• 7979 Citations
  • 39 h-Index
19952020

Research output per year

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Research Output

Whole-body MRI for metastatic cancer detection using T2-weighted imaging with fat and fluid suppression

Wang, X., Pirasteh, A., Brugarolas, J., Rofsky, N. M., Lenkinski, R. E., Pedrosa, I. & Madhuranthakam, A. J., Oct 1 2018, In : Magnetic Resonance in Medicine. 80, 4, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

What is the role of nephrectomy following complete response to checkpoint inhibitors?

Woldu, S. L., Brugarolas, J., Kapur, P. & Margulis, V., May 1 2018, In : Urology Case Reports. 18, p. 60-63 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Using "rationally designed drugs" rationally

Brugarolas, J., Clark, J. W. & Chabner, B., May 24 2003, In : Lancet. 361, 9371, p. 1758-1759 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Kim, H., Rodriguez-Navas, C., Kollipara, R. K., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R. & Ye, J., Oct 20 2015, In : Cell Reports. 13, 3, p. 495-503 9 p., 2062.

Research output: Contribution to journalArticle

21 Scopus citations

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

Kucejova, B., Sunny, N. E., Nguyen, A. D., Hallac, R., Fu, X., Pẽa-Llopis, S., Mason, R. P., Deberardinis, R. J., Xie, X. J., Debose-Boyd, R., Kodibagkar, V. D., Burgess, S. C. & Brugarolas, J., May 5 2011, In : Oncogene. 30, 18, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
25 Scopus citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R. & Kaelin, W. G., Aug 1 2003, In : Cancer Cell. 4, 2, p. 147-158 12 p.

Research output: Contribution to journalArticle

419 Scopus citations

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

Hasan, M., Koch, J., Rakheja, D., Pattnaik, A. K., Brugarolas, J. B., Dozmorov, I., Levine, B., Wakeland, E. K., Lee-Kirsch, M. A. & Yan, N., Jan 1 2013, In : Nature immunology. 14, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

Attardi, L. D., Lowe, S. W., Brugarolas, J. & Jacks, T., Jul 15 1996, In : EMBO Journal. 15, 14, p. 3693-3701 9 p.

Research output: Contribution to journalArticle

239 Scopus citations

Towards a genomic-based diagnosis

Brugarolas, J., Haynes, B. F. & Nevins, J. R., Jan 27 2001, In : Lancet. 357, 9252, p. 249-250 2 p.

Research output: Contribution to journalComment/debate

13 Scopus citations

The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval tumor thrombus

Cost, N. G., Delacroix, S. E., Sleeper, J. P., Smith, P. J., Youssef, R. F., Chapin, B. F., Karam, J. A., Culp, S., Abel, E. J., Brugarolas, J. B., Raj, G., Sagalowsky, A. I., Wood, C. G. & Margulis, V., Jun 1 2011, In : European urology. 59, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

The cyclin kinase inhibitor p21(WAF1/CIP1) is required for glomerular hypertrophy in experimental diabetic nephropathy

Al-Douahji, M., Brugarolas, J., Brown, P. A. J., Stehman-Breen, C. O., Alpers, C. E. & Shankland, S. J., Jan 1 1999, In : Kidney international. 56, 5, p. 1691-1699 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

The cyclin kinase inhibitor p21(CIP1/WAF1) limits glomerular epithelial cell proliferation in experimental glomerulonephritis

Yoon-Goo, K., Alpers, C. E., Brugarolas, J., Johnson, R. J., Couser, W. G. & Shankland, S. J., Jan 1 1999, In : Kidney international. 55, 6, p. 2349-2361 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Puertollano, R., Ferguson, S. M., Brugarolas, J. & Ballabio, A., Jun 1 2018, In : EMBO Journal. 37, 11, e98804.

Research output: Contribution to journalReview article

51 Scopus citations

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

Peña-Llopis, S. & Brugarolas, J., Dec 1 2011, In : Cell Cycle. 10, 23, p. 3987-3988 2 p.

Research output: Contribution to journalEditorial

24 Scopus citations

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

Kinch, L., Grishin, N. V. & Brugarolas, J., Oct 18 2011, In : Cancer Cell. 20, 4, p. 418-420 3 p.

