• 1789 Citations
  • 20 h-Index
19982019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1789 Citations
  • 20 h-Index
  • 31 Article
  • 5 Review article
1998

The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions

Di Noia, J. M., D'Orso, I., Åslund, L., Sánchez, D. O. & Frasch, A. C. C., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 10843-10850 8 p.

Research output: Contribution to journalArticle

65 Scopus citations
2000

AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency

Di Noia, J. M., D'Orso, I., Sánchez, D. O. & Frasch, A. C. C., Apr 7 2000, In : Journal of Biological Chemistry. 275, 14, p. 10218-10227 10 p.

Research output: Contribution to journalArticle

112 Scopus citations
2001
44 Scopus citations

TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes

D'Orso, I. & Frasch, A. C. C., Sep 14 2001, In : Journal of Biological Chemistry. 276, 37, p. 34801-34809 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
2002
62 Scopus citations
2003

RNA-binding proteins and mRNA turnover in trypanosomes

D'Orso, I., De Gaudenzi, J. G. & Frasch, A. C. C., Apr 1 2003, In : Trends in Parasitology. 19, 4, p. 151-155 5 p.

Research output: Contribution to journalReview article

48 Scopus citations

RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo

De Gaudenzi, J. G., D'Orso, I. & Frasch, A. C. C., May 23 2003, In : Journal of Biological Chemistry. 278, 21, p. 18884-18894 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Solution structure of the C-terminal domain from poly(A)-binding protein in trypanosoma cruzi: A vegetal PABC domain

Siddiqui, N., Kozlov, G., D'Orso, I., Trempe, J. F. & Gehring, K., Sep 1 2003, In : Protein Science. 12, 9, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

Insights into a CRM1-mediated RNA-nuclear export pathway in Trypanosoma cruzi

Cuevas, I. C., Frasch, A. C. C. & D'Orso, I., Jan 1 2005, In : Molecular and Biochemical Parasitology. 139, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: Contribution of a β hairpin to RNA binding

Volpon, L., D'Orso, I., Young, C. R., Frasch, A. C. & Gehring, K., Mar 15 2005, In : Biochemistry. 44, 10, p. 3708-3717 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007

mRNA maturation by two-step trans-splicing/polyadenylation processing in trypanosomes

Jäger, A. V., De Gaudenzi, J. G., Cassola, A., D'Orso, I. & Frasch, A. C., Feb 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 7, p. 2035-2042 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes

Hartmann, C., Benz, C., Brems, S., Ellis, L., Luu, V. D., Stewart, M., D'Orso, I., Busold, C., Fellenberg, K., Frasch, A. C. C., Carrington, M., Hoheisel, J. & Clayton, C. E., Nov 1 2007, In : Eukaryotic Cell. 6, 11, p. 1964-1978 15 p.

Research output: Contribution to journalArticle

33 Scopus citations
2008

A Solution to Limited Genomic Capacity: Using Adaptable Binding Surfaces to Assemble the Functional HIV Rev Oligomer on RNA

Daugherty, M. D., D'Orso, I. & Frankel, A. D., Sep 26 2008, In : Molecular cell. 31, 6, p. 824-834 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

Targeting Tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes

D'Orso, I., Grunwell, J. R., Nakamura, R. L., Das, C. & Frankel, A. D., Oct 1 2008, In : Journal of virology. 82, 19, p. 9492-9504 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009

Host cell factors in HIV replication: Meta-analysis of genome-wide studies

Bushman, F. D., Malani, N., Fernandes, J., D'Orso, I., Cagney, G., Diamond, T. L., Zhou, H., Hazuda, D. J., Espeseth, A. S., König, R., Bandyopadhyay, S., Ideker, T., Goff, S. P., Krogan, N. J., Frankel, A. D., Young, J. A. T. & Chanda, S. K., May 1 2009, In : PLoS pathogens. 5, 5, e1000437.

Research output: Contribution to journalReview article

334 Scopus citations
52 Scopus citations
2010

HIV-1 Tat: Its dependence on host factors is crystal clear

D'Orso, I. & Frankel, A. D., Oct 1 2010, In : Viruses. 2, 10, p. 2226-2234 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

D'Orso, I. & Frankel, A. D., Jul 1 2010, In : Nature Structural and Molecular Biology. 17, 7, p. 815-821 7 p.

Research output: Contribution to journalArticle

78 Scopus citations
2011

Purification and characterization of HIV-human protein complexes

Jäger, S., Gulbahce, N., Cimermancic, P., Kane, J., He, N., Chou, S., D'Orso, I., Fernandes, J., Jang, G., Frankel, A. D., Alber, T., Zhou, Q. & Krogan, N. J., Jan 1 2011, In : Methods. 53, 1, p. 13-19 7 p.

