• 7914 Citations
  • 39 h-Index
19952019

Research output per year

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Research Output

1995

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannon, G. J., Oct 12 1995, In : Nature. 377, 6549, p. 552-557 6 p.

Research output: Contribution to journalLetter

1082 Scopus citations
1996

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

Attardi, L. D., Lowe, S. W., Brugarolas, J. & Jacks, T., Jul 15 1996, In : EMBO Journal. 15, 14, p. 3693-3701 9 p.

Research output: Contribution to journalArticle

239 Scopus citations
1997

Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality

Montes de Oca Luna, R., Amelse, L. L., Chavez-Reyes, A., Evans, S. C., Brugarolas, J., Jacks, T. & Lozano, G., Aug 1 1997, In : Nature genetics. 16, 4, p. 336-337 2 p.

Research output: Contribution to journalArticle

16 Scopus citations

Double indemnity: p53, BRCA and cancer

Brugarolas, J. & Jacks, T., Jul 1 1997, In : Nature medicine. 3, 7, p. 721-722 2 p.

Research output: Contribution to journalShort survey

98 Scopus citations
1998

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm(-/-) mice

Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T. & Baltimore, D., Jul 1998, In : Molecular and cellular biology. 18, 7, p. 4385-4390 6 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells

Brugarolas, J., Bronson, R. T. & Jacks, T., Apr 20 1998, In : Journal of Cell Biology. 141, 2, p. 503-514 12 p.

Research output: Contribution to journalArticle

129 Scopus citations
1999

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after γ-irradiation

Brugarolas, J., Moberg, K., Boyd, S. D., Taya, Y., Jacks, T. & Lees, J. A., Feb 2 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 3, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

The cyclin kinase inhibitor p21(CIP1/WAF1) limits glomerular epithelial cell proliferation in experimental glomerulonephritis

Yoon-Goo, K., Alpers, C. E., Brugarolas, J., Johnson, R. J., Couser, W. G. & Shankland, S. J., Jan 1 1999, In : Kidney international. 55, 6, p. 2349-2361 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

The cyclin kinase inhibitor p21(WAF1/CIP1) is required for glomerular hypertrophy in experimental diabetic nephropathy

Al-Douahji, M., Brugarolas, J., Brown, P. A. J., Stehman-Breen, C. O., Alpers, C. E. & Shankland, S. J., Jan 1 1999, In : Kidney international. 56, 5, p. 1691-1699 9 p.

Research output: Contribution to journalArticle

83 Scopus citations
2001

Towards a genomic-based diagnosis

Brugarolas, J., Haynes, B. F. & Nevins, J. R., Jan 27 2001, In : Lancet. 357, 9252, p. 249-250 2 p.

Research output: Contribution to journalComment/debate

13 Scopus citations
2003

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R. & Kaelin, W. G., Aug 1 2003, In : Cancer Cell. 4, 2, p. 147-158 12 p.

Research output: Contribution to journalArticle

417 Scopus citations

Using "rationally designed drugs" rationally

Brugarolas, J., Clark, J. W. & Chabner, B., May 24 2003, In : Lancet. 361, 9371, p. 1758-1759 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
2004

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J. & Kaelin, W. G., Jul 2004, In : Cancer Cell. 6, 1, p. 7-10 4 p.

Research output: Contribution to journalReview article

134 Scopus citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Majumder, P. K., Febbo, P. G., Bikoff, R., Berger, R., Xue, Q., McMahon, L. M., Manolal, J., Brugarolas, J., J McDonnell, T., Golub, T. R., Loda, M., Lane, H. A. & Sellers, W. R., Jun 1 2004, In : Nature medicine. 10, 6, p. 594-601 8 p.

Research output: Contribution to journalArticle

778 Scopus citations

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. & Kaelin, W. G., Dec 1 2004, In : Genes and Development. 18, 23, p. 2893-2904 12 p.

Research output: Contribution to journalArticle

847 Scopus citations
2007

Renal-cell carcinoma - Molecular pathways and therapies

Brugarolas, J., Jan 11 2007, In : New England Journal of Medicine. 356, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorial

217 Scopus citations
2008

In reply

Brugarolas, J., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5653-5654 2 p.

Research output: Contribution to journalLetter

Sirolimus in metatastic renal cell carcinoma

Brugarolas, J. B., Lotan, Y., Watumull, L. M. & Kabbani, W., Sep 15 2008, In : Journal of Clinical Oncology. 26, 20, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1

Zhou, J., Brugarolas, J. & Parada, L. F., Nov 9 2009, In : Human molecular genetics. 18, 22, p. 4428-4441 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
2010

Sirolimus and temsirolimus for epithelioid angiomyolipoma

Wolff, N., Kabbani, W., Bradley, T., Raj, G., Watumull, L. & Brugarolas, J., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. e65-e68

Research output: Contribution to journalArticle

48 Scopus citations

Structural analysis and functional implications of the negative mTORC1 regulator REDD1

