Hua Zhang

  • 2184 Citations
  • 22 h-Index
20032019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2003 2019

  • 2184 Citations
  • 22 h-Index
  • 31 Article
2019
2 Citations (Scopus)

Derivatives of piperazines as potential therapeutic agents for Alzheimer’s disease

Popugaeva, E., Chernyuk, D., Zhang, H., Postnikova, T. Y., Pats, K., Fedorova, E., Poroikov, V., Zaitsev, A. V. & Bezprozvanny, I., Apr 1 2019, In : Molecular Pharmacology. p. 337-348 12 p.

Research output: Contribution to journalArticle

Piperazines
Alzheimer Disease
Neuroprotective Agents
Spine
Therapeutics
1 Citation (Scopus)

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R., Nov 1 2019, In : Nature methods. 16, 11, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Tissue
Light
Immersion
2017
8 Citations (Scopus)

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

Pchitskaya, E., Kraskovskaya, N., Chernyuk, D., Popugaeva, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Dec 1 2017, In : Scientific Reports. 7, 1, 17625.

Research output: Contribution to journalArticle

Dendritic Spines
Agaricales
Spine
Neurons
Alzheimer Disease
2016
36 Citations (Scopus)

Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

Zhang, H., Sun, S., Wu, L., Pchitskaya, E., Zakharova, O., Tacer, K. F. & Bezprozvanny, I., Nov 23 2016, In : Journal of Neuroscience. 36, 47, p. 11837-11850 14 p.

Research output: Contribution to journalArticle

Agaricales
Calcium Channels
Alzheimer Disease
Spine
Dendritic Spines
2015
36 Citations (Scopus)

Calcium Signaling, Excitability, and Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease

Zhang, H., Liu, J., Sun, S., Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., 2015, In : Journal of Alzheimer's Disease. 45, 2, p. 561-580 20 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Calcium Signaling
Alzheimer Disease
Calcium
Neurons

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

Popugaeva, E., Pchitskaya, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Jan 1 2015, In : Open Life Sciences. 10, 1, p. 433-436 4 p.

Research output: Contribution to journalArticle

amyloid
Alzheimer disease
Amyloid
Neurons
Toxicity
75 Citations (Scopus)

Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-in mouse model of Alzheimer’s disease

Zhang, H., Wu, L., Pchitskaya, E., Zakharova, O., Saito, T., Saido, T. & Bezprozvanny, I., Sep 30 2015, In : Journal of Neuroscience. 35, 39, p. 13275-13286 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Agaricales
Alzheimer Disease
Spine
Calcium
27 Citations (Scopus)

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

Popugaeva, E., Pchitskaya, E., Speshilova, A., Alexandrov, S., Zhang, H., Vlasova, O. & Bezprozvanny, I., Aug 15 2015, In : Molecular Neurodegeneration. 10, 1, 37.

Research output: Contribution to journalArticle

Agaricales
Amyloid
Spine
Alzheimer Disease
Calcium-Calmodulin-Dependent Protein Kinases
2014
125 Citations (Scopus)

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice

Sun, S., Zhang, H., Liu, J., Popugaeva, E., Xu, N. J., Feske, S., White, C. L. & Bezprozvanny, I., Apr 2 2014, In : Neuron. 82, 1, p. 79-93 15 p.

Research output: Contribution to journalArticle

Presenilins
Agaricales
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Spine
Calcium-Calmodulin-Dependent Protein Kinases
30 Citations (Scopus)

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Liu, J., Supnet, C., Sun, S., Zhang, H., Good, L., Popugaeva, E. & Bezprozvanny, I., 2014, In : Channels. 8, 3, p. 230-242 13 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Alzheimer Disease
Pathology
Agaricales
Neurons
2012
9 Citations (Scopus)

Response to Shilling et al. (10.1074/jbc.M111.300491)

Bezprozvanny, I., Supnet, C., Sun, S., Zhang, H. & De Strooper, B., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20469 1 p.

