• 7758 Citations
  • 39 h-Index
19952019
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Research Output 1995 2019

  • 7758 Citations
  • 39 h-Index
  • 96 Article
  • 5 Review article
  • 2 Comment/debate
  • 1 Chapter
2019
Renal Cell Carcinoma
Human Body
Neoplasms
Therapeutics
Clone Cells

DEFOR: Depth- and frequency-based somatic copy number alteration detector

Zhang, H., Zhan, X., Brugarolas, J. & Xie, Y., Oct 1 2019, In : Bioinformatics. 35, 19, p. 3824-3825 2 p.

Research output: Contribution to journalArticle

Open Access
Exome
Tumors
Sequencing
Detector
Detectors

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J. B., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, P. B. & Hsieh, J-T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Ionizing Radiation
Renal Cell Carcinoma
Down-Regulation
Gene Expression
Heterografts
1 Citation (Scopus)

Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights

Carlo, M. I., Hakimi, A. A., Stewart, G. D., Bratslavsky, G., Brugarolas, J. B., Chen, Y. B., Linehan, W. M., Maher, E. R., Merino, M. J., Offit, K., Reuter, V. E., Shuch, B. & Coleman, J. A., Jan 1 2019, In : European urology.

Research output: Contribution to journalReview article

Kidney Neoplasms
Renal Cell Carcinoma
Leiomyomatosis
Genetic Databases
Precision Medicine
1 Citation (Scopus)
Kidney Neoplasms
Neoplasm Metastasis
Survival
Brain
Renal Cell Carcinoma

Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess

Patel, A. R., Connors, S., Wardak, Z., Brugarolas, J. B. & Patel, T. R., Sep 1 2019, In : World Neurosurgery. 129, p. 354-358 5 p.

Research output: Contribution to journalArticle

Brain Abscess
Radiosurgery
Craniotomy
Limbic Encephalitis
Apraxias
Nephrectomy
Renal Cell Carcinoma
Operative Time
Length of Stay
Metastasectomy
4 Citations (Scopus)
Open Access
Renal Cell Carcinoma
Ligands
Positron-Emission Tomography
Neoplasms
nivolumab
1 Citation (Scopus)

Scina: Semi-supervised analysis of single cells in silico

Zhang, Z., Luo, D., Zhong, X., Choi, J. H., Ma, Y., Wang, S., Mahrt, E., Guo, W., Stawiski, E. W., Modrusan, Z., Seshagiri, S., Kapur, P., Hon, G. C., Brugarolas, J. & Wang, T., Jul 1 2019, In : Genes. 10, 7, 531.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
RNA Sequence Analysis
Computer Simulation
Neoplasms
Oligodendroglia
3 Citations (Scopus)
Renal Cell Carcinoma
radiation therapy
therapy
Radiotherapy
cancer
2018
10 Citations (Scopus)

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Wang, T., Lu, R., Kapur, P., Jaiswal, B. S., Hannan, R., Zhang, Z., Pedrosa, I., Luke, J. J., Zhang, H., Goldstein, L. D., Yousuf, Q., Gu, Y. F., McKenzie, T., Joyce, A., Kim, M. S., Wang, X., Luo, D., Onabolu, O., Stevens, C., Xie, Z. & 11 others, Chen, M., Filatenkov, A., Torrealba, J., Luo, X., Guo, W., He, J., Stawiski, E., Modrusan, Z., Durinck, S., Seshagiri, S. & Brugarolas, J., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Renal Cell Carcinoma
Neoplasms
Inflammation
RNA Sequence Analysis
7 Citations (Scopus)

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J. B., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

Gene-Environment Interaction
Precision Medicine
Carcinogenesis
Neoplasms
Intrinsic Factor
2 Citations (Scopus)

Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study

Woldu, S. L., Matulay, J. T., Clinton, T. N., Singla, N., Freifeld, Y., Sanli, O. M., Krabbe, L. M., Hutchinson, R. C., Lotan, Y., Hammers, H., Hannan, R., Brugarolas, J. B., Bagrodia, A. & Margulis, V., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Nephrectomy
Renal Cell Carcinoma
Registries
Incidence
Neoplasms
5 Citations (Scopus)

Personalized Management of Advanced Kidney Cancer

Graham, J., Heng, D. Y. C., Brugarolas, J. B. & Vaishampayan, U., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 330-341 12 p.

