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Article
2019

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis

Villalobos, E., Criollo, A., Schiattarella, G. G., Altamirano, F., French, K. M., May, H. I., Jiang, N., Nguyen, N. U. N., Romero, D., Roa, J. C., García, L., Diaz-Araya, G., Morselli, E., Ferdous, A., Conway, S. J., Sadek, H. A., Gillette, T. G., Lavandero, S. & Hill, J. A., May 14 2019, In : Circulation. 139, 20, p. 2342-2357 16 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Neonatal Heart Regeneration

Lam, N. T. & Sadek, H. A., Jul 24 2018, In : Circulation. 138, 4, p. 412-423 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis

Rotter, D., Peiris, H., Grinsfelder, D. B., Martin, A. M., Burchfield, J., Parra, V., Hull, C., Morales, C. R., Jessup, C. F., Matusica, D., Parks, B. W., Lusis, A. J., Nguyen, N. U. N., Oh, M., Iyoke, I., Jakkampudi, T., McMillan, D. R., Sadek, H. A., Watt, M. J., Gupta, R. K. & 3 others, Pritchard, M. A., Keating, D. J. & Rothermel, B. A., Jan 1 2018, (Accepted/In press) In : EMBO Reports. e44706.

Research output: Contribution to journalArticle

3 Scopus citations

The Effect of Hypoxia on Cardiovascular Disease: Friend or Foe?

Savla, J. J., Levine, B. D. & Sadek, H. A., Jun 1 2018, In : High Altitude Medicine and Biology. 19, 2, p. 124-130 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Cardiomyocyte regeneration: A consensus statement

Eschenhagen, T., Bolli, R., Braun, T., Field, L. J., Fleischmann, B. K., Frisén, J., Giacca, M., Hare, J. M., Houser, S., Lee, R. T., Marbán, E., Martin, J. F., Molkentin, J. D., Murry, C. E., Riley, P. R., Ruiz-Lozano, P., Sadek, H. A., Sussman, M. A. & Hill, J. A., Aug 1 2017, In : Circulation. 136, 7, p. 680-686 7 p.

Research output: Contribution to journalArticle

138 Scopus citations

Cardiomyocyte renewal in the human heart: Insights fromthe fall-out

Lázár, E., Sadek, H. A. & Bergmann, O., Aug 7 2017, In : European Heart Journal. 38, 30, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association

on behalf of the American Heart Association Council on Basic Cardiovascular Sciences; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Stroke Council, Jun 26 2017, (Accepted/In press) In : Circulation Research.

Research output: Contribution to journalArticle

3 Scopus citations

Hypoxia-induced myocardial regeneration

Kimura, W., Nakada, Y. & Sadek, H. A., Dec 1 2017, In : Journal of applied physiology (Bethesda, Md. : 1985). 123, 6, p. 1676-1681 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hypoxia induces heart regeneration in adult mice

Nakada, Y., Canseco, D. C., Thet, S., Abdisalaam, S., Aroumougame, A., Santos, C. X., Shah, A. M., Zhang, H., Faber, J. E., Kinter, M. T., Szweda, L. I., Xing, C., Hu, Z., DeBerardinis, R. J., Schiattarella, G., Hill, J. A., Oz, O. K., Lu, Z., Zhang, C., Kimura, W. & 1 others, Sadek, H. A., Jan 12 2017, In : Nature. 541, 7636, p. 222-227 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Hypoxia promotes primitive glycosaminoglycan-rich extracellular matrix composition in developing heart valves

Amofa, D., Hulin, A., Nakada, Y., Sadek, H. A. & Yutzey, K. E., Dec 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 6, p. H1143-H1154

Research output: Contribution to journalArticle

7 Scopus citations
2016

Erratum: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart (Nature (2015) 523 (226-230) DOI: 10.1038/nature14582)

Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet, S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Aroumougame, A., Liang, H., Xing, C., Lu, Z., Zhang, C. & Sadek, H. A., Apr 14 2016, In : Nature. 532, 7598, p. 268 1 p.