Research output: Contribution to journalArticle

Presenilin-2
Presenilin-1
Calcium Channels
Endoplasmic Reticulum
Animals
138 Citations (Scopus)

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

Yang, F., Sun, L., Li, Q., Han, X., Lei, L., Zhang, H. & Shang, Y., Jan 4 2012, In : EMBO Journal. 31, 1, p. 110-123 14 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cadherins
Breast Neoplasms
Neoplasm Metastasis
Tumors
2010
111 Citations (Scopus)

Role of presenilins in neuronal calcium homeostasis

Zhang, H., Sun, S., Herreman, A., De Strooper, B. & Bezprozvanny, I., Jun 23 2010, In : Journal of Neuroscience. 30, 25, p. 8566-8580 15 p.

Research output: Contribution to journalArticle

Presenilins
Homeostasis
Endoplasmic Reticulum
Calcium
Alzheimer Disease
2009
10 Citations (Scopus)

GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function

Liang, J., Zhang, H., Zhang, Y., Zhang, Y. & Shang, Y., 2009, In : EMBO Reports. 10, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Steroid Receptors
Estrogen Receptors
Glutamic Acid
Transcription
Nuclear Receptor Coactivator 2
48 Citations (Scopus)

JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation

Sun, L., Shi, L., Li, W., Yu, W., Liang, J., Zhang, H., Yang, X., Wang, Y., Li, R., Yao, X., Yi, X. & Shang, Y., Jun 23 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 25, p. 10195-10200 6 p.

Research output: Contribution to journalArticle

F-Box Proteins
Ligases
Ubiquitin
Maintenance
Forensic Anthropology
420 Citations (Scopus)

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

Wang, Y., Zhang, H., Chen, Y., Sun, Y., Yang, F., Yu, W., Liang, J., Sun, L., Yang, X., Shi, L., Li, R., Li, Y., Zhang, Y., Li, Q., Yi, X. & Shang, Y., Aug 21 2009, In : Cell. 138, 4, p. 660-672 13 p.

Research output: Contribution to journalArticle

Mi-2 Nucleosome Remodeling and Deacetylase Complex
Lysine
Breast Neoplasms
Neoplasm Metastasis
Chromatin Assembly and Disassembly
40 Citations (Scopus)

ZIP: A novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis

Li, R., Zhang, H., Yu, W., Chen, Y., Gui, B., Liang, J., Wang, Y., Sun, L., Yang, X., Zhang, Y., Shi, L., Li, Y. & Shang, Y., Sep 16 2009, In : EMBO Journal. 28, 18, p. 2763-2776 14 p.

Research output: Contribution to journalArticle

Transcription
Oncogenes
Epidermal Growth Factor Receptor
Carcinogenesis
Breast
2008
22 Citations (Scopus)

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts

Zhang, H., Das, S., Li, Q. Z., Dragatsis, I., Repa, J., Zeitlin, S., Hajnóczky, G. & Bezprozvanny, I., Apr 15 2008, In : BMC Neuroscience. 9, 38.

Research output: Contribution to journalArticle

Microarray Analysis
Fibroblasts
Huntington Disease
Gene Deletion
Genome
88 Citations (Scopus)

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Zhang, H., Li, Q., Graham, R. K., Slow, E., Hayden, M. R. & Bezprozvanny, I., Jul 2008, In : Neurobiology of Disease. 31, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Glutamic Acid
Apoptosis
Neurons
2007
35 Citations (Scopus)

SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm

Zhang, Y., Zhang, H., Liang, J., Yu, W. & Shang, Y., Jun 6 2007, In : EMBO Journal. 26, 11, p. 2645-2657 13 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Steroid Receptors
Cytoplasm
Receptor-Interacting Protein Serine-Threonine Kinases
Proteins
2006
75 Citations (Scopus)

CaV1.2 and CaV1.3 neuronal L-type calcium channels: Differential targeting and signaling to pCREB

Zhang, H., Fu, Y., Altier, C., Platzer, J., Surmeier, D. J. & Bezprozvanny, I., May 2006, In : European Journal of Neuroscience. 23, 9, p. 2297-2310 14 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Neurons
Synapsins
Corpus Striatum
Calcium Channels
22 Citations (Scopus)

Localization of L-type calcium channel CaV1.3 in cat lumbar spinal cord - with emphasis on motoneurons

