• 11718 Citations
  • 58 h-Index
1991 …2019
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Research Output 1991 2019

  • 11718 Citations
  • 58 h-Index
  • 158 Article
  • 8 Review article
  • 2 Editorial
  • 1 Chapter
2019

Amyloid β perturbs elevated heme flux induced with neuronal development

Vidal, C., Daescu, K., Fitzgerald, K. E., Starokadomska, A., Bezprozvanny, I. & Zhang, L., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 27-37 11 p.

Research output: Contribution to journalArticle

Heme
Amyloid
Alzheimer Disease
Enzymes
Respiration

An Optoelectronic Neurostimulation System with Adaptive Feedback

Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In : Neuroscience and Behavioral Physiology.

Research output: Contribution to journalArticle

Optogenetics
Neurons
Light
Microcomputers
Neurodegenerative Diseases

An Optogenetic Study of the Electrophysiological Properties of Hippocampal Neurons in PS1-M146V Transgenic Mice (a model of Alzheimer’s disease)

Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In : Neuroscience and Behavioral Physiology.

Research output: Contribution to journalArticle

Optogenetics
Transgenic Mice
Alzheimer Disease
Neurons
Presenilin-1

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

Chernyuk, D., Zernov, N., Kabirova, M., Bezprozvanny, I. & Popugaeva, E., Jul 1 2019, In : Neuroscience. 410, p. 118-127 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Agaricales
Calcium
Neurons
Spine
2 Citations (Scopus)

Derivatives of piperazines as potential therapeutic agents for Alzheimer’s disease

Popugaeva, E., Chernyuk, D., Zhang, H., Postnikova, T. Y., Pats, K., Fedorova, E., Poroikov, V., Zaitsev, A. V. & Bezprozvanny, I., Apr 1 2019, In : Molecular Pharmacology. p. 337-348 12 p.

Research output: Contribution to journalArticle

Piperazines
Alzheimer Disease
Neuroprotective Agents
Spine
Therapeutics
1 Citation (Scopus)

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R., Nov 1 2019, In : Nature methods. 16, 11, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Tissue
Light
Immersion

Light stimulation parameters determine neuron dynamic characteristics

Erofeev, A., Gerasimov, E., Lavrova, A., Bolshakova, A., Postnikov, E., Bezprozvanny, I. & Vlasova, O. L., Sep 1 2019, In : Applied Sciences (Switzerland). 9, 18, 3673.

Research output: Contribution to journalArticle

Open Access
neurons
stimulation
dynamic characteristics
Neurons
Halorhodopsins

Mechanism of action of the new ethanolamine derivative bis{2-[(2E)-4-hydroxy-4-oxobut-2-enoyloxy]-N,N-diethylethanaminium}butanedioate

Sysoev, Y. I., Popugaeva, E. A., Chernyuk, D. P., Titovich, I. A., Zagladkina, E. V., Bolotova, V. C., Bezprozvanny, I. & Okovityi, S. V., Jan 1 2019, In : Eksperimental'naya i Klinicheskaya Farmakologiya. 82, 4, p. 3-10 8 p.

Research output: Contribution to journalArticle

Ethanolamine
Dendritic Spines
Calcium
Derivatives
Cytidine Diphosphate Choline
2 Citations (Scopus)

Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2

Egorova, P. A. & Bezprozvanny, I., Jan 1 2019, (Accepted/In press) In : Neurotherapeutics.

Research output: Contribution to journalReview article

Spinocerebellar Ataxias
Therapeutics
Inborn Genetic Diseases
Palliative Care

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

Ryskamp, D. A., Zhemkov, V. & Bezprozvanny, I., Sep 19 2019, In : Frontiers in Neuroscience. 13, 1012.

Research output: Contribution to journalArticle

Open Access
Agaricales
Spine
sigma-1 receptor
Clustered Regularly Interspaced Short Palindromic Repeats
Presenilin-1

Neuronal sigma-1 receptors: Signaling functions and protective roles in neurodegenerative diseases

Ryskamp, D. A., Korban, S., Zhemkov, V., Kraskovskaya, N. & Bezprozvanny, I., Jan 1 2019, In : Frontiers in Neuroscience. 13, AUG, 862.

Research output: Contribution to journalReview article

Open Access
Neurodegenerative Diseases
Endoplasmic Reticulum
Mitochondrial Membranes
Ion Channels
sigma-1 receptor
5 Citations (Scopus)

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

Ryskamp, D., Wu, L., Wu, J., Kim, D., Rammes, G., Geva, M., Hayden, M. & Bezprozvanny, I., Apr 1 2019, In : Neurobiology of Disease. 124, p. 489-504 16 p.