Research output: Contribution to journalArticle

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer

Mani, R. S., Amin, M. A., Li, X., Kalyana-Sundaram, S., Veeneman, B. A., Wang, L., Ghosh, A., Aslam, A., Ramanand, S. G., Rabquer, B. J., Kimura, W., Tran, M., Cao, X., Roychowdhury, S., Dhanasekaran, S. M., Palanisamy, N., Sadek, H. A., Kapur, P., Koch, A. E. & Chinnaiyan, A. M., Dec 6 2016, In : Cell Reports. 17, 10, p. 2620-2631 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Redox regulation of heart regeneration: An evolutionary tradeoff

Elhelaly, W. M., Lam, N. T., Hamza, M., Xia, S. & Sadek, H. A., Dec 15 2016, In : Frontiers in Cell and Developmental Biology. 4, DEC, 137.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2015

Defining the Limit of Embryonic Heart Regeneration

Nakada, Y., Kimura, W. & Sadek, H. A., Jul 14 2015, In : Circulation. 132, 2, p. 77-78 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human ventricular unloading induces cardiomyocyte proliferation

Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby, A., Mammen, P. P. A. & Sadek, H. A., Mar 10 2015, In : Journal of the American College of Cardiology. 65, 9, p. 892-900 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet, S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Aroumougame, A., Liang, H., Xing, C., Lu, Z., Zhang, C. & Sadek, H. A., Jul 9 2015, In : Nature. 523, 7559, p. 226-230 5 p.

Research output: Contribution to journalArticle

133 Scopus citations

Hypoxic metabolism in human hematopoietic stem cells

Kocabas, F., Xie, L., Xie, J., Yu, Z., DeBerardinis, R. J., Kimura, W., Thet, S. W., Elshamy, A. F., Abouellail, H., Muralidhar, S., Liu, X., Chen, C., Sadek, H. A., Zhang, C. C. & Zheng, J., Jul 17 2015, In : Cell and Bioscience. 5, 1, 39.

Research output: Contribution to journalArticle

19 Scopus citations

Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

Rimmelé, P., Liang, R., Bigarella, C. L., Kocabas, F., Xie, J., Serasinghe, M. N., Chipuk, J., Sadek, H. A., Zhang, C. & Ghaffari, S., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1164-1176 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Macrophages are required for neonatal heart regeneration

Aurora, A. B., Porrello, E. R., Tan, W., Mahmoud, A. I., Hill, J. A., Bassel-Duby, R., Sadek, H. A. & Olson, E. N., Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1382-1392 11 p.

Research output: Contribution to journalArticle

301 Scopus citations

Metabolic characterization of hematopoietic stem cells

Kocabas, F., Zheng, J., Zhang, C. & Sadek, H. A., 2014, In : Methods in molecular biology (Clifton, N.J.). 1185, p. 155-164 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow

Zheng, J., Lu, Z., Kocabas, F., Böttcher, R. T., Costell, M., Kang, X., Liu, X., DeBerardinis, R. J., Wang, Q., Chen, G. Q., Sadek, H. A. & Zhang, C., Feb 13 2014, In : Blood. 123, 7, p. 992-1001 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Surgical models for cardiac regeneration in neonatal mice

Mahmoud, A. I., Porrello, E. R., Kimura, W., Olson, E. N. & Sadek, H. A., Feb 1 2014, In : Nature Protocols. 9, 2, p. 305-311 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., Apr 24 2014, In : Cell. 157, 3, p. 565-579 15 p.

Research output: Contribution to journalArticle

269 Scopus citations
2013

Hippo pathway effector Yap promotes cardiac regeneration

Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., Richardson, J. A., Sadek, H. A., Bassel-Duby, R. & Olson, E. N., Aug 28 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 34, p. 13839-13844 6 p.

Research output: Contribution to journalArticle

380 Scopus citations

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

Mahmoud, A. I., Kocabas, F., Muralidhar, S. A., Kimura, W., Koura, A. S., Thet, S., Porrello, E. R. & Sadek, H. A., Apr 18 2013, In : Nature. 497, 7448, p. 249-253 5 p.

Research output: Contribution to journalArticle

256 Scopus citations

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

Porrello, E. R., Mahmoud, A. I., Simpson, E., Johnson, B. A., Grinsfelder, D., Canseco, D., Mammen, P. P., Rothermel, B. A., Olson, E. N. & Sadek, H. A., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 187-192 6 p.

Research output: Contribution to journalArticle

344 Scopus citations
2012

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

Kocabas, F., Zheng, J., Thet, S., Copeland, N. G., Jenkins, N. A., DeBerardinis, R. J., Zhang, C. & Sadek, H. A., Dec 13 2012, In : Blood. 120, 25, p. 4963-4972 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca 2+ overload and cell death

Aurora, A. B., Mahmoud, A. I., Luo, X., Johnson, B. A., Van Rooij, E., Matsuzaki, S., Humphries, K. M., Hill, J. A., Bassel-Duby, R. S., Sadek, H. A. & Olson, E. N., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1222-1232 11 p.

