui, N., Toriumi, K., Chatterjee, P., Douglas, C., Tamminga, C. A., Preuss, T. M., Yi, S. V. & Konopka, G., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24334-24342 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cell type-specific epigenetic links to schizophrenia risk in the brain

Mendizabal, I., Berto, S., Usui, N., Toriumi, K., Chatterjee, P., Douglas, C., Huh, I., Jeong, H., Layman, T., Tamminga, C. A., Preuss, T. M., Konopka, G. & Yi, S. V., Jul 9 2019, In : Genome biology. 20, 1, 135.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes

Hickey, S. L., Berto, S. & Konopka, G., May 7 2019, In : Cell Reports. 27, 6, p. 1699-1711.e9

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities

Shimada, I. S., Somatilaka, B. N., Hwang, S. H., Anderson, A. G., Shelton, J. M., Rajaram, V., Konopka, G. & Mukhopadhyay, S., Jun 1 2019, In : Developmental Biology. 450, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue

Onder, Y., Laothamatas, I., Berto, S., Sewart, K., Kilaru, G., Bordieanu, B., Stubblefield, J. J., Konopka, G., Mishra, P. & Green, C. B., Sep 27 2019, In : iScience. 19, p. 83-92 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Human Genomic Signatures of Brain Oscillations During Memory Encoding

Berto, S., Wang, G. Z., Germi, J., Lega, B. C. & Konopka, G., May 1 2018, In : Cerebral cortex (New York, N.Y. : 1991). 28, 5, p. 1733-1748 16 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Cognitive genomics: Linking genes to behavior in the human brain

Konopka, G., Jan 1 2017, In : Network Neuroscience. 1, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity

Araujo, D. J., Toriumi, K., Escamilla, C. O., Kulkarni, A., Anderson, A. G., Harper, M., Usui, N., Ellegood, J., Lerch, J. P., Birnbaum, S. G., Tucker, H. O., Powell, C. M. & Konopka, G., Nov 8 2017, In : Journal of Neuroscience. 37, 45, p. 10917-10931 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Foxp1 regulation of neonatal vocalizations via cortical development

Usui, N., Araujo, D. J., Kulkarni, A., Co, M., Ellegood, J., Harper, M., Toriumi, K., Lerch, J. P. & Konopka, G., Oct 15 2017, In : Genes and Development. 31, 20, p. 2039-2055 17 p.

Research output: Contribution to journalArticle

17 Scopus citations

Kctd13 deletion reduces synaptic transmission via increased RhoA

Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z. X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S. B., López-García, I. A., Mendoza, D. B., Usui, N., Ellegood, J., Eisch, A. J., Konopka, G., Lerch, J. P., Schier, A. F., Speed, H. E. & Powell, C. M., Nov 9 2017, In : Nature. 551, 7679, p. 227-231 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Novel transcriptional networks regulated by clock in human neurons

Fontenot, M. R., Berto, S., Liu, Y., Werthmann, G., Douglas, C., Usu, N., Gleason, K., Tamminga, C. A., Takahashi, J. S. & Konopka, G., Nov 1 2017, In : Genes and Development. 31, 21, p. 2121-2135 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution

Mendizabal, I., Shi, L., Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T. F., Hu, E., Zhang, Z., Su, B. & Yi, S. V., Nov 1 2016, In : Molecular biology and evolution. 33, 11, p. 2947-2959 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism

Berto, S., Usui, N., Konopka, G. & Fogel, B. L., Jun 15 2016, In : Human molecular genetics. 25, 12, p. 2451-2464 14 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Insights into the Neural and Genetic Basis of Vocal Communication

Konopka, G. & Roberts, T. F., Mar 10 2016, In : Cell. 164, 6, p. 1269-1276 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

Harrington, A. J., Raissi, A., Rajkovich, K., Berto, S., Kumar, J., Molinaro, G., Raduazzo, J., Guo, Y., Loerwald, K., Konopka, G., Huber, K. M. & Cowan, C. W., Oct 25 2016, In : eLife. 5, OCTOBER2016, e20059.

