• 7832 Citations
  • 39 h-Index
19952019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 7832 Citations
  • 39 h-Index
  • 96 Article
  • 5 Review article
  • 2 Comment/debate
  • 1 Chapter
21 Scopus citations

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Wang, T., Lu, R., Kapur, P., Jaiswal, B. S., Hannan, R., Zhang, Z., Pedrosa, I., Luke, J. J., Zhang, H., Goldstein, L. D., Yousuf, Q., Gu, Y. F., McKenzie, T., Joyce, A., Kim, M. S., Wang, X., Luo, D., Onabolu, O., Stevens, C., Xie, Z. & 11 others, Chen, M., Filatenkov, A., Torrealba, J., Luo, X., Guo, W., He, J., Stawiski, E., Modrusan, Z., Durinck, S., Seshagiri, S. & Brugarolas, J., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1142-1155 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma

Farley, M. N., Schmidt, L. S., Mester, J. L., Peña-Llopis, S., Pavia-Jimenez, A., Christie, A., Vocke, C. D., Ricketts, C. J., Peterson, J., Middelton, L., Kinch, L., Grishin, N., Merino, M. J., Metwalli, A. R., Xing, C., Xie, X. J., Dahia, P. L. M., Eng, C., Linehan, W. M. & Brugarolas, J., Sep 2013, In : Molecular Cancer Research. 11, 9, p. 1061-1071 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma

Sivanand, S., Peña-Llopis, S., Zhao, H., Kucejova, B., Spence, P., Pavia-Jimenez, A., Yamasaki, T., McBride, D. J., Gillen, J., Wolff, N. C., Morlock, L., Lotan, Y., Raj, G., Sagalowsky, A. I., Margulis, V., Cadeddu, J. A., Ross, M. T., Bentley, D. R., Kabbani, W., Xie, X-J. & 3 others, Kapur, P., Williams, N. S. & Brugarolas, J. B., Jun 6 2012, In : Science Translational Medicine. 4, 137, 137ra75.

Research output: Contribution to journalArticle

112 Scopus citations

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

Eckel-Passow, J. E., Serie, D. J., Cheville, J. C., Ho, T. H., Kapur, P., Brugarolas, J., Thompson, R. H., Leibovich, B. C., Kwon, E. D., Joseph, R. W. & Parker, A. S., Mar 21 2017, In : BMC Urology. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma

Kapur, P., Christie, A., Raman, J. D., Then, M. T., Nuhn, P., Buchner, A., Bastian, P., Seitz, C., Shariat, S. F., Bensalah, K., Rioux-Leclercq, N., Xie, X-J., Lotan, Y., Margulis, V. & Brugarolas, J. B., Mar 2014, In : Journal of Urology. 191, 3, p. 603-610 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Wang, S. S., Gu, Y. F., Wolff, N., Stefanius, K., Christie, A., Dey, A., Hammer, R. E., Xie, X-J., Rakheja, D., Pedrosa, I., Carroll, T. J., McKay, R. M., Kapur, P. & Brugarolas, J. B., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16538-16543 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

BAP1 loss defines a new class of renal cell carcinoma

Peña-Llopis, S., Vega-Rubín-De-Celis, S., Liao, A., Leng, N., Pavía-Jiménez, A., Wang, S., Yamasaki, T., Zhrebker, L., Sivanand, S., Spence, P., Kinch, L., Hambuch, T., Jain, S., Lotan, Y., Margulis, V., Sagalowsky, A. I., Summerour, P. B., Kabbani, W., Wong, S. W. W., Grishin, N. V. & 7 others, Laurent, M., Xie, X-J., Haudenschild, C. D., Ross, M. T., Bentley, D. R., Kapur, P. & Brugarolas, J. B., Jul 2012, In : Nature Genetics. 44, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

469 Scopus citations

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

Wolff, N. C., Vega-Rubin-de-Celis, S., Xie, X. J., Castrillon, D. H., Kabbani, W. & Brugarolas, J., May 2011, In : Molecular and Cellular Biology. 31, 9, p. 1870-1884 15 p.