Research output: Contribution to journalShort survey

54 Scopus citations

Structural analysis and functional implications of the negative mTORC1 regulator REDD1

Vega-Rubin-de-Celis, S., Abdallah, Z., Kinch, L., Grishin, N. V., Brugarolas, J. & Zhang, X., Mar 23 2010, In : Biochemistry. 49, 11, p. 2491-2501 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Stereotactic radiation therapy of renal cancer inferior vena cava tumor thrombus

Hannan, R., Margulis, V., Chun, S. G., Cannon, N., Kim, D. W. N., Abdulrahman, R. E., Sagalowsky, A. I., Pedrosa, I., Choy, H., Brugarolas, J. B. & Timmerman, R., Jan 1 2015, In : Cancer Biology and Therapy. 16, 5, p. 657-661 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations
3 Scopus citations

State of the science: An update on renal cell carcinoma

Jonasch, E., Futreal, P. A., Davis, I. J., Bailey, S. T., Kim, W. Y., Brugarolas, J., Giaccia, A. J., Kurban, G., Pause, A., Frydman, J., Zurita, A. J., Rini, B. I., Sharma, P., Atkins, M. B., Walker, C. L. & Rathmell, W. K., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 859-880 22 p.

Research output: Contribution to journalReview article

113 Scopus citations

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Durinck, S., Stawiski, E. W., Pavía-Jiménez, A., Modrusan, Z., Kapur, P., Jaiswal, B. S., Zhang, N., Toffessi-Tcheuyap, V., Nguyen, T. T., Pahuja, K. B., Chen, Y. J., Saleem, S., Chaudhuri, S., Heldens, S., Jackson, M., Peña-Llopis, S., Guillory, J., Toy, K., Ha, C., Harris, C. J. & 21 others, Holloman, E., Hill, H. M., Stinson, J., Rivers, C. S., Janakiraman, V., Wang, W., Kinch, L. N., Grishin, N. V., Haverty, P. M., Chow, B., Gehring, J. S., Reeder, J., Pau, G., Wu, T. D., Margulis, V., Lotan, Y., Sagalowsky, A. I., Pedrosa, I., De Sauvage, F. J., Brugarolas, J. B. & Seshagiri, S., 2015, In : Nature Genetics. 47, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

154 Scopus citations

Sirolimus in metatastic renal cell carcinoma

Brugarolas, J. B., Lotan, Y., Watumull, L. M. & Kabbani, W., Sep 15 2008, In : Journal of Clinical Oncology. 26, 20, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sirolimus and temsirolimus for epithelioid angiomyolipoma

Wolff, N., Kabbani, W., Bradley, T., Raj, G., Watumull, L. & Brugarolas, J., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. e65-e68

Research output: Contribution to journalArticle

48 Scopus citations

Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications

Peña-Llopis, S. & Brugarolas, J., Nov 8 2013, In : Nature Protocols. 8, 11, p. 2240-2255 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Selective Efficacy of Temsirolimus on Bone Metastases in Chromophobe Renal Cell Carcinoma

Huelsmann, L., Kim, D. N. W., Hannan, R., Watumull, L. M. & Brugarolas, J., Nov 22 2014, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Scina: Semi-supervised analysis of single cells in silico

Zhang, Z., Luo, D., Zhong, X., Choi, J. H., Ma, Y., Wang, S., Mahrt, E., Guo, W., Stawiski, E. W., Modrusan, Z., Seshagiri, S., Kapur, P., Hon, G. C., Brugarolas, J. & Wang, T., Jul 1 2019, In : Genes. 10, 7, 531.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases

Wang, C. J., Christie, A., Lin, M-H., Jung, M., Weix, D., Huelsmann, L., Kuhn, K., Meyer, J. J., Desai, N. B., Kim, D. W. N., Pedrosa, I., Margulis, V., Cadeddu, J. A., Sagalowsky, A. I., Gahan, J., Laine, A. M., Xie, X-J., Choy, H., Brugarolas, J. B., Timmerman, R. & 1 others, Hannan, R., May 1 2017, In : International Journal of Radiation Oncology Biology Physics. 98, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy

Mohamad, O., Diaz de Leon, A., Schroeder, S., Leiker, A., Christie, A., Zhang-Velten, E., Trivedi, L., Khan, S., Desai, N. B., Laine, A., Albuquerque, K., Iyengar, P., Arriaga, Y., Courtney, K., Gerber, D. E., Hammers, H., Choy, H., Timmerman, R., Brugarolas, J. & Hannan, R., Jul 3 2018, In : OncoImmunology. 7, 7, e1440168.