Research output: Contribution to journalReview article

Kidney Neoplasms
Renal Cell Carcinoma
Biomarkers
Translational Medical Research
Transcriptome
4 Citations (Scopus)

Perspectives in immunotherapy: Meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)

Ascierto, P. A., Brugarolas, J., Buonaguro, L., Butterfield, L. H., Carbone, D., Daniele, B., Ferris, R., Fox, B. A., Galon, J., Gridelli, C., Kaufman, H. L., Klebanoff, C. A., Melero, I., Nathan, P., Paulos, C. M., Ruella, M., Sullivan, R., Zarour, H. & Puzanov, I., Jul 11 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 69.

Research output: Contribution to journalReview article

Immunotherapy
Italy
Neoplasms
CTLA-4 Antigen
Adoptive Transfer
60 Citations (Scopus)

Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2a antagonist in patients with previously treated advanced clear cell renal cell carcinoma

Courtney, K. D., Infante, J. R., Lam, E. T., Figlin, R. A., Rini, B. I., Brugarolas, J., Zojwalla, N. J., Lowe, A. M., Wang, K., Wallace, E. M., Josey, J. A. & Choueiri, T. K., Jan 1 2018, In : Journal of Clinical Oncology. 36, 9, p. 867-874 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Safety
Pharmacokinetics
Hypoxia
Therapeutics
8 Citations (Scopus)
Renal Cell Carcinoma
Mutation
Genes
Sensitivity and Specificity
Genomics
3 Citations (Scopus)

Renal-Cell Carcinoma Pseudoprogression With Clinical Deterioration: To Hospice and Back

Elias, R., Kapur, P., Pedrosa, I. & Brugarolas, J., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Hospices
Renal Cell Carcinoma
Immunotherapy
Infection
8 Citations (Scopus)

Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy

Mohamad, O., Diaz de Leon, A., Schroeder, S., Leiker, A., Christie, A., Zhang-Velten, E., Trivedi, L., Khan, S., Desai, N. B., Laine, A., Albuquerque, K., Iyengar, P., Arriaga, Y., Courtney, K., Gerber, D. E., Hammers, H., Choy, H., Timmerman, R., Brugarolas, J. & Hannan, R., Mar 10 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Radiotherapy
Safety
Disease-Free Survival
Fatigue
Melanoma
Radiosurgery
Renal Cell Carcinoma
Neoplasm Metastasis
Brain
Radiotherapy
43 Citations (Scopus)

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Puertollano, R., Ferguson, S. M., Brugarolas, J. & Ballabio, A., Jun 1 2018, In : EMBO Journal. 37, 11, e98804.

Research output: Contribution to journalReview article

Phosphorylation
Polytetrafluoroethylene
Transcription Factors
Lysosomes
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
5 Citations (Scopus)

What is the role of nephrectomy following complete response to checkpoint inhibitors?

Woldu, S. L., Brugarolas, J., Kapur, P. & Margulis, V., May 1 2018, In : Urology Case Reports. 18, p. 60-63 4 p.

Research output: Contribution to journalArticle

Nephrectomy
Renal Cell Carcinoma
1 Citation (Scopus)

Whole-body MRI for metastatic cancer detection using T2-weighted imaging with fat and fluid suppression

Wang, X., Pirasteh, A., Brugarolas, J., Rofsky, N. M., Lenkinski, R. E., Pedrosa, I. & Madhuranthakam, A. J., Oct 1 2018, In : Magnetic Resonance in Medicine. 80, 4, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

Fats
Neoplasms
Whole Body Imaging
Body Image
Renal Cell Carcinoma
2017
15 Citations (Scopus)

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
Renal Cell Carcinoma
Neoplasms
Fats
Lipids
Lipid Metabolism
9 Citations (Scopus)