Research output: Contribution to journalReview article

42 Scopus citations
2012

Global landscape of HIV-human protein complexes

Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., Hernandez, H., Jang, G. M., Roth, S. L., Akiva, E., Marlett, J., Stephens, M., D'Orso, I., Fernandes, J., Fahey, M., Mahon, C. & 17 others, Oĝdonoghue, A. J., Todorovic, A., Morris, J. H., Maltby, D. A., Alber, T., Cagney, G., Bushman, F. D., Young, J. A., Chanda, S. K., Sundquist, W. I., Kortemme, T., Hernandez, R. D., Craik, C. S., Burlingame, A., Sali, A., Frankel, A. D. & Krogan, N. J., Jan 19 2012, In : Nature. 481, 7381, p. 365-370 6 p.

Research output: Contribution to journalArticle

390 Scopus citations

Transcription control by long non-coding RNAs

Faust, T., Frankel, A. D. & D'Orso, I., Jan 1 2012, In : Transcription. 3, 2, p. 78-86 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transition step during assembly of HIV tat: P-TEFb transcription complexes and transfer to TAR RNA

D'orso, I., Jang, G. M., Pastuszak, A. W., Faust, T. B., Quezada, E., Booth, D. S. & Frankel, A. D., Dec 1 2012, In : Molecular and cellular biology. 32, 23, p. 4780-4793 14 p.

Research output: Contribution to journalArticle

32 Scopus citations
2013

Mechanisms of eukaryotic transcription: a meeting report August 27–31, 2013, CSHL, Cold Spring Harbor, New York

D'Orso, I., Jan 1 2013, In : Transcription. 4, 5, p. 273-285 13 p.

Research output: Contribution to journalArticle

Open Access

Transcription factors mediate the enzymatic disassembly of promoter-bound 7sk snrnp to locally recruit p-tefb for transcription elongation

McNamara, R., McCann, J., Gudipaty, S. A. & D'Orso, I., Dec 12 2013, In : Cell Reports. 5, 5, p. 1256-1268 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2015

Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein

Cassola, A., Romaniuk, M. A., Primrose, D., Cervini, G., D'Orso, I. & Frasch, A. C., Sep 1 2015, In : Molecular Microbiology. 97, 6, p. 1079-1096 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

Reeder, J. E., Kwak, Y. T., McNamara, R. P., Forst, C. V. & D’Orso, I., Oct 21 2015, In : eLife. 4, OCTOBER2015, 08955.

Research output: Contribution to journalArticle

15 Scopus citations

PPM1G binds 7SK RNA and Hexim1 to block P-TEFb assembly into the 7SK snRNP and sustain transcription elongation

Gudipaty, S. A., McNamara, R. P., Morton, E. L. & D'Orso, I., 2015, In : Molecular and Cellular Biology. 35, 22, p. 3810-3828 19 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

7SKiing on chromatin: Move globally, act locally

D'Orso, I., Jun 2 2016, In : RNA Biology. 13, 6, p. 545-553 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II

McNamara, R. P., Guzman, C., Reeder, J. E. & D'Orso, I., Mar 1 2016, In : Genomics Data. 7, p. 250-255 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II

McNamara, R. P., Reeder, J. E., McMillan, E. A., Bacon, C. W., McCann, J. L. & D'Orso, I., Jan 7 2016, In : Molecular Cell. 61, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

Transcription elongation control by the 7SK snRNP complex: Releasing the pause

McNamara, R. P., Bacon, C. W. & D'Orso, I., Aug 17 2016, In : Cell Cycle. 15, 16, p. 2115-2123 9 p.

Research output: Contribution to journalReview article

14 Scopus citations
2017
5 Scopus citations

Tandem affinity purification of protein complexes from eukaryotic cells

Ma, Z., Fung, V. & D'orso, I., Jan 26 2017, In : Journal of Visualized Experiments. 2017, 119, e55236.

Research output: Contribution to journalArticle

1 Scopus citations
2018

The HIV-1 tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

Faust, T. B., Li, Y., Bacon, C. W., Jang, G. M., Weiss, A., Jayaraman, B., Newton, B. W., Krogan, N. J., D’orso, I. & Frankel, A. D., May 30 2018, In : eLife. 7, e31879.

Research output: Contribution to journalArticle

4 Scopus citations
2019

CDK9: a signaling hub for transcriptional control

Bacon, C. W. & D'orso, I., Mar 15 2019, In : Transcription. 10, 2, p. 57-75 19 p.

Research output: Contribution to journalReview article

10 Scopus citations

Transcriptional Circuit Fragility Influences HIV Proviral Fate

Morton, E. L., Forst, C. V., Zheng, Y., DePaula-Silva, A. B., Ramirez, N. G. P., Planelles, V. & D'orso, I., Apr 2 2019, In : Cell Reports. 27, 1, p. 154-171.e9

Research output: Contribution to journalArticle

Open Access
1 Scopus citations