Vega-Rubin-de-Celis, S., Abdallah, Z., Kinch, L., Grishin, N. V., Brugarolas, J. & Zhang, X., Mar 23 2010, In : Biochemistry. 49, 11, p. 2491-2501 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
2011

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

Wolff, N. C., Vega-Rubin-de-Celis, S., Xie, X. J., Castrillon, D. H., Kabbani, W. & Brugarolas, J., May 2011, In : Molecular and cellular biology. 31, 9, p. 1870-1884 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

Mata, M. A., Satterly, N., Versteeg, G. A., Frantz, D., Wei, S., Williams, N., Schmolke, M., Peña-Llopis, S., Brugarolas, J., Forst, C. V., White, M. A., García-Sastre, A., Roth, M. G. & Fontoura, B. M. A., Oct 2011, In : Nature chemical biology. 7, 10, p. 712-719 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

Yamasaki, T., Tran, T. A. T., Oz, O. K., Raj, G. V., Schwarz, R. E., DeBerardinis, R. J., Zhang, X. & Brugarolas, J., Apr 1 2011, In : Nature Reviews Urology. 8, 3, p. 165-171 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma

Kucejova, B., Peña-Llopis, S., Yamasaki, T., Sivanand, S., Tran, T. A. T., Alexander, S., Wolff, N. C., Lotan, Y., Xie, X-J., Kabbani, W., Kapur, P. & Brugarolas, J. B., Sep 1 2011, In : Molecular Cancer Research. 9, 9, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

mMTORC1 activation in childhood ependymoma and response to sirolimus

Bowers, D. C., Kucejova, B., Margraf, L., Gargan, L. & Brugarolas, J., Jul 1 2011, In : Journal of Neuro-Oncology. 103, 3, p. 797-801 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Regulation of TFEB and V-ATPases by mTORC1

Peña-Llopis, S., Vega-Rubin-De-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X. J., Corey, D. R. & Brugarolas, J., Aug 17 2011, In : EMBO Journal. 30, 16, p. 3242-3258 17 p.

Research output: Contribution to journalArticle

248 Scopus citations

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

Kinch, L., Grishin, N. V. & Brugarolas, J., Oct 18 2011, In : Cancer Cell. 20, 4, p. 418-420 3 p.

Research output: Contribution to journalShort survey

51 Scopus citations

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

Peña-Llopis, S. & Brugarolas, J., Dec 1 2011, In : Cell Cycle. 10, 23, p. 3987-3988 2 p.

Research output: Contribution to journalEditorial

24 Scopus citations

The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval tumor thrombus

Cost, N. G., Delacroix, S. E., Sleeper, J. P., Smith, P. J., Youssef, R. F., Chapin, B. F., Karam, J. A., Culp, S., Abel, E. J., Brugarolas, J. B., Raj, G., Sagalowsky, A. I., Wood, C. G. & Margulis, V., Jun 1 2011, In : European urology. 59, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

Kucejova, B., Sunny, N. E., Nguyen, A. D., Hallac, R., Fu, X., Pẽa-Llopis, S., Mason, R. P., Deberardinis, R. J., Xie, X. J., Debose-Boyd, R., Kodibagkar, V. D., Burgess, S. C. & Brugarolas, J., May 5 2011, In : Oncogene. 30, 18, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2012

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma

Sivanand, S., Peña-Llopis, S., Zhao, H., Kucejova, B., Spence, P., Pavia-Jimenez, A., Yamasaki, T., McBride, D. J., Gillen, J., Wolff, N. C., Morlock, L., Lotan, Y., Raj, G., Sagalowsky, A. I., Margulis, V., Cadeddu, J. A., Ross, M. T., Bentley, D. R., Kabbani, W., Xie, X-J. & 3 others, Kapur, P., Williams, N. S. & Brugarolas, J. B., Jun 6 2012, In : Science Translational Medicine. 4, 137, 137ra75.

Research output: Contribution to journalArticle

113 Scopus citations

BAP1 loss defines a new class of renal cell carcinoma

Peña-Llopis, S., Vega-Rubín-De-Celis, S., Liao, A., Leng, N., Pavía-Jiménez, A., Wang, S., Yamasaki, T., Zhrebker, L., Sivanand, S., Spence, P., Kinch, L., Hambuch, T., Jain, S., Lotan, Y., Margulis, V., Sagalowsky, A. I., Summerour, P. B., Kabbani, W., Wong, S. W. W., Grishin, N. V. & 7 others, Laurent, M., Xie, X-J., Haudenschild, C. D., Ross, M. T., Bentley, D. R., Kapur, P. & Brugarolas, J. B., Jul 1 2012, In : Nature genetics. 44, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

475 Scopus citations

Research translation and personalized medicine

Brugarolas, J., Nov 1 2012, Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets. Springer US, Vol. 9781461424000. p. 161-191 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

State of the science: An update on renal cell carcinoma

Jonasch, E., Futreal, P. A., Davis, I. J., Bailey, S. T., Kim, W. Y., Brugarolas, J., Giaccia, A. J., Kurban, G., Pause, A., Frydman, J., Zurita, A. J., Rini, B. I., Sharma, P., Atkins, M. B., Walker, C. L. & Rathmell, W. K., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 859-880 22 p.