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

Eckel-Passow, J. E., Serie, D. J., Cheville, J. C., Ho, T. H., Kapur, P., Brugarolas, J., Thompson, R. H., Leibovich, B. C., Kwon, E. D., Joseph, R. W. & Parker, A. S., Mar 21 2017, In : BMC Urology. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Neoplasms
Renal Cell Carcinoma
Clear-cell metastatic renal cell carcinoma
Mutation
Immunohistochemistry
Emotions
Neoplasms
Hypoxia
mechanistic target of rapamycin complex 1
9 Citations (Scopus)
Tissue and Organ Procurement
Fungi
Magnetic Resonance Imaging
Technology
Kidney
12 Citations (Scopus)
Hydroxymethylglutaryl CoA Reductases
Hypoxia-Inducible Factor 1
Transcription
Liver
Genes
29 Citations (Scopus)

Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade

Gu, Y. F., Cohn, S., Christie, A., McKenzie, T., Wolff, N., Do, Q. N., Madhuranthakam, A. J., Pedrosa, I., Wang, T., Dey, A., Busslinger, M., Xie, X-J., Hammer, R. E., McKay, R. M., Kapur, P. & Brugarolas, J. B., 2017, In : Cancer Discovery. 7, 8, p. 900-917 18 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Bowman Capsule
Carcinogenesis
Alleles
12 Citations (Scopus)

Multicenter validation of enhancer of zeste homolog 2 expression as an independent prognostic marker in localized clear cell renal cell carcinoma

Ho, T. H., Eckel-Passow, J. E., Cheville, J. C., Houston Thompson, R., Kapur, P., Christie, A., Panwar, V., Brugarolas, J., Homayoun, F., Joseph, R. W., Serie, D. J. & Parker, A. S., Nov 10 2017, In : Journal of Clinical Oncology. 35, 32, p. 3706-3713 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Necrosis
Atlases
Neoplasms
Enhancer of Zeste Homolog 2 Protein
39 Citations (Scopus)

Multistep regulation of TFEB by MTORC1

Vega-Rubin-de-Celis, S., Peña-Llopis, S., Konda, M. & Brugarolas, J., Mar 4 2017, (Accepted/In press) In : Autophagy. p. 1-9 9 p.

Research output: Contribution to journalArticle

Mutation
Lysosomes
Cytoplasm
Phosphorylation
In Vitro Techniques
19 Citations (Scopus)

Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases

Wang, C. J., Christie, A., Lin, M-H., Jung, M., Weix, D., Huelsmann, L., Kuhn, K., Meyer, J. J., Desai, N. B., Kim, D. W. N., Pedrosa, I., Margulis, V., Cadeddu, J. A., Sagalowsky, A. I., Gahan, J., Laine, A. M., Xie, X-J., Choy, H., Brugarolas, J. B., Timmerman, R. & 1 others, Hannan, R., May 1 2017, In : International Journal of Radiation Oncology Biology Physics. 98, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

metastasis
Renal Cell Carcinoma
radiation therapy
safety
Radiotherapy
3 Citations (Scopus)
Decision Trees
Neoplasm Grading
Renal Cell Carcinoma
Cluster Analysis
Magnetic Resonance Imaging
2016
58 Citations (Scopus)

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression

Joseph, R. W., Kapur, P., Serie, D. J., Parasramka, M., Ho, T. H., Cheville, J. C., Frenkel, E., Parker, A. S. & Brugarolas, J., Jan 1 2016, In : Journal of Urology. 195, 1, p. 180-187 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Proportional Hazards Models
Necrosis
Immunohistochemistry
6 Citations (Scopus)

Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma

De Velasco, G., Xie, W., Donskov, F., Albiges, L., Beuselinck, B., Srinivas, S., Agarwal, N., Lee, J. L., Brugarolas, J., Wood, L. A., Rha, S. Y., Kollmannsberger, C., North, S., Kanesvaran, R., Rini, B. I., Broom, R., Yamamoto, H., Kaymakcalan, M. D., Heng, D. Y. C. & Choueiri, T. K., Nov 7 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Therapeutics
Disease Progression
Confidence Intervals
15 Citations (Scopus)

Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinoma

Tran, T. A., Leong, H. S., Pavia-Jimenez, A., Fedyshyn, S., Yang, J., Kucejova, B., Sivanand, S., Spence, P., Xie, X. J., Peña-Llopis, S., Power, N. & Brugarolas, J., 2016, In : Molecular and Cellular Biology. 36, 13, p. 1836-1855 20 p.