Zhang, M., Sukiasyan, N., Møller, M., Bezprozvanny, I., Zhang, H., Wienecke, J. & Hultborn, H., Oct 16 2006, In : Neuroscience Letters. 407, 1, p. 42-47 6 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Motor Neurons
Spinal Cord
Dendrites
Cats
67 Citations (Scopus)

The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription

Zhang, H., Sun, L., Liang, J., Yu, W., Zhang, Y., Wang, Y., Chen, Y., Li, R., Sun, X. & Shang, Y., Sep 20 2006, In : EMBO Journal. 25, 18, p. 4223-4233 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Transcription
Estrogen Receptors
Catalytic Domain
Steroid Receptors
2005
97 Citations (Scopus)

Association of Cav1.3 L-type calcium channels with shank

Zhang, H., Maximov, A., Fu, Y., Xu, F., Tang, T. S., Tkatch, T., Surmeier, D. J. & Bezprozvanny, I., Feb 2 2005, In : Journal of Neuroscience. 25, 5, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

L-Type Calcium Channels
Cyclic AMP Response Element-Binding Protein
Neurons
PDZ Domains
Macromolecular Substances

Erratum: G-protein-coupled receptor modulation of striatal Ca v1.3 L-type Ca2+ channels is dependent on a shank-binding domain (The Journal of Neuroscience (February 2, 2005) (1050-1062))

Olson, P. A., Tkatch, T., Hernandez-Lopez, S., Ulrich, S., Ilijic, E., Mugnaini, E., Zhang, H., Bezprozvanny, I. & Surmeier, D. J., Mar 2 2005, In : Journal of Neuroscience. 25, 9, p. 2445-2446 2 p.

Research output: Contribution to journalArticle

Corpus Striatum
Neurosciences
G-Protein-Coupled Receptors
187 Citations (Scopus)

G-protein-coupled receptor modulation of striatal Cav1.3 L-type Ca2+ channels is dependent on a shank-binding domain

Olson, P. A., Tkatch, T., Hernandez-Lopez, S., Ulrich, S., Ilijic, E., Mugnaini, E., Zhang, H., Bezprozvanny, I. & Surmeier, D. J., Feb 2 2005, In : Journal of Neuroscience. 25, 5, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

Corpus Striatum
G-Protein-Coupled Receptors
Neurons
PDZ Domains
Post-Synaptic Density
213 Citations (Scopus)

Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

Wu, H., Chen, Y., Liang, J., Shi, B., Wu, G., Zhang, Y., Wang, D., Li, R., Yi, X., Zhang, H., Sun, L. & Shang, Y., Dec 15 2005, In : Nature. 438, 7070, p. 981-987 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Carcinogenesis
Overlapping Genes
Endometrial Neoplasms
Endometrium
2004
80 Citations (Scopus)

Differential gene regulation by the SRC family of coactivators

Zhang, H., Yi, X., Sun, X., Yin, N., Shi, B., Wu, H., Wang, D., Wu, G. & Shang, Y., Jul 15 2004, In : Genes and Development. 18, 14, p. 1753-1765 13 p.

Research output: Contribution to journalArticle

Steroid Receptors
Nuclear Receptor Coactivator 1
Genes
Nuclear Receptor Coactivators
Hormones
16 Citations (Scopus)

DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression

Sun, X., Zhang, H., Wang, D., Ma, D., Shen, Y. & Shang, Y., Jul 30 2004, In : Journal of Biological Chemistry. 279, 31, p. 32839-32847 9 p.

Research output: Contribution to journalArticle

RNA Precursors
Cell Cycle
Cells
Spliceosomes
Proteins
158 Citations (Scopus)

Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin

Yin, N., Wang, D., Zhang, H., Yi, X., Sun, X., Shi, B., Wu, H., Wu, G., Wang, X. & Shang, Y., Aug 15 2004, In : Cancer Research. 64, 16, p. 5870-5875 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Nuclear Receptor Coactivator 1
Leptin
Breast Neoplasms
Nuclear Receptor Coactivator 2
2003
8 Citations (Scopus)

Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor

Mao, Z., Shan, S., Zhu, Y., Yi, X., Zhang, H., Shang, Y. & Tong, T., Jul 10 2003, In : Oncogene. 22, 28, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

losigame
Antigens
Intestinal Mucosa
proctolin
Colonic Neoplasms