Research output: Contribution to journalReview article

113 Scopus citations
2013

Ablation of a site of progression with stereotactic body radiation therapy extends sunitinib treatment from 14 to 22 months

Straka, C., Kim, D. W. N., Timmerman, R. D., Pedrosa, I., Jacobs, C. & Brugarolas, J., Aug 10 2013, In : Journal of Clinical Oncology. 31, 23, p. e401-e403

Research output: Contribution to journalArticle

21 Scopus citations

A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma

Farley, M. N., Schmidt, L. S., Mester, J. L., Peña-Llopis, S., Pavia-Jimenez, A., Christie, A., Vocke, C. D., Ricketts, C. J., Peterson, J., Middelton, L., Kinch, L., Grishin, N., Merino, M. J., Metwalli, A. R., Xing, C., Xie, X. J., Dahia, P. L. M., Eng, C., Linehan, W. M. & Brugarolas, J., Sep 1 2013, In : Molecular Cancer Research. 11, 9, p. 1061-1071 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

Cooperation and antagonism among cancer genes: The renal cancer paradigm

Peña-Llopis, S., Christie, A., Xie, X. J. & Brugarolas, J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4173-4179 7 p.

Research output: Contribution to journalReview article

46 Scopus citations

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation

Kapur, P., Peña-Llopis, S., Christie, A., Zhrebker, L., Pavía-Jiménez, A., Rathmell, W. K., Xie, X. J. & Brugarolas, J., Feb 1 2013, In : The Lancet Oncology. 14, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

240 Scopus citations

Metabolism of kidney cancer: From the lab to clinical practice

Sudarshan, S., Karam, J. A., Brugarolas, J., Thompson, R. H., Uzzo, R., Rini, B., Margulis, V., Patard, J. J., Escudier, B. & Linehan, W. M., Feb 1 2013, In : European urology. 63, 2, p. 244-251 8 p.

Research output: Contribution to journalReview article

45 Scopus citations

PBRM1 and BAP1 as novel targets for renal cell carcinoma

Brugarolas, J., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 324-332 9 p.

Research output: Contribution to journalReview article

58 Scopus citations

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

Tran, T. A., Kinch, L., Peña-Llopis, S., Kockel, L., Grishin, N., Jiang, H. & Brugarolas, J., Nov 6 2013, In : Molecular and cellular biology. 33, 19, p. 3762-3779 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prolonged survival of a patient with papillary renal cell carcinoma and brain metastases using pazopanib

Jacobs, C., Kim, D. W. N., Straka, C., Timmerman, R. D. & Brugarolas, J., Mar 1 2013, In : Journal of Clinical Oncology. 31, 7, p. e114-e117

Research output: Contribution to journalArticle

17 Scopus citations

Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications

Peña-Llopis, S. & Brugarolas, J., Nov 8 2013, In : Nature Protocols. 8, 11, p. 2240-2255 16 p.

Research output: Contribution to journalArticle

38 Scopus citations

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

Hasan, M., Koch, J., Rakheja, D., Pattnaik, A. K., Brugarolas, J. B., Dozmorov, I., Levine, B., Wakeland, E. K., Lee-Kirsch, M. A. & Yan, N., Jan 1 2013, In : Nature immunology. 14, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

94 Scopus citations
2014

BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma

Kapur, P., Christie, A., Raman, J. D., Then, M. T., Nuhn, P., Buchner, A., Bastian, P., Seitz, C., Shariat, S. F., Bensalah, K., Rioux-Leclercq, N., Xie, X-J., Lotan, Y., Margulis, V. & Brugarolas, J. B., Mar 1 2014, In : Journal of Urology. 191, 3, p. 603-610 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Wang, S. S., Gu, Y. F., Wolff, N., Stefanius, K., Christie, A., Dey, A., Hammer, R. E., Xie, X-J., Rakheja, D., Pedrosa, I., Carroll, T. J., McKay, R. M., Kapur, P. & Brugarolas, J. B., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16538-16543 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing

Pavía-Jiménez, A., Tcheuyap, V. T. & Brugarolas, J., Aug 2014, In : Nature Protocols. 9, 8, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma

Joseph, R. W., Kapur, P., Serie, D. J., Eckel-Passow, J. E., Parasramka, M., Ho, T., Cheville, J. C., Frenkel, E. P., Rakheja, D., Brugarolas, J. B. & Parker, A., Jan 1 2014, In : Cancer. 120, 7, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Molecular genetics of clear-cell renal cell carcinoma

Brugarolas, J., Jun 20 2014, In : Journal of Clinical Oncology. 32, 18, p. 1968-1976 9 p.

Research output: Contribution to journalArticle

143 Scopus citations