Research output: Contribution to journalArticle

254 Scopus citations
48 Scopus citations

The hypoxic epicardial and subepicardial microenvironment

Kocabas, F., Mahmoud, A. I., Sosic, D., Porrello, E. R., Chen, R., Garcia, J. A., Deberardinis, R. J. & Sadek, H. A., Oct 2012, In : Journal of cardiovascular translational research. 5, 5, p. 654-665 12 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Transient regenerative potential of the neonatal mouse heart

Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N. & Sadek, H. A., Feb 25 2011, In : Science. 331, 6020, p. 1078-1080 3 p.

Research output: Contribution to journalArticle

1119 Scopus citations
2010

Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction

Small, E. M., Thatcher, J. E., Sutherland, L. B., Kinoshita, H., Gerard, R. D., Richardson, J. A., Dimaio, J. M., Sadek, H., Kuwahara, K. & Olson, E. N., Jul 23 2010, In : Circulation research. 107, 2, p. 294-304 11 p.

Research output: Contribution to journalArticle

225 Scopus citations

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. & Sadek, H. A., Sep 3 2010, In : Cell Stem Cell. 7, 3, p. 380-390 11 p.

Research output: Contribution to journalArticle

545 Scopus citations
2009

Bone-marrow-derived side population cells for myocardial regeneration

Sadek, H. A., Martin, C. M., Latif, S. S., Garry, M. G. & Garry, D. J., Jun 1 2009, In : Journal of cardiovascular translational research. 2, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Cardiogenic small molecules that enhance myocardial repair by stem cells

Sadek, H. A., Hannack, B., Choe, E., Wang, J., Latif, S., Garry, M. G., Garry, D. J., Longgood, J., Frantz, D. E., Olson, E. N., Hsieh, J. & Schneider, J. W., Apr 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6063-6068 6 p.

Research output: Contribution to journalArticle

104 Scopus citations

Hypoxia-inducible factor-2α transactivates Abcg2 and promotes cytoprotection in cardiac side population cells

Martin, C. M., Ferdous, A., Gallardo, T., Humphries, C., Sadek, H., Caprioli, A., Garcia, J. A., Szweda, L. I., Garry, M. G. & Garry, D. J., May 1 2008, In : Circulation research. 102, 9, p. 1075-1081 7 p.

Research output: Contribution to journalArticle

101 Scopus citations

Use of ferumoxides for stem cell labeling

Sadek, H., Latif, S., Collins, R., Garry, M. G. & Garry, D. J., Dec 1 2008, In : Regenerative Medicine. 3, 6, p. 807-816 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Real time embolization of a mitral valve vegetation

Sadek, H. A. & Hoit, B. D., Aug 1 2007, In : Echocardiography. 24, 7, p. 768-769 2 p.

Research output: Contribution to journalArticle

2006

Case of anomalous right superior vena cava

Sadek, H., Gilkeson, R. C., Hoit, B. D. & Brozovich, F. V., Oct 1 2006, In : Circulation. 114, 15, p. e532-e533

Research output: Contribution to journalArticle

4 Scopus citations
2004

Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate

Nulton-Persson, A. C., Szweda, L. I. & Sadek, H. A., Nov 1 2004, In : Journal of Cardiovascular Pharmacology. 44, 5, p. 591-595 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Modulation of mitochondrial complex I activity by reversible Ca 2+ and NADH mediated superoxide anion dependent inhibition

Sadek, H. A., Szweda, P. A. & Szweda, L. I., Jul 6 2004, In : Biochemistry. 43, 26, p. 8494-8502 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2002

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

Sadek, H. A., Humphries, K. M., Szweda, P. A. & Szweda, L. I., Jan 1 2002, In : Archives of Biochemistry and Biophysics. 406, 2, p. 222-228 7 p.

Research output: Contribution to journalArticle

80 Scopus citations
2001

Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

Bulteau, A. L., Lundberg, K. C., Humphries, K. M., Sadek, H. A., Szweda, P. A., Friguet, B. & Szweda, L. I., Aug 10 2001, In : Journal of Biological Chemistry. 276, 32, p. 30057-30063 7 p.

Research output: Contribution to journalArticle

304 Scopus citations