Research output: Contribution to journalArticle

Agaricales
Alzheimer Disease
Spine
Presenilin-1
Calcium
2018
2 Citations (Scopus)

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

Pchitskaya, E. I., Zhemkov, V. A. & Bezprozvanny, I. B., Sep 1 2018, In : Biochemistry (Moscow). 83, 9, p. 1068-1074 7 p.

Research output: Contribution to journalReview article

Dendritic Spines
Pathology
Microtubules
Tubulin
Alzheimer Disease
5 Citations (Scopus)

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease

Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Oct 20 2018, In : Antioxidants and Redox Signaling. 29, 12, p. 1176-1188 13 p.

Research output: Contribution to journalReview article

Calcium Signaling
Alzheimer Disease
Calcium
Critical Pathways
Pathology
9 Citations (Scopus)
Huntington Disease
Calcium
Spine
Neurons
Corpus Striatum
14 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

Egorova, P. A. & Bezprozvanny, I. B., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Cell death
Neurodegenerative Diseases
Neurons
Cell Death
2 Citations (Scopus)

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

Egorova, P. A., Gavrilova, A. V. & Bezprozvanny, I. B., Jun 6 2018, (Accepted/In press) In : Cerebellum. p. 1-11 11 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Purkinje Cells
Transgenic Mice
Harmaline
Cerebellar Ataxia
3 Citations (Scopus)

Pin1 mediates Aβ42-induced dendritic spine loss

Stallings, N. R., O'Neal, M. A., Hu, J., Kavalali, E. T., Bezprozvanny, I. & Malter, J. S., Mar 20 2018, In : Science Signaling. 11, 522, eaap8734.

Research output: Contribution to journalArticle

Dendritic Spines
Calcineurin
Pathology
cis-trans-Isomerases
Alzheimer Disease

Reactions of Cyclometalated Platinum(II) [Pt(NC)(PR3)Cl] Complexes with Imidazole and Imidazole-Containing Biomolecules: Fine-Tuning of Reactivity and Photophysical Properties via Ligand Design

Solomatina, A. I., Chelushkin, P. S., Abakumova, T. O., Zhemkov, V. A., Kim, M. W., Bezprozvanny, I., Gurzhiy, V. V., Melnikov, A. S., Anufrikov, Y. A., Koshevoy, I. O., Su, S. H., Chou, P. T. & Tunik, S. P., Jan 1 2018, (Accepted/In press) In : Inorganic Chemistry.

Research output: Contribution to journalArticle

Biomolecules
Platinum
imidazoles
platinum
reactivity
1 Citation (Scopus)

STIM proteins as regulators of neuronal store-operated calcium influx

Popugaeva, E. & Bezprozvanny, I., Feb 1 2018, In : Neurodegenerative disease management. 8, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

Hippocampus
Alzheimer Disease
Calcium
Proteins
2017
3 Citations (Scopus)

AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation

Ivachtchenko, A. V., Okun, I., Aladinskiy, V., Ivanenkov, Y., Koryakova, A., Karapetyan, R., Mitkin, O., Salimov, R., Ivashchenko, A. & Bezprozvanny, I., 2017, In : Journal of Alzheimer's Disease. 58, 4, p. 1043-1063 21 p.

Research output: Contribution to journalArticle

Biological Availability
Obesity
Scopolamine Hydrobromide
Dizocilpine Maleate
Apomorphine
55 Citations (Scopus)

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., 2017, (Accepted/In press) In : Cell Calcium.

Research output: Contribution to journalArticle

Calcium Signaling
Neurodegenerative Diseases
Calcium
Neuronal Plasticity
Huntington Disease
1 Citation (Scopus)

Misery loves company – shared features of neurodegenerative disorders

Bezprozvanny, I., Sorgato, M. C. & Carafoli, E., Feb 19 2017, In : Biochemical and Biophysical Research Communications. 483, 4, p. 979-980 2 p.

Research output: Contribution to journalEditorial

Neurodegenerative diseases
Mitochondria
Neurons
Aging of materials
Calcium
1 Citation (Scopus)

Mutational re-modeling of di-aspartyl intramembrane proteases: Uncoupling physiologically-relevant activities from those associated with Alzheimer's disease

Grigorenko, A. P., Moliaka, Y. K., Plotnikova, O. V., Smirnov, A., Nikishina, V. A., Goltsov, A. Y., Gusev, F., Andreeva, T. V., Nelson, O., Bezprozvanny, I. & Rogaev, E. I., 2017, In : Oncotarget. 8, 47, p. 82006-82026 21 p.

