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Research Output 2006 2019

  • 845 Citations
  • 13 h-Index
  • 16 Article
  • 1 Comment/debate
  • 1 Letter
  • 1 Review article
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Article
2019

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells
2018
13 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
5 Citations (Scopus)

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Dimerization
Toll-Like Receptors
Screening
Toll-Like Receptor 2
Macrophages
2016
3 Citations (Scopus)

Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893))

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. E2096

Research output: Contribution to journalArticle

76 Citations (Scopus)

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D. C., Shi, H., Gorka, O., Koenig, P. A., Fromm, S., Magnani, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A. A. B., Cooper, M. A., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P. & 7 others, Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F. & Groß, O., Oct 18 2016, In : Immunity. 45, 4, p. 761-773 13 p.

Research output: Contribution to journalArticle

imiquimod
Inflammasomes
Mitochondria
Toll-Like Receptor 7
Skin Neoplasms
50 Citations (Scopus)

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M. R. P., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M. Y., Berger, M., Zhan, X., Zhang, H., Boger, D. L. & Beutler, B., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E884-E893

Research output: Contribution to journalArticle

Lipopolysaccharides
Lipid A
Ligands
Peptidomimetics
Toll-Like Receptor 4
2015
158 Citations (Scopus)

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C. & 4 others, Moresco, E. M. Y., Monson, N. L., Ulevitch, R. J. & Beutler, B., Dec 7 2015, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Inflammasomes
Mitosis
Caspase 1
Interleukin-18
Protein-Serine-Threonine Kinases
29 Citations (Scopus)

Real-time resolution of point mutations that cause phenovariance in mice

Wang, T., Zhan, X., Bua, C. H., Lyona, S., Pratta, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E. E., Chen, Z., Zhang Ph.D., D-W., Yue, T., Wang, Y., Shi, H-X., Wang, J., Sun, L., SoRelle, J., McAlpine, W. & 28 others, Hutchins, N., Zhan, X., Fin, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J. L., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M. Y., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. & Beutler, B. A., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E440-E449

Research output: Contribution to journalArticle

Point Mutation
Mutation
Ethylnitrosourea
Phenotype
High-Throughput Nucleotide Sequencing
2012
47 Citations (Scopus)

iRhom2 is required for the secretion of mouse TNFα

Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. & Beutler, B., Jun 14 2012, In : Blood. 119, 24, p. 5769-5771 3 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Gene encoding
Macrophages
Toll-Like Receptors
Missense Mutation
2011
36 Citations (Scopus)

Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action

Shi, H. X., Liu, X., Wang, Q., Tang, P. P., Liu, X. Y., Shan, Y. F. & Wang, C., May 1 2011, In : PLoS Pathogens. 7, 5, e1002057.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Toll-Like Receptors
Mitochondria
imiquimod
2010
124 Citations (Scopus)

Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

Shi, H. X., Yang, K., Liu, X., Liu, X. Y., Wei, B., Shan, Y. F., Zhu, L. H. & Wang, C., May 1 2010, In : Molecular and Cellular Biology. 30, 10, p. 2424-2436 13 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Antiviral Agents
Virus Diseases
Ubiquitins
Sendai virus
58 Citations (Scopus)

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

Liu, X. Y., Wei, B., Shi, H. X., Shan, Y. F. & Wang, C., Sep 1 2010, In : Cell Research. 20, 9, p. 994-1011 18 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Mitochondria
Phosphotransferases
Membranes
RNA Virus Infections
2009
107 Citations (Scopus)

TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response

Yang, K., Shi, H. X., Liu, X. Y., Shan, Y. F., Wei, B., Chen, S. & Wang, C., Mar 15 2009, In : Journal of Immunology. 182, 6, p. 3782-3792 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Antiviral Agents
RNA Virus Infections
Ubiquitination
Virus Diseases
2007
38 Citations (Scopus)

UXT is a novel and essential cofactor in the NF-κB transcriptional enhanceosome

Sun, S., Tang, Y., Lou, X., Zhu, L., Yang, K., Zhang, B., Shi, H. & Wang, C., Jul 16 2007, In : Journal of Cell Biology. 178, 2, p. 231-244 14 p.

Research output: Contribution to journalArticle

RNA Interference
Human Activities
Immunity
Prostatic Neoplasms
Cytoplasm
2006
26 Citations (Scopus)

An ankyrin repeat-containing protein, characterized as a ubiquitin ligase, is closely associated with membrane-enclosed organelles and required for pollen germination and pollen tube growth in lily

Huang, J., Chen, F., Del Casino, C., Autino, A., Shen, M., Yuan, S., Peng, J., Shi, H., Wang, C., Cresti, M. & Li, Y., Apr 1 2006, In : Plant Physiology. 140, 4, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

Lilium
Ankyrin Repeat
Pollen Tube
ankyrins
pollen germination
64 Citations (Scopus)

Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells

Yang, K., Shi, H., Qi, R., Sun, S., Tang, Y., Zhang, B. & Wang, C., Mar 1 2006, In : Molecular Biology of the Cell. 17, 3, p. 1461-1471 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
HSP90 Heat-Shock Proteins
Sendai virus
Phosphorylation
Viruses