Research output: Contribution to journalArticle

43 Scopus citations

Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects

Hanners, N. W., Eitson, J. L., Usui, N., Richardson, R. B., Wexler, E. M., Konopka, G. & Schoggins, J. W., Jun 14 2016, In : Cell Reports. 15, 11, p. 2315-2322 8 p.

Research output: Contribution to journalArticle

69 Scopus citations
2015
17 Scopus citations

Correspondence between Resting-State Activity and Brain Gene Expression

Wang, G. Z., Belgard, T. G., Mao, D., Chen, L., Berto, S., Preuss, T. M., Lu, H., Geschwind, D. H. & Konopka, G., Nov 18 2015, In : Neuron. 88, 4, p. 659-666 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H. C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R. & Konopka, G., Oct 15 2015, In : Genes and Development. 29, 20, p. 2081-2096 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development

Usui, N., Co, M., Harper, M., Rieger, M. A., Dougherty, J. D. & Konopka, G., Aug 11 2015, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

Wang, G. Z., Hickey, S. L., Shi, L., Huang, H. C., Nakashe, P., Koike, N., Tu, B. P., Takahashi, J. S. & Konopka, G., Dec 18 2014, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

19 Scopus citations

Decoding the molecular evolution of human cognition using comparative genomics

Usui, N., Co, M. & Konopka, G., Nov 7 2014, In : Brain, Behavior and Evolution. 84, 2, p. 103-116 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Influencing circadian and sleep-wake regulation for prevention and intervention in mood and anxiety disorders: What makes a good homeostat?

Frank, E., Benabou, M., Bentzley, B., Bianchi, M., Goldstein, T., Konopka, G., Maywood, E., Pritchett, D., Sheaves, B. & Thomas, J., Dec 1 2014, In : Annals of the New York Academy of Sciences. 1334, 1, p. 1-25 25 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2

Fogel, B. L., Cho, E., Wahnich, A., Gao, F., Becherel, O. J., Wang, X., Fike, F., Chen, L., Criscuolo, C., De Michele, G., Filla, A., Collins, A., Hahn, A. F., Gatti, R. A., Konopka, G., Perlman, S., Lavin, M. F., Geschwind, D. H. & Coppola, G., Sep 2014, In : Human molecular genetics. 23, 18, p. 4758-4769 12 p., ddu190.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Connecting signaling pathways underlying communication to ASD vulnerability

Lepp, S., Anderson, A. & Konopka, G., 2013, In : International Review of Neurobiology. 113, p. 97-133 37 p.

Research output: Contribution to journalArticle

7 Scopus citations

Decoding human gene expression signatures in the brain

Wang, G. Z. & Konopka, G., Jan 1 2013, In : Transcription. 4, 3

Research output: Contribution to journalArticle

4 Scopus citations
2012

Differential functional constraints on the evolution of postsynaptic density proteins in neocortical laminae

Wang, G. Z. & Konopka, G., Jun 28 2012, In : PloS one. 7, 6, e39686.

Research output: Contribution to journalArticle

1 Scopus citations

Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution

Zeng, J., Konopka, G., Hunt, B. G., Preuss, T. M., Geschwind, D. & Yi, S. V., Sep 7 2012, In : American Journal of Human Genetics. 91, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Human-Specific Transcriptional Networks in the Brain

Konopka, G., Friedrich, T., Davis-Turak, J., Winden, K., Oldham, M. C., Gao, F., Chen, L., Wang, G. Z., Luo, R., Preuss, T. M. & Geschwind, D. H., Aug 23 2012, In : Neuron. 75, 4, p. 601-617 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Modeling the functional genomics of autism using human neurons

Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K. & Geschwind, D. H., Feb 2012, In : Molecular psychiatry. 17, 2, p. 202-214 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development

Fogel, B. L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G. & Geschwind, D. H., Oct 2012, In : Human molecular genetics. 21, 19, p. 4171-4186 16 p., dds240.

