Irene R Iscla

  • 439 Citations
  • 13 h-Index
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  • 1 Similar Profiles
Membranes Medicine & Life Sciences
Leeches Medicine & Life Sciences
Disulfides Medicine & Life Sciences
Emergencies Medicine & Life Sciences
Cysteine Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Proteins Medicine & Life Sciences
Dihydrostreptomycin Sulfate Medicine & Life Sciences

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Research Output 1999 2019

  • 439 Citations
  • 13 h-Index
  • 19 Article
Anti-Bacterial Agents
Microbial Viability
Mycobacterium smegmatis
6 Citations (Scopus)

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

Wray, R., Iscla, I., Gao, Y., Li, H., Wang, J. & Blount, P., Jun 9 2016, In : PLoS Biology. 14, 6, e1002473.

Research output: Contribution to journalArticle

Dihydrostreptomycin Sulfate
Genetic Testing
Protein Biosynthesis
17 Citations (Scopus)

A new antibiotic with potent activity targets MscL

Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A. L., Ausubel, F. M., Ramu, S., Kavanagh, A., Huang, J. X., Blaskovich, M. A., Cooper, M. A., Obregon-Henao, A., Orme, I., Tjandra, E. S., Stroeher, U. H., Brown, M. H., Macardle, C., Van Holst, N., Ling Tong, C., Slattery, A. D. & 3 others, Gibson, C. T., Raston, C. L. & Boulos, R. A., Jul 29 2015, In : Journal of Antibiotics. 68, 7, p. 453-462 10 p.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Methicillin-Resistant Staphylococcus aureus
Computer Simulation
Caenorhabditis elegans
8 Citations (Scopus)

Scanning MscL channels with targeted post-translational modifications for functional alterations

Iscla, I., Wray, R., Eaton, C. & Blount, P., Sep 14 2015, In : PLoS One. 10, 9, e0137994.

Research output: Contribution to journalArticle

post-translational modification
Post Translational Protein Processing
Escherichia coli
21 Citations (Scopus)

Streptomycin potency is dependent on MscL channel expression

Iscla, I., Wray, R., Wei, S., Posner, B. & Blount, P., 2014, In : Nature Communications. 5, 4891.

Research output: Contribution to journalArticle

Dihydrostreptomycin Sulfate