Research output: Contribution to journalArticle

9 Scopus citations

Research translation and personalized medicine

Brugarolas, J., Nov 1 2012, Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets. Springer US, Vol. 9781461424000. p. 161-191 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
1 Scopus citations

Renal-Cell Carcinoma Pseudoprogression With Clinical Deterioration: To Hospice and Back

Elias, R., Kapur, P., Pedrosa, I. & Brugarolas, J., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

3 Scopus citations

Renal-cell carcinoma - Molecular pathways and therapies

Brugarolas, J., Jan 11 2007, In : New England Journal of Medicine. 356, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorial

218 Scopus citations
8 Scopus citations

Regulation of TFEB and V-ATPases by mTORC1

Peña-Llopis, S., Vega-Rubin-De-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X. J., Corey, D. R. & Brugarolas, J., Aug 17 2011, In : EMBO Journal. 30, 16, p. 3242-3258 17 p.

Research output: Contribution to journalArticle

249 Scopus citations

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. & Kaelin, W. G., Dec 1 2004, In : Genes and Development. 18, 23, p. 2893-2904 12 p.

Research output: Contribution to journalArticle

852 Scopus citations

REDD1/DDIT4-independent mTORC1 inhibition and apoptosis by glucocorticoids in thymocytes

Wolff, N. C., McKay, R. M. & Brugarolas, J., Jun 2014, In : Molecular Cancer Research. 12, 6, p. 867-877 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannon, G. J., Oct 12 1995, In : Nature. 377, 6549, p. 552-557 6 p.

Research output: Contribution to journalLetter

1083 Scopus citations

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma

Gayed, B. A., Gillen, J., Christie, A., Peña-Llopis, S., Xie, X-J., Yan, J., Karam, J. A., Raj, G., Sagalowsky, A. I., Lotan, Y., Margulis, V. & Brugarolas, J. B., Apr 3 2015, In : BMC Urology. 15, p. 24 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Prolonged survival of a patient with papillary renal cell carcinoma and brain metastases using pazopanib

Jacobs, C., Kim, D. W. N., Straka, C., Timmerman, R. D. & Brugarolas, J., Mar 1 2013, In : Journal of Clinical Oncology. 31, 7, p. e114-e117

Research output: Contribution to journalArticle

17 Scopus citations
3 Scopus citations

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

Tran, T. A., Kinch, L., Peña-Llopis, S., Kockel, L., Grishin, N., Jiang, H. & Brugarolas, J., Nov 6 2013, In : Molecular and cellular biology. 33, 19, p. 3762-3779 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2a antagonist in patients with previously treated advanced clear cell renal cell carcinoma

Courtney, K. D., Infante, J. R., Lam, E. T., Figlin, R. A., Rini, B. I., Brugarolas, J., Zojwalla, N. J., Lowe, A. M., Wang, K., Wallace, E. M., Josey, J. A. & Choueiri, T. K., Jan 1 2018, In : Journal of Clinical Oncology. 36, 9, p. 867-874 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Perspectives in immunotherapy: Meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)

Ascierto, P. A., Brugarolas, J., Buonaguro, L., Butterfield, L. H., Carbone, D., Daniele, B., Ferris, R., Fox, B. A., Galon, J., Gridelli, C., Kaufman, H. L., Klebanoff, C. A., Melero, I., Nathan, P., Paulos, C. M., Ruella, M., Sullivan, R., Zarour, H. & Puzanov, I., Jul 11 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 69.

Research output: Contribution to journalReview article

5 Scopus citations

Personalized Management of Advanced Kidney Cancer

Graham, J., Heng, D. Y. C., Brugarolas, J. B. & Vaishampayan, U., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 330-341 12 p.

Research output: Contribution to journalReview article

5 Scopus citations
Open Access
8 Scopus citations

PBRM1 and BAP1 as novel targets for renal cell carcinoma

Brugarolas, J., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 324-332 9 p.

Research output: Contribution to journalReview article

58 Scopus citations
1 Scopus citations