Research output: Contribution to journalArticle

112 Scopus citations

STAT3-iNOS signaling mediates EGFRvIII-induced glial proliferation and transformation

Puram, S. V., Yeung, C. M., Jahani-Asl, A., Lin, C., de la Iglesia, N., Konopka, G., Jackson-Grusby, L. & Bonni, A., Jun 6 2012, In : Journal of Neuroscience. 32, 23, p. 7806-7818 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

DeLaForest, A., Nagaoka, M., Si-Tayeb, K., Noto, F. K., Konopka, G., Battle, M. A. & Duncan, S. A., Oct 1 2011, In : Development. 138, 19, p. 4143-4153 11 p.

Research output: Contribution to journalArticle

123 Scopus citations

Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk

Mukame, Z., Konopka, G., Wexler, E., Osborn, G. E., Dong, H., Bergman, M. Y., Levitt, P. & Geschwind, D. H., Aug 10 2011, In : Journal of Neuroscience. 31, 32, p. 11437-11442 6 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Human-specific transcriptional regulation of CNS development genes by FOXP2

Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A. & Geschwind, D. H., Nov 12 2009, In : Nature. 462, 7270, p. 213-217 5 p.

Research output: Contribution to journalArticle

255 Scopus citations
2008

Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness

De La Iglesia, N., Konopka, G., Lim, K. L., Nutt, C. L., Bromberg, J. F., Frank, D. A., Mischel, P. S., Louis, D. N. & Bonni, A., Jun 4 2008, In : Journal of Neuroscience. 28, 23, p. 5870-5878 9 p.

Research output: Contribution to journalArticle

116 Scopus citations

Functional organization of the transcriptome in human brain

Oldham, M. C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S. & Geschwind, D. H., Nov 1 2008, In : Nature neuroscience. 11, 11, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

464 Scopus citations

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

De La Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J., Levy, D. E., DePinho, R. A. & Bonni, A., Feb 15 2008, In : Genes and Development. 22, 4, p. 449-462 14 p.

Research output: Contribution to journalArticle

241 Scopus citations
2007

Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain

Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B. & Geschwind, D. H., 2007, In : American Journal of Human Genetics. 81, 6, p. 1144-1157 14 p.

Research output: Contribution to journalArticle

178 Scopus citations

Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells

Konopka, G., Tekiela, J., Iverson, M., Wells, C. & Duncan, S. A., Sep 21 2007, In : Journal of Biological Chemistry. 282, 38, p. 28137-28148 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006

Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M. & Duncan, S. A., May 30 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 22, p. 8419-8424 6 p.

Research output: Contribution to journalArticle

178 Scopus citations
2004

Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain

Chylack, L. T., Fu, L., Mancini, R., Martin-Rehrmann, M. D., Saunders, A. J., Konopka, G., Tian, D., Hedley-Whyte, E. T., Folkerth, R. D. & Goldstein, L. E., Dec 1 2004, In : Experimental Eye Research. 79, 6, p. 941-948 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2001

Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid β-peptide

Puglielli, L., Konopka, G., Pack-Chung, E., Ingano, L. A. M., Berezovska, O., Hyman, B. T., Chang, T. Y., Tanzi, R. E. & Kovacs, D. M., Oct 22 2001, In : Nature Cell Biology. 3, 10, p. 905-912 8 p.

Research output: Contribution to journalArticle

338 Scopus citations
2000

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose)polymerase

Simbulan-Rosenthal, C. M., Ly, D. H., Rosenthal, D. S., Konopka, G., Luo, R., Wang, Z. Q., Schultz, P. G. & Smulson, M. E., Oct 10 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 21, p. 11274-11279 6 p.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations
1997

Mechanism and prevention of neurotoxicity caused by β-amyloid peptides: Relation to Alzheimer's disease

Blanchard, B. J., Konopka, G., Russell, M. & Ingram, V. M., Nov 21 1997, In : Brain Research. 776, 1-2, p. 40-50 11 p.

Research output: Contribution to journalArticle

60 Scopus citations