Research output: Contribution to journalArticle

48 Scopus citations

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

Mata, M. A., Satterly, N., Versteeg, G. A., Frantz, D., Wei, S., Williams, N., Schmolke, M., Peña-Llopis, S., Brugarolas, J., Forst, C. V., White, M. A., García-Sastre, A., Roth, M. G. & Fontoura, B. M. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 712-719 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression

Joseph, R. W., Kapur, P., Serie, D. J., Parasramka, M., Ho, T. H., Cheville, J. C., Frenkel, E., Parker, A. S. & Brugarolas, J., Jan 1 2016, In : Journal of Urology. 195, 1, p. 180-187 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J. B., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Cooperation and antagonism among cancer genes: The renal cancer paradigm

Peña-Llopis, S., Christie, A., Xie, X. J. & Brugarolas, J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4173-4179 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

DEFOR: Depth- and frequency-based somatic copy number alteration detector

Zhang, H., Zhan, X., Brugarolas, J. & Xie, Y., Oct 1 2019, In : Bioinformatics. 35, 19, p. 3824-3825 2 p.

Research output: Contribution to journalArticle

Open Access

Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality.

Montes de Oca Luna, R., Amelse, L. L., Chavez-Reyes, A., Evans, S. C., Brugarolas, J., Jacks, T. & Lozano, G., Aug 1997, In : Nature Genetics. 16, 4, p. 336-337 2 p.

Research output: Contribution to journalArticle

16 Scopus citations
10 Scopus citations

Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma

De Velasco, G., Xie, W., Donskov, F., Albiges, L., Beuselinck, B., Srinivas, S., Agarwal, N., Lee, J. L., Brugarolas, J., Wood, L. A., Rha, S. Y., Kollmannsberger, C., North, S., Kanesvaran, R., Rini, B. I., Broom, R., Yamamoto, H., Kaymakcalan, M. D., Heng, D. Y. C. & Choueiri, T. K., Nov 7 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

6 Scopus citations

Double indemnity: p53, BRCA and cancer

Brugarolas, J. & Jacks, T., Jul 1997, In : Nature Medicine. 3, 7, p. 721-722 2 p.

Research output: Contribution to journalArticle

98 Scopus citations

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J. B., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, P. B. & Hsieh, J-T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J. & Kaelin, W. G., Jul 2004, In : Cancer Cell. 6, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

134 Scopus citations

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation

Kapur, P., Peña-Llopis, S., Christie, A., Zhrebker, L., Pavía-Jiménez, A., Rathmell, W. K., Xie, X. J. & Brugarolas, J., Feb 2013, In : The Lancet Oncology. 14, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

238 Scopus citations

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing

Pavía-Jiménez, A., Tcheuyap, V. T. & Brugarolas, J., 2014, In : Nature Protocols. 9, 8, p. 1848-1859 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

Yamasaki, T., Tran, T. A. T., Oz, O. K., Raj, G. V., Schwarz, R. E., DeBerardinis, R. J., Zhang, X. & Brugarolas, J., Apr 2011, In : Nature Reviews Urology. 8, 3, p. 165-171 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights

Carlo, M. I., Hakimi, A. A., Stewart, G. D., Bratslavsky, G., Brugarolas, J. B., Chen, Y. B., Linehan, W. M., Maher, E. R., Merino, M. J., Offit, K., Reuter, V. E., Shuch, B. & Coleman, J. A., Jan 1 2019, In : European urology.

Research output: Contribution to journalReview article

2 Scopus citations

Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinoma

Tran, T. A., Leong, H. S., Pavia-Jimenez, A., Fedyshyn, S., Yang, J., Kucejova, B., Sivanand, S., Spence, P., Xie, X. J., Peña-Llopis, S., Power, N. & Brugarolas, J., 2016, In : Molecular and Cellular Biology. 36, 13, p. 1836-1855 20 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

Kucejova, B., Duarte, J., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J. & Burgess, S. C., Jul 12 2016, In : Cell Reports. 16, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Wolff, N. C., Pavía-Jiménez, A., Tcheuyap, V. T., Alexander, S., Vishwanath, M., Christie, A., Xie, X. J., Williams, N. S., Kapur, P., Posner, B., McKay, R. M. & Brugarolas, J., 2015, In : Oncotarget. 6, 19, p. 16951-16962 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
12 Scopus citations

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

7 Scopus citations
1 Scopus citations

Incidence and Outcomes of Delayed Targeted Therapy After Cytoreductive Nephrectomy for Metastatic Renal-Cell Carcinoma: A Nationwide Cancer Registry Study

Woldu, S. L., Matulay, J. T., Clinton, T. N., Singla, N., Freifeld, Y., Sanli, O. M., Krabbe, L. M., Hutchinson, R. C., Lotan, Y., Hammers, H., Hannan, R., Brugarolas, J. B., Bagrodia, A. & Margulis, V., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess

Patel, A. R., Connors, S., Wardak, Z., Brugarolas, J. B. & Patel, T. R., Sep 1 2019, In : World Neurosurgery. 129, p. 354-358 5 p.

Research output: Contribution to journalArticle

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after γ-irradiation

Brugarolas, J., Moberg, K., Boyd, S. D., Taya, Y., Jacks, T. & Lees, J. A., Feb 2 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 3, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

198 Scopus citations

In reply

Brugarolas, J., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5653-5654 2 p.

Research output: Contribution to journalArticle

Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma

Kucejova, B., Peña-Llopis, S., Yamasaki, T., Sivanand, S., Tran, T. A. T., Alexander, S., Wolff, N. C., Lotan, Y., Xie, X-J., Kabbani, W., Kapur, P. & Brugarolas, J. B., Sep 2011, In : Molecular Cancer Research. 9, 9, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
13 Scopus citations

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm(-/-) mice

Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T. & Baltimore, D., Jul 1998, In : Molecular and Cellular Biology. 18, 7, p. 4385-4390 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma

Joseph, R. W., Kapur, P., Serie, D. J., Eckel-Passow, J. E., Parasramka, M., Ho, T., Cheville, J. C., Frenkel, E. P., Rakheja, D., Brugarolas, J. B. & Parker, A., 2014, In : Cancer. 120, 7, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies

Zhou, J., Luo, J., Wu, K., Yun, E. J., Kapur, P., Pong, R. C., Du, Y., Wang, B., Authement, C., Hernandez, E., Yang, J., Xiao, G., Cha, T. L., Wu, H. C., Wu, D., Margulis, V., Lotan, Y., Brugarolas, J. B., He, D. & Hsieh, J-T., Feb 15 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

13 Scopus citations

Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Tong, P., Wang, J., Castle, E. P., Stanton, M. L., Cheville, J. C., Jonasch, E., Brugarolas, J. & Parker, A. S., Oct 30 2015, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

19 Scopus citations

Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Parasramka, M., Cheville, J. C., Wu, K. J., Frenkel, E. P., Rakheja, D., Stefanius, K., Brugarolas, J. B. & Parker, A. S., Jan 1 2015, In : Urologic Oncology. 33, 1

Research output: Contribution to journalArticle

24 Scopus citations

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1

Zhou, J., Brugarolas, J. & Parada, L. F., 2009, In : Human Molecular Genetics. 18, 22, p. 4428-4441 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Metabolism of kidney cancer: From the lab to clinical practice

Sudarshan, S., Karam, J. A., Brugarolas, J., Thompson, R. H., Uzzo, R., Rini, B., Margulis, V., Patard, J. J., Escudier, B. & Linehan, W. M., Feb 2013, In : European Urology. 63, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

mMTORC1 activation in childhood ependymoma and response to sirolimus

Bowers, D. C., Kucejova, B., Margraf, L., Gargan, L. & Brugarolas, J., Jul 2011, In : Journal of Neuro-Oncology. 103, 3, p. 797-801 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade

Gu, Y. F., Cohn, S., Christie, A., McKenzie, T., Wolff, N., Do, Q. N., Madhuranthakam, A. J., Pedrosa, I., Wang, T., Dey, A., Busslinger, M., Xie, X-J., Hammer, R. E., McKay, R. M., Kapur, P. & Brugarolas, J. B., 2017, In : Cancer Discovery. 7, 8, p. 900-917 18 p.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular genetics of clear-cell renal cell carcinoma

Brugarolas, J., Jun 20 2014, In : Journal of Clinical Oncology. 32, 18, p. 1968-1976 9 p.

Research output: Contribution to journalArticle

143 Scopus citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Majumder, P. K., Febbo, P. G., Bikoff, R., Berger, R., Xue, Q., McMahon, L. M., Manolal, J., Brugarolas, J., J McDonnell, T., Golub, T. R., Loda, M., Lane, H. A. & Sellers, W. R., Jun 2004, In : Nature Medicine. 10, 6, p. 594-601 8 p.

Research output: Contribution to journalArticle

776 Scopus citations