• 952 Citations
  • 12 h-Index
20092020

Research output per year

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Research Output

  • 952 Citations
  • 12 h-Index
  • 13 Article
  • 2 Book
  • 1 Comment/debate
  • 1 Review article
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Article
2019

Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase

Hoxhaj, G., Ben-Sahra, I., Lockwood, S. E., Timson, R. C., Byles, V., Henning, G. T., Gao, P., Selfors, L. M., Asara, J. M. & Manning, B. D., 2019, In : Science. 363, 6431, p. 1088-1092 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

Howell, J. J., Hellberg, K., Turner, M., Talbott, G., Kolar, M. J., Ross, D. S., Hoxhaj, G., Saghatelian, A., Shaw, R. J. & Manning, B. D., Feb 7 2017, In : Cell Metabolism. 25, 2, p. 463-471 9 p.

Research output: Contribution to journalArticle

Open Access
94 Scopus citations

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

Heintz, C., Doktor, T. K., Lanjuin, A., Escoubas, C. C., Zhang, Y., Weir, H. J., Dutta, S., Silva-García, C. G., Bruun, G. H., Morantte, I., Hoxhaj, G., Manning, B. D., Andresen, B. S. & Mair, W. B., Jan 5 2017, In : Nature. 541, 7635, p. 102-106 5 p.

Research output: Contribution to journalArticle

66 Scopus citations

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Hoxhaj, G., Hughes-Hallett, J., Timson, R. C., Ilagan, E., Yuan, M., Asara, J. M., Ben-Sahra, I. & Manning, B. D., Oct 31 2017, In : Cell Reports. 21, 5, p. 1331-1346 16 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
2016

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M. & Manning, B. D., Feb 12 2016, In : Science. 351, 6274, p. 728-733 6 p.

Research output: Contribution to journalArticle

Open Access
243 Scopus citations

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., Apr 22 2016, In : eLife. 5, APRIL2016, e12278.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2014

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & MacKintosh, C., 2014, In : Database. 2014

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

Menon, S., Dibble, C. C., Talbott, G., Hoxhaj, G., Valvezan, A. J., Takahashi, H., Cantley, L. C. & Manning, B. D., Feb 13 2014, In : Cell. 156, 4, p. 771-785 15 p.

Research output: Contribution to journalArticle

Open Access
354 Scopus citations
2013

Effect of IRS4 Levels on PI 3-Kinase Signalling

Hoxhaj, G., Dissanayake, K. & MacKintosh, C., Sep 10 2013, In : PloS one. 8, 9, e73327.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2012

MENA is a transcriptional target of the Wnt/beta-catenin pathway

Najafov, A., Şeker, T., Even, I., Hoxhaj, G., Selvi, O., Özel, D. E., Koman, A. & Birgül-Iyison, N., May 17 2012, In : PloS one. 7, 5, e37013.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 2012, In : Journal of cell science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2010

Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets

Kavak, E., Najafov, A., Ozturk, N., Seker, T., Cavusoglu, K., Aslan, T., Duru, A. D., Saygili, T., Hoxhaj, G., Hiz, M. C., Unal, D. O., Birgül-Iyison, N., Ozturk, M. & Koman, A., Oct 2010, In : Cellular Signalling. 22, 10, p. 1523-1535 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2009

An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells

Jeong, J. Y., Hoxhaj, G., Socha, A. L., Sytkowski, A. J. & Feldman, L., Jul 2009, In : Molecular Cancer Research. 7, 7, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations