• 7979 Citations
  • 39 h-Index
19952020

Research output per year

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Research Output

2020
Open Access
1 Scopus citations
2019

DEFOR: Depth- and frequency-based somatic copy number alteration detector

Zhang, H., Zhan, X., Brugarolas, J. & Xie, Y., Oct 1 2019, In : Bioinformatics. 35, 19, p. 3824-3825 2 p.

Research output: Contribution to journalArticle

Open Access

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, B. P. C. & Hsieh, J. T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights

Carlo, M. I., Hakimi, A. A., Stewart, G. D., Bratslavsky, G., Brugarolas, J. B., Chen, Y. B., Linehan, W. M., Maher, E. R., Merino, M. J., Offit, K., Reuter, V. E., Shuch, B. & Coleman, J. A., Jan 1 2019, In : European urology.

Research output: Contribution to journalReview article

7 Scopus citations
3 Scopus citations

Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess

Patel, A. R., Connors, S., Wardak, Z., Brugarolas, J. B. & Patel, T. R., Sep 1 2019, In : World Neurosurgery. 129, p. 354-358 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations
Open Access
8 Scopus citations

Scina: Semi-supervised analysis of single cells in silico

Zhang, Z., Luo, D., Zhong, X., Choi, J. H., Ma, Y., Wang, S., Mahrt, E., Guo, W., Stawiski, E. W., Modrusan, Z., Seshagiri, S., Kapur, P., Hon, G. C., Brugarolas, J. & Wang, T., Jul 1 2019, In : Genes. 10, 7, 531.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
3 Scopus citations
2018

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Wang, T., Lu, R., Kapur, P., Jaiswal, B. S., Hannan, R., Zhang, Z., Pedrosa, I., Luke, J. J., Zhang, H., Goldstein, L. D., Yousuf, Q., Gu, Y. F., McKenzie, T., Joyce, A., Kim, M. S., Wang, X., Luo, D., Onabolu, O., Stevens, C., Xie, Z. & 11 others, Chen, M., Filatenkov, A., Torrealba, J., Luo, X., Guo, W., He, J., Stawiski, E., Modrusan, Z., Durinck, S., Seshagiri, S. & Brugarolas, J., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study

Woldu, S. L., Matulay, J. T., Clinton, T. N., Singla, N., Freifeld, Y., Sanli, O. M., Krabbe, L. M., Hutchinson, R. C., Lotan, Y., Hammers, H., Hannan, R., Brugarolas, J. B., Bagrodia, A. & Margulis, V., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Personalized Management of Advanced Kidney Cancer

Graham, J., Heng, D. Y. C., Brugarolas, J. B. & Vaishampayan, U., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 330-341 12 p.

Research output: Contribution to journalReview article

5 Scopus citations

Perspectives in immunotherapy: Meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)

Ascierto, P. A., Brugarolas, J., Buonaguro, L., Butterfield, L. H., Carbone, D., Daniele, B., Ferris, R., Fox, B. A., Galon, J., Gridelli, C., Kaufman, H. L., Klebanoff, C. A., Melero, I., Nathan, P., Paulos, C. M., Ruella, M., Sullivan, R., Zarour, H. & Puzanov, I., Jul 11 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 69.

Research output: Contribution to journalReview article

5 Scopus citations

Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2a antagonist in patients with previously treated advanced clear cell renal cell carcinoma

Courtney, K. D., Infante, J. R., Lam, E. T., Figlin, R. A., Rini, B. I., Brugarolas, J., Zojwalla, N. J., Lowe, A. M., Wang, K., Wallace, E. M., Josey, J. A. & Choueiri, T. K., Jan 1 2018, In : Journal of Clinical Oncology. 36, 9, p. 867-874 8 p.

Research output: Contribution to journalArticle

68 Scopus citations
8 Scopus citations

Renal-Cell Carcinoma Pseudoprogression With Clinical Deterioration: To Hospice and Back

Elias, R., Kapur, P., Pedrosa, I. & Brugarolas, J., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

3 Scopus citations

Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy

Mohamad, O., Diaz de Leon, A., Schroeder, S., Leiker, A., Christie, A., Zhang-Velten, E., Trivedi, L., Khan, S., Desai, N. B., Laine, A., Albuquerque, K., Iyengar, P., Arriaga, Y., Courtney, K., Gerber, D. E., Hammers, H., Choy, H., Timmerman, R., Brugarolas, J. & Hannan, R., Jul 3 2018, In : OncoImmunology. 7, 7, e1440168.

Research output: Contribution to journalArticle

9 Scopus citations

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Puertollano, R., Ferguson, S. M., Brugarolas, J. & Ballabio, A., Jun 1 2018, In : EMBO Journal. 37, 11, e98804.

Research output: Contribution to journalReview article

51 Scopus citations

What is the role of nephrectomy following complete response to checkpoint inhibitors?

Woldu, S. L., Brugarolas, J., Kapur, P. & Margulis, V., May 1 2018, In : Urology Case Reports. 18, p. 60-63 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Whole-body MRI for metastatic cancer detection using T2-weighted imaging with fat and fluid suppression

Wang, X., Pirasteh, A., Brugarolas, J., Rofsky, N. M., Lenkinski, R. E., Pedrosa, I. & Madhuranthakam, A. J., Oct 1 2018, In : Magnetic Resonance in Medicine. 80, 4, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI Insight. 2, 15

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

Eckel-Passow, J. E., Serie, D. J., Cheville, J. C., Ho, T. H., Kapur, P., Brugarolas, J., Thompson, R. H., Leibovich, B. C., Kwon, E. D., Joseph, R. W. & Parker, A. S., Mar 21 2017, In : BMC Urology. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
11 Scopus citations
15 Scopus citations

Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade

Gu, Y. F., Cohn, S., Christie, A., McKenzie, T., Wolff, N., Do, Q. N., Madhuranthakam, A. J., Pedrosa, I., Wang, T., Dey, A., Busslinger, M., Xie, X-J., Hammer, R. E., McKay, R. M., Kapur, P. & Brugarolas, J. B., 2017, In : Cancer Discovery. 7, 8, p. 900-917 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Multicenter validation of enhancer of zeste homolog 2 expression as an independent prognostic marker in localized clear cell renal cell carcinoma

Ho, T. H., Eckel-Passow, J. E., Cheville, J. C., Houston Thompson, R., Kapur, P., Christie, A., Panwar, V., Brugarolas, J., Homayoun, F., Joseph, R. W., Serie, D. J. & Parker, A. S., Nov 10 2017, In : Journal of Clinical Oncology. 35, 32, p. 3706-3713 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Multistep regulation of TFEB by MTORC1

Vega-Rubin-de-Celis, S., Peña-Llopis, S., Konda, M. & Brugarolas, J., Mar 4 2017, (Accepted/In press) In : Autophagy. p. 1-9 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases

Wang, C. J., Christie, A., Lin, M-H., Jung, M., Weix, D., Huelsmann, L., Kuhn, K., Meyer, J. J., Desai, N. B., Kim, D. W. N., Pedrosa, I., Margulis, V., Cadeddu, J. A., Sagalowsky, A. I., Gahan, J., Laine, A. M., Xie, X-J., Choy, H., Brugarolas, J. B., Timmerman, R. & 1 others, Hannan, R., May 1 2017, In : International Journal of Radiation Oncology Biology Physics. 98, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
3 Scopus citations
2016

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression

Joseph, R. W., Kapur, P., Serie, D. J., Parasramka, M., Ho, T. H., Cheville, J. C., Frenkel, E., Parker, A. S. & Brugarolas, J., Jan 1 2016, In : Journal of Urology. 195, 1, p. 180-187 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma

De Velasco, G., Xie, W., Donskov, F., Albiges, L., Beuselinck, B., Srinivas, S., Agarwal, N., Lee, J. L., Brugarolas, J., Wood, L. A., Rha, S. Y., Kollmannsberger, C., North, S., Kanesvaran, R., Rini, B. I., Broom, R., Yamamoto, H., Kaymakcalan, M. D., Heng, D. Y. C. & Choueiri, T. K., Nov 7 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

6 Scopus citations

Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinoma

Tran, T. A., Leong, H. S., Pavia-Jimenez, A., Fedyshyn, S., Yang, J., Kucejova, B., Sivanand, S., Spence, P., Xie, X. J., Peña-Llopis, S., Power, N. & Brugarolas, J., 2016, In : Molecular and Cellular Biology. 36, 13, p. 1836-1855 20 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

Kucejova, B., Duarte, J., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J. & Burgess, S. C., Jul 12 2016, In : Cell Reports. 16, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
15 Scopus citations

Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies

Zhou, J., Luo, J., Wu, K., Yun, E. J., Kapur, P., Pong, R. C., Du, Y., Wang, B., Authement, C., Hernandez, E., Yang, J., Xiao, G., Cha, T. L., Wu, H. C., Wu, D., Margulis, V., Lotan, Y., Brugarolas, J. B., He, D. & Hsieh, J-T., Feb 15 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

13 Scopus citations
13 Scopus citations
3 Scopus citations
1 Scopus citations

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

205 Scopus citations
25 Scopus citations
2015

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Wolff, N. C., Pavía-Jiménez, A., Tcheuyap, V. T., Alexander, S., Vishwanath, M., Christie, A., Xie, X. J., Williams, N. S., Kapur, P., Posner, B., McKay, R. M. & Brugarolas, J., Jan 1 2015, In : Oncotarget. 6, 19, p. 16951-16962 12 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

7 Scopus citations

Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Tong, P., Wang, J., Castle, E. P., Stanton, M. L., Cheville, J. C., Jonasch, E., Brugarolas, J. & Parker, A. S., Oct 30 2015, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

20 Scopus citations

Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Parasramka, M., Cheville, J. C., Wu, K. J., Frenkel, E. P., Rakheja, D., Stefanius, K., Brugarolas, J. B. & Parker, A. S., Jan 1 2015, In : Urologic Oncology: Seminars and Original Investigations. 33, 1, p. 23.e9-23.e14

Research output: Contribution to journalArticle

25 Scopus citations

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma

Gayed, B. A., Gillen, J., Christie, A., Peña-Llopis, S., Xie, X-J., Yan, J., Karam, J. A., Raj, G., Sagalowsky, A. I., Lotan, Y., Margulis, V. & Brugarolas, J. B., Apr 3 2015, In : BMC Urology. 15, p. 24 1 p.

Research output: Contribution to journalArticle

3 Scopus citations