Research output: Contribution to journalArticle

Aspartic Acid Proteases
Presenilins
Alzheimer Disease
Mutation
Endoplasmic Reticulum
2 Citations (Scopus)

Neurons from skin mimic brain holes

Bezprozvanny, I. & Kiselev, S. L., 2017, In : Oncotarget. 8, 6, p. 8997-8998 2 p.

Research output: Contribution to journalEditorial

Neurosciences
Calcium
Neurons
Skin
Brain
4 Citations (Scopus)

Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

Bol’shakova, A. V., Kraskovskaya, N. A., Gainullina, A. N., Kukanova, E. O., Vlasova, O. L. & Bezprozvanny, I. B., Dec 1 2017, In : Bulletin of Experimental Biology and Medicine. 164, 2, p. 252-258 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Neuroprotective Agents
Neurons
Nervous System Heredodegenerative Disorders

Neurostimulation opto-electrode system with adaptive feedback

Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 86-93 8 p.

Research output: Contribution to journalReview article

Optogenetics
Electrodes
Microcomputers
Neurodegenerative Diseases
Transgenic Mice

Optogenetic light pulses generator

Erofeev, A. I., Matveev, M. V., Zakharova, O. A., Terekhin, S. G., Kilimnik, V. A., Bezprozvanny, I. B. & Vlasova, O. L., Nov 23 2017, In : Journal of Physics: Conference Series. 917, 4, 042023.

Research output: Contribution to journalArticle

neurology
pulse generators

Optogenetic research of hippocampal neuron activity in vitro in the ps1-m146v mouse model of Alzheimer's disease

Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. B. & Vlasova, O. L., Jan 1 2017, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 67, 5, p. 63-74 12 p.

Research output: Contribution to journalReview article

Optogenetics
Alzheimer Disease
Neurons
Research
Presenilin-1
8 Citations (Scopus)

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

Pchitskaya, E., Kraskovskaya, N., Chernyuk, D., Popugaeva, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Dec 1 2017, In : Scientific Reports. 7, 1, 17625.

Research output: Contribution to journalArticle

Dendritic Spines
Agaricales
Spine
Neurons
Alzheimer Disease
35 Citations (Scopus)

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

Ryskamp, D., Wu, J., Geva, M., Kusko, R., Grossman, I., Hayden, M. & Bezprozvanny, I., Jan 1 2017, In : Neurobiology of Disease. 97, p. 46-59 14 p.

Research output: Contribution to journalArticle

Huntington Disease
Endoplasmic Reticulum
Corpus Striatum
Calcium
Spine
2016
17 Citations (Scopus)

AF710B, a novel M1/σ1 agonist with therapeutic efficacy in animal models of Alzheimer's disease

Fisher, A., Bezprozvanny, I., Wu, L., Ryskamp, D. A., Bar-Ner, N., Natan, N., Brandeis, R., Elkon, H., Nahum, V., Gershonov, E., LaFerla, F. M. & Medeiros, R., Feb 1 2016, In : Neurodegenerative Diseases. 16, 1-2, p. 95-110 16 p.

Research output: Contribution to journalArticle

Muscarinic M1 Receptors
Nootropic Agents
Alzheimer Disease
Animal Models
Trihexyphenidyl
9 Citations (Scopus)
MEF2 Transcription Factors
Autistic Disorder
Synapses
Chromatin
Genes
58 Citations (Scopus)

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Sep 6 2016, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Alzheimer Disease
Homeostasis
Calcium
Presenilins
Calcium Signaling
53 Citations (Scopus)

Enhanced store-operated calcium entry leads to striatal synaptic loss in a huntington’s disease mouse model

Wu, J., Ryskamp, D. A., Liang, X., Egorova, P., Zakharova, O., Hung, G. & Bezprozvanny, I., Jan 6 2016, In : Journal of Neuroscience. 36, 1, p. 125-141 17 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Spine
Calcium
Neurons
25 Citations (Scopus)

In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model

Egorova, P. A., Zakharova, O. A., Vlasova, O. L. & Bezprozvanny, I. B., Jun 1 2016, In : Journal of Neurophysiology. 115, 6, p. 2840-2851 12 p.

Research output: Contribution to journalArticle

Purkinje Cells
Transgenic Mice
Chlorzoxazone
Intraperitoneal Injections
Spinocerebellar Ataxias
36 Citations (Scopus)

Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

Zhang, H., Sun, S., Wu, L., Pchitskaya, E., Zakharova, O., Tacer, K. F. & Bezprozvanny, I., Nov 23 2016, In : Journal of Neuroscience. 36, 47, p. 11837-11850 14 p.