Research output: Contribution to journalArticle

Paracrine Communication
Fibroblast Growth Factor Receptors
Renal Cell Carcinoma
Endothelial Cells
Vascular Endothelial Growth Factor A
13 Citations (Scopus)

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

Kucejova, B., Duarte, J., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J. & Burgess, S. C., Jul 12 2016, In : Cell Reports. 16, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

Metabolism
Obesity
Insulin
Insulin Receptor
Liver
13 Citations (Scopus)
Renal Cell Carcinoma
Perfusion
Microvessels
Neoplasms
Magnetic Resonance Imaging
13 Citations (Scopus)

Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies

Zhou, J., Luo, J., Wu, K., Yun, E. J., Kapur, P., Pong, R. C., Du, Y., Wang, B., Authement, C., Hernandez, E., Yang, J., Xiao, G., Cha, T. L., Wu, H. C., Wu, D., Margulis, V., Lotan, Y., Brugarolas, J. B., He, D. & Hsieh, J-T., Feb 15 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Sirolimus
Renal Cell Carcinoma
Growth
Drug Resistance
ras GTPase-Activating Proteins
12 Citations (Scopus)
Renal Cell Carcinoma
Thrombosis
Neoplasms
Survival
Thrombectomy
2 Citations (Scopus)
Renal Cell Carcinoma
Biomarkers
Therapeutics
1 Citation (Scopus)
Renal Cell Carcinoma
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Lung
Confidence Intervals
189 Citations (Scopus)

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Carcinogenesis
Genetic Suppression
Mutation
25 Citations (Scopus)
Microvessels
Magnetic Resonance Imaging
Kidney
Perfusion
Renal Cell Carcinoma
2015
12 Citations (Scopus)

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Wolff, N. C., Pavía-Jiménez, A., Tcheuyap, V. T., Alexander, S., Vishwanath, M., Christie, A., Xie, X. J., Williams, N. S., Kapur, P., Posner, B., McKay, R. M. & Brugarolas, J., 2015, In : Oncotarget. 6, 19, p. 16951-16962 12 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Lethal Genes
Synthetic Genes
Kidney Neoplasms
7 Citations (Scopus)

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
doxorubicin
response elements
Biomarkers
Doxorubicin
19 Citations (Scopus)

Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Tong, P., Wang, J., Castle, E. P., Stanton, M. L., Cheville, J. C., Jonasch, E., Brugarolas, J. & Parker, A. S., Oct 30 2015, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Histones
Lysine
Survival
Atlases
24 Citations (Scopus)

Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Parasramka, M., Cheville, J. C., Wu, K. J., Frenkel, E. P., Rakheja, D., Stefanius, K., Brugarolas, J. B. & Parker, A. S., Jan 1 2015, In : Urologic Oncology. 33, 1

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Staining and Labeling
Neoplasms
BRCA1 Protein
Immunohistochemistry
3 Citations (Scopus)

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma

Gayed, B. A., Gillen, J., Christie, A., Peña-Llopis, S., Xie, X-J., Yan, J., Karam, J. A., Raj, G., Sagalowsky, A. I., Lotan, Y., Margulis, V. & Brugarolas, J. B., Apr 3 2015, In : BMC Urology. 15, p. 24 1 p.

Research output: Contribution to journalArticle

Angiopoietin-2
Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Nephrolithiasis
Pyruvate Kinase
147 Citations (Scopus)

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Durinck, S., Stawiski, E. W., Pavía-Jiménez, A., Modrusan, Z., Kapur, P., Jaiswal, B. S., Zhang, N., Toffessi-Tcheuyap, V., Nguyen, T. T., Pahuja, K. B., Chen, Y. J., Saleem, S., Chaudhuri, S., Heldens, S., Jackson, M., Peña-Llopis, S., Guillory, J., Toy, K., Ha, C., Harris, C. J. & 21 others, Holloman, E., Hill, H. M., Stinson, J., Rivers, C. S., Janakiraman, V., Wang, W., Kinch, L. N., Grishin, N. V., Haverty, P. M., Chow, B., Gehring, J. S., Reeder, J., Pau, G., Wu, T. D., Margulis, V., Lotan, Y., Sagalowsky, A. I., Pedrosa, I., De Sauvage, F. J., Brugarolas, J. B. & Seshagiri, S., 2015, In : Nature Genetics. 47, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Genes
Exome
RNA Sequence Analysis
Mutation