Research output: Contribution to journalArticle

Agaricales
Calcium Channels
Alzheimer Disease
Spine
Dendritic Spines
6 Citations (Scopus)

The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3

Zhemkov, V. A., Kulminskaya, A. A., Bezprozvanny, I. B. & Kim, M., Feb 1 2016, In : FEBS Open Bio. 6, 3, p. 168-178 11 p.

Research output: Contribution to journalArticle

Crystal structure
Glutamine
Hydrogen
Hydrogen bonds
Machado-Joseph Disease
5 Citations (Scopus)

Use of optogenetic technology in cell culture models

Erofeev, A. I., Zakharova, O. A., Matveev, M. V., Terekhin, S. G., Bezprozvanny, I. B. & Vlasova, O. L., Sep 15 2016, In : Journal of Physics: Conference Series. 741, 1, 012067.

Research output: Contribution to journalArticle

neurons
stimulation
electrical properties
membranes
2015
36 Citations (Scopus)

Calcium Signaling, Excitability, and Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease

Zhang, H., Liu, J., Sun, S., Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., 2015, In : Journal of Alzheimer's Disease. 45, 2, p. 561-580 20 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Calcium Signaling
Alzheimer Disease
Calcium
Neurons
28 Citations (Scopus)

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Egorova, P., Popugaeva, E. & Bezprozvanny, I., Apr 1 2015, In : Seminars in Cell and Developmental Biology. 40, p. 127-133 7 p.

Research output: Contribution to journalArticle

Spinocerebellar Degenerations
Spinocerebellar Ataxias
Calcium Signaling
Neurodegenerative Diseases
Alzheimer Disease

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

Popugaeva, E., Pchitskaya, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Jan 1 2015, In : Open Life Sciences. 10, 1, p. 433-436 4 p.

Research output: Contribution to journalArticle

amyloid
Alzheimer disease
Amyloid
Neurons
Toxicity
75 Citations (Scopus)

Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-in mouse model of Alzheimer’s disease

Zhang, H., Wu, L., Pchitskaya, E., Zakharova, O., Saito, T., Saido, T. & Bezprozvanny, I., Sep 30 2015, In : Journal of Neuroscience. 35, 39, p. 13275-13286 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Agaricales
Alzheimer Disease
Spine
Calcium

Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective

Popugaeva, E., Vlasova, O. L. & Bezprozvanny, I., Oct 1 2015, In : Neurodegenerative disease management. 5, 5, p. 395-398 4 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Homeostasis
Calcium
Calcium Signaling
Neurodegenerative Diseases
8 Citations (Scopus)

Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective

Popugaeva, E., Vlasova, O. L. & Bezprozvanny, I., Oct 1 2015, In : Neurodegenerative disease management. 5, 5, p. 395-398 4 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Homeostasis
Calcium
Calcium Signaling
Neurodegenerative Diseases
27 Citations (Scopus)

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

Popugaeva, E., Pchitskaya, E., Speshilova, A., Alexandrov, S., Zhang, H., Vlasova, O. & Bezprozvanny, I., Aug 15 2015, In : Molecular Neurodegeneration. 10, 1, 37.

Research output: Contribution to journalArticle

Agaricales
Amyloid
Spine
Alzheimer Disease
Calcium-Calmodulin-Dependent Protein Kinases
2014
17 Citations (Scopus)

Can the calcium hypothesis explain synaptic loss in alzheimer's disease?

Popugaeva, E. & Bezprozvanny, I., Jan 2014, In : Neurodegenerative Diseases. 13, 2-3, p. 139-141 3 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Calcium
Presenilins
Memory Disorders
Endoplasmic Reticulum
3 Citations (Scopus)
Parkinson Disease
Glutamic Acid
Neurons
3 Citations (Scopus)

Huntington’s disease: Cellular and molecular basis of pathology

Korzhova, V. V., Artamonov, D. N., Vlasova, O. L. & Bezprozvanny, I. B., 2014, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 64, 4, p. 359-375 17 p.

Research output: Contribution to journalArticle

Molecular Pathology
Huntington Disease
Corpus Striatum
Glutamine
Synaptic Transmission
21 Citations (Scopus)

Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors

Fedorenko, O. A., Popugaeva, E., Enomoto, M., Stathopulos, P. B., Ikura, M. & Bezprozvanny, I., Sep 15 2014, In : European Journal of Pharmacology. 739, C, p. 39-48 10 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Calcium Channels
Protein Isoforms
Physiological